Multiparametric Quantitative Mri Of The Cervical Spinal Cord To Measure Microstructure And Tissue Injury

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Multiparametric Quantitative MRI of the Cervical Spinal Cord to Measure Microstructure and Tissue Injury

Author : Allan Russell Martin
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (133 download)

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Book Synopsis Multiparametric Quantitative MRI of the Cervical Spinal Cord to Measure Microstructure and Tissue Injury by : Allan Russell Martin

Download or read book Multiparametric Quantitative MRI of the Cervical Spinal Cord to Measure Microstructure and Tissue Injury written by Allan Russell Martin and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: An array of spinal cord (SC) quantitative MRI (qMRI) techniques can measure aspects of microstructure and tissue injury. This research develops a clinically feasible multiparametric MRI protocol, including diffusion tensor imaging (DTI) fractional anisotropy (FA), magnetization transfer ratio (MTR), and measurement of SC cross-sectional area (CSA). A novel biomarker of white matter (WM) injury is also introduced, normalizing T2*WI WM signal intensity by grey matter (T2*WI WM/GM). A study of 40 healthy subjects establishes methods, normalization procedures, normative values, and reliability. 58 patients with degenerative cervical myelopathy (DCM) are studied, showing significant differences in 10 metrics. Combining these measures using multivariate methods overcomes the limitations of each technique, achieving good diagnostic accuracy and clinical correlation. T2*WI WM/GM shows strong potential as a novel biomarker, comparing favourably with established biomarkers FA and MTR. Our study of healthy subjects identifies an alarming rate of asymptomatic SC compression (ASCC) at 50%. Objective criteria and automated shape analysis are developed to create a new definition of SC compression, and qMRI demonstrates significant tissue injury in this group. This finding suggests the potential for pre-symptomatic diagnosis of DCM and other spinal pathologies. Finally, a longitudinal study compares multiparametric qMRI with clinical measures for monitoring disease progression in DCM, indicating that modified Japanese Orthopedic Association (mJOA) score is insensitive to detect progression, whereas qMRI showed tissue progression more often than comprehensive clinical assessments. These results suggest that natural history studies employing mJOA underestimate progression, due to neuroplasticity and behavioural adaptation. Combined qMRI and clinical data are now being used to inform surgical decision-making for individual patients. Reliable multiparametric assessment of SC microstructure is possible using clinically suitable methods. This approach shows strong clinical utility for individual patients, including good diagnostic accuracy, correlations with impairment, detection of tissue injury in asymptomatic individuals, and detection of progressive tissue injury in DCM patients.

MULTIPARAMETRIC MRI OF THE PEDIATRIC SPINAL CORD

Author : Shiva Shahrampour
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis MULTIPARAMETRIC MRI OF THE PEDIATRIC SPINAL CORD by : Shiva Shahrampour

Download or read book MULTIPARAMETRIC MRI OF THE PEDIATRIC SPINAL CORD written by Shiva Shahrampour and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative magnetic resonance imaging (MRI) measurements of the pediatric spinal cord is important for both diagnostic and treatment planning. In recent years several quantitative MRI (qMRI) techniques that have been developed and tested to measure functional and structural information of the spinal cord tissue and microstructure. Several of the existing structural and functional imaging biomarkers (i.e., diffusion tensor imaging (DTI)) have demonstrated potential for providing microstructural information about the spinal cord. However, due to the lack of a standard anatomical template of the pediatric spinal cord, quantification of the spinal cord tissue has been challenging. Therefore, one of the goals of this work is to develop and test tools for quantification as well as the creation of a standard structural template of the typically developing (TD) pediatric spinal cord. This will allow automated measurement of normative values of the spinal cord cross-sectional area (SCCSA) at various levels of the spinal cord. Furthermore, to examine the white matter (WM) microstructure of the pediatric cord we developed a processing pipeline for the atlas-based generation of TD pediatric spinal cord WM tracts. This will facilitate the measurements of normative diffusion values for various WM tracts.A group of 30 TD subjects (age range of 6-17 years old (12.38 ±2.81)), who had no evidence of spinal cord injury or pathology were recruited. We utilized a multiparametric MRI protocol, including high-resolution T2-w structural and diffusion-weighted MRI images to scan the subjects on a 3T MRI scanner. The diffusion data were acquired using a novel iFOV DTI sequence. For quantification, a post-processing pipeline was utilized to generate the structural pediatric template. Next, WM tracts were generated using an atlas-based approach, and diffusion metrics (FA, MD, RD and AD) were quantified in 34 tracts identified in the processing pipeline. Normative SCCSA and DTI diffusion indices were generated for the TD population. Lastly, we demonstrated that DTI indices (i.e. FA) can be a predictive measure of components of the clinical test for spinal cord injury, as well as an indicator of the white matter tracts integrity. Therefore, in the final step of this work, we expanded our quantitative analysis to look at the microstructural and macrostructural changes in 15 children with chronic spinal cord injury (SCI) (AIS A-D, mean age of 12.8 ± 3.1 years). This included measurements of SCCSA, diffusion metrics and T2* WM/GM ratio of various white matter tracts in the patient population. We also examined the relationships between all the metrics and the ISNCSCI clinical scores in SCI subjects. We then compared these measurements between the TD and SCI patients to evaluate the diagnostic utility of these techniques and biomarkers. Statistically significant difference was observed between the two populations in the studied metrics. The results show that the proposed techniques may have the potential to be used as surrogate biomarkers for the quantification of the injured spinal cord. Keywords: diffusion tensor imaging, typically developing, spinal cord injury, spinal cord cross-sectional area, fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity.

