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Author : Bradley W. Arbogast
Publisher : Gower Publishing Company, Limited
ISBN 13 :
Total Pages : 374 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Mechanisms of Preeclampsia written by Bradley W. Arbogast and published by Gower Publishing Company, Limited. This book was released on 1996 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Berthold Huppertz
Publisher :
ISBN 13 : 9783036525297
Total Pages : 402 pages
Book Rating : 4.5/5 (252 download)
Download or read book Molecular and Cellular Mechanisms of Preeclampsia written by Berthold Huppertz and published by . This book was released on 2022 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue on the “Molecular and Cellular Mechanisms of Preeclampsia” belongs to the section “Molecular Pathology, Diagnostics, and Therapeutics” of the International Journal of Molecular Sciences. It was a very successful Special Issue as it contains 20 published papers, including one editorial, nine original research papers, and ten reviews on the topic. The original publications cover a wide spectrum of topics, including alterations and involvement of specific factors during preeclampsia, new non-invasive technologies to identify changes, new treatment options, animal models, gender aspects, and effects of the pregnancy pathology later in life. The review publications again cover a wide spectrum of topics, including factors and pathways involved in preeclampsia, effects on the maternal vascular and immune systems, effects on the placenta and the trophoblast, epigenetic changes, new preventive strategies, and new views on the current hypotheses on preeclampsia. Taken together, this Special Issue gives a fantastic overview on a broad spectrum of topics, all of which are important to identify the real etiology of preeclampsia and to finally develop real treatment options.
Author : Berthold Huppertz
Publisher : Mdpi AG
ISBN 13 : 9783036525280
Total Pages : 402 pages
Book Rating : 4.5/5 (252 download)
Download or read book Molecular and Cellular Mechanisms of Preeclampsia written by Berthold Huppertz and published by Mdpi AG. This book was released on 2022-01-21 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue on the "Molecular and Cellular Mechanisms of Preeclampsia" belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics" of the International Journal of Molecular Sciences. It was a very successful Special Issue as it contains 20 published papers, including one editorial, nine original research papers, and ten reviews on the topic. The original publications cover a wide spectrum of topics, including alterations and involvement of specific factors during preeclampsia, new non-invasive technologies to identify changes, new treatment options, animal models, gender aspects, and effects of the pregnancy pathology later in life. The review publications again cover a wide spectrum of topics, including factors and pathways involved in preeclampsia, effects on the maternal vascular and immune systems, effects on the placenta and the trophoblast, epigenetic changes, new preventive strategies, and new views on the current hypotheses on preeclampsia. Taken together, this Special Issue gives a fantastic overview on a broad spectrum of topics, all of which are important to identify the real etiology of preeclampsia and to finally develop real treatment options.
Author : Brooke A. Grimaldi
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (417 download)
Download or read book Molecular Mechanisms Involving PPARγ in the Placental Pathophysiology of Preeclampsia written by Brooke A. Grimaldi and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author : Robert N. Taylor
Publisher : Elsevier
ISBN 13 : 0124079458
Total Pages : 500 pages
Book Rating : 4.1/5 (24 download)
Download or read book Chesley's Hypertensive Disorders in Pregnancy written by Robert N. Taylor and published by Elsevier. This book was released on 2014-08-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chesley's Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial. The fourth edition of Chesley's Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia. - Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis - Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management - Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia - Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book
Author : Christoph Lees
Publisher : Cambridge University Press
ISBN 13 : 1107157374
Total Pages : 281 pages
Book Rating : 4.1/5 (71 download)
Download or read book Maternal Hemodynamics written by Christoph Lees and published by Cambridge University Press. This book was released on 2018-05-03 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover new concepts in cardiovascular and hemodynamic functionality in feto-maternal medicine, from leading experts in the field.
Author : Yuping Wang
Publisher : Biota Publishing
ISBN 13 : 1615047514
Total Pages : 126 pages
Book Rating : 4.6/5 (15 download)
Download or read book Vascular Biology of the Placenta written by Yuping Wang and published by Biota Publishing. This book was released on 2017-06-23 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.
Author : Protasio L. Da Luz
Publisher : Academic Press
ISBN 13 : 0128125519
Total Pages : 760 pages
Book Rating : 4.1/5 (281 download)
Download or read book Endothelium and Cardiovascular Diseases written by Protasio L. Da Luz and published by Academic Press. This book was released on 2018-02-03 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. - Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information - Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress - Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Author : Nidhi Sharma
Publisher : BoD – Books on Demand
ISBN 13 : 1789847222
Total Pages : 156 pages
Book Rating : 4.7/5 (898 download)
Download or read book Prediction of Maternal and Fetal Syndrome of Preeclampsia written by Nidhi Sharma and published by BoD – Books on Demand. This book was released on 2019-10-02 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical syndrome of preeclampsia is due to vasospasm, endothelial dysfunction, and altered red cell zeta potential. It is a culmination of multiple etiologies and pathophysiologies modified by epigenetics and the human immune system. Since the etiology and pathogenesis of preeclampsia are segregated and multifactorial, there is no single clinical, biophysical, or biochemical marker that can predict all types of this condition. This book provides a set of tentative specific prediction markers that can be used to identify different subtypes of preeclampsia, classify pathogenesis, categorize treatment, and identify early signs of complications.
Author : Webb
Publisher : Oxford University Press
ISBN 13 : 0198855435
Total Pages : 1961 pages
Book Rating : 4.1/5 (988 download)
Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030910159X
Total Pages : 791 pages
Book Rating : 4.3/5 (91 download)
Download or read book Preterm Birth written by Institute of Medicine and published by National Academies Press. This book was released on 2007-05-23 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing prevalence of preterm birth in the United States is a complex public health problem that requires multifaceted solutions. Preterm birth is a cluster of problems with a set of overlapping factors of influence. Its causes may include individual-level behavioral and psychosocial factors, sociodemographic and neighborhood characteristics, environmental exposure, medical conditions, infertility treatments, and biological factors. Many of these factors co-occur, particularly in those who are socioeconomically disadvantaged or who are members of racial and ethnic minority groups. While advances in perinatal and neonatal care have improved survival for preterm infants, those infants who do survive have a greater risk than infants born at term for developmental disabilities, health problems, and poor growth. The birth of a preterm infant can also bring considerable emotional and economic costs to families and have implications for public-sector services, such as health insurance, educational, and other social support systems. Preterm Birth assesses the problem with respect to both its causes and outcomes. This book addresses the need for research involving clinical, basic, behavioral, and social science disciplines. By defining and addressing the health and economic consequences of premature birth, this book will be of particular interest to health care professionals, public health officials, policy makers, professional associations and clinical, basic, behavioral, and social science researchers.
Author : Rachel Dahn
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Deciphering the Molecular Mechanisms of Endothelial Cell Dysfunction in Preeclampsia written by Rachel Dahn and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preeclampsia (PE) is characterized by endothelial cell (EC) dysfunction, loss of vasodilatory capacity, and loss of EC integrity. In a healthy pregnancy, there is a 'normal' increase in inflammatory factors, including TNF-[alpha]. TNF-[alpha] abundance increases beyond compensatory limits in PE. The first aim examined the requirement of SRC (using inhibitors PP2, PP3, SRC-I1, Dasatinib*, Saracatinib*, *denotes clinical inhibitor), MEK (using inhibitors U0126, PD98059, PD0325901), and P38MAPK (using inhibitors SB203580, BIRB0796) in maintaining resistance (a hallmark of EC integrity) in P-UAECs via ECIS in the absence and presence of TNF-[alpha]. Our results showed that these inhibitors (and combinations) have differential responses in the absence and presence of TNF-[alpha]. While some inhibitors (and combinations) were stimulatory in the absence, none were able to provide complete or full protection in the presence of TNF-[alpha]-mediated destruction. We concluded the resistance of the P-UAEC monolayer is regulated by SRC, MEK, and P38MAPK. The second aim was to identify the effect of other inflammatory mediators, including interleukin 1[beta] (IL-1[beta]), interleukin 6 (IL-6), and interleukin 8 (IL-8) in the absence and presence of TNF-[alpha] (using P-UAECs via ECIS). In addition, we attempted to discern the effects of GP130 and the downstream signaling pathway JAK (using inhibitor AG490) and SRC (using inhibitor PP2) on EC integrity in the absence and presence of TNF-[alpha], IL-1[beta], or TNF+IL-1[beta]. In the absence of TNF-[alpha] several inhibitors (or combinations) increased resistances above control. However, none of the agents tested (alone or in combination) could prevent or provide full rescue of P-UAEC integrity from the effects of TNF-[alpha] alone or the IL-1[beta]+TNF-[alpha] combination. We conclude that while IL-1[beta] and TNF-[alpha] share some signaling pathways, they are clearly under distinct mechanisms of control. In the third and final aim, we examined if P-UAECs undergo cell surface changes (a process known as immune modulation) in response to long-term exposure (20hrs) to different cytokines TNF-[alpha] , IL-1[beta], or IFN-[gamma] and identify if there were subpopulations of cells (using multiparameter flow cytometry experiments). The novel discovery of this collection of work is that PUAEC subpopulations were formed and changes of these populations depend upon the type of cytokine treatment. Immune modulation is indeed at play in regulating endothelial subpopulations, damage, and, therefore, the pathogenesis of preeclampsia.
Author : Michael E. Symonds
Publisher : Cambridge University Press
ISBN 13 : 0521887097
Total Pages : 217 pages
Book Rating : 4.5/5 (218 download)
Download or read book Maternal-Fetal Nutrition During Pregnancy and Lactation written by Michael E. Symonds and published by Cambridge University Press. This book was released on 2010-01-28 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aim to improve clinicians' understanding of the important effects nutrition can have on maternal health and fetal and neonatal development, Maternal-Fetal Nutrition During Pregnancy and Lactation defines the nutritional requirements with regard to the stage of development and growth, placing scientific developments into clinical context.
Author : Alexander Heazell
Publisher : Cambridge University Press
ISBN 13 : 1139490869
Total Pages : pages
Book Rating : 4.1/5 (394 download)
Download or read book Hypertension in Pregnancy written by Alexander Heazell and published by Cambridge University Press. This book was released on 2010-08-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertensive disorders are among the most common medical complications of pregnancy, with an incidence of approximately 6-10%. This spectrum of conditions includes essential hypertension, pre-eclampsia and HELLP syndrome. For patients with pre-existing hypertension, management ideally commences prior to conception, and continues through pregnancy to the postnatal period. This book provides information on the evidence-based management of women with hypertension throughout pregnancy, supported by important background information on the etiology, risk-factors and pathophysiology of these disorders. Illustrated with accompanying algorithms, tables and lists for quick reference on diagnostic criteria, drugs and side-effects, this book will help clinicians rapidly gain access to the information they need to care for these patients. This will to be of interest to all grades of obstetric trainees as well as specialists, obstetric anesthetists and anesthetic trainees, midwives and maternal-fetal physicians.
Author : Yumjirmaa Mandakh
Publisher :
ISBN 13 : 9789180213486
Total Pages : 0 pages
Book Rating : 4.2/5 (134 download)
Download or read book Placental Molecular Mechanisms as Pathways Linking Prenatal Exposure to Ambient Air Pollution to Preeclampsia and Fetal Growth written by Yumjirmaa Mandakh and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christoph Lees
Publisher : Cambridge University Press
ISBN 13 : 1108548180
Total Pages : 300 pages
Book Rating : 4.1/5 (85 download)
Download or read book Placental-Fetal Growth Restriction written by Christoph Lees and published by Cambridge University Press. This book was released on 2018-03-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the effective evaluation, analysis and management of placental-fetal growth restriction (PFGR), reducing the risk of perinatal mortality and morbidity in patients worldwide. Extensively researched by international experts, this manual provides practitioners with a detailed, hands-on approach to the practical 'pearls' for direct patient management. This authoritative volume advises on matters such as the correct evaluation and management of high-risk patients in danger of PFGR through to delivery. Extensive and wide-ranging, this book is an invaluable companion to the developing research interest and clinical applications in PFGR, including developmental outcomes in early childhood. Featuring a critical evaluation of a variety of abnormal conditions, such as fetal hypoxia, which are clearly displayed through extensive illustrations. This essential toolkit ensures that practitioners of all levels can effectively limit the risk of mortality and morbidity, and reach the correct diagnosis, first-time.
