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Author : Ann-Christin Malmborg
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Recognition in Antibody Engineering written by Ann-Christin Malmborg and published by . This book was released on 1996 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Florian Rüker
Publisher : Springer Nature
ISBN 13 : 3030546306
Total Pages : 388 pages
Book Rating : 4.0/5 (35 download)
Download or read book Introduction to Antibody Engineering written by Florian Rüker and published by Springer Nature. This book was released on 2021-01-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.
Author : Jason A. McEvoy
Publisher :
ISBN 13 : 9781612094786
Total Pages : 322 pages
Book Rating : 4.0/5 (947 download)
Download or read book Molecular Recognition written by Jason A. McEvoy and published by . This book was released on 2011 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term 'molecular recognition' refers to the specific interaction between two or more molecules through noncovalent bonding. This book presents research in the study of molecular recognition, including next generation molecular imprinted polymers; applications of molecular imprinting; recent advances in DNA-Ligand molecular recognition and allosteric interactions; the proteomic code and the molecular recognition of odorant-binding proteins in insect olfaction.
Author : Damien Nevoltris
Publisher : Humana Press
ISBN 13 : 9781493986477
Total Pages : 543 pages
Book Rating : 4.9/5 (864 download)
Download or read book Antibody Engineering written by Damien Nevoltris and published by Humana Press. This book was released on 2018-09-24 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed new edition provides complete and easy access to a variety of antibody engineering techniques. The volume explores topics such as the generation of native, synthetic, or immune antibody libraries, the selection of lead candidates via the different powerful and innovative display technologies, Fc engineering, as well as their production, characterization, and optimization of antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Antibody Engineering: Methods and Protocols, Third Edition presents the reader with an extensive toolbox to create the powerful molecules of tomorrow.
Author : Benny K. C. Lo
Publisher : Springer Science & Business Media
ISBN 13 : 1592596665
Total Pages : 555 pages
Book Rating : 4.5/5 (925 download)
Download or read book Antibody Engineering written by Benny K. C. Lo and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to a wide range of disease states, and the potential ability to direct the host’s immune s- tem for a therapeutic response. The initial excitement in finding Paul Ehrlich’s “magic bullet,” however, was met with widespread disappointment when it was demonstrated that murine antibodies frequently elicit the human anti-murine an- body (HAMA) response, thus rendering them ineffective and potentially unsafe in humans. Despite this setback, advances in recombinant DNA techniques over the last 15–20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA. The ability to p- duce bulk quantities of recombinant proteins from bacterial fermentation also fueled the design of numerous creative antibody constructs. To date, the United States Food and Drug Administration has approved more than 10 recombinant antibodies for human use, and hundreds more are in the development pipeline. The recent explosion in genomic and proteomic information appears ready to deliver many more disease targets amenable to antibody-based therapy.
Author : Wlodzimierz Kutner
Publisher : Royal Society of Chemistry
ISBN 13 : 1782626476
Total Pages : 482 pages
Book Rating : 4.7/5 (826 download)
Download or read book Molecularly Imprinted Polymers for Analytical Chemistry Applications written by Wlodzimierz Kutner and published by Royal Society of Chemistry. This book was released on 2018-04-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: A summary of the latest developments and applications of molecular imprinting for selective chemical sensing.
Author : Chaim Putterman
Publisher : Academic Press
ISBN 13 : 0128033703
Total Pages : 192 pages
Book Rating : 4.1/5 (28 download)
Download or read book Structural Biology in Immunology written by Chaim Putterman and published by Academic Press. This book was released on 2018-05-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles
Author : Bo Mattiasson
Publisher : Springer
ISBN 13 : 3319207296
Total Pages : 231 pages
Book Rating : 4.3/5 (192 download)
Download or read book Molecularly Imprinted Polymers in Biotechnology written by Bo Mattiasson and published by Springer. This book was released on 2015-07-14 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Controlled radical polymerization techniques for molecular imprinting, by Mark E. Byrne From bulk polymers to nanoparticles, by Lei Ye Post-imprinting and in-cavity functionalization, by Toshifumi Takeuchi Characterization of MIPs (affinity, selectivity, site heterogeneity...), by Richard Ansell Theoretical aspects and computer modelling, by Ian Nicholls MIPs in aqueous environments, by Bin Lu MIPs for binding macromolecules, by Kenneth J. Shea Solid phase extraction, by Ecevit Yilmaz Sensors, by Sergey A. Piletsky MIPs for catalysis and synthesis, by Marina Resmini Wastewater treatment, by Bo Mattiasson MIPs as tools for bioassays, biotransformation and drug delivery, by Meiping Zhao
Author : Carlos F. Barbas
Publisher : CSHL Press
ISBN 13 : 0879697407
Total Pages : 724 pages
Book Rating : 4.8/5 (796 download)
Download or read book Phage Display written by Carlos F. Barbas and published by CSHL Press. This book was released on 2001 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.
