Molecular Toxicology Protocols

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Molecular Toxicology Protocols

Author : Phouthone Keohavong
Publisher : Springer Science & Business Media
ISBN 13 : 1592598404
Total Pages : 478 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Molecular Toxicology Protocols by : Phouthone Keohavong

Download or read book Molecular Toxicology Protocols written by Phouthone Keohavong and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.

PCR Protocols in Molecular Toxicology

Author : John P. Vanden Heuvel
Publisher : CRC Press
ISBN 13 : 9781439805800
Total Pages : 258 pages
Book Rating : 4.8/5 (58 download)

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Book Synopsis PCR Protocols in Molecular Toxicology by : John P. Vanden Heuvel

Download or read book PCR Protocols in Molecular Toxicology written by John P. Vanden Heuvel and published by CRC Press. This book was released on 2019-05-07 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular toxicology is an emerging discipline that utilizes molecular and cell biology to understand how drugs and chemicals result in their unwanted effects. PCR Protocols in Molecular Toxicology is a practical guide to the use of polymerase chain reaction (PCR) to help examine, on a molecular and cellular level, how toxic responses are manifested. It offers a basic understanding of PCR and its optimization, as well as describing specific, high-impact areas of molecular toxicology and recent advances. The following techniques are described in detail: Quantitative reverse transcriptase PCR and methods to examine gene expression Differential display cloning Cloning and library screening by PCR Genotype and polymorphism analysis of drug and toxicant metabolizing enzymes Basic, non-PCR based molecular biology methods PCR Protocols in Molecular Toxicology will aid both novices and experienced PCR practitioners in using PCR to its fullest potential.

Molecular and Biochemical Toxicology

Author : Robert C. Smart
Publisher : John Wiley & Sons
ISBN 13 : 1119042410
Total Pages : 1060 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Molecular and Biochemical Toxicology by : Robert C. Smart

Download or read book Molecular and Biochemical Toxicology written by Robert C. Smart and published by John Wiley & Sons. This book was released on 2018-01-04 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Molecular Toxicology Protocols

Author : Phouthone Keohavong
Publisher : Humana Press
ISBN 13 : 9781627037389
Total Pages : 0 pages
Book Rating : 4.0/5 (373 download)

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Book Synopsis Molecular Toxicology Protocols by : Phouthone Keohavong

Download or read book Molecular Toxicology Protocols written by Phouthone Keohavong and published by Humana Press. This book was released on 2014-03-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Toxicology Protocols, Second Edition aims to bring together a series of articles describing validated methods to elucidate specific molecular aspects of toxicology, the emphasis being on the application of molecular methods to genetic toxicology. The volume is divided into ten parts, roughly corresponding to the spectrum of biomarkers intermediate between exposure and disease outcomes as proposed in molecular epidemiology models. Subjects of these new chapters range from preparation of fluid specimens for analysis of cellular inflammatory responses to genotoxic insults to sensitive methods for proteomic analysis and aberrant DNA methylation patterns. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Molecular Toxicology Protocols, Second Edition addresses not only the needs of molecular biologists and toxicologists, but also those of individuals interested in applying molecular methods to clinical applications, such as geneticists, pathologists, biochemists, and epidemiologists.

Molecular Toxicology

Author : Nick Plant
Publisher : Taylor & Francis
ISBN 13 : 1000150216
Total Pages : 164 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Molecular Toxicology by : Nick Plant

Download or read book Molecular Toxicology written by Nick Plant and published by Taylor & Francis. This book was released on 2021-02-26 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

Genetic Toxicology

Author : James M. Parry
Publisher : Humana Press
ISBN 13 : 9781617794209
Total Pages : 433 pages
Book Rating : 4.7/5 (942 download)

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Book Synopsis Genetic Toxicology by : James M. Parry

Download or read book Genetic Toxicology written by James M. Parry and published by Humana Press. This book was released on 2011-12-07 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Current Protocols in Toxicology

Author : Mahin D. Maines
Publisher : Current Protocols
ISBN 13 : 9780471241065
Total Pages : 700 pages
Book Rating : 4.2/5 (41 download)

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Book Synopsis Current Protocols in Toxicology by : Mahin D. Maines

Download or read book Current Protocols in Toxicology written by Mahin D. Maines and published by Current Protocols. This book was released on 1998 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the latest models and methods from molecular biology, cell biology, biochemistry, and genetics, plus sophisticated toxicological procedures from leading laboratories. Also offers guidelines for evaluating the effects of substances on human physiology and metabolism and reference information, including stock solutions and equipment and commonly used techniques.

