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Mr Contrast Agents An Issue Of Magnetic Resonance Imaging Clinics
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Book Synopsis MR Contrast Agents, An Issue of Magnetic Resonance Imaging Clinics by : Marco Essig
Download or read book MR Contrast Agents, An Issue of Magnetic Resonance Imaging Clinics written by Marco Essig and published by Elsevier Health Sciences. This book was released on 2012-11-28 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI contrast agents improve visibility of internal body structures. This issue offers a complete, practically focused review of the use of a variety of contrast agents for MR Imaging. A contrast agent not only must be safe, but also efficacious and cost-effective, and the articles in this issue address all three of these concerns and the uses of contrast agents for a variety of applications.
Book Synopsis Update on Imaging Contrast Agents, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book by : Carlos A. Zamora
Download or read book Update on Imaging Contrast Agents, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book written by Carlos A. Zamora and published by Elsevier Health Sciences. This book was released on 2017-10-11 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on Update on Imaging Contrast Agents, and is edited by Drs. Carlos Zamora, Mauricio Castillo, Richard Semelka. Articles will include: Historical Perspective of Imaging Contrast Agents; Current Radiographic Iodinated Contrast Agents; Contrast-enhanced Sonography; Myelography: From Lipid-based to Gadolinium-based Contrast Agents; Acute Allergic Reactions with Gadolinium-based Contrast Agents: Diagnosis and Treatment; Deposition and Chronic Toxicity of Gadolinium-based Contrast Agents; Managing Allergic Reactions to Contrast Agents; Safety of Contrast Material Use in Children; Molecular Imaging and Contrast Agents; Contrast Agents for MR Imaging: Gadolinium, Manganese, SPIO, Superparamagnetic Iron Platinum, and Oral Agents; Contrast-induced Nephropathy: Pathophysiology, Manifestations, Prevention, and Management; and more!
Book Synopsis The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging by : Andre S. Merbach
Download or read book The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging written by Andre S. Merbach and published by John Wiley & Sons. This book was released on 2013-04-15 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine
Book Synopsis MR Safety, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book by : Robert E Watson
Download or read book MR Safety, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book written by Robert E Watson and published by Elsevier Health Sciences. This book was released on 2020-10-23 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on MR Safety and is edited by Dr. Robert E. Watson. Articles will include: Key elements of clinical MRI safety; Standardized approaches to MR safety assessment of patients with implanted devices; Performing MRI safely in patients with implanted electronic devices: cardiac electronic implanted devices and neurostimulators; Implanted devices: SAR considerations for common diagnostic examinations; Testing of commonly implanted devices for MR conditional labelling; MR safety in the 7T environment; Physics of MR safety; MRI safety considerations of gadolinium based contrast agents: gadolinium retention and nephrogenic systemic fibrosis; MRI safety: Siting and zoning considerations; Elements of effective patient screening to improve safety in MRI, including use of ferromagnetic detection systems; MRI safety in the interventional environment; MRI Safety: Pregnancy and Lactation; MR safety: Computer MRI simulations for testing of electronic devices; and more!
Book Synopsis Contrast Agents for Body MR Imaging by : Neil M. Rofsky
Download or read book Contrast Agents for Body MR Imaging written by Neil M. Rofsky and published by . This book was released on 1996 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MR in the Emergency Room, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book by : John Conklin
Download or read book MR in the Emergency Room, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book written by John Conklin and published by Elsevier Health Sciences. This book was released on 2022-08-28 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Magnetic Resonance Imaging Clinics, guest editors Drs. John Conklin and Michael Lev bring their considerable expertise to the topic of MR in the Emergency Room. Top experts in the field cover key topics such as penile and scrotal trauma, thoracic emergencies, biliary obstruction, GI/GU emergencies, abdominal and pelvic emergencies in the pregnant patient, pediatric emergencies, and more. Contains 14 relevant, practice-oriented topics including acute stroke; intracranial trauma, hemorrhage, and other non-stroke vascular emergencies; spinal emergencies; head and neck emergencies; musculoskeletal trauma and infection; and more. Provides in-depth clinical reviews on MR in the emergency room, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis MR-Guided Interventions, An Issue of Magnetic Resonance Imaging Clinics of North America by : Clare M. Tempany
Download or read book MR-Guided Interventions, An Issue of Magnetic Resonance Imaging Clinics of North America written by Clare M. Tempany and published by Elsevier Health Sciences. This book was released on 2015-10-30 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guest editors Claire Tempany and Tina Kapur review MR-Guided Interventions in this important issue in MRI Clinics of North America. Articles include: MR sequences and rapid acquisition for MR-guided interventions; MR-guided breast interventions: role in biopsy targeting and lumpectomies; MR-guided passive catheter tracking for endovascular therapy; MRgFUS update on clinical applications; MR-guided spine Interventions; MR-guided prostate biopsy; Interventional MRI Clinic: the Emory experience; MR-guided cardiac interventions; MR-guided functional neurosurgery; MR-guided active catheter tracking; MR-guided drug delivery; MR-guided thermal therapy for localized and recurrent prostate cancer; MR neurography for guiding nerve blocks and its role in pain management; MR-guided gynecologic brachytherapy; and more!
Book Synopsis MR in the Emergency Room, An issue of Magnetic Resonance Imaging Clinics of North America, E-Book by : Jorge A Soto
Download or read book MR in the Emergency Room, An issue of Magnetic Resonance Imaging Clinics of North America, E-Book written by Jorge A Soto and published by Elsevier Health Sciences. This book was released on 2016-07-28 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on MR in the Emergency Room. Articles will include: MR Imaging of Stroke; MR Imaging of Acute Head and Neck Infections; Use of MR in the Evaluation of Cranial Trauma; MR of Spinal Emergencies; Emergency MR Imaging of Musculoskeletal Trauma; Use of MR in Non-traumatic Musculoskeletal Emergencies; MR Imaging of Abdominal Pain in Pregnancy; MR of Pelvic and Gastrointestinal Emergencies; Use of MR in Pediatric Emergencies; Use of MR in Pancreatico-Biliary Emergencies; and more!
Book Synopsis Contrast Agents for MRI by : Valérie C Pierre
Download or read book Contrast Agents for MRI written by Valérie C Pierre and published by Royal Society of Chemistry. This book was released on 2017-11-17 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents. The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.
Book Synopsis Novel Contrast Agents for Magnetic Resonance Imaging by : Shing-Chung Cheung
Download or read book Novel Contrast Agents for Magnetic Resonance Imaging written by Shing-Chung Cheung and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging by : André E. Merbach
Download or read book The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging written by André E. Merbach and published by Wiley. This book was released on 2001-04-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a huge increase in the use of MRI and contrast agents in medicine in recent years as evidenced by a big increase in the number of hospitals with MRI machines and the ever-increasing number of examinations using contrast agents. Contrast agents have revolutionized the use of Magnetic Resonance Imaging (MRI) in medical diagnostics, allowing doctors to distinguish between normal and abnormal tissues and ultimately improving prognosis for the patient. This monograph covers all aspects of production, use, operating mechanisms and theory of these diagnostic agents, used to produce high contrast images in MRI. It will therefore be unique resource for what is currently a very active domain of research both in universities and in industry. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging is a comprehensive treatise: * written by the most active scientists in the field of contrast agents for medical MRI - from both university and industrial backgrounds * covering the topic from every angle from synthesis to safety considerations * invaluable to physicists, chemists, biologists as well as physicians * the first in-depth coverage of this topic
Book Synopsis Contrast Agents I by : Werner Krause
Download or read book Contrast Agents I written by Werner Krause and published by Springer Science & Business Media. This book was released on 2002-01-22 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].
Book Synopsis Novel Polymeric Magnetic Resonance Imaging (MRI) Contrast Agents by : Steven MacLellan
Download or read book Novel Polymeric Magnetic Resonance Imaging (MRI) Contrast Agents written by Steven MacLellan and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MRI Contrast Agents by : Sophie Laurent
Download or read book MRI Contrast Agents written by Sophie Laurent and published by Springer. This book was released on 2016-11-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc.
Book Synopsis Next Generation Magnetic Resonance Imaging Contrast Agents by : Piper Julia Klemm
Download or read book Next Generation Magnetic Resonance Imaging Contrast Agents written by Piper Julia Klemm and published by . This book was released on 2012 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is one of the most powerful diagnostic techniques at the disposal of the medical community. Its success in the clinic, with 75 to 90 million scans performed worldwide annually, can be attributed in part to the use of injectable contrast agents to improve signal differentiation between healthy and pathological tissue. These contrast agents primarily use Gd(III) as the paramagnetic metal ion to induce contrast. With seven unpaired electrons, Gd(III) has the most paramagnetic character of any nonradioactive element. Aqueous Gd(III), however, is highly toxic; hence contrast agents use chelators to encapsulate the Gd(III) ion, which protects the patient from from the Gd(III) ion. While these chelators are necessary, they greatly decrease the relaxivity of the current commercial contrast agents. Commercial contrast agents are similar in that they are heteroatom chelators (N, O) and octadentate coordination, leaving only one open site for water coordination. Additionally, given their steric bulk, the water exchange mechanism with bulk solvent is a laboriously hindered dissociative mechanism. These factors contribute to the low efficiency of these Gd(III) complexes, as measured in relaxivity. Diagnostic scans typically inject 8-10 g of these complexes to achieve sufficient signal. Hydroxypyridinone (HOPO) chelators have emerged as a superior alternative to current commercial compounds. Using a tris(2-aminoethyl)amine (TREN) capping moiety, three bidentate HOPO chelators form a hexadentate ligand. These TREN-tris-HOPO ligands leave multiple open sites for water coordination and exhibit rapid water exchange with bulk solvent, due to their reduced steric bulk and associative exchange mechanism. These ligands use all-oxygen-donor chelators, capitalizing on the oxophilicity of Gd(III) to form highly stable complexes. From this superior family of chelators, a variety of approaches can be used to develop the next generation of MRI contrast agents. Increasing molecular weight and tumbling time has been a strategy for increasing relaxivity and efficiency of MRI contrast agents. Through macromolecular conjugation, relaxivity is readily increased; simultaneously, these macromolecules provide the potential for building multimodal and multifunctional diagnostic and therapeutic agents. The potential applications for this class of materials are further increased with the addition of targeting functionality. These agents must have the ability to be fully and rapidly excreted and have facile and uniform large-scale syntheses to be candidates for the clinic. The esteramide (EA) dendrimer is one such macromolecular platform. With eight sites for contrast agent conjugation, the esteramide dendrimer readily loads many distinct HOPO ligands with multiple lanthanides for multimodal imaging. With close to 40 kDa of polyethylene glycol units, the Gd-HOPO-EA macromolecular architecture is highly soluble and biocompatible. Furthermore, the ester core of the dendrimer is degradable under in vivo conditions, easing renal clearance with four smaller moieties. The superior properties of this system inspired investigation into a variety of other macromolecular systems. Porous silica mesoparticles provide a rigid architecture that is much larger than other macromolecules evaluated and can hold greater than 108 small molecule MRI contrast complexes. The surfaces of these particles are readily functionalized and suitable for conjugation with most small molecule MRI contrast agents. These structures use a nontoxic silica infrastructure and are excreted renally despite their large size, making them viable candidates for further in vitro and in vivo study. Gold nanoparticles (AuNP) as a solid-support system have the most potential for use as multifunctional diagnostic and therapeutic compounds. AuNP have been long used for enhancing computed tomography (CT) imaging and have recently emerged as a cancer therapeutic when their structure is irradiated. These compounds are readily synthesized in large scales and have loading sites that are close together to hold multi-tethered Gadolinium-HOPO systems for multifunctional imaging. Using a variety of macromolecules to capitalize on the structural relationship between relaxivity and size, per-Gd and per-macromolecule-Gd relaxivity have been increased dramatically at clinically and physiologically relevant conditions. These improvements show that the combination of carefully designed macromolecules with excellent HOPO chelators produces an ideal MRI contrast agent for the clinic of the future.
Book Synopsis MRI of the Genitourinary System, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book by : Ersan Altun
Download or read book MRI of the Genitourinary System, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book written by Ersan Altun and published by Elsevier Health Sciences. This book was released on 2018-11-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on MR Imaging of the Genitourinary System, and is edited by Dr. Ersan Altun. Articles will include: Future Perspectives in Multiparametric Prostate MR Imaging; MRI-Guided Focal Therapies of Prostate Cancer; Infectious and Inflammatory Diseases of the Urinary Tract: Role of MRI; MRI of the Perirenal Space and Retroperitoneum; Tumors of Renal Collecting Systems, Renal Pelvis and Ureters: Role of MRI and MR Urography versus CT Urography; Radiomics of Kidney Cancer; MRI of the Bladder Tumors – What Is the Incremental value of PET-MRI?; MRI of the Penis and Urethra; MRI of the Testicular and Extratesticular Tumors: When Do We Need?; MRI Evaluation of Kidneys in Patients with Renal Impairment: Non-Contrast Techniques versus Contrast-Enhanced Techniques; Classification and Diagnosis of Cystic Renal Tumors: Role of MRI versus Contrast–Enhanced Ultrasound; and more!
Book Synopsis MR Perfusion, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book by : Max Wintermark
Download or read book MR Perfusion, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book written by Max Wintermark and published by Elsevier Health Sciences. This book was released on 2023-11-28 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of MRI Clinics, guest editors Drs. Max Wintermark and Ananth Madhuranthakam bring their considerable expertise to the topic of MR Perfusion. Top experts in the field discuss all three MR perfusion techniques (DSC, DCE, and ASL), as well as provide separate articles on evaluation of gliomas, breast cancer, musculoskeletal, prostate, and heart. Contains 13 relevant, practice-oriented topics including perfusion imaging for brain tumors; dynamic susceptibility contrast (DSC) MR perfusion; arterial spin labelling (ASL) MR perfusion; MR perfusion imaging of prostate; dynamic contrast-enhanced (DCE) MR perfusion; MR perfusion imaging for breast cancer; and more. Provides in-depth clinical reviews on MR perfusion, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
