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Author : M. L. Tyan
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.3/5 (91 download)
Download or read book Mouse Fetal Liver written by M. L. Tyan and published by . This book was released on 1963 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bonnie Gay Wood
Publisher :
ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (517 download)
Download or read book A Comparative Study of a Mouse Fetal Liver Cell Line and Primary Cultures of Mouse Fetal Liver Cells written by Bonnie Gay Wood and published by . This book was released on 1972 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Strain
Publisher : Springer Science & Business Media
ISBN 13 : 9780412712609
Total Pages : 1320 pages
Book Rating : 4.7/5 (126 download)
Download or read book Liver Growth and Repair written by A. Strain and published by Springer Science & Business Media. This book was released on 1997-12-31 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
Author : Joyce A. Lloyd
Publisher : Humana Press
ISBN 13 : 9781493974276
Total Pages : 298 pages
Book Rating : 4.9/5 (742 download)
Download or read book Erythropoiesis written by Joyce A. Lloyd and published by Humana Press. This book was released on 2017-10-27 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides thorough protocols describing how to use genetics to study mouse and zebrafish erythropoiesis in whole animal models and for genetically manipulating cultured mouse and human erythroid cells. Protocols include strategies to analyze circulating red blood cell parameters, as well as progenitor cell status, stage of differentiation, and enucleation. Methods for the study of erythroid cell gene regulation using chromatin immunoprecipitation and chromatin conformation capture are detailed. Furthermore, protocols are provided to examine stress erythropoiesis, erythroblastic islands, and erythroblast structure. The collection also includes reviews on the available mouse models of erythropoiesis, as well as on future considerations for good manufacturing practice in order to translate the manufacture of erythrocytes to the clinic. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Erythropoiesis: Methods and Protocols provides a definitive source for molecular and cellular biology protocols to study erythropoiesis and to move this vital field forward.
Author : Marvin L. Tyan
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (227 download)
Download or read book Fetal Liver and Thymus: Roles in the Ontogenesis of the Mouse Immune System written by Marvin L. Tyan and published by . This book was released on 1965 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver cells or thymic grafts from homozygous embryonic mice were subjected to passage through appropriate nonoperated or thymectomized adult F1 hybrids. Passage through a nonthymectomized host was required for maturation of potential immunologically competent cells derived from embryonic liver; this was not true with regard to cells derived from a fetal thymic graft. Cells from embryonic liver were found first in the host thymus while those from thymic grafts appeared to migrate exclusively to peripheral lymphoid tissues. (Author).
Author : Isabelle Godin
Publisher : Springer Science & Business Media
ISBN 13 : 0387335358
Total Pages : 188 pages
Book Rating : 4.3/5 (873 download)
Download or read book Hematopoietic Stem Cell Development written by Isabelle Godin and published by Springer Science & Business Media. This book was released on 2010-05-27 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.
Author : Margaret Isabelle Fish
Publisher :
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.:/5 (124 download)
Download or read book Erythropoiesis in Fetal Mouse Liver written by Margaret Isabelle Fish and published by . This book was released on 1959 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : S. Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387763
Total Pages : 386 pages
Book Rating : 4.3/5 (877 download)
Download or read book Hepatocyte Transplantation written by S. Gupta and published by Springer Science & Business Media. This book was released on 2002-09-30 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on `Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309170427
Total Pages : 112 pages
Book Rating : 4.3/5 (91 download)
Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Author : Victor J. Stevens
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (11 download)
Download or read book The Development of Fetal Mouse Liver in Culture written by Victor J. Stevens and published by . This book was released on 1974 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.1/5 (89 download)
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Author : Kenneth Cornell Kasper
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (67 download)
Download or read book Development of Functional B Lymphocytes from Mouse Fetal Liver Cells written by Kenneth Cornell Kasper and published by . This book was released on 1978 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lichuan Qian
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.E/5 ( download)
