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Multiple Action Based Design Approaches To Antibacterials
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Book Synopsis Multiple Action-Based Design Approaches to Antibacterials by : John Bremner
Download or read book Multiple Action-Based Design Approaches to Antibacterials written by John Bremner and published by Springer Nature. This book was released on 2021-04-05 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.
Book Synopsis Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to Overcome by : Gilberto Igrejas
Download or read book Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to Overcome written by Gilberto Igrejas and published by Frontiers Media SA. This book was released on 2017-03-29 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017
Book Synopsis Post-genomic Approaches in Drug and Vaccine Development by : Kishore R. Sakharkar
Download or read book Post-genomic Approaches in Drug and Vaccine Development written by Kishore R. Sakharkar and published by CRC Press. This book was released on 2022-09-01 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T
Book Synopsis Antimicrobial Peptides by : Guangshun Wang
Download or read book Antimicrobial Peptides written by Guangshun Wang and published by CABI. This book was released on 2017-09-01 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.
Book Synopsis Community Series in Antimicrobial Peptides: Molecular Design, Structure Function Relationship and Biosynthesis Optimization by : Jianhua Wang
Download or read book Community Series in Antimicrobial Peptides: Molecular Design, Structure Function Relationship and Biosynthesis Optimization written by Jianhua Wang and published by Frontiers Media SA. This book was released on 2023-02-20 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antibacterial Agents by : Ranjith Kumavath
Download or read book Antibacterial Agents written by Ranjith Kumavath and published by BoD – Books on Demand. This book was released on 2017-05-31 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: New drugs are frequently entering into the market along with the existing drugs. The antibacterial agents can be discussed in five major classes, i.e. classification based on the type of action, source, spectrum of activity, chemical structure and function. Resistance of bacteria to antibiotics is an urgent problem of the humanity, which leads us to the lack of therapy for serious bacterial infections. Development of new antibiotics has almost ceased in the last decades - even when a new antibiotic is launched, very soon the resistance of bacteria appears. Industrial textiles exposed as awnings, screens, tents; upholstery used in large public areas such as hospitals, hotels and stations; fabrics for transports; protective clothing and personal protective equipment; bed sheets and blankets; textiles left wet between processing steps; intimate apparel, underwear, socks and sportswear, disinfection of air and water for white rooms, hospitals and operating theatres, food and pharma industries, water depuration, drinkable water supplying and air conditioning systems. Many clinicians recommend alternative approaches to using antimicrobial substances. Moreover, the majority of bioagents demonstrate on antibiotics for treatment of a wide range of diseases in human sectors. However, the misuse and mishandling of drugs lead to microbial, particularly bacterial, resistance as well as result in the difficulty of treating microbial diseases. Hence, the proposed book will give more precise information on novel antibacterial compound(s).
Book Synopsis Antimicrobial Resistance Multi-Partner Trust Fund annual report 2021 by : World Health Organization
Download or read book Antimicrobial Resistance Multi-Partner Trust Fund annual report 2021 written by World Health Organization and published by World Health Organization. This book was released on 2022-06-30 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antimicrobials by : Flavia Marinelli
Download or read book Antimicrobials written by Flavia Marinelli and published by Springer Science & Business Media. This book was released on 2013-10-04 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
Book Synopsis The Resistance Phenomenon in Microbes and Infectious Disease Vectors by : Institute of Medicine
Download or read book The Resistance Phenomenon in Microbes and Infectious Disease Vectors written by Institute of Medicine and published by National Academies Press. This book was released on 2003-03-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.
Book Synopsis Contemporary Approaches to Mitigating Antibacterial Drug Resistance by : Grewal, Ajmer Singh
Download or read book Contemporary Approaches to Mitigating Antibacterial Drug Resistance written by Grewal, Ajmer Singh and published by IGI Global. This book was released on 2024-04-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: In infectious disease management, antibacterial agents have long been viewed as pivotal tools in the relentless battle against microorganisms. However, the escalating threat of antibacterial drug resistance has emerged as a formidable challenge to global health. Contemporary Approaches to Mitigating Antibacterial Drug Resistance delves into the heart of this critical issue, exploring the mechanisms, consequences, and innovative strategies to counteract the surge of resistance, a phenomenon becoming increasingly pervasive and threatening worldwide. Antibacterial drug resistance, a pressing public health concern, transcends geographical boundaries. In regions where antibiotic accessibility and overuse prevail, resistance rates soar, giving rise to the ominous "superbugs." This book unravels the intricacies of drug resistance, examining its impact on infectious disease management, healthcare economics, and societal well-being. The exploration begins with a foundational understanding of antibacterial drug resistance, navigating through the intricate mechanisms that drive its rapid proliferation. Environmental and genetic factors, often overlooked, are dissected for their roles in fostering resistance. The book explores the interplay of antibacterial drugs with micro-biodiversity, shedding light on the indirect repercussions on human and environmental ecosystems. The primary audience, encompassing undergraduate and postgraduate students, medical practitioners, academicians, and researchers, will find in-depth insights into emerging therapeutic targets and recent advances in drug development. The secondary audience, including authorities in antibacterial drug resistance and institutional libraries, will discover a valuable resource addressing the multifaceted dimensions of this global menace.
Book Synopsis Antibacterial Agents by : Rosaleen Anderson
Download or read book Antibacterial Agents written by Rosaleen Anderson and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Book Synopsis Non-traditional Approaches to Combat Antimicrobial Drug Resistance by : Mohmmad Younus Wani
Download or read book Non-traditional Approaches to Combat Antimicrobial Drug Resistance written by Mohmmad Younus Wani and published by Springer Nature. This book was released on 2023-02-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed overview of the progress and challenges of non-traditional approaches for tackling antimicrobial resistance. The first chapter covers the factors that make microbes more likely to develop multidrug resistance. The book goes on to discuss the antimicrobial properties of propolis, essential oils and other microbial constituents that are used or under investigation to treat multidrug-resistant infections. Additionally, it covers alternative compounds that work as antimicrobial agents, their mechanisms of action, and how they might be utilized in conjunction with conventional drugs to circumvent drug resistance. The book explores the application of phage therapy and recent advancements in phage-based infection control with an emphasis on multidrug-resistant infections and discusses drug repurposing as a strategy to develop new antimicrobial agents efficiently and expeditiously. Additionally, it discusses the uses of nanoparticles in the treatment of infections brought on by multidrug-resistant pathogens and examines the use of different nanotechnology-based approaches to fudge microbial resistance mechanisms. It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections. The book is an invaluable source of knowledge and information for academics, basic and clinical researchers, clinicians, and paramedic staff involved in one way or the other in the development and use of antimicrobial agents and strategies to combat multidrug resistance.
Book Synopsis Antibacterial Drug Discovery to Combat MDR by : Iqbal Ahmad
Download or read book Antibacterial Drug Discovery to Combat MDR written by Iqbal Ahmad and published by Springer Nature. This book was released on 2019-11-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.
Book Synopsis Proceedings of 6th World Congress on Medicinal Chemistry and Drug Design 2017 by : ConferenceSeries
Download or read book Proceedings of 6th World Congress on Medicinal Chemistry and Drug Design 2017 written by ConferenceSeries and published by ConferenceSeries. This book was released on 2017-06-01 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: June 07-08, 2017 Milan,. Italy Key Topics : Medicinal Chemistry, Synthetic Organic Chemistry, Drug Design and Drug Development, CADD (Computer Aided Drug Design), Bioorganic and Medicinal Chemistry, Pharmacology and toxicology, BioInorganic Chemistry, Organometallic Chemistry, Radiopharmaceuticals, Chemical Biology, Anticancer agents in Medicinal Chemistry, Pharmaceutical Industry, Clinical Pharmacology, Pharmaceutical Sciences, Bioisostere, Analytical Chemistry, Nanomedicine, Stereochemistry, Pharmacovigilance,
Book Synopsis Facing the Upcoming of Multidrug-Resistant and Extensively Drug-Resistant Bacteria: Novel Antimicrobial Therapies (NATs) by : Angel León-Buitimea
Download or read book Facing the Upcoming of Multidrug-Resistant and Extensively Drug-Resistant Bacteria: Novel Antimicrobial Therapies (NATs) written by Angel León-Buitimea and published by Frontiers Media SA. This book was released on 2021-04-01 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Food and Agriculture Organization of the United Nations Publisher :Food & Agriculture Org. ISBN 13 :9251345848 Total Pages :54 pages Book Rating :4.2/5 (513 download)
Book Synopsis Antimicrobial Resistance Multi-Partner Trust Fund: Forging Tripartite collaboration for urgent global and country action against antimicrobial resistance (AMR) by : Food and Agriculture Organization of the United Nations
Download or read book Antimicrobial Resistance Multi-Partner Trust Fund: Forging Tripartite collaboration for urgent global and country action against antimicrobial resistance (AMR) written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2021-07-15 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2019, the Tripartite Joint Secretariat (FAO, OIE, and WHO) launched the AMR Multi-Partner Trust Fund (MPTF) to scale up action in low- and lower-middle-income countries to address antimicrobial resistance (AMR) as well as set up joint, global-level activities. In 2020, the Tripartite put in place the necessary frameworks, tools, and standards to select countries and develop global programmes that will be supported by the MPTF. The following report will provide an overview of the country and global projects, their current implementation status, the fund’s financial resources as well as the next steps.
Download or read book Antibacterials written by Jed F. Fisher and published by Springer. This book was released on 2018-06-28 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors
