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Mtor Inhibition For Cancer Therapy Past Present And Future
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Book Synopsis mTOR Inhibition for Cancer Therapy: Past, Present and Future by : Monica Mita
Download or read book mTOR Inhibition for Cancer Therapy: Past, Present and Future written by Monica Mita and published by Springer. This book was released on 2015-11-18 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.
Book Synopsis Targeted Therapies in Breast Cancer by : Gw Sledge
Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.
Book Synopsis Molecules to Medicine with mTOR by : Kenneth Maiese
Download or read book Molecules to Medicine with mTOR written by Kenneth Maiese and published by Academic Press. This book was released on 2016-02-21 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. - Covers the role of mTOR by internationally recognized expert contributors in the field. - Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. - Includes analysis of the role of mTOR and in both health and disease. - Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.
Book Synopsis The Chemotherapy Source Book by : Michael Clinton Perry
Download or read book The Chemotherapy Source Book written by Michael Clinton Perry and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.
Book Synopsis Successes and Limitations of Targeted Cancer Therapy by : S. Peters
Download or read book Successes and Limitations of Targeted Cancer Therapy written by S. Peters and published by Karger Medical and Scientific Publishers. This book was released on 2014-02-19 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.
Download or read book Killing Cancer written by Tuula Kallunki and published by MDPI. This book was released on 2020-11-17 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled “Killing Cancer: Discovery and Selection of New Target Molecules”. These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.
Book Synopsis Thymus Therapy: The Past, Present and Future by : Michelle B.F. Wong
Download or read book Thymus Therapy: The Past, Present and Future written by Michelle B.F. Wong and published by Europa Edizioni. This book was released on 2024-07-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dense study conducted by Prof. Dr. Mike K.S. Chan and Prof. Dr. Michelle B.F. Wong, with the support of a professional team of researchers, highlights how important is to delve deeper into the study of the thymus gland which plays a crucial role in immune system health. As we read in the forewords the topics presented are the results of a collaboration between experts coming from various fields such as immunology, gerontology, regenerative medicine, and clinical practice. This comprehensive book can strengthen the communication and collaboration among these disciplines, fostering a more holistic approach to addressing age-related health challenges. Bioregenerative medicine in general, and Thymic regeneration therapies are an important part of the daily medical practice. THYMUS THERAPY represents a pivotal study and another scientific milestone that puts once again Prof. Chan and his Team at the forefront worldwide. Prof. Dato Sri Dr. Mike K.S. Chan, is a pioneer of Cellular, Organo and Cell Membrane Therapies in Europe and Asia since the early 1980’s. He founded one of the world’s largest research groups of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, bio-regenerative medicine, and stemcell therapies. Author & co-author of numerous books and articles in the fields of cell therapy, immunology, bio-regenerative sciences, nutrition, and innovator of cellular based nutraceuticals & cosmeceuticals, Prof. Mike Chan is also the founder of European Wellness Biomedical Group—an International chain of research and treatment facilities (European Wellness Centers & Retreats) involved in anti-aging, longevity and education (European Wellness Academy). He chairs and also sits on board on numerous prominent antiaging and cell therapy associations of the world. Prof. Dato Sri Dr. Michelle Wong Bi Fah, ND, PhD is a scientist, researcher and educator actively involved in research and development (R&D) work on stem cells focusing on Fetal Precursor Stem-Cell Therapy. She is the Co-Founder/Senior Technical Advisor and Researcher in FCTI Inc., specialising in Stem cell Research and Bio-Regenerative Medicine for more than three decades. A prominent speaker, Michelle Wong presents at educational programs and global conferences on stem cells, cell therapy and biological medicine for physicians and healthcare practitioners worldwide.
Book Synopsis Drug Repurposing in Cancer Therapy by : Kenneth K.W. To
Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Book Synopsis Metabolism in Cancer by : Thorsten Cramer
Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Book Synopsis A Beginner's Guide to Targeted Cancer Treatments and Cancer Immunotherapy by : Elaine Vickers
Download or read book A Beginner's Guide to Targeted Cancer Treatments and Cancer Immunotherapy written by Elaine Vickers and published by John Wiley & Sons. This book was released on 2025-03-10 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demystifying the science behind new cancer treatments A clear and accessible guide written in everyday language for nurses and other healthcare professionals A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy helps readers understand the science behind many of the newer drug treatments for cancer. Assuming only a basic familiarity with cell biology, this easy-to-digest guide describes how our increased understanding of cancer has been translated into the creation of new cancer treatments with a wide range of targets. Gifted communicator and educator Dr. Elaine Vickers helps you understand the mechanisms of a wide range of individual targeted therapies and immunotherapies — enabling you to communicate effectively with your colleagues and patients. Concise chapters explain how new cancer drugs and immunotherapies work, discuss their benefits, identify their limitations, and more. Now in its second edition, this popular handbook is fully revised to reflect the latest developments in targeted drug therapies and immunotherapies. Entirely new chapters on advancements in various immunotherapies are accompanied by more than 100 new and updated color illustrations. Provides an up-to-date overview of relevant treatment targets for all major cancer types, including hematological cancers Describes cancer biology and the relationship between cancer and the immune system Offers valuable insights into cell communication pathways as a common target Covers small molecule drugs, antibody-based treatments, and cellular therapies, including novel immunotherapies A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy is a must-have resource for trainees, practicing nurses, and other healthcare professionals involved in the care of cancer patients, as well as non-specialists who encounter cancer data or cancer terminology in their field.
Book Synopsis Renal Cell Carcinoma by : Hendrik Van Poppel
Download or read book Renal Cell Carcinoma written by Hendrik Van Poppel and published by BoD – Books on Demand. This book was released on 2011-12-16 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgical and medical oncologists have been unable to decrease renal cell carcinoma mortality for uncertain reasons, although a lot of progress has been made in diagnosis and imaging, recognition of different genetic and pathological entities, management of localized disease and in the research on new drug treatments for advanced stages of the disease, potentially combined with surgery. The purpose of this book, which tackles a number of separate interesting topics, is to provide further insight into the disease and the management of early and advanced renal cell carcinoma. The volume is divided into different parts; the first part covers the characterization of renal masses and the second part covers rare distinct pathological entity. In the management section, active surveillance, partial nephrectomy and radiofrequency ablation are presented. A separate chapter reviews the management of Von Hippel Lindau disease, and finally, conventional and aberrant signaling pathways are explored.
Book Synopsis Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy by : Vivek Asati
Download or read book Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy written by Vivek Asati and published by Elsevier. This book was released on 2024-04-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1. The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets. - Discusses recently discovered molecular targets for cancer therapy - Brings updated literature of heterocyclic compounds, an important construction motif for the development of new anticancer drugs - Encompasses comprehensive compilation of recently introduced anticancer drugs in the market and their health outcomes and pharmacoeconomics
Book Synopsis Advances in Precision Medicine Oncology by : Hilal Arnouk
Download or read book Advances in Precision Medicine Oncology written by Hilal Arnouk and published by BoD – Books on Demand. This book was released on 2021-07-21 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects.
Book Synopsis Ferroptosis in cancer and beyond by : Yanqing Liu
Download or read book Ferroptosis in cancer and beyond written by Yanqing Liu and published by Frontiers Media SA. This book was released on 2023-02-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Secrets of the Lighthouse by : Santa Montefiore
Download or read book Secrets of the Lighthouse written by Santa Montefiore and published by Simon and Schuster. This book was released on 2013-07-18 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sweeping story of divided family, buried secrets and a love that will never die from the number one bestselling author of Songs of Love and War... Ellen Trawton has run away from London to the sweeping landscape of Connemara, hoping to find a place she can cut off all contact with the past. But beneath the wild beauty of the Irish landscape lie secrets which have been hidden for years… Conor Macausland cuts a dark, lonely figure. His young wife, Caitlin, died tragically at the old lighthouse, and her loss has devastated him. But when he and Ellen meet, a connection sparks between them. Ellen soon realizes that Conor’s past is not all it seems, and there’s more to her family history than she knew too. As the secrets are finally revealed, the truth must be told… ***PRAISE FOR SANTA MONTEFIORE*** ‘Nobody does epic romance like Santa Montefiore’ JOJO MOYES ‘An enchanting read overflowing with deliciously poignant moments’ DINAH JEFFERIES on Songs of Love and War ‘Santa Montefiore hits the spot for my like few other writers’ SARRA MANNING ‘One of our personal favourites’ THE TIMES on The Last Secret of the Deverills ‘Accomplished and poetic’ Daily Mail ‘Santa Montefiore is a marvel’ Sunday Express
Book Synopsis Translational Research in Breast Cancer by : Erwei Song
Download or read book Translational Research in Breast Cancer written by Erwei Song and published by Springer. This book was released on 2017-12-28 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.
Book Synopsis Tumor Invasion and Metastasis by : L.A. Liotta
Download or read book Tumor Invasion and Metastasis written by L.A. Liotta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical significance of tumor spread has always been appreciated. Yet, in spite of the pioneering work and outstanding contributions of investigators such as D. Coman, H. Green, B. Fisher, S. Wood and I. Zeidman, studies on metastasis rarely achieved the popularity afforded to more esoteric areas of tumor biology. Tumor dissemination, occurring as it does in a responding host and being composed of a series of dynamic int~ractions, is a highly complex phenomenon. Few investigators were brave enough to attempt to unravel the mechanisms involved. Paradoxically, this very complexity may have contributed, in part, to the recent upsurge of interest in metastasis research. More and more researchers are becoming fascinated by the complexities of the cellular interactions involved in tumor spread. Accompanying this intellectual stimulation have been technological advances in related fields which allow the derivation of new model systems. The mechanisms of metastatic spread are increasingly amenable to both the reductionist and holistic approaches and it is the purpose of this volume to present many of these model systems while emphasizing the intricacy and complexity of the processes they mimic. We have attempted to emphasize two topics not previously covered in depth in previous books on metastases. These are in vitro models of invasion and in teractions of tumor cells with connective tissue.
