Multiple Sclerosis And Related Disorders Challenges And Approaches To Mechanisms Biomarkers And Therapeutic Targets

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Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets

Author : Jinzhou Feng
Publisher : Frontiers Media SA
ISBN 13 : 2832549551
Total Pages : 119 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets by : Jinzhou Feng

Download or read book Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets written by Jinzhou Feng and published by Frontiers Media SA. This book was released on 2024-05-28 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is an autoimmune condition that causes inflammatory damage to the central nervous system. The pathologic features are diffuse and focal inflammation, demyelination, gliosis, and neuronal damage in the optic nerves, brain, and spinal cord. Multiple sclerosis remains a challenging and disabling disease. There is a greater understanding of the underlying genetic and environmental factors driving the disorder, including low vitamin D levels, smoking, and obesity. Early and accurate diagnosis is essential and needs to be supported by diagnostic criteria, including imaging and spinal fluid abnormalities in patients with clinically isolated syndromes. Other demyelinating diseases are neuromyelitis optica spectrum disorders (NMOSD), anti-myelin oligodendrocyte glycoprotein antibody disease (MOGAD), and acute disseminated encephalomyelitis (ADEM).

White Matter Diseases

Author : Massimo Filippi
Publisher : Springer Nature
ISBN 13 : 303038621X
Total Pages : 215 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis White Matter Diseases by : Massimo Filippi

Download or read book White Matter Diseases written by Massimo Filippi and published by Springer Nature. This book was released on 2020-02-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.

Multiple Sclerosis

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309072859
Total Pages : 457 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Multiple Sclerosis by : Institute of Medicine

Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Multiple Sclerosis and Related Disorders

Author : Douglas S. Goodin
Publisher : Elsevier
ISBN 13 : 044463309X
Total Pages : 734 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Multiple Sclerosis and Related Disorders by : Douglas S. Goodin

Download or read book Multiple Sclerosis and Related Disorders written by Douglas S. Goodin and published by Elsevier. This book was released on 2014-02-05 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners. A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options Each chapter is translational and focuses on current research and impact on diagnosis and treatment options

Multiple Sclerosis

Author :
Publisher :
ISBN 13 :
Total Pages : 52 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Multiple Sclerosis by :

Download or read book Multiple Sclerosis written by and published by . This book was released on 1996 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multiple Sclerosis Therapeutics

Author : Richard Rudick
Publisher : CRC Press
ISBN 13 : 9780415805827
Total Pages : 598 pages
Book Rating : 4.8/5 (58 download)

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Book Synopsis Multiple Sclerosis Therapeutics by : Richard Rudick

Download or read book Multiple Sclerosis Therapeutics written by Richard Rudick and published by CRC Press. This book was released on 1999-09-01 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.

Inflammatory Immune Disease: Molecular Mechanisms, Translational Approaches and Therapeutics

Author : Tao Xu
Publisher : Frontiers Media SA
ISBN 13 : 2889747956
Total Pages : 1224 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Inflammatory Immune Disease: Molecular Mechanisms, Translational Approaches and Therapeutics by : Tao Xu

Download or read book Inflammatory Immune Disease: Molecular Mechanisms, Translational Approaches and Therapeutics written by Tao Xu and published by Frontiers Media SA. This book was released on 2022-07-05 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuromuscular Disorders

Author : Tulio E. Bertorini
Publisher : Elsevier Health Sciences
ISBN 13 : 0323720935
Total Pages : 627 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Neuromuscular Disorders by : Tulio E. Bertorini

Download or read book Neuromuscular Disorders written by Tulio E. Bertorini and published by Elsevier Health Sciences. This book was released on 2021-06-29 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools and strategies for minimizing disability and maximizing quality of life. Dr. Tulio Bertorini, an expert in clinical neuromuscular care, and a team of world-renowned contributors cover all management and therapeutic considerations regarding the full range of neuromuscular disorders and resulting complications. Provides comprehensive coverage of evaluation and diagnosis, treatments, and outcomes, including the latest management tools and targeted therapeutic strategies. Includes the latest updates in the field: genetic causes of hereditary disease, new autoimmune diseases, promising new therapies such as antisense oligonucleotides and gene therapies, and more. Features numerous drug tables, treatment algorithms, and clinical images throughout to aid in diagnosis and treatment.

Emerging Therapeutics for Immune Tolerance

Author : Hyewon Phee
Publisher : Frontiers Media SA
ISBN 13 : 2889717410
Total Pages : 327 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Emerging Therapeutics for Immune Tolerance by : Hyewon Phee

Download or read book Emerging Therapeutics for Immune Tolerance written by Hyewon Phee and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurobiology of Disease

Author : Michael V. Johnston
Publisher : Oxford University Press
ISBN 13 : 0199937834
Total Pages : 1435 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Neurobiology of Disease by : Michael V. Johnston

Download or read book Neurobiology of Disease written by Michael V. Johnston and published by Oxford University Press. This book was released on 2016 with total page 1435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by Neurobiology of disease / edited by Sid Gilman. 2007.

Multiple Sclerosis

Author : Ian S. Zagon
Publisher :
ISBN 13 : 9780994438133
Total Pages : 137 pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis Multiple Sclerosis by : Ian S. Zagon

Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Brain Neurotrauma

Author : Firas H. Kobeissy
Publisher : CRC Press
ISBN 13 : 1466565993
Total Pages : 718 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy

Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.

New Paradigms in Neuroscience and Related Targets for Drug Discovery

Author : Salvatore Salomone
Publisher : Frontiers Media SA
ISBN 13 : 2889638200
Total Pages : 277 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis New Paradigms in Neuroscience and Related Targets for Drug Discovery by : Salvatore Salomone

Download or read book New Paradigms in Neuroscience and Related Targets for Drug Discovery written by Salvatore Salomone and published by Frontiers Media SA. This book was released on 2020-07-02 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antibody-mediated autoimmune diseases of the CNS: Challenges and approaches to diagnosis and management

Author : Mei-Ping Ding
Publisher : Frontiers Media SA
ISBN 13 : 288974745X
Total Pages : 359 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Antibody-mediated autoimmune diseases of the CNS: Challenges and approaches to diagnosis and management by : Mei-Ping Ding

Download or read book Antibody-mediated autoimmune diseases of the CNS: Challenges and approaches to diagnosis and management written by Mei-Ping Ding and published by Frontiers Media SA. This book was released on 2022-03-21 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Contemporary Challenges in Immunologic Testing in Clinical and Research Laboratories

Author : Pablo Engel
Publisher : Frontiers Media SA
ISBN 13 : 2832532144
Total Pages : 343 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Contemporary Challenges in Immunologic Testing in Clinical and Research Laboratories by : Pablo Engel

Download or read book Contemporary Challenges in Immunologic Testing in Clinical and Research Laboratories written by Pablo Engel and published by Frontiers Media SA. This book was released on 2023-08-24 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along the last several decades, it has been progressively appreciated that immunology plays an overwhelming role in the physiology and pathophysiology of most organs, tissues, and biological systems in multicellular organisms. Accordingly, several immunological parameters are used in research and clinical laboratories with the purpose of investigating, diagnosing, and monitoring a variety of pathological conditions. The rapidly evolving field of laboratory testing in immunology poses several challenges to professionals working in research and clinical laboratories, medical practice, educational activities, in vitro diagnostic industry, and regulatory agencies. Regular analytes, such as albumin, glucose, and insulin, are homogeneous among individuals of the same species. This property represents an advantage when it comes to optimize the determination methods as well as to establish standardization and quality assessment strategies. In contrast, several immunologic analytes present tremendous variability across individuals in the same species. In fact, some are unique at the individual level. For example, the repertoire of immunoglobulins specific for a given pathogen (e.g., rubella) is specific for each individual in terms of the balance of targeted antigens and epitopes, immunoglobulin isotypes, antibody avidity, Fc glycosylation rate, and so on. As a corollary, the panel of anti-rubella antibodies is necessarily different from one to other individual. This also applies to autoantibodies and to IgE to allergens. Polymorphism is prevalent for other immunologic parameters, such as Complement components, cell receptors (cluster differentiation molecules - CD) and downstream signal transduction mediators.

Neurodegeneration in Multiple Sclerosis

Author : M. Filippi
Publisher : Springer Science & Business Media
ISBN 13 : 8847003911
Total Pages : 233 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Neurodegeneration in Multiple Sclerosis by : M. Filippi

Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.