Author : Mohammed Zourob
Publisher : Springer
ISBN 13 : 9781493939404
Total Pages : 880 pages
Book Rating : 4.9/5 (394 download)
Download or read book Recognition Receptors in Biosensors written by Mohammed Zourob and published by Springer. This book was released on 2016-04-01 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a significant and up-to-date review of the various recognition receptors, their immobilization, and an overview of the used surface characterization techniques. It includes more than 150 illustrations that help explain the ideas presented.
Author : Anthony R. Rees
Publisher : Oxford Medical Histories
ISBN 13 : 0199646570
Total Pages : 385 pages
Book Rating : 4.1/5 (996 download)
Download or read book The Antibody Molecule written by Anthony R. Rees and published by Oxford Medical Histories. This book was released on 2015 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'The Antibody Molecule' is a beautifully illustrated review of the remarkable developments within immunology from the discovery of the antibody molecule to its exploitation in medicine and the scientists and pioneers who were involved. This engaging and authoritative history will appeal to a wide audience
Author : Thomas Böldicke
Publisher : BoD – Books on Demand
ISBN 13 : 9535138251
Total Pages : 314 pages
Book Rating : 4.5/5 (351 download)
Download or read book Antibody Engineering written by Thomas Böldicke and published by BoD – Books on Demand. This book was released on 2018-02-21 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.
Author : Jean-Pierre Schermann
Publisher : Elsevier
ISBN 13 : 0080558224
Total Pages : 499 pages
Book Rating : 4.0/5 (85 download)
Download or read book Spectroscopy and Modeling of Biomolecular Building Blocks written by Jean-Pierre Schermann and published by Elsevier. This book was released on 2007-10-16 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectroscopy and Modeling of Biomolecular Building Blocks presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy, quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties of biomolecular systems and those induced by the presence of their environment. The first chapters provide background in modelling (I), frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD techniques (III). Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations. The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes; chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular systems. The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules. Offer a new perspective to the understanding of isolated elementary building blocks of bio molecules Includes case studies of experimental investigations coupled to quantum or classical calculations
Author : Floris van Delft
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162635
Total Pages : 477 pages
Book Rating : 4.8/5 (391 download)
Download or read book Chemical Linkers in Antibody-Drug Conjugates (ADCs) written by Floris van Delft and published by Royal Society of Chemistry. This book was released on 2021-12-22 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.
Author : Margaret Ackerman
Publisher : Academic Press
ISBN 13 : 0123948185
Total Pages : 376 pages
Book Rating : 4.1/5 (239 download)
Download or read book Antibody Fc written by Margaret Ackerman and published by Academic Press. This book was released on 2013-08-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system
Author : Gunnar Houen
Publisher : Humana
ISBN 13 : 9781493929986
Total Pages : 0 pages
Book Rating : 4.9/5 (299 download)
Download or read book Peptide Antibodies written by Gunnar Houen and published by Humana. This book was released on 2015-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive volume covers basic and advanced aspects of peptide antibody production, characterization and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest, such as phosphorylation, citrullination and others, while different forms of recombinant peptide antibodies are gaining interest, notably nanobodies, single chain antibodies, TCR-like antibodies, among others. Within this volume, those areas are covered, as well as several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells and T cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Peptide Antibodies: Methods and Protocols serves as an ideal reference for researchers exploring this vital and expansive area of study.
Author : Heddy Zola
Publisher : CRC Press
ISBN 13 : 1482242680
Total Pages : 232 pages
Book Rating : 4.4/5 (822 download)
Download or read book Monoclonal Antibodies written by Heddy Zola and published by CRC Press. This book was released on 2013-11-20 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and th
