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Molecular Immunotoxicology
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Book Synopsis Molecular Immunotoxicology by : Emanuela Corsini
Download or read book Molecular Immunotoxicology written by Emanuela Corsini and published by John Wiley & Sons. This book was released on 2014-08-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Book Synopsis Molecular, Clinical and Environmental Toxicology by : Andreas Luch
Download or read book Molecular, Clinical and Environmental Toxicology written by Andreas Luch and published by Springer Science & Business Media. This book was released on 2012-06-07 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Book Synopsis Immunotoxicity, Immune Dysfunction, and Chronic Disease by : Rodney R. Dietert
Download or read book Immunotoxicity, Immune Dysfunction, and Chronic Disease written by Rodney R. Dietert and published by Springer Science & Business Media. This book was released on 2012-06-05 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases. To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on ”Key Points” as well as “Recommendations” where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.
Book Synopsis Investigative Immunotoxicology by : Helen Tryphonas
Download or read book Investigative Immunotoxicology written by Helen Tryphonas and published by CRC Press. This book was released on 2005-01-27 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus
Book Synopsis An Introduction to Interdisciplinary Toxicology by : Carey N. Pope
Download or read book An Introduction to Interdisciplinary Toxicology written by Carey N. Pope and published by Academic Press. This book was released on 2020-02-21 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.
Book Synopsis Molecular and Biochemical Toxicology by : Robert C. Smart
Download or read book Molecular and Biochemical Toxicology written by Robert C. Smart and published by John Wiley & Sons. This book was released on 2017-11-03 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition
Book Synopsis Glossary of Terms Used in Molecular Toxicology by : Douglas M Templeton
Download or read book Glossary of Terms Used in Molecular Toxicology written by Douglas M Templeton and published by Royal Society of Chemistry. This book was released on 2020-05-27 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This glossary expands upon the Comprehensive Glossary of Terms Used in Toxicology. Like its predecessor, it addresses the need for harmonized toxicology terminology, and has undergone a full, comprehensive and rigorous review by IUPAC Committees. It serves as the reference glossary for students and researchers studying the chemical and molecular biological bases of toxicology, and for those involved in chemicals legislation, regulation and risk assessment. Toxicology uses terminology from many disciplines that have been revolutionized by recent developments in molecular biology and biochemistry, and this glossary provides a compilation of definitions of molecular entities that impact on toxicology. Extensive Notes are included to provide context for many of the proteins and important genes defined, with disambiguation where entities are referred to by different names in the literature. We hope that this will be helpful to students and professionals alike.
Book Synopsis A Comprehensive Guide to Toxicology in Preclinical Drug Development by : Ali S. Faqi
Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-10-18 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. - Chapters written by world-renowned contributors who are experts in their fields - Includes the latest research in preclinical drug testing and international guidelines - Covers preclinical toxicology in small molecules and biologics in one single source
Book Synopsis Introduction To Immunotoxicology by : Jacques Descotes
Download or read book Introduction To Immunotoxicology written by Jacques Descotes and published by CRC Press. This book was released on 2003-09-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotoxicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro methods, biomarkers of immunotixicity and risk assessment.
Book Synopsis Information Resources in Toxicology, Volume 1: Background, Resources, and Tools by :
Download or read book Information Resources in Toxicology, Volume 1: Background, Resources, and Tools written by and published by Academic Press. This book was released on 2020-05-16 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources - Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles - Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals - Explores recent internet trends, web-based databases, and software tools in a section on the online environment - Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents - Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field
Book Synopsis Principles and Methods of Immunotoxicology by : Jacques Descotes
Download or read book Principles and Methods of Immunotoxicology written by Jacques Descotes and published by Elsevier. This book was released on 2004-10-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.
Book Synopsis Principles of Genetic Toxicology by : D. Brusick
Download or read book Principles of Genetic Toxicology written by D. Brusick and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.
Book Synopsis Information Resources in Toxicology by : Philip Wexler
Download or read book Information Resources in Toxicology written by Philip Wexler and published by Academic Press. This book was released on 2000 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...
Book Synopsis Molecular Immunotoxicology by : Emanuela Corsini
Download or read book Molecular Immunotoxicology written by Emanuela Corsini and published by John Wiley & Sons. This book was released on 2014-11-24 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Book Synopsis Toxicological Risk Assessment and Multi-System Health Impacts from Exposure by : Aristidis M. Tsatsakis
Download or read book Toxicological Risk Assessment and Multi-System Health Impacts from Exposure written by Aristidis M. Tsatsakis and published by Elsevier. This book was released on 2021-08-01 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Book Synopsis Veterinary Toxicology by : Ramesh C Gupta
Download or read book Veterinary Toxicology written by Ramesh C Gupta and published by Elsevier. This book was released on 2011-04-28 with total page 1233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pharmaceuticals and much more. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology. - New chapters covering important and timely topics such as melamine and cyanuric acid, toxicogenomics, toxic gases and veterinary medical geology - Expanded look at international topics, such as epidemiology of animal poisonings, regulatory guidelines and poisonous plants in Europe - Heavily contributed book with chapters written by qualified and well-experienced authorities across all areas of veterinary toxicology - Problem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology
Book Synopsis Information Resources in Toxicology by : P.J. Bert Hakkinen
Download or read book Information Resources in Toxicology written by P.J. Bert Hakkinen and published by Academic Press. This book was released on 2009-08-19 with total page 1553 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the "hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. - International in scope, with contributions from over 30 countries - Numerous key references and relevant Web links - Concise narratives about toxicologic sub-disciplines - Valuable appendices such as the IUPAC Glossary of Terms in Toxicology - Authored by experts in their respective sub-disciplines within toxicology
