Molecular Neurobiology Of Alzheimer Disease And Related Disorders

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Molecular Neurobiology of Alzheimer Disease and Related Disorders

Author : Masatoshi Takeda
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 380557603X
Total Pages : 312 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Molecular Neurobiology of Alzheimer Disease and Related Disorders by : Masatoshi Takeda

Download or read book Molecular Neurobiology of Alzheimer Disease and Related Disorders written by Masatoshi Takeda and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimers disease affects 6-10% of the elderly population, causing impairment in cognitive functions and significant disability in daily living for more than ten years. Neurofibrillary tangles, amyloid deposits and neuronal loss are the three hallmarks of Alzheimers disease. Due to insolubility of these unique structures in Alzheimer brain tissue, they were very difficult to study by usual biochemical methods in the past. Active research is now going on to elucidate the pathogenesis of Alzheimers disease. Major topics of neurobiological study of Alzheimers disease include the unraveling of the molecular mechanism of neurofibrillary tangle formation in neuronal and glial cells, the molecular processing of amyloid precursor protein in intracellular organella and in extra-cellular space, and the molecular mechanism of neuronal loss. The articles in this book were selected from contributions presented by leading scientists in this field at the international symposium which took place in Osaka in 2002. This publication is essential reading for all researchers, clinicians, basic and social scientists, neurologists and psychiatrists to promote the understanding of this formidable disease.

Neurobiology of Alzheimer's Disease

Author : David Dawbarn
Publisher : Oxford University Press
ISBN 13 : 0191034584
Total Pages : pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Neurobiology of Alzheimer's Disease by : David Dawbarn

Download or read book Neurobiology of Alzheimer's Disease written by David Dawbarn and published by Oxford University Press. This book was released on 2007-05-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associated proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Neurobiology of Alzheimer's Disease

Author : David Dawbarn
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.X/5 (4 download)

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Book Synopsis Neurobiology of Alzheimer's Disease by : David Dawbarn

Download or read book Neurobiology of Alzheimer's Disease written by David Dawbarn and published by Oxford University Press, USA. This book was released on 2001 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised edition of a book first published in 1995, presents an accessible overview of Alzheimer's disease, with an emphasis on research into the molecular mechanisms of neuronal degeneration. International experts have provided in-depth reviews of their areas of expertise, including coverage of the key molecules known to be involved, such as Ab, tau, apolipoprotein E and the presenilins. Other areas covered include neuropathology, genetics, neurochemical pathology, inflammation, diagnosis, models of the disease and opportunities for treatment, employing both existing and emerging drug therapies. The book will provide a readable introduction for those new to the subject, as well as covering a wide range of specialist topics for more experienced researchers and those interested in the overlap with other related specialist areas. Also included are appendices detailing gene and protein information on APP, tau, the presenilins, apolipoprotein E and the newly cloned therapeutic target, BACE.

Alzheimer's Disease

Author : Sangram S. Sisodia
Publisher : Springer Science & Business Media
ISBN 13 : 0387351353
Total Pages : 291 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Alzheimer's Disease by : Sangram S. Sisodia

Download or read book Alzheimer's Disease written by Sangram S. Sisodia and published by Springer Science & Business Media. This book was released on 2007-02-16 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Handbook of Neurochemistry and Molecular Neurobiology

Author : Moussa B.H. Youdim
Publisher : Springer Science & Business Media
ISBN 13 : 0387303448
Total Pages : 430 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Moussa B.H. Youdim

Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Moussa B.H. Youdim and published by Springer Science & Business Media. This book was released on 2007-12-14 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Molecular and Cellular Basis of Neurodegenerative Diseases

Author : Michael S. Wolfe
Publisher : Academic Press
ISBN 13 : 0128113057
Total Pages : 560 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Molecular and Cellular Basis of Neurodegenerative Diseases by : Michael S. Wolfe

Download or read book The Molecular and Cellular Basis of Neurodegenerative Diseases written by Michael S. Wolfe and published by Academic Press. This book was released on 2018-03-29 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Molecular Pathology of Alzheimer's Disease

Author : Rudy Castellani
Publisher : Biota Publishing
ISBN 13 : 1615046399
Total Pages : 93 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Molecular Pathology of Alzheimer's Disease by : Rudy Castellani

Download or read book Molecular Pathology of Alzheimer's Disease written by Rudy Castellani and published by Biota Publishing. This book was released on 2013-10-01 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Neurodegenerative Diseases

Author : Nagehan Ersoy Tunalı
Publisher : BoD – Books on Demand
ISBN 13 : 1838801499
Total Pages : 180 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Neurodegenerative Diseases by : Nagehan Ersoy Tunalı

Download or read book Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and published by BoD – Books on Demand. This book was released on 2021-01-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Molecular Mechanisms of Neurodegenerative Diseases

Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
ISBN 13 : 1592590063
Total Pages : 416 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Molecular Mechanisms of Neurodegenerative Diseases by : Marie-Francoise Chesselet

Download or read book Molecular Mechanisms of Neurodegenerative Diseases written by Marie-Francoise Chesselet and published by Springer Science & Business Media. This book was released on 2000-10-19 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Molecular Neurology

Author : Stephen Waxman
Publisher : Elsevier
ISBN 13 : 9780080546186
Total Pages : 600 pages
Book Rating : 4.5/5 (461 download)

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Book Synopsis Molecular Neurology by : Stephen Waxman

Download or read book Molecular Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2010-07-26 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

Current Hypotheses and Research Milestones in Alzheimer's Disease

Author : Ricardo B. Maccioni
Publisher : Springer Science & Business Media
ISBN 13 : 0387879951
Total Pages : 242 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Current Hypotheses and Research Milestones in Alzheimer's Disease by : Ricardo B. Maccioni

Download or read book Current Hypotheses and Research Milestones in Alzheimer's Disease written by Ricardo B. Maccioni and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost four decades of innovative and intensive research on Alzheimer’s disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease. Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD. These chapters grew out of “Current Hypothesis on Alzheimer’s Disease”, held in Viña del Mar, Chile, in November of 2007. Participants included the world’s leading Alzheimer’s researchers, whose work has illuminated AD investigations during the past few decades. Students, academics and medical professionals will find this text an invaluable addition to the study of this important subject.

Molecular Biology of Neurodegenerative Diseases

Author :
Publisher : Academic Press
ISBN 13 : 0123858844
Total Pages : 498 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Molecular Biology of Neurodegenerative Diseases by :

Download or read book Molecular Biology of Neurodegenerative Diseases written by and published by Academic Press. This book was released on 2012-05-22 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Genes, Environment and Alzheimer's Disease

Author : Orly Lazarov
Publisher : Academic Press
ISBN 13 : 0128028858
Total Pages : 448 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genes, Environment and Alzheimer's Disease by : Orly Lazarov

Download or read book Genes, Environment and Alzheimer's Disease written by Orly Lazarov and published by Academic Press. This book was released on 2016-02-25 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease

Author : Roger N. Rosenberg
Publisher : Butterworth-Heinemann
ISBN 13 : 9780750673600
Total Pages : 898 pages
Book Rating : 4.6/5 (736 download)

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Book Synopsis The Molecular and Genetic Basis of Neurologic and Psychiatric Disease by : Roger N. Rosenberg

Download or read book The Molecular and Genetic Basis of Neurologic and Psychiatric Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 2003 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inside the third edition of this reference, the reader will find thorough and authoritative discussions of all of these developments and their implications for clinical practice. It includes a major new section on Psychiatric Diseases; descriptions of the molecular and genetic basis of the spongiform encephalopathies as well as the expression of the prion gene under physiologic and pathologic conditions; additional coverage examines the human genome project and neurologic disease; and coverage on alzheimer's disease and related dementias.

Alzheimer Disease

Author : Robert Becker
Publisher : Springer Science & Business Media
ISBN 13 : 9780817638795
Total Pages : 636 pages
Book Rating : 4.6/5 (387 download)

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Book Synopsis Alzheimer Disease by : Robert Becker

Download or read book Alzheimer Disease written by Robert Becker and published by Springer Science & Business Media. This book was released on 1996-12-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the new potential treatments and research in the area of Alzheimer's disease. Special attention is given to international developments in all fields relevant to new drug development. Topics discussed include: progress in the international harmonization of drug development guidelines for dementia drugs; bioethics and law; development of rating instruments; behavioural treatments; and the activities of the Reagan Foundation. The text integrates basic and clinical research findings, and provides evaluation of new approaches to therapy by world leaders in the field. The potential benefit for Alzheimer patients and families resulting from these research programmes, from molecular biology to clinical pharmacology, is reviewed and evaluated.

Handbook of Neurochemistry and Molecular Neurobiology

Author : Abel Lajtha
Publisher : Springer Science & Business Media
ISBN 13 : 0387326707
Total Pages : 332 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Abel Lajtha

Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Abel Lajtha and published by Springer Science & Business Media. This book was released on 2008-06-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nervous system is highly fragile, especially during aging, illness and trauma. This book addresses a small sampling of major constituents of neural function at the cellular and molecular level that play crucial roles in development and aging.

Degenerative Disorders of the Brain

Author : Darren R. Hocking
Publisher : Routledge
ISBN 13 : 135120890X
Total Pages : 266 pages
Book Rating : 4.3/5 (512 download)

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Book Synopsis Degenerative Disorders of the Brain by : Darren R. Hocking

Download or read book Degenerative Disorders of the Brain written by Darren R. Hocking and published by Routledge. This book was released on 2019-04-05 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects. Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation. Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.