Molecular Pathology Of Gastroenterological Cancer

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Molecular Pathology of Gastroenterological Cancer

Author : Eiichi Tahara
Publisher : Springer Science & Business Media
ISBN 13 : 4431659153
Total Pages : 360 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Molecular Pathology of Gastroenterological Cancer by : Eiichi Tahara

Download or read book Molecular Pathology of Gastroenterological Cancer written by Eiichi Tahara and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.

Molecular Pathology of Neoplastic Gastrointestinal Diseases

Author : Antonia R. Sepulveda
Publisher : Springer Science & Business Media
ISBN 13 : 1461460158
Total Pages : 276 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Molecular Pathology of Neoplastic Gastrointestinal Diseases by : Antonia R. Sepulveda

Download or read book Molecular Pathology of Neoplastic Gastrointestinal Diseases written by Antonia R. Sepulveda and published by Springer Science & Business Media. This book was released on 2013-01-28 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on: the molecular basis of the individual disease molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies recommended guidelines for clinical application of molecular tests are included whenever available molecular testing for hereditary predisposition or disease risk animal models and cell culture models of disease

Future Perspectives of Gastric Cancer Treatment

Author : Wataru Yasui
Publisher :
ISBN 13 : 9783805598835
Total Pages : 0 pages
Book Rating : 4.5/5 (988 download)

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Book Synopsis Future Perspectives of Gastric Cancer Treatment by : Wataru Yasui

Download or read book Future Perspectives of Gastric Cancer Treatment written by Wataru Yasui and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highest rates of gastric cancer are observed in eastern Asia, South America and eastern Europe. More than half of all cases worldwide occur in eastern Asia. Distinguished experts in Asia have reviewed current topics and future perspectives for gastric cancer treatment in molecular pathology, tissue engineering, surgery and chemotherapy. Advances in diagnosis and treatment offer excellent long-term survival rates in the case of early cancer diagnosis, but the prognosis of advanced cancer still remains poor. A detailed understanding of molecular pathogenesis and the individual characteristics of gastric cancer and the development of new medical technologies and therapeutic agents help to provide personalized cancer care for patients of early and advanced cancer. For ongoing success, interactions and developments between bench and bedside as well as clinics and bench are crucial. This special issue is recommended for researchers, pathologists, surgeons, physicians and oncologists in the field of gastroenterology, who are interested in the current topics and future perspectives of molecular pathology, tissue engineering, surgery and chemotherapy of gastric cancer.

Molecular Pathogenesis of Colorectal Cancer

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
ISBN 13 : 146148412X
Total Pages : 319 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Molecular Pathogenesis of Colorectal Cancer by : Kevin M. Haigis, Ph.D.

Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and published by Springer Science & Business Media. This book was released on 2013-10-02 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Precision Molecular Pathology of Liver Cancer

Author : Chen Liu
Publisher : Springer
ISBN 13 : 331968082X
Total Pages : 274 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Precision Molecular Pathology of Liver Cancer by : Chen Liu

Download or read book Precision Molecular Pathology of Liver Cancer written by Chen Liu and published by Springer. This book was released on 2018-01-09 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.

Neoplastic Gastrointestinal Pathology: An Illustrated Guide

Author : Laura W. Lamps, MD
Publisher : Springer Publishing Company
ISBN 13 : 1617051217
Total Pages : 408 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Neoplastic Gastrointestinal Pathology: An Illustrated Guide by : Laura W. Lamps, MD

Download or read book Neoplastic Gastrointestinal Pathology: An Illustrated Guide written by Laura W. Lamps, MD and published by Springer Publishing Company. This book was released on 2015-07-15 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concisely written, abundantly illustrated guide to a wide range of topics in gastrointestinal neoplasia facilitates the evaluation and accurate diagnosis of gastrointestinal neoplasms, both straightforward and challenging. This approachable guide covers the entire tubular GI tract and features more than 600 high quality images. Written and arranged with the busy practicing pathologist in mind, this practical guide includes, for each entity, definitions and terminology, gross and morphologic features, differential diagnoses, useful ancillary tests, staging and grading parameters, and clinical considerations. Beautiful color figures throughout the volume highlight essential histologic features as well as differential diagnoses and potential diagnostic pitfalls. The book is organized into six introductory chapters focused on approaches to neoplasia, followed by 6 organ-specific chapters covering each segment of the GI tract. The final two chapters offer an in-depth discussion of immunohistochemistry and molecular pathology of gastrointestinal neoplasia. This book is a vital reference for practicing pathologists, and with its clear, concise presentation it is also an excellent resource for pathologists in training. Key Features: Provides clear, concise coverage of neoplastic disease across the entire tubular gastrointestinal tract Offers over 600 high-quality images highlighting key differential points and potentially misleading variants Comprehensive tables cover diagnostic features, tumor types, and other crucial data for pathologists About the Authors: Laura W. Lamps, MD, is Professor and Vice-Chair for Academic Affairs, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR Andrew M Bellizzi, MD, is Clinical Associate Professor, Department of Pathology, University of Iowa Hospitals and Clinics, University of Iowa Carver College of Medicine; Co-Director of Immunopathology Laboratory and Co-Director of GI Pathology, Holden Comprehensive Cancer Center, Iowa City, IA

Gastric Cancer In The Precision Medicine Era

Author : Vincenzo Canzonieri
Publisher : Springer
ISBN 13 : 3030048616
Total Pages : 256 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Gastric Cancer In The Precision Medicine Era by : Vincenzo Canzonieri

Download or read book Gastric Cancer In The Precision Medicine Era written by Vincenzo Canzonieri and published by Springer. This book was released on 2019-05-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Gastrointestinal Oncology

Author : James L. Abbruzzese
Publisher :
ISBN 13 : 0195133722
Total Pages : 938 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Gastrointestinal Oncology by : James L. Abbruzzese

Download or read book Gastrointestinal Oncology written by James L. Abbruzzese and published by . This book was released on 2004 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important to gastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers each of the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management of specific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.

Current Topics in Gastritis

Author : Gyula Mozsik
Publisher : IntechOpen
ISBN 13 : 9789535109075
Total Pages : 276 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis Current Topics in Gastritis by : Gyula Mozsik

Download or read book Current Topics in Gastritis written by Gyula Mozsik and published by IntechOpen. This book was released on 2013-01-16 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastritis, as a medical term, exists for the last 150 years, however, terminology and etiology (including the prognosis ) has changed. Gastritis related medical problems are in the focus of different sub-disciplines: internists , gastroenterologists, pathologists, immunologists, bacteriologists, genetics, biologists etc. After the publications by Marshall and Warren most of the clinicians accepted only the etiopathological role of Helicobacter pylori in the development of gastric and duodenal ulcer , as well as in the gastric cancer. This book presents chapters abou the history of gastritis terminology, animal models, epidemiology, new gastric mucosal endogenous defensive neural mechanism (capsaicin-sinsitive afferentation), different research and clinical methods applied to the background studies and the molecular pathology, biochemistry and genetics involved in the pathways from Helicobacter pylori infection to development of gastric cancer. Intended audience of this book are internists, gastroenterologists, pathologists, bacteriologists, pharmacologists, genetics, biologists , immunologists and other interested researchers.

Molecular Pathology of Neoplastic Gastrointestinal Diseases

Author : Antonia R. Sepulveda
Publisher : Springer
ISBN 13 : 9781461460169
Total Pages : 277 pages
Book Rating : 4.4/5 (61 download)

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Book Synopsis Molecular Pathology of Neoplastic Gastrointestinal Diseases by : Antonia R. Sepulveda

Download or read book Molecular Pathology of Neoplastic Gastrointestinal Diseases written by Antonia R. Sepulveda and published by Springer. This book was released on 2013-01-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on: the molecular basis of the individual disease molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies recommended guidelines for clinical application of molecular tests are included whenever available molecular testing for hereditary predisposition or disease risk animal models and cell culture models of disease

WHO Classification of Tumours. Digestive System Tumours

Author :
Publisher : International Agency for Research on Cancer
ISBN 13 : 9789283244998
Total Pages : 0 pages
Book Rating : 4.2/5 (449 download)

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Book Synopsis WHO Classification of Tumours. Digestive System Tumours by :

Download or read book WHO Classification of Tumours. Digestive System Tumours written by and published by International Agency for Research on Cancer. This book was released on 2019-07-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Digestive System Tumours is the first volume in the fifth edition of the WHO series on the classification of human tumors. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumors and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education.

Current Topics in Gastritis

Author : Gyula Mozsik
Publisher : IntechOpen
ISBN 13 : 9789535109075
Total Pages : 276 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis Current Topics in Gastritis by : Gyula Mozsik

Early Gastrointestinal Cancers

Author : Florian Otto
Publisher : Springer Science & Business Media
ISBN 13 : 3642316298
Total Pages : 312 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Early Gastrointestinal Cancers by : Florian Otto

Download or read book Early Gastrointestinal Cancers written by Florian Otto and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recommendations regarding diagnosis and treatment are provided, and areas of consensus and controversy, identified. While the principal focus is on esophageal and gastric cancer, advances in the treatment of colorectal and pancreatic cancer are also discussed in some detail. This book will be of interest to every clinician involved in the care of patients with gastrointestinal malignancies.

Molecular Pathogenesis of Colorectal Cancer

Author : Kevin M. Haigis
Publisher :
ISBN 13 : 9781461484134
Total Pages : 326 pages
Book Rating : 4.4/5 (841 download)

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Book Synopsis Molecular Pathogenesis of Colorectal Cancer by : Kevin M. Haigis

Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis and published by . This book was released on 2013-10-31 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WHO Classification of Tumours of the Digestive System

Author : F. T. Bosman
Publisher : International Agency for Research on Cancer
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis WHO Classification of Tumours of the Digestive System by : F. T. Bosman

Download or read book WHO Classification of Tumours of the Digestive System written by F. T. Bosman and published by International Agency for Research on Cancer. This book was released on 2010-10-15 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].

Principles and Practice of Gastrointestinal Oncology

Author : David Kelsen
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781776172
Total Pages : 786 pages
Book Rating : 4.7/5 (761 download)

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Book Synopsis Principles and Practice of Gastrointestinal Oncology by : David Kelsen

Download or read book Principles and Practice of Gastrointestinal Oncology written by David Kelsen and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated for its Second Edition, this text provides comprehensive, interdisciplinary coverage of gastrointestinal cancer, including molecular biology, diagnosis, medical, surgical, and radiation therapy, and palliative care. The initial section, Principles of Gastrointestinal Oncology, includes an expanded radiation oncology chapter, an extensively revised cancer genetics chapter, and a completely rewritten medical oncology chapter emphasizing new agents. Subsequent sections focus on esophageal, gastric, pancreatic, hepatocellular, biliary tree, and colorectal cancer. Coverage of each anatomic site includes epidemiology, screening, and prevention; molecular biology and genetics; pathology; anatomy and staging; and clinical management. The final section on uncommon cancers includes new chapters on neuroendocrine tumors and small bowel cancers. A companion Website provides instant access to the complete, fully searchable text.

Management of Gastrointestinal Cancer

Author : P. McCulloch
Publisher : BMJ Books
ISBN 13 : 9780727910714
Total Pages : 404 pages
Book Rating : 4.9/5 (17 download)

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Book Synopsis Management of Gastrointestinal Cancer by : P. McCulloch

Download or read book Management of Gastrointestinal Cancer written by P. McCulloch and published by BMJ Books. This book was released on 1996-12-31 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This major textbook discussed the management, both surgical and medical, of all types of gastrointestinal cancer, and includes discussion of the epidemiology, molecular pathology, and novel methods of therapy for the different types of this very common disease.