Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Molecular Genetics Of Type 2 Diabetes
Download Molecular Genetics Of Type 2 Diabetes full books in PDF, epub, and Kindle. Read online Molecular Genetics Of Type 2 Diabetes ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis The Genetic Landscape of Diabetes by : Laura Dean
Download or read book The Genetic Landscape of Diabetes written by Laura Dean and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Genetics of Type 2 Diabetes by : Anna Louise Gloyn
Download or read book Molecular Genetics of Type 2 Diabetes written by Anna Louise Gloyn and published by . This book was released on 2000 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Genetics of Type 2 Diabetes by : Philip John Saker
Download or read book The Molecular Genetics of Type 2 Diabetes written by Philip John Saker and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Genetics of Type 2 Diabetes by : Andrew Tym Hattersley
Download or read book The Molecular Genetics of Type 2 Diabetes written by Andrew Tym Hattersley and published by . This book was released on 1997 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Genetics of Type 2 Diabetes by : Pushpa Patel
Download or read book Molecular Genetics of Type 2 Diabetes written by Pushpa Patel and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Genetics of Type 2 Diabetes and Related Traits by : Jose C. Florez
Download or read book The Genetics of Type 2 Diabetes and Related Traits written by Jose C. Florez and published by Springer. This book was released on 2016-04-11 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.
Book Synopsis Molecular Biology of Diabetes by : Boris Draznin
Download or read book Molecular Biology of Diabetes written by Boris Draznin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.
Book Synopsis Molecular Genetics of Type 2 Diabetes by : Yun Zhang
Download or read book Molecular Genetics of Type 2 Diabetes written by Yun Zhang and published by . This book was released on 1996 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Francesco Belfiore Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805566441 Total Pages :270 pages Book Rating :4.8/5 (55 download)
Book Synopsis Molecular and Cell Biology of Type 2 Diabetes and Its Complications by : Francesco Belfiore
Download or read book Molecular and Cell Biology of Type 2 Diabetes and Its Complications written by Francesco Belfiore and published by Karger Medical and Scientific Publishers. This book was released on 1998-01-01 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glucokinase as glucose sensor. Moreover, insulin action is analyzed with regard to both nonoxidative glucose utilization and glucose oxidation. Concerning the complications in chronic diabetes, topics covered include the effects of high glucose concentration on cellular and endothelial functions and on the glucose phosphorylation rate in non-insulin-sensitive tissues. Furthermore, the role of oxidative stress and advanced glycation end products as well as the significance of alterations in lipoprotein structure are considered. Finally, the pericyte loss in retinopathy and microalbuminuria as related to cardiovascular risk are discussed. Taken as a whole, the contributions included in this book represent a large body of information that will be of great interest to diabetologists, endocrinologists and internists interested in both the basic and clinical aspects of diabetes and its complications.
Book Synopsis Molecular Genetics of Type 2 Diabetes by : Luosheng Li
Download or read book Molecular Genetics of Type 2 Diabetes written by Luosheng Li and published by . This book was released on 2002 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Genetics of Type 2 Diabetes by : M. N. Weedon
Download or read book Molecular Genetics of Type 2 Diabetes written by M. N. Weedon and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetics in Diabetes by : A.L. Gloyn
Download or read book Genetics in Diabetes written by A.L. Gloyn and published by Karger Medical and Scientific Publishers. This book was released on 2014-09-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: 0
Download or read book Type 2 Diabetes written by Claire Stocker and published by Springer Nature. This book was released on 2009 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is now reaching epidemic proportions, and the associated complications of this disease can be disabling and even life-threatening. In Type 2 Diabetes: Methods and Protocols, leading investigators provide up-to-date explanations of commonly used laboratory protocols used in diabetes research. Covering the commonly described in vivo and in vitro model systems, the volume ultimately leads to an overall view of how cellular dysfunction and degeneration leads to susceptibility and diabetes disease progression. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Type 2 Diabetes: Methods and Protocols offers succinct, proven techniques to aid research scientists and clinicians in continuing the study of this debilitating disease.
Book Synopsis International Textbook of Diabetes Mellitus by : R. A. DeFronzo
Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Book Synopsis Molecular Genetics of Type 2 Diabetes in New Zealand Polynesians by : Nicola Renee Poa
Download or read book Molecular Genetics of Type 2 Diabetes in New Zealand Polynesians written by Nicola Renee Poa and published by . This book was released on 2001 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Diabetes Mellitus in Children by : Mark A. Sperling
Download or read book Diabetes Mellitus in Children written by Mark A. Sperling and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Using Genetics to Understand the Aetiology of Type 2 Diabetes by : Niletthi Maneka Gayanthi De Silva
Download or read book Using Genetics to Understand the Aetiology of Type 2 Diabetes written by Niletthi Maneka Gayanthi De Silva and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The aetiology of type 2 diabetes is complex with both genetic and environmental factors playing a role. Largely through genome-wide association studies, some proportion of the genetic component of type 2 diabetes and its related traits has been identified. However, there are some limitations in those study designs including possible overestimation of disease risk in the general population and a large proportion of unexplained heritability in the disease or trait of concern. There are several approaches that can be taken, to better understand the aetiology of type 2 diabetes. These include studying closely related quantitative traits such as fasting glucose levels and expanding the current efforts in discovering susceptibility variants to other classes of variation beyond common variants. Although, observational associations between type 2 diabetes and related quantitative traits may provide further clues to the aetiology of type 2 diabetes and its related traits causal nature of such associations are not clear. This thesis presents a series of studies that address the above concerns, and explore approaches of how known common variants associated with metabolic traits can be used to understand their role in the aetiology of the associated disease or trait. Chapter 1 is an introduction to the molecular genetics of type 2 diabetes, fasting glucose and birth weight and discusses the biological implications of these genetic findings. Chapter 2 describes a study that shows how genetic factors are important regardless of how patients are recruited using a common variant robustly 2 ociated with type 2 diabetes in the TCF7L2 locus. This was the first study to empirically show that the risk estimates from genetic studies involving genetically enriched cases are likely to be overestimated. Chapter 3 describes a study that was designed to identify rare or low frequency variants associated with fasting glucose levels in the G6PC2 gene where common variation in the same gene is robustly associated with fasting glucose levels. We found no evidence that the identified rare variants were associated with normal variation in fasting glucose levels. Chapter 4 describes a study that was designed to test the hypothesis that common genetic variants associated with fasting glucose and triglyceride levels would alter the same traits in pregnancy and influence fetal growth and development. We found evidence that the common variants alerting fasting glucose and triglyceride levels outside pregnancy largely alters these traits in pregnancy to the same extent. We also found preliminary evidence that the relationship between raised mothers glucose levels and increased birth weight is causal. Chapter 5 describes a study that utilises the Mendelian randomisation approach to test whether the observed correlations between raised circulating triglyceride levels and type 2 diabetes, fasting glucose and fasting insulin levels are causal. We found no evidence that raised circulating triglycerides are causal for type 2 diabetes, fasting glucose or fasting insulin levels. The observed correlations are therefore confounded or likely to be secondary to the diabetes disease process.