Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Multidimensional Solid State Nmr Studies Of Membrane Proteins full books in PDF, epub, and Kindle. Read online Multidimensional Solid State Nmr Studies Of Membrane Proteins ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Download or read book Multidimensional Solid-State NMR Studies of Membrane Proteins written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frances Separovic
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739102
Total Pages : 632 pages
Book Rating : 4.8/5 (497 download)
Download or read book Advances in Biological Solid-State NMR written by Frances Separovic and published by Royal Society of Chemistry. This book was released on 2014 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions
Author : Clore
Publisher : CRC Press
ISBN 13 : 9780849377716
Total Pages : 328 pages
Book Rating : 4.3/5 (777 download)
Download or read book NMR of Proteins written by Clore and published by CRC Press. This book was released on 1993 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Determination of structures of larger proteins in solution by three- and four-dimensional heteronuclear magnetic resonance spectroscopy. Methodological advances in protein NMR. Determination of high-resolution NMR structures of proteins. Multidimensional NMR studies of immunosuppressant/immunophilin complexes. NMR studies of the structure and role of modules involved in protein-protein interactions. NMR structural studies of membrane proteins. Heteronuclear NMR studies of the molecular synamics of staphylococcal nuclease. Study of protein dynamics by NMR. The folding, stability and dynamics of T4 lysozyme: a perspective using nuclear magnetic resonance.
Author : Hazime Saitô
Publisher : Springer Science & Business Media
ISBN 13 : 1402043031
Total Pages : 455 pages
Book Rating : 4.4/5 (2 download)
Download or read book Solid State NMR Spectroscopy for Biopolymers written by Hazime Saitô and published by Springer Science & Business Media. This book was released on 2006-08-05 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘‘Biopolymers’’ are polymeric materials of biological origin, including globular, membrane, and fibrous proteins, polypeptides, nucleic acids, po- saccharides, lipids, etc. and their assembly, although preference to respe- ive subjects may be different among readers who are more interested in their biological significance or industrial and/or medical applications. Nevert- less, characterizing or revealing their secondary structure and dynamics may be an equally very important and useful issue for both kinds of readers. Special interest in revealing the 3D structure of globular proteins, nucleic acids, and peptides was aroused in relation to the currently active Structural Biology. X-ray crystallography and multidimensional solution NMR sp- troscopy have proved to be the standard and indispensable means for this purpose. There remain, however, several limitations to this end, if one intends to expand its scope further. This is because these approaches are not always straightforward to characterize fibrous or membrane proteins owing to extreme difficulty in crystallization in the former, and insufficient spectral resolution due to sparing solubility or increased effective molecular mass in the presence of surrounding lipid bilayers in the latter.
Author : Guang Zhu
Publisher : Springer Science & Business Media
ISBN 13 : 3642289169
Total Pages : 255 pages
Book Rating : 4.6/5 (422 download)
Download or read book NMR of Proteins and Small Biomolecules written by Guang Zhu and published by Springer Science & Business Media. This book was released on 2012-03-28 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Application of NMR and Molecular Docking in Structure-Based Drug Discovery, by Jaime L. Stark and Robert Powers NMR as a Unique Tool in Assessment and Complex Determination of Weak Protein-Protein Interactions, by Olga Vinogradova and Jun Qin The Use of Residual Dipolar Coupling in Studying Proteins by NMR, by Kang Chen und Nico Tjandra NMR Studies of Metalloproteins, by Hongyan Li and Hongzhe Sun Recent Developments in 15N NMR Relaxation Studies that Probe Protein Backbone Dynamics, by Rieko Ishima Contemporary Methods in Structure Determination of Membrane Proteins by Solution NMR, by Tabussom Qureshi and Natalie K. Goto Protein Structure Determination by Solid-State NMR, by Xin Zhao Dynamic Nuclear Polarization: New Methodology and Applications, by Kong Hung Sze, Qinglin Wu, Ho Sum Tse and Guang Zhu
Author : Sorin Luca
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (615 download)
Download or read book Solid State NMR Studies of Globular and Membrane Proteins written by Sorin Luca and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lindsay J. Sperling
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (774 download)
Download or read book Solid-state NMR Studies of Membrane Proteins and Membrane Protein Complexes written by Lindsay J. Sperling and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane proteins help control nearly every process in the cell, which is why approximately 50% of pharmaceuticals currently on the market target membrane proteins. Knowledge of structure-function relationships of these proteins could be leveraged to produce more efficient drugs. However, the traits that make membrane proteins so interesting also make them difficult targets for traditional structure elucidation techniques. X-ray crystallography relies on the use of single crystals, production of which are elusive for membrane proteins due to their inherent dynamic loops and stretches of hydrophobic residues, which contribute to aggregation and/or loss of function without the presence of a lipid environment. Solution NMR experiences difficulty dealing with slow molecular tumbling due to the large sizes of membrane proteins. Conversely, solid-state NMR (SSNMR) has no inherent size limitation and does not require the use of crystals, which presents SSNMR with the unique capability to study membrane proteins in native environments at atomic-resolution. However, this technique is still a relatively new tool for solving structures of biomolecules. Here, we begin to develop strategies for solid-state NMR de novo structure determination. We provide a 0́−divide-and-conquer0́+ investigation of an E. coli 41 kDa membrane protein complex, DsbA/DsbB. We begin by completing chemical shift assignments, the first step in structure determination in NMR studies, of the 21 kDa protein DsbA to optimize sensitivity and resolution of data collection and analysis of large systems. We then use this study to drive forward structural examination of the disulfide bond forming system DsbA/DsbB. Finally, SSNMR techniques are used to study a 144 kDa cytochrome bo3 ubiquinol oxidase demonstrating the power of this technique to investigate large membrane complexes in native environments.
