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Mutagenesis In Sub Mammalian Systems
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Book Synopsis Mutagenesis in Sub-Mammalian Systems by : G.E. Paget
Download or read book Mutagenesis in Sub-Mammalian Systems written by G.E. Paget and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Toxicology Toxicology is a science that stands at the intersection of several interests and disciplines. These intersecting forces are by no means all scientific since some are legal and some are commercial. All have valid things to say about the conduct and interpretation of toxicity experiments. The practising toxicologist must bear all these sometimes conflicting forces in mind as he carries out his duties. This is especially true, of course, of the toxicologist in industry. Toxicology is also a field in which contract research particularly flourishes and a number of major contract research companies have established over the years a reputation for contributing usefully to the practice of this skill. These contract research organisations are particu larly favoured to develop an appreciation of the problems of the industrial toxicologist, since it is very common for such a company to service the toxicological needs of companies in several sectors of industry producing new chemical compounds, and the contract research company, therefore, is aware of a wider diversity of problems than probably affects a single toxicologist in one industry.
Book Synopsis Stress-Induced Mutagenesis by : David Mittelman
Download or read book Stress-Induced Mutagenesis written by David Mittelman and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
Download or read book Energy Research Abstracts written by and published by . This book was released on 1983 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inventory of Federal Energy-related Environment and Safety Research for FY 1979 by :
Download or read book Inventory of Federal Energy-related Environment and Safety Research for FY 1979 written by and published by . This book was released on 1980 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comparative Chemical Mutagenesis by : Frederick De Serres
Download or read book Comparative Chemical Mutagenesis written by Frederick De Serres and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 1113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari sons. To restate the first comparison: is the chemical under ques tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Short-Term Tests for Chemical Carcinogens by : H.F. Stich
Download or read book Short-Term Tests for Chemical Carcinogens written by H.F. Stich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.
Book Synopsis Inventory of Federal Energy-related Environment and Safety Research for ... by :
Download or read book Inventory of Federal Energy-related Environment and Safety Research for ... written by and published by . This book was released on 1979 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inventory of Federal Energy-related Environment and Safety Research for FY 1978: Project listings and indexes by :
Download or read book Inventory of Federal Energy-related Environment and Safety Research for FY 1978: Project listings and indexes written by and published by . This book was released on 1979 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Food and Agriculture Organization of the United Nations Publisher :Food & Agriculture Org. ISBN 13 :9251305269 Total Pages :319 pages Book Rating :4.2/5 (513 download)
Book Synopsis Manual on MUTATION BREEDING THIRD EDITION by : Food and Agriculture Organization of the United Nations
Download or read book Manual on MUTATION BREEDING THIRD EDITION written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2018-10-09 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper provides guidelines for new high-throughput screening methods – both phenotypic and genotypic – to enable the detection of rare mutant traits, and reviews techniques for increasing the efficiency of crop mutation breeding.
Download or read book EPA-600/7 written by and published by . This book was released on 1976 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1983 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Congress. House. Committee on Appropriations. Subcommittee on Agriculture, Rural Development, and Related Agencies Publisher : ISBN 13 : Total Pages :1360 pages Book Rating :4.3/5 (91 download)
Book Synopsis Agriculture, Rural Development, and Related Agencies Appropriations for 1979 by : United States. Congress. House. Committee on Appropriations. Subcommittee on Agriculture, Rural Development, and Related Agencies
Download or read book Agriculture, Rural Development, and Related Agencies Appropriations for 1979 written by United States. Congress. House. Committee on Appropriations. Subcommittee on Agriculture, Rural Development, and Related Agencies and published by . This book was released on 1978 with total page 1360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Translocation X;Y Test by : Polly A. Foureman
Download or read book The Translocation X;Y Test written by Polly A. Foureman and published by . This book was released on 1983 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Environmental Protection Agency. EPA Oil Shale Work Group Publisher : ISBN 13 : Total Pages :84 pages Book Rating :4.3/5 (91 download)
Book Synopsis EPA Program Status Report, Oil Shale by : United States. Environmental Protection Agency. EPA Oil Shale Work Group
Download or read book EPA Program Status Report, Oil Shale written by United States. Environmental Protection Agency. EPA Oil Shale Work Group and published by . This book was released on 1979 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fiscal Year 1976 Health and Environmental Effects Research Program Abstracts by : United States. Environmental Protection Agency
Download or read book Fiscal Year 1976 Health and Environmental Effects Research Program Abstracts written by United States. Environmental Protection Agency and published by . This book was released on 1977 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
