Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Molecular Genetic Abnormalities In Non Small Cell Lung Cancer full books in PDF, epub, and Kindle. Read online Molecular Genetic Abnormalities In Non Small Cell Lung Cancer ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Kwun Meng Fong
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.:/5 (37 download)
Download or read book Molecular Genetic Abnormalities in Non-small Cell Lung Cancer written by Kwun Meng Fong and published by . This book was released on 1995 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David N Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3540269541
Total Pages : 399 pages
Book Rating : 4.5/5 (42 download)
Download or read book The Molecular Genetics of Lung Cancer written by David N Cooper and published by Springer Science & Business Media. This book was released on 2005-11-20 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
Author : Philip T. Cagle
Publisher : Springer Science & Business Media
ISBN 13 : 1461431972
Total Pages : 217 pages
Book Rating : 4.4/5 (614 download)
Download or read book Molecular Pathology of Lung Cancer written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2012-06-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Author : Alan Weitberg
Publisher : Springer Science & Business Media
ISBN 13 : 1592590934
Total Pages : 352 pages
Book Rating : 4.5/5 (925 download)
Download or read book Cancer of the Lung written by Alan Weitberg and published by Springer Science & Business Media. This book was released on 2001-10-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alan B. Weitberg, MD, and a panel of internationally recognized basic scientists and clinicians present a comprehensive discussion of lung cancer, including a practice-oriented review of its diagnosis, evaluation, and treatment. The contributors offer not only an understandable description of its molecular origins-an essential key to developing future therapies and preventive measures-but also rigorously discuss well-tested approaches, as well as those that are currently being evaluated for future use in both the laboratory and clinic. The book also elucidates the creation and effective deployment of treatment guidelines introduced by third party payers to improve clinical outcomes, even while lowering healthcare costs.
Author : Lai-Shan Tai
Publisher :
ISBN 13 : 9781361205044
Total Pages : pages
Book Rating : 4.2/5 (5 download)
Download or read book Molecular Genetic Characterizations of Human Non-Small Cell Lung Cancer written by Lai-Shan Tai and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Molecular Genetic Characterizations of Human Non-small Cell Lung Cancer" by Lai-shan, Tai, 戴麗珊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Molecular genetic characterizations of human Non-Small Cell Lung Cancer Submitted by TAI Lai-Shan For the degree of Doctor of Philosophy at the University of Hong Kong in April 2005 Lung cancer is one of the most common malignances worldwide. It is the first leading cause of cancer death in both men and women in Hong Kong and in the United States. The prognosis of this prevalent disease is poor with a 5-year survival rate at about 15%. A better understanding of the underlying genetic molecular mechanism is crucial and essential for better diagnosis and therapeutic design purposes for cancer treatment. However, a clear molecular machinery for the carcinogenesis remains far to be discovered. In this study, genetic alterations of non-small cell lung cancer, the major subtype of human lung cancer were extensively studied. By using comparative genomic hybridization, the most frequent chromosomal regions showing DNA copy number gains and losses were investigated. Besides, patterns of chromosomal aberrations between adenocarcinoma and squamous cell carcinoma of NSCLC were compared and found to be greatly different. Results indicated that chromosome 3q gain is the most prominent difference between the two sub-groups (pAssociation between genetic alterations and clinical significance was also investigated. Interestingly, we found that gains of chromosomes 5p and 20q and loss of 5q were significantly correlated to the advanced stage of NSCLC (pWe have established three human primary NSCLC cell lines and performed cytogenetic and molecular characterization of each. All of the three cells exhibited complex numerical and structural chromosomal changes. EGFR and FGF3 were found to be highly amplified and expressed in one of the NSCLC cell line. By studying protein expression in large sample population profile, we were the first to report the expression of FGF3 in NSCLC. Here we demonstrated the use of in vitro cell model for cancer-related genes identification and provide tools for further mechanistic and functional study. Apart from chromosomal gains, regions with DNA loss are also the study targets in tumorgenesis investigation. According to our CGH results, chromosome 3p is the region found with the most frequent copy number loss. Here we reported the use of SNP markers for high resolution 3p allelic loss study using Sequenom platform. Our data serve the basis for putative tumor suppressor genes identification in the future. An abstract of 412 words DOI: 10.5353/th_b3137531 Subjects: Lungs - Cancer - Genetic aspects Molecular genetics
Author : Mary O'Brien
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318070106
Total Pages : 148 pages
Book Rating : 4.3/5 (18 download)
Download or read book Fast Facts: Non-Small-Cell Lung Cancer written by Mary O'Brien and published by Karger Medical and Scientific Publishers. This book was released on 2022-02-28 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases
Author : Barbara Driscoll
Publisher : Springer Science & Business Media
ISBN 13 : 1592593232
Total Pages : 589 pages
Book Rating : 4.5/5 (925 download)
Download or read book Lung Cancer written by Barbara Driscoll and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research. Lung Cancer: Volume 1: Molecular Pathology Me- ods and Reviews presents an overview of the current status of assays employed to detect and characterize the multitude of pathologies that contribute to the development of this deadly disease. As with all volumes in the Methods in Molecular Medicine series, the reader should find that each methods-based chapter provides clear instructions for the performance of various protocols, supplemented by additional technical notes that provide valuable insight. These notes are designed to enable the reader to acquire the techniques described with a proficiency not easily achieved by re- ing standard method formats. No volume can exhaustively cover every aspect of biological research and there will be gaps in this endeavor that one or another research group will id- tify. Each section herein could readily be expanded into a book in its own right. However, I have sought to include a spectrum of techniques that should allow for the acquisition of key skills in each area covered.
Author : Mehdi Pirooznia
Publisher : Frontiers Media SA
ISBN 13 : 2832542964
Total Pages : 233 pages
Book Rating : 4.8/5 (325 download)
Download or read book Recent Advances in the Molecular Genetics and Precision Medicine of Lung Carcinoma written by Mehdi Pirooznia and published by Frontiers Media SA. This book was released on 2024-01-25 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Carcinoma is the 2nd most common cancer worldwide, with more than 2.2 million cases recorded globally in the year 2020, as well as 1.8 million deaths. It is the most common cancer in men and the 2nd most common cancer in women, with an estