Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics

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Publisher :
ISBN 13 : 9783036515069
Total Pages : 170 pages
Book Rating : 4.5/5 (15 download)

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Book Synopsis Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics by : Srdjan M Vlajkovic

Download or read book Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics written by Srdjan M Vlajkovic and published by . This book was released on 2021-10-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a timely way, hearing loss can severely reduce the quality of life at various stages. Some causes of hearing loss can be prevented, for example from occupational or leisure noise. The World Health Organization estimates that more than 1 billion young people put themselves at risk of permanent hearing loss by listening to loud music over long periods of time. Mitigating such risks through public health action is essential to reduce the impact of hearing loss in the community. The etiology of sensorineural hearing loss is complex and multifactorial, arising from congenital and acquired causes. This book highlights the diverse range of approaches to sensorineural hearing loss, from designing new animal models of age-related hearing loss, to the use of microRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of agerelated and noise-induced hearing loss. Further investigation into the underlying molecular mechanisms of sensorineural hearing loss and the integration of the novel drug, cell, and gene therapy strategies into controlled clinical studies will permit significant advances in a field where there are currently many unmet needs.

Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear

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Publisher : Academic Press
ISBN 13 : 9780121531577
Total Pages : 490 pages
Book Rating : 4.5/5 (315 download)

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Book Synopsis Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear by : Raymond Romand

Download or read book Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear written by Raymond Romand and published by Academic Press. This book was released on 2003-12-10 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike. * Scores of high-quality, full- color figures * Detailed schemes on the structure and timing of ear development * Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology

Magnesium in the Central Nervous System

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Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Hereditary Hearing Loss and Its Syndromes

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Publisher : Oxford University Press
ISBN 13 : 0199313881
Total Pages : 576 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Hereditary Hearing Loss and Its Syndromes by : Helga V. Toriello

Download or read book Hereditary Hearing Loss and Its Syndromes written by Helga V. Toriello and published by Oxford University Press. This book was released on 2013-06-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third edition of the foremost medical reference on hereditary hearing loss. Chapters on epidemiology, embryology, non-syndromic hearing loss, and syndromic forms of hearing loss have all been updated with particular attention to the vast amount of new information on molecular mechanisms, and chapters on clinical and molecular diagnosis and on genetic susceptibility to ototoxic factors have been added. As in previous editions, the syndromes are grouped by system (visual, metabolic, cardiologic, neurologic, musculoskeletal, endocrine, etc.), with each chapter written by a recognized expert in the field. Written for practicing clinicians, this volume is an excellent reference for physicians, audiologists, and other professionals working with individuals with hearing loss and their families, and can also serve as a text for clinical training programs and for researchers in the hearing sciences.

Guidelines for Human Embryonic Stem Cell Research

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Publisher : National Academies Press
ISBN 13 : 0309096537
Total Pages : 224 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Guidelines for Human Embryonic Stem Cell Research by : National Research Council

Download or read book Guidelines for Human Embryonic Stem Cell Research written by National Research Council and published by National Academies Press. This book was released on 2005-09-15 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research. Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind. In addition, hES cell research touches on many ethical, legal, scientific, and policy issues that are of concern to the public. This report provides guidelines for the conduct of hES cell research to address both ethical and scientific concerns. The guidelines are intended to enhance the integrity of privately funded hES cell research by encouraging responsible practices in the conduct of that research.

The Human Auditory Cortex

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Publisher : Springer Science & Business Media
ISBN 13 : 1461423139
Total Pages : 404 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis The Human Auditory Cortex by : David Poeppel