Quantitative MRI of the Spinal Cord

Author : Julien Cohen-Adad
Publisher : Academic Press
ISBN 13 : 0123972825
Total Pages : 331 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Quantitative MRI of the Spinal Cord by : Julien Cohen-Adad

Download or read book Quantitative MRI of the Spinal Cord written by Julien Cohen-Adad and published by Academic Press. This book was released on 2014-01-16 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord. Chapters authored by international experts in the field of MRI of the spinal cord Contains “cooking recipes —examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice Ideal for clinical settings

Multi-parametric Magnetic Resonance Imaging of the Spinal Cord at 9.4T

Author : Tung-Lin Wu
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Multi-parametric Magnetic Resonance Imaging of the Spinal Cord at 9.4T by : Tung-Lin Wu

Download or read book Multi-parametric Magnetic Resonance Imaging of the Spinal Cord at 9.4T written by Tung-Lin Wu and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quantitative Magnetic Resonance Imaging

Author : Nicole Seiberlich
Publisher : Academic Press
ISBN 13 : 0128170581
Total Pages : 1094 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Quantitative Magnetic Resonance Imaging by : Nicole Seiberlich

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Biomarkers and Clinical Indicators in Motor Neuron Disease

Author : Pierre-Francois Pradat
Publisher : Frontiers Media SA
ISBN 13 : 2889634159
Total Pages : 393 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Biomarkers and Clinical Indicators in Motor Neuron Disease by : Pierre-Francois Pradat

Download or read book Biomarkers and Clinical Indicators in Motor Neuron Disease written by Pierre-Francois Pradat and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Traumatic Brain and Spinal Cord Injury

Author : Cristina Morganti-Kossmann
Publisher : Cambridge University Press
ISBN 13 : 1107007437
Total Pages : 361 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Traumatic Brain and Spinal Cord Injury by : Cristina Morganti-Kossmann

Download or read book Traumatic Brain and Spinal Cord Injury written by Cristina Morganti-Kossmann and published by Cambridge University Press. This book was released on 2012-07-19 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume.

MRI of the Lung

Author : Hans-Ulrich Kauczor
Publisher : Springer Science & Business Media
ISBN 13 : 354034618X
Total Pages : 315 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis MRI of the Lung by : Hans-Ulrich Kauczor

Download or read book MRI of the Lung written by Hans-Ulrich Kauczor and published by Springer Science & Business Media. This book was released on 2008-11-12 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.

Primary Progressive Multiple Sclerosis

Author : M. Filippi
Publisher : Springer Science & Business Media
ISBN 13 : 8847022347
Total Pages : 188 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Primary Progressive Multiple Sclerosis by : M. Filippi

Download or read book Primary Progressive Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.

Small Animal Imaging

Author : Fabian Kiessling
Publisher : Springer
ISBN 13 : 3319422022
Total Pages : 871 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Small Animal Imaging by : Fabian Kiessling

Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Quantitative MRI of the Brain

Author : Paul Tofts
Publisher : John Wiley & Sons
ISBN 13 : 0470869496
Total Pages : 650 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Quantitative MRI of the Brain by : Paul Tofts

Download or read book Quantitative MRI of the Brain written by Paul Tofts and published by John Wiley & Sons. This book was released on 2005-08-19 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2004 BMA Medical Book Competition Winner (Radiology category) “This is an exciting book, with a new approach to use of the MRI scanner. It bridges the gap between clinical research and general neuro-radiological practice. It is accessible to the clinical radiologist, and yet thorough in its treatment of the underlying physics and of the science of measurement. It is likely to become a classic.” British Medical Association This indispensable 'how to' manual of quantitative MR is essential for anyone who wants to use the gamut of modern quantitative methods to measure the effects of neurological disease, its progression, and its response to treatment. It contains both the methodology and clinical applications, reflecting the increasing interest in quantitative MR in studying disease and its progression. The editor is an MR scientist with an international reputation for high quality research The contributions are written jointly by MR physicists and MR clinicians, producing a practical book for both the research and medical communities A practical book for both the research and medical communities “Paul Tofts has succeeded brilliantly in capturing the essence of what needs to become the future of radiology in particular, and medicine in general – quantitative measurements of disease.” Robert I. Grossman, M.D. New York, University School of Medicine (from the Foreword)

Signs in MR-Mammography

Author : Werner A. Kaiser
Publisher : Springer Science & Business Media
ISBN 13 : 3540732926
Total Pages : 399 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Signs in MR-Mammography by : Werner A. Kaiser

Download or read book Signs in MR-Mammography written by Werner A. Kaiser and published by Springer Science & Business Media. This book was released on 2008-11-27 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the leading cause of cancer-related deaths in women, and its prevalence has been steadily rising in recent decades. This book describes morphologic and kinetic signs that are important in the analysis of breast MR images before and after contrast administration and in various pulse sequences. It will help broaden the clinical application of MRM so that as many physicians as possible can make more accurate diagnoses.

Neuroimaging, Part I

Author :
Publisher : Newnes
ISBN 13 : 0702045373
Total Pages : 724 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Neuroimaging, Part I by :

Download or read book Neuroimaging, Part I written by and published by Newnes. This book was released on 2016-07-12 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders. Provides a relevant description of the technologies used in neuroimaging, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and several others Ideal resource for anyone studying the nervous system, from beginners to specialists interested in recent advances in neuroimaging of the adult brain Discusses the application of imaging techniques to the study of brain and spinal cord disease and its use in various syndromes Contains vibrant, colorful images to illustrate key points

Magnetic Resonance Neurography

Author : Chhabra Avneesh
Publisher : JAYPEE BROTHERS PUBLISHERS
ISBN 13 : 9350905574
Total Pages : 213 pages
Book Rating : 4.3/5 (59 download)

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Book Synopsis Magnetic Resonance Neurography by : Chhabra Avneesh

Download or read book Magnetic Resonance Neurography written by Chhabra Avneesh and published by JAYPEE BROTHERS PUBLISHERS. This book was released on 2012-12-15 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first of its kind, combination of concise explanations and focused clinical information satisfies the needs of practicing radiologists, neurologists, neurosurgeons, plastic and other peripheral nerve surgeons in need of a handy reference and technologists performing MRN studies. Written by two experts of magnetic resonance neurography (MRN) practitioners and educators, this thoroughly illustrated resource delivers how the information you need to perform and interpret peripheral nerve MR imaging studies with confidence. Concise descriptions and high quality illustrations combined wit.

Neuroimaging of Pain

Author : Luca Saba
Publisher : Springer
ISBN 13 : 3319480464
Total Pages : 509 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Neuroimaging of Pain by : Luca Saba

Download or read book Neuroimaging of Pain written by Luca Saba and published by Springer. This book was released on 2017-06-08 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.

Imaging of Traumatic Brain Injury

Author : Yoshimi Anzai
Publisher : Thieme
ISBN 13 : 1604067292
Total Pages : 519 pages
Book Rating : 4.6/5 (4 download)

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Book Synopsis Imaging of Traumatic Brain Injury by : Yoshimi Anzai

Download or read book Imaging of Traumatic Brain Injury written by Yoshimi Anzai and published by Thieme. This book was released on 2015-03-11 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: An image-rich text on neuroimaging of trauma patients Imaging of Traumatic Brain Injury is a radiological reference that covers all aspects of neurotrauma imaging and provides a clinical overview of traumatic brain injury (TBI). It describes the imaging features of acute head trauma, the pathophysiology of TBI, and the application of advanced imaging technology to brain-injured patients. Key Features: Covers acute as well as chronic traumatic brain injury Written in an easily accessible format, with pearls and summary boxes at the end of each chapter Includes state-of-the-art imaging techniques, including the multiplanar format, the utility of multiplanar reformats, perfusion imaging, susceptibility weighted imaging, and advanced MRI techniques Contains over 250 high-quality images This book will serve as a practical reference for practicing radiologists as well as radiology residents and fellows, neurosurgeons, trauma surgeons, and emergency physicians.

Magnetic Resonance Spectroscopy in Multiple Sclerosis

Author : M. Filippi
Publisher : Springer Science & Business Media
ISBN 13 : 884702109X
Total Pages : 180 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Magnetic Resonance Spectroscopy in Multiple Sclerosis by : M. Filippi

Download or read book Magnetic Resonance Spectroscopy in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".