Download or read book Three-dimensional Culture of Fetal Liver Cells written by Lichuan Qian and published by . This book was released on 2006 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis explored the influence of culture environment on proliferation and hepatic differentiation of fetal liver cells. Specifically, signals provided by soluble factors and culture substrates were examined. Comparison of a variety of culture medium conditions suggested that hepatocyte growth factor (HGF) is required throughout the culture period to induce the differentiation of liver stem cells into hepatic precursors, and to ensure the continual proliferation of stem cells and their progeny. On the other hand, timing of the addition of maturation-inducing factors such as oncostatin M (OSM) determines the kinetics of cell maturation. In the presence of HGF, adding OSM from the beginning results in concurrent growth and differentiation. In addition, the constant presence of protective agents such as ascorbic acid helps to enhance cell survival, leading to improved cell expansion and hepatocyte functions. Based on these findings, a modified culture medium was developed to achieve both optimal growth and differentiation. Cell expansion in this medium was about 2 fold of that under other tested conditions, whereas the specific albumin secretion rate was 2 - 3 times of the maximal values obtained with other conditions. Subsequently, characterization of fetal liver cells cultured on a variety of threedimensional (3D) scaffolds, including decellularized liver matrices, collagen scaffolds, and poly(lactic-co-glycolic acid) (PLGA) scaffolds, showed that the cellular responses to soluble signals are modulated by culture substrates. Experiments using scaffolds prepared from blends of PLGA(50:50) and polycaprolactone (PCL) further suggested that cell expansion requires rigid and porous scaffolds, whereas differentiation is enhanced on more pliable substrates. Together, these results demonstrated that the in vitro behavior of fetal liver cells is regulated by both the soluble and physical cues present in their microenvironment. Furthermore, cell growth and differentiation are influenced not only by the regulatory factors that are present, but also by the timing of their addition. These findings would help to develop a culture system that employs dynamic integration of biochemical and substrate-related signals to control the growth and differentiation kinetics of fetal liver cells. They may also provide a foundation for developing technologies for applications of other liver stem cells and progenitors. (Abstract).
Author : M. L. Tyan
Publisher :
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (227 download)
Download or read book Fetal Liver Cells: a Source of Specific Immunoglobulin Production in Radiation Chimeras written by M. L. Tyan and published by . This book was released on 1967 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult-thymectomized and intact (C57L x A)F1 mice were X-irradiated (870 rad), and injected ip with 20-33 x 10 to the 6th power nucleated cells from livers of 14-21 day C57B1/6 x C57B1/6 embryos. In other experiments the mice received 300,000 syngeneic bone marrow cells (iv), and dissociated gut cells from 14-21 day C57B1/6 x C57B1/6 embryos (ip). The sera from these chimeras were assayed for the presence of donor-type gamma-globulins. These mice were also sensitized to a synthetic polypeptide (TGAL), and their sera tested for total and for donor-type anti-TGAL antibody. All the mice, thymectomized as well as intact, which received fetal liver cells, had significant quantities of donor-type gamma-globulins in their sera by 58 days postirradiation. Only 1 of 14 mice injected with embryonic gut cells was found to have donor-type gamma-globulins by 95 days postirradiation. Following immunization with TGAL, the fetal liver cell chimeras (intact thymus) exhibited specific antibody (10/10), while none of the thymectomized chimeras (0/21) were positive for this antibody. In the immunized, intact-thymus group, significant amounts of the specific anti-TGAL antibody was of donor origin. Thus, mouse fetal liver, as early as the 14th day of gestation, contains lymphoid stem cells capable of immunoglobulin synthesis in the absence of thymus. However, their ability to form certain specific antibodies is dependent upon intact thymic function. The results suggest that the donor-type immunoglobulins synthesized in the absence of the thymus may be 'nonsense' of 'defective' antibody-like molecules. (Author).
Author : Jagjit Singh Gill
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.:/5 (427 download)
Download or read book Immunocytochemical Characterization of Components of the Hemopoietic Microenvironment in the Mouse Fetal Liver written by Jagjit Singh Gill and published by . This book was released on 1989 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Light microscope observations also showed areas of close cell associations involving two classes of central cells and peripheral erythroid cells. Such associations were distinguished based on their immunocytochemical characteristics (AFP vs. Mac-1 central cells) and quantitative appearance throughout cytospots." --
Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)
Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)
Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