Download or read book The Human Auditory Cortex written by David Poeppel and published by Springer Science & Business Media. This book was released on 2012-04-12 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: We live in a complex and dynamically changing acoustic environment. To this end, the auditory cortex of humans has developed the ability to process a remarkable amount of diverse acoustic information with apparent ease. In fact, a phylogenetic comparison of auditory systems reveals that human auditory association cortex in particular has undergone extensive changes relative to that of other species, although our knowledge of this remains incomplete. In contrast to other senses, human auditory cortex receives input that is highly pre-processed in a number of sub-cortical structures; this suggests that even primary auditory cortex already performs quite complex analyses. At the same time, much of the functional role of the various sub-areas in human auditory cortex is still relatively unknown, and a more sophisticated understanding is only now emerging through the use of contemporary electrophysiological and neuroimaging techniques. The integration of results across the various techniques signify a new era in our knowledge of how human auditory cortex forms basis for auditory experience. This volume on human auditory cortex will have two major parts. In Part A, the principal methodologies currently used to investigate human auditory cortex will be discussed. Each chapter will first outline how the methodology is used in auditory neuroscience, highlighting the challenges of obtaining data from human auditory cortex; second, each methods chapter will provide two or (at most) three brief examples of how it has been used to generate a major result about auditory processing. In Part B, the central questions for auditory processing in human auditory cortex are covered. Each chapter can draw on all the methods introduced in Part A but will focus on a major computational challenge the system has to solve. This volume will constitute an important contemporary reference work on human auditory cortex. Arguably, this will be the first and most focused book on this critical neurological structure. The combination of different methodological and experimental approaches as well as a diverse range of aspects of human auditory perception ensures that this volume will inspire novel insights and spurn future research.

Aminoglycoside Ototoxicity

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Publisher : Little, Brown Medical Division
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Aminoglycoside Ototoxicity by : Stephen A. Lerner

Download or read book Aminoglycoside Ototoxicity written by Stephen A. Lerner and published by Little, Brown Medical Division. This book was released on 1981 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hearing Loss: From Pathogenesis to Treatment

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Publisher : Frontiers Media SA
ISBN 13 : 2889765008
Total Pages : 216 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Hearing Loss: From Pathogenesis to Treatment by : Zuhong He

Download or read book Hearing Loss: From Pathogenesis to Treatment written by Zuhong He and published by Frontiers Media SA. This book was released on 2022-07-05 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sex Hormones in Neurodegenerative Processes and Diseases

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Publisher : BoD – Books on Demand
ISBN 13 : 1789230144
Total Pages : 360 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Sex Hormones in Neurodegenerative Processes and Diseases by : Gorazd Drevensek

Download or read book Sex Hormones in Neurodegenerative Processes and Diseases written by Gorazd Drevensek and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Encyclopedia of Otolaryngology, Head and Neck Surgery

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Author :
Publisher : Springer
ISBN 13 : 9783642234989
Total Pages : 3082 pages
Book Rating : 4.2/5 (349 download)

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Book Synopsis Encyclopedia of Otolaryngology, Head and Neck Surgery by :

Download or read book Encyclopedia of Otolaryngology, Head and Neck Surgery written by and published by Springer. This book was released on 2013-03-28 with total page 3082 pages. Available in PDF, EPUB and Kindle. Book excerpt: Otolaryngology Head and Neck Surgery is the medical and surgical specialty addressing disorders of the head and neck in both adult and pediatric populations. The goal of the encyclopedia is to serve as a single and comprehensive source of all the information that is essential for students and practitioners of the specialty. The vast amount of information included in the encyclopedia is divided into 5 volumes in line with the subspecialties of general otolaryngology, head and neck surgery, pediatric otolaryngology, otology–neurotology, and facial plastics. All volume editors are internationally recognized otolaryngologists with experience in publishing. Each section editor recruited experienced authors from all over the world to contribute on structured topics, and all entries are supported by published references. Thus, all information included in the encyclopedia is from credible sources and has been carefully screened for accuracy. The strength of the encyclopedia is its online availability and quick search features, which allow rapid retrieval of definitions and more in-depth information. Key words are hyperlinked to provide a gateway to numerous referenced manuscripts, journals, and books.

Purinergic Signalling in Neuron-Glia Interactions

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Publisher : John Wiley & Sons
ISBN 13 : 0470032235
Total Pages : 302 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Purinergic Signalling in Neuron-Glia Interactions by : Derek J. Chadwick

Download or read book Purinergic Signalling in Neuron-Glia Interactions written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-05-01 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: ATP, the intracellular energy source, is also an extremely important cell–cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry of ATP and its derivatives is complex, and the multiple membrane receptors that it activates are linked to many intracellular signalling systems. Purinergic signalling affects a diverse range of cellular phenomena, including ion channel function, cytoskeletal dynamics, gene expression, secretion, cell proliferation, differentiation and cell death. Recently, this class of signalling molecules and receptors has been found to mediate communication between neurons and non-neuronal cells (glia) in the central and peripheral nervous systems. Glia are critical for normal brain function, development and response to injury. Neural impulse activity is detected by glia and purinergic signalling is emerging as a major means of integrating functional activity between neurons, glia and vascular cells in the nervous system. These interactions mediate effects of neural activity on the development of the nervous system and in association with injury, neurodegeneration, myelination and cancer. Bringing together contributions from experts in diverse fields, including glial biologists, neurobiologists and specialists in purinergic receptor structure and pharmacology, this book considers how extracellular ATP acts to integrate communication between different types of glia, and between neurons and glia. Beginning with an overview of glia and purinergic signalling, it contains detailed coverage of purine release, receptors and reagents, purinergic signalling in the neural control of glial development, glial involvement in information processing, and discussion of the interactions between neurons and microglia.

Encyclopedia of Molecular Mechanisms of Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 3540671366
Total Pages : 2348 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Encyclopedia of Molecular Mechanisms of Disease by : Florian Lang

Download or read book Encyclopedia of Molecular Mechanisms of Disease written by Florian Lang and published by Springer Science & Business Media. This book was released on 2009-03-19 with total page 2348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.

Genetics of Deafness

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318058564
Total Pages : 146 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Genetics of Deafness by : B. Vona

Download or read book Genetics of Deafness written by B. Vona and published by Karger Medical and Scientific Publishers. This book was released on 2016-04-21 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Deafness offers a journey through areas crucial for understanding the causes and effects of hearing loss. It covers such topics as the latest approaches in diagnostics and deafness research and the current status and future promise of gene therapy for hearing restoration. The book begins by bringing attention to how hearing loss affects the individual and society. Methods of hearing loss detection and management throughout the lifespan are highlighted as is a particularly new development in newborn hearing screening. The challenges of hearing loss, an extremely heterogeneous impairment, are addressed. Additional topics include current research interests, ranging from novel gene identification to their functional validation in the mouse and zebrafish. The book ends with a chapter on the state of the art of gene therapy—an area that is certain to gain increasing attention as molecular mechanisms of deafness are better understood. Genetics of Deafness, written by leading authors in the field, is a must read for clinicians, researchers, and students. It provides much needed insight into the diagnosis and research of hereditary hearing loss.

The Mechanism on Development and Regeneration of Inner Ear Hair Cells

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 283250003X
Total Pages : 139 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Mechanism on Development and Regeneration of Inner Ear Hair Cells by : Dongdong Ren

Download or read book The Mechanism on Development and Regeneration of Inner Ear Hair Cells written by Dongdong Ren and published by Frontiers Media SA. This book was released on 2022-09-20 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Vision, Hearing, Balance, and Sensory Impairment in Americans Aged 70 Years and Over

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Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Vision, Hearing, Balance, and Sensory Impairment in Americans Aged 70 Years and Over by :

Download or read book Vision, Hearing, Balance, and Sensory Impairment in Americans Aged 70 Years and Over written by and published by . This book was released on 2010 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NIH Consensus Development Conference on Cochlear Implants in Adults and Children

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Author :
Publisher :
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis NIH Consensus Development Conference on Cochlear Implants in Adults and Children by :

Download or read book NIH Consensus Development Conference on Cochlear Implants in Adults and Children written by and published by . This book was released on 1995 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NIH Almanac

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Publisher :
ISBN 13 :
Total Pages : 170 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis NIH Almanac by : National Institutes of Health (U.S.). Division of Public Information

Download or read book NIH Almanac written by National Institutes of Health (U.S.). Division of Public Information and published by . This book was released on 1998 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: