Mouse Oocyte Development

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Mouse Development

Author : Jacek Z. Kubiak
Publisher : Springer Science & Business Media
ISBN 13 : 3642304060
Total Pages : 436 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Mouse Development by : Jacek Z. Kubiak

Download or read book Mouse Development written by Jacek Z. Kubiak and published by Springer Science & Business Media. This book was released on 2012-08-23 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse is a perfect model organism to study mammalian, and thus indirectly also human, embryology. Most scientific achievements that have had an important impact on the understanding of basic mechanisms governing embryo development in humans, originated from mouse embryology. Stem cell research, which now offers the promise of regenerative medicine, began with the isolation and culture of mouse embryonic stem cells by Martin Evans (who received the Nobel Prize in medicine in 2007 for this achievement) and Matthew Kaufman. This book provides an overview of mouse development, spanning from oocytes before fertilization to the state-of-the-art description of embryonic and adult stem cells. The chapters, written by the leading specialists in the field, deal with the most recent discoveries in this extremely fast-developing area of research.

Mouse Oocyte Development

Author : Marie-Hélène Verlhac
Publisher : Humana
ISBN 13 : 9781493993406
Total Pages : 174 pages
Book Rating : 4.9/5 (934 download)

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Book Synopsis Mouse Oocyte Development by : Marie-Hélène Verlhac

Download or read book Mouse Oocyte Development written by Marie-Hélène Verlhac and published by Humana. This book was released on 2019-07-15 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details methods on various aspects of the very final stages of mouse oocyte development. Chapters guide the reader through in vitro growth of follicles, production of a fully-grown competent mouse oocyte, meiosis resumption, analysis of spindle assembly and chromosome segregation, analysis of the oocyte and early embryo transcriptome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Oocyte Development: Methods and Protocols aims to help scientists with the set up both live and fix experiments required to study the process of oocyte meiotic maturation.

RNA Synthesis in Immature Mouse Oocyte Development

Author : Sallie Jean L. Fourcroy
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis RNA Synthesis in Immature Mouse Oocyte Development by : Sallie Jean L. Fourcroy

Download or read book RNA Synthesis in Immature Mouse Oocyte Development written by Sallie Jean L. Fourcroy and published by . This book was released on 1977 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oocyte Growth and Maturation

Author : T.A. Dettlaff
Publisher : Springer Science & Business Media
ISBN 13 : 1468406825
Total Pages : 456 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Oocyte Growth and Maturation by : T.A. Dettlaff

Download or read book Oocyte Growth and Maturation written by T.A. Dettlaff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of oogenesis occupy an important place in current in vestigations in developmental biology. Today no one has any doubt whatsoever that oogenesis is not just the prelude to development, but is development itself, and a very essential part of it. These words of an eminent Soviet scientist, B. L. As taurov , taken by T. B. Aizenshtadt as an epigraph to her chapter in this book, make a good epigraph for the entire book. It is now clear that during oogenesis not only vast reserves of ribosomes and mitochondria, of yolk, carbohydrates, and lipids, and of enzymes for protein and nucleic acid synthesis and for carbohydrate and fat metabolism (which ensures the energy supply and metabolism of the oocyte and the developing embryo) are formed, but also long-lived mRNA and proteins are synthesized, which determine both the completion of oocyte maturation and the initial stages of embryonic development. In the last 15-20 years, the use of molecular biology methods, electron microscopy, autoradiography, and microsurgical methods of experimental embryology in studying the pre-embryonic development of animals has greatly increased our knowledge of oogenesis. This has led to the need to systematize the data obtained, to reinter pret old ideas, and to review the results obtained by new research trends which have emerged in the last few years and which are of general biological interest. Such a task was undertaken in the book Sovremennye Problemy Oogeneza (Current Problems of Oogenesis), published in 1977 (in Russian).