Molecular and Cellular Methods in Developmental Toxicology

Author : George P. Daston
Publisher : CRC Press
ISBN 13 : 1439810664
Total Pages : 336 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Molecular and Cellular Methods in Developmental Toxicology by : George P. Daston

Download or read book Molecular and Cellular Methods in Developmental Toxicology written by George P. Daston and published by CRC Press. This book was released on 2019-04-30 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

Current Protocols in Molecular Biology

Author :
Publisher :
ISBN 13 : 9780471503385
Total Pages : pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Current Protocols in Molecular Biology by :

Download or read book Current Protocols in Molecular Biology written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

In Silico Methods for Predicting Drug Toxicity

Author : Emilio Benfenati
Publisher :
ISBN 13 : 9781071619605
Total Pages : 680 pages
Book Rating : 4.6/5 (196 download)

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Book Synopsis In Silico Methods for Predicting Drug Toxicity by : Emilio Benfenati

Download or read book In Silico Methods for Predicting Drug Toxicity written by Emilio Benfenati and published by . This book was released on 2021 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated book explores all-new and revised protocols involving the use of in silico models, particularly with regard to pharmaceuticals. Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice necessary for successful results. Authoritative and comprehensive, In Silico Methods for Predicting Drug Toxicity, Second Edition aims to guide the reader through the correct procedures needed to harness in silico models, a field which now touches a wide variety of research specialties.

Advances in Molecular Toxicology

Author : Claude Reiss
Publisher : VSP
ISBN 13 : 9789067642781
Total Pages : 590 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Advances in Molecular Toxicology by : Claude Reiss

Download or read book Advances in Molecular Toxicology written by Claude Reiss and published by VSP. This book was released on 1998-02 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.

Genotoxicity Assessment

Author : Alok Dhawan
Publisher : Humana
ISBN 13 : 9781493963027
Total Pages : 0 pages
Book Rating : 4.9/5 (63 download)

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Book Synopsis Genotoxicity Assessment by : Alok Dhawan

Download or read book Genotoxicity Assessment written by Alok Dhawan and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.

Computational Toxicology

Author : Orazio Nicolotti
Publisher : Humana
ISBN 13 : 9781493993192
Total Pages : 587 pages
Book Rating : 4.9/5 (931 download)

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Book Synopsis Computational Toxicology by : Orazio Nicolotti

Download or read book Computational Toxicology written by Orazio Nicolotti and published by Humana. This book was released on 2019-12-10 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply with both scientific and regulatory sides; computational toxicology in drug discovery; and strategies on how to predict various human-health toxicology endpoints. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the methods and software tools used, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Computational Toxicology: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this expanding field.

Environmental Toxicology and Toxicogenomics

Author : Xiaoping Pan
Publisher : Humana
ISBN 13 : 9781071615164
Total Pages : 366 pages
Book Rating : 4.6/5 (151 download)

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Book Synopsis Environmental Toxicology and Toxicogenomics by : Xiaoping Pan

Download or read book Environmental Toxicology and Toxicogenomics written by Xiaoping Pan and published by Humana. This book was released on 2022-06-22 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.

Molecular Biomethods Handbook

Author : John M. Walker
Publisher : Springer Science & Business Media
ISBN 13 : 1603273751
Total Pages : 1105 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Molecular Biomethods Handbook by : John M. Walker

Download or read book Molecular Biomethods Handbook written by John M. Walker and published by Springer Science & Business Media. This book was released on 2008-11-04 with total page 1105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. This book expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Written by a well-established panel of research scientists, the book provides an up-to-date collection of methods used regularly in the authors’ own research programs.

Developmental Toxicology

Author : Craig Harris
Publisher : Humana Press
ISBN 13 : 9781617798665
Total Pages : 0 pages
Book Rating : 4.7/5 (986 download)

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Book Synopsis Developmental Toxicology by : Craig Harris

Download or read book Developmental Toxicology written by Craig Harris and published by Humana Press. This book was released on 2012-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology. The science of developmental toxicology also borrows from other research areas that are concerned with regulation of cell growth, migration, differentiation and cell death, as such are central to the study of stem cells, cancer, and chronic diseases. In Developmental Toxicology: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study developmental toxicology highlighting the evolution of methods from classical teratology approaches to the dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Developmental Toxicology: Methods and Protocols is a valuable resource to those planning experiments to investigate consequences of environmental, nutritional, or chemical effects caused during development.

Cell Biology Protocols

Author : J. Robin Harris
Publisher : Wiley
ISBN 13 : 9780470033463
Total Pages : 418 pages
Book Rating : 4.0/5 (334 download)

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Book Synopsis Cell Biology Protocols by : J. Robin Harris

Download or read book Cell Biology Protocols written by J. Robin Harris and published by Wiley. This book was released on 2012-01-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a modern composite scientific discipline, Cell Biology has expanded and moved forward rapidly in recent years. Cell Biologists now require a wide range of techniques, including those of analytical biochemistry and microscopy in all its diverse forms. These are often used alongside the techniques of molecular biology and molecular genetics. This book contains numerous useful protocols, covering light and electron microscopy, cell culture, cell separation, subcellular fractionation, organelle and membrane isolation, and the use of in vitro reassembly systems in Cell Biology. Many of these protocols feature helpful notes and safety information for practical application. The format favours easy use at the bench with space for notes and important safety information. An appendix contains essential analytical information that will prove invaluable to those working on all aspects of cell biology. This book will be of interest to students and more experienced cell biologists, as well as molecular biologists and those working in genomics and proteomics who are looking for cellular techniques to validate their findings within intact cells.