Author : Lawrence Berliner
Publisher : Springer
ISBN 13 : 9781489978264
Total Pages : 185 pages
Book Rating : 4.9/5 (782 download)
Download or read book Protein NMR written by Lawrence Berliner and published by Springer. This book was released on 2016-10-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a “toolbox” for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: • A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome • A pedagogical approach to the methodology • Engaging the reader and student with a clear, yet critical presentation of the applications
Author : Chin Hsiang Wu
Publisher :
ISBN 13 :
Total Pages : 254 pages
Book Rating : 4.:/5 (187 download)
Download or read book Multidimensional Solid-state NMR Spectroscopy of Peptides and Proteins written by Chin Hsiang Wu and published by . This book was released on 1994 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : N. Rama Krishna
Publisher : Springer Science & Business Media
ISBN 13 : 0306470837
Total Pages : 400 pages
Book Rating : 4.3/5 (64 download)
Download or read book Modern Techniques in Protein NMR written by N. Rama Krishna and published by Springer Science & Business Media. This book was released on 2006-03-16 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 16 marks the beginning of a special topic series devoted to modern techniques in protein NMR, under the Biological Magnetic Resonance series. This volume is being followed by Volume 17 with the subtitle Structure Computation and Dynamics in Protein NMR. Volumes 16 and 17 present some of the recent, significant advances in biomolecular NMR field with emphasis on developments during the last five years. We are honored to have brought together in these volumes some of the world’s foremost experts who have provided broad leadership in advancing this field. Volume 16 contains advances in two broad categories: the first, Large Proteins, Complexes, and Membrane Proteins, and second, Pulse Methods. Volume 17, which will follow covers major advances in Computational Methods, and Structure and Dynamics. In the opening chapter of Volume 16, Marius Clore and Angela Gronenborn give a brief review of NMR strategies including the use of long range restraints in the structure determination of large proteins and protein complexes. In the next two chapters, Lewis Kay and Ron Venters and their collaborators describe state-of-t- art advances in the study of perdeuterated large proteins. They are followed by Stanley Opella and co-workers who present recent developments in the study of membrane proteins. (A related topic dealing with magnetic field induced residual dipolar couplings in proteins will appear in the section on Structure and Dynamics in Volume 17).
Author : Jerry C. C. Chan
Publisher : Springer Science & Business Media
ISBN 13 : 3642248020
Total Pages : 328 pages
Book Rating : 4.6/5 (422 download)
Download or read book Solid State NMR written by Jerry C. C. Chan and published by Springer Science & Business Media. This book was released on 2011-10-26 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dipolar Recoupling, by Niels Chr. Nielsen, Lasse A. Strassø and Anders B. Nielsen.- Solid-State NMR Techniques for the Structural Determination of Amyloid Fibrils, by Jerry C. C. Chan.- Solid-State 19F-NMR of Peptides in Native Membranes, by Katja Koch, Sergii Afonin, Marco Ieronimo, Marina Berditsch and Anne S. Ulrich.- Probing Quadrupolar Nuclei by Solid-State NMR Spectroscopy: Recent Advances, by Christian Fernandez and Marek Pruski.- Solid State NMR of Porous Materials Zeolites and Related Materials, by Hubert Koller and Mark Weiß.- Solid-State NMR of Inorganic Semiconductors, by James P. Yesinowski.-
Author : A. Ramamoorthy
Publisher : CRC Press
ISBN 13 : 9781574444964
Total Pages : 368 pages
Book Rating : 4.4/5 (449 download)
Download or read book NMR Spectroscopy of Biological Solids written by A. Ramamoorthy and published by CRC Press. This book was released on 2005-09-22 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, a myriad of techniques have shown that solid-state nuclear magnetic resonance (NMR) can be used in a broad spectrum of applications with exceptionally impressive results. Solid-state NMR results can yield high-resolution details on the structure and function of many important biological solids, including viruses, fibril-forming molecules, and molecules embedded in the cell membrane. Filling a void in the current literature, NMR Spectroscopy of Biological Solids examines all the recent developments, implementation, and interpretation of solid-state NMR experiments and the advantages of applying them to biological systems. The book emphasizes how these techniques can be used to realize the structure of non-crystalline systems of any size. It explains how these isotropic and anisotropic couplings interactions are used to determine atomic-level structures of biological molecules in a non-soluble state and extrapolate the three-dimensional structure of membrane proteins using magic-angle spinning (MAS). The book also focuses on the use of multidimensional solid-state NMR methods in the study of aligned systems to provide basic information about the mechanisms of action of a variety of biologically active molecules. Addressing principles, methods, and applications, this book provides a critical selection of solid-state NMR methods for solving a wide range of practical problems that arise in both academic and industrial research of biomolecules in the solid state. NMR Spectroscopy of Biological Solids is a forward-thinking resource for students and researchers in analytical chemistry, bioengineering, material sciences, and structural genomics.
Author : Frances Separovic
Publisher : Biophysical Society-Iop
ISBN 13 : 9780750325301
Total Pages : 416 pages
Book Rating : 4.3/5 (253 download)
Download or read book Solid-State NMR: Applications in Biomembrane Structure written by Frances Separovic and published by Biophysical Society-Iop. This book was released on 2020-12-03 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methodology and applications of solid-state NMR spectroscopy to studies of membrane proteins, membrane-active peptides and model biological membranes. As well as structural studies it contains coverage of membrane interactions and molecular motions. Advances in biological solid-state NMR are very pertinent with high-field developments seeing applications in biological membranes and whole cells. Many of the chapter authors and contributors are world-class experts and leaders in the development and application of biological solid-state NMR. Key Features Addresses principles, methods and applications of solid-state NMR methods to biomembrane studies Introduction to biological solid-state NMR and applications to biological membranes Structure and dynamics of membrane lipids, proteins and peptides NMR studies of membrane interactions and molecular motion
Author : Earle Raymond Adams
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.:/5 (418 download)
Download or read book Solid State and Solution NMR Studies of Model Systems for Parts of Membrane Proteins written by Earle Raymond Adams and published by . This book was released on 1994 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : N. Rama Krishna
Publisher : Springer Science & Business Media
ISBN 13 : 0306474484
Total Pages : 345 pages
Book Rating : 4.3/5 (64 download)
Download or read book Protein NMR for the Millennium written by N. Rama Krishna and published by Springer Science & Business Media. This book was released on 2003-01-31 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein NMR for the Millennium is the third volume in a special thematic series devoted to the latest developments in protein NMR under the Biological Magnetic Resonance umbrella. This book is divided into three major sections dealing with significant recent advances in the study of large proteins in solution and solid state, structure refinement, and screening of bioactive ligands. Key Features: TROSY, Segmental isotope labeling of proteins, Hydrogen bond scalar couplings, Structure refinement based on residual dipolar couplings, Written by the world's foremost experts who have provided broad leadership in advancing the protein NMR field.
Author : Eugene Chun-Chin Lin
Publisher :
ISBN 13 : 9781321649161
Total Pages : 148 pages
Book Rating : 4.6/5 (491 download)
Download or read book Development of Solid-state NMR Spectroscopy for Membrane Proteins and the Application to Vpu from HIV-1 written by Eugene Chun-Chin Lin and published by . This book was released on 2015 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid-state nuclear magnetic resonance (NMR) spectroscopy is a robust method to solve the structures of membrane proteins in their native bilayer environments. Two systems have been well established: oriented samples (OS) are referred to proteins incorporated in the magnetic aligned bicelles, and rotationally aligned (RA) samples are referred to proteins undergoing fast rotational diffusion in proteoliposomes. 1H-15N and 1H-13C dipolar couplings are measured as the angular restraints for the structure calculations. New separated-local-field experiment, Dual-PISEMO, is developed for OS solid-state NMR to measure 1H-13C dipolar couplings of the uniformly 13C labeled proteins, which provide both backbone and side-chain conformations. In order to obtain the full assignments and restraints in OS solid-state NMR, 1H-irradiations with mismatched conditions are implemented to improve the crucial step: the magnetization transfer between 15N and 13C. Non-uniform sampling (NUS) is an alternative approach to further the experimental time of high-dimensional solid-state NMR experiments. Compressed sensing (CS) is able to reconstruct the spectra with 25 ~ 33% of data with the optimized sampling scheme, and covariance spectroscopy provides promising results with alternative States sampling scheme, which requires 50% of data or less. Viral protein "u" (Vpu) from HIV-1 is a type I membrane protein consisting of a transmembrane domain and a cytoplasmic domain, which are associated with different biological activities to enhance viral infectivity. It is essential to determine the three-dimensional structure of Vpu in order to understand its mechanisms in the molecular level and to develop new classes of anti-viral drugs. Magic-angle spinning (MAS) experiments providing high-sensitivity and high- resolution spectra, are implemented to study Vpu incorporated into proteoliposomes. 15N, 13C chemical shift and 1H-15N, 1H-13C dipolar couplings are measured and converted to equivalent structural restraints.
Author : Valérie Copié
Publisher :
ISBN 13 :
Total Pages : 572 pages
Book Rating : 4.:/5 (241 download)
Download or read book Solid-state NMR Studies of Protein Structures and Molecular Dynamics written by Valérie Copié and published by . This book was released on 1990 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