Maternal Control of Development in Vertebrates

Author : Florence Louise Marlow
Publisher : Morgan & Claypool Publishers
ISBN 13 : 161504051X
Total Pages : 221 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Maternal Control of Development in Vertebrates by : Florence Louise Marlow

Download or read book Maternal Control of Development in Vertebrates written by Florence Louise Marlow and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References

Oocytes

Author : Malgorzata Kloc
Publisher : Springer
ISBN 13 : 331960855X
Total Pages : 505 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Oocytes by : Malgorzata Kloc

Download or read book Oocytes written by Malgorzata Kloc and published by Springer. This book was released on 2017-08-02 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines the most recent knowledge on the maternal, i.e. oocyte/egg-specific, molecules and processes. The volume covers the most recent advances in a plethora of subjects such as: maternal transfer of immunity, localized RNAs functions and mechanisms of RNA localization, transcriptional repression of maternal messages, maternal inheritance and maternal role of CRISPR/Cas9-based genome editing, chromatin remodeling and epigenetic modifications, maternal function of nucleosomes, maternal mitochondria and energy supply, role of bacterial symbionts and their maternal transmission, acquisition of oocyte polarity and evolution of maternal effect genes, germ plasm and oosome origin and functions, mechanisms of oocyte activation and soma germ cells communication. Currently, no other book on the market combines such a comprehensive list of subjects in one volume. Moreover, the information provided is a cross-section through oocytes from various invertebrate and vertebrate species, which is another unique feature of this book. The readers, therefore, get a completely new and invaluable perspective on all covered subjects.

The Future of the Oocyte

Author : John Eppig
Publisher : Springer Science & Business Media
ISBN 13 : 3662049600
Total Pages : 224 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis The Future of the Oocyte by : John Eppig

Download or read book The Future of the Oocyte written by John Eppig and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first successful transfer of an in vitro fertilised human egg in 1976, modern endocrinology, genetics, and assisted reproductive technologies have opened new frontiers of research with the aim to treat infertile women. In this workshop we set out to promote an interdisciplinary discussion between experts from various fields of basic, company-based and clinical research related to folliculogenesis and oocyte development. The aim of this workshop was to present, discuss and assess novel approaches in mammalian folliculogenesis and oocyte development that may have an impact on fertility/ infertility in the near or distant future. Key issues were the understanding of new modulators of folliculogenesis and regulators of cytoplasmic as well as meiotic oocyte maturation, modern technologies, the aging oocyte and pathogenetic mechanisms of infertility.

Protein 14-3-3 (YWHA) Isoforms and Their Roles in Regulating Mouse Oocyte Maturation

Author : Santanu De
Publisher :
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.:/5 (896 download)

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Book Synopsis Protein 14-3-3 (YWHA) Isoforms and Their Roles in Regulating Mouse Oocyte Maturation by : Santanu De

Download or read book Protein 14-3-3 (YWHA) Isoforms and Their Roles in Regulating Mouse Oocyte Maturation written by Santanu De and published by . This book was released on 2014 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 14-3-3 (YWHA) is a highly conserved, ubiquitously expressed protein family regulating important cellular processes including cell cycle. This work, for the first time, explored the differential expression and roles of 14-3-3 isoforms during mouse oocyte maturation. All seven mammalian 14-3-3 isoforms were identified in mouse eggs and ovarian follicular cells including oocytes, by Western blotting. Immunocytochemical and immunohistochemical staining confirmed the presence of all 14-3-3 isoforms in oocytes, eggs and ovarian follicles with characteristic similarities and differences in their distributions. Mammalian oocytes are arrested at meiosis prophase I by an inhibitory phosphorylation on Cyclin-Dependent Kinase I (CDK1), released by CDC25B phosphatase which is bound and inactivated in phosphorylated form by 14-3-3 in oocyte cytoplasm. Here, in situ Proximity Ligation Assays (PLA) revealed that all 14-3-3 isoforms interact with CDC25B in oocytes, with reduced interactions in eggs. Phosphorylation of CDC25B at Ser-149 was found to be reduced in eggs compared to oocytes. Microinjection of a translation-blocking morpholino oligonucleotide against 14-3-3eta mRNA caused germinal vesicle breakdown in significantly higher percentage of oocytes compared to oocytes injected with morpholinos targeting other 14-3-3 isoforms. Thus, interaction of 14-3-3eta with CDC25B is required for maintaining prophase I arrest in oocytes. Protein 14-3-3eta was observed to accumulate and co-localize with alpha-tubulin at both meiosis I and II spindles during mouse oocyte maturation in vivo as well as in vitro. It interacts directly with alpha-tubulin with an accumulation of the interactions at meiotic spindles, detected by in situ PLA. In a significant 76% of mouse oocytes microinjected with the morpholino against 14-3-3eta mRNA, meiotic spindles were deformed or absent with clumped chromosomes, no accumulation of 14-3-3eta and no polar body formation. All control eggs showed normal, bipolar spindles with accumulation of 14-3-3eta. Therefore, 14-3-3eta is essential for normal meiotic spindle formation during in vitro maturation of mouse oocytes, in part by interacting with alpha-tubulin, to regulate the assembly of microtubules. These studies reveal 14-3-3 isoform-specific interactions with key proteins involved in mouse oocyte maturation, such as CDC25B and alpha-tubulin. The results help to elucidate the roles of 14-3-3 proteins in mammalian oogenesis and reproductive development.

Quality Control of Mammalian Oocyte Meiotic Maturation: Causes, Molecular Mechanisms and Solutions

Author : Shao-Chen Sun
Publisher : Frontiers Media SA
ISBN 13 : 2889715132
Total Pages : 452 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Quality Control of Mammalian Oocyte Meiotic Maturation: Causes, Molecular Mechanisms and Solutions by : Shao-Chen Sun

Download or read book Quality Control of Mammalian Oocyte Meiotic Maturation: Causes, Molecular Mechanisms and Solutions written by Shao-Chen Sun and published by Frontiers Media SA. This book was released on 2021-10-20 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Laboratory Guide to the Mammalian Embryo

Author : David K. Gardner
Publisher : Oxford University Press
ISBN 13 : 9780195142266
Total Pages : 434 pages
Book Rating : 4.1/5 (422 download)

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Book Synopsis A Laboratory Guide to the Mammalian Embryo by : David K. Gardner

Download or read book A Laboratory Guide to the Mammalian Embryo written by David K. Gardner and published by Oxford University Press. This book was released on 2004-01-08 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Never before has there been such a comprehensive book of protocols. This compendium offers a full range of research techniques-from cell culture, to biochemical, to microscopic and genetic. More focused books, like Cold Spring Harbor's Manipulating the Mouse Embryo, are similar though more narrow in scope. This book will appeal to a broad range of researchers, from basic experimental scientists to clinical and animal scientists.

Cytoskeleton Dynamics

Author : Helder Maiato
Publisher : Humana
ISBN 13 : 9781071602188
Total Pages : 0 pages
Book Rating : 4.6/5 (21 download)

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Book Synopsis Cytoskeleton Dynamics by : Helder Maiato

Download or read book Cytoskeleton Dynamics written by Helder Maiato and published by Humana. This book was released on 2019-12-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details comprehensive state-of-the-art methods on actin microfilaments and microtubules and how they work to achieve different cellular functions in different cellular contexts. Chapters guide readers through protein purification, in vitro reconstitution of several cytoskeleton properties, analyses of microtubule- and actin-based structures, functional dissection of post-translational modifications, and roles in several biological processes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cytoskeleton Dynamics: Methods and Protocols aims to provide a wide range of experimental approaches and be an invaluable resource for present and future generations of cytoskeleton researchers. The chapter “Visualization and Functional Analysis of Spindle Actin and Chromosome Segregation in Mammalian Oocytes” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Biology and Pathology of the Oocyte

Author : Alan Trounson
Publisher : Cambridge University Press
ISBN 13 : 1107470293
Total Pages : 464 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Biology and Pathology of the Oocyte by : Alan Trounson

Download or read book Biology and Pathology of the Oocyte written by Alan Trounson and published by Cambridge University Press. This book was released on 2013-10-24 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human egg - the rarest and most rapidly aging cell in the body - is a topic of intense scientific study. Assisted reproduction clinics are constantly vying to improve success rates - choosing the best gametes is a key step in this process. This new edition of what one reviewer of the first edition described as 'possibly the definitive work on the oocyte' covers the development, biology and pathology of the oocyte, and technologies to manipulate, enhance and control fertility. These technologies are used to overcome infertility, avoid inherited diseases, and create genetically engineered embryos from stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book. The new edition is thoroughly updated and includes major new research on reprogramming, oocyte molecular development, cryopreservation and viability. We are in exciting times for the egg.

M-Phase Kinases in Mouse Oocyte Maturation and Early Embryo Development

Author : Bedra Usam Ismail Sharif
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis M-Phase Kinases in Mouse Oocyte Maturation and Early Embryo Development by : Bedra Usam Ismail Sharif

Download or read book M-Phase Kinases in Mouse Oocyte Maturation and Early Embryo Development written by Bedra Usam Ismail Sharif and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Textbook of Clinical Embryology

Author : Kevin Coward
Publisher : Cambridge University Press
ISBN 13 : 110727625X
Total Pages : 408 pages
Book Rating : 4.1/5 (72 download)

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Book Synopsis Textbook of Clinical Embryology by : Kevin Coward

Download or read book Textbook of Clinical Embryology written by Kevin Coward and published by Cambridge University Press. This book was released on 2013-10-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.

Oogenesis

Author : Marie-Helene Verlhac
Publisher : John Wiley & Sons
ISBN 13 : 9780470687987
Total Pages : 516 pages
Book Rating : 4.6/5 (879 download)

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Book Synopsis Oogenesis by : Marie-Helene Verlhac

Download or read book Oogenesis written by Marie-Helene Verlhac and published by John Wiley & Sons. This book was released on 2010-03-04 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research. This book describes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction. This volume is an essential resource for all students, researchers and clinicians in developmental and reproductive biology. Key features: Reaches beyond the study of simply meiosis to cover all aspects of oogenesis Synthesizes recent advances in the field, drawing on studies from different model species Chapter sequence designed to follow the time line in vivo Written by an international panel of expert researchers

Human Assisted Reproductive Technology

Author : David K. Gardner
Publisher : Cambridge University Press
ISBN 13 : 1139501046
Total Pages : 363 pages
Book Rating : 4.1/5 (395 download)

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Book Synopsis Human Assisted Reproductive Technology by : David K. Gardner

Download or read book Human Assisted Reproductive Technology written by David K. Gardner and published by Cambridge University Press. This book was released on 2011-03-31 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice offers a collection of concise, practical review articles on cutting-edge topics within reproductive medicine. Each article presents a balanced view of clinically relevant information and looks ahead to how practice will change over the next five years. The clinical section discusses advances in reproductive surgery and current use of robotic surgery for tubal reversal and removal of fibroids. It looks into the refinement of surgical procedures for fertility preservation purposes. Chapters also discuss non-invasive diagnosis of endometriosis with proteomics technology, new concepts in ovarian stimulation and in the management of polycystic ovary syndrome, and evidence-based ART. The embryology section discusses issues ranging from three-dimensional in-vitro ovarian follicle culture, and morphometric and proteomics analysis of embryos, to oocyte and embryo cyropreservation. This forward-looking volume of review articles is key reading for reproductive medicine physicians, gynecologists, reproductive endocrinologists, urologists and andrologists.

Human Reproductive and Prenatal Genetics

Author : Peter C.K. Leung
Publisher : Elsevier
ISBN 13 : 0323913814
Total Pages : 930 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Reproductive and Prenatal Genetics by : Peter C.K. Leung

Download or read book Human Reproductive and Prenatal Genetics written by Peter C.K. Leung and published by Elsevier. This book was released on 2023-03-22 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. Features chapter contributions from leading international scientists and clinicians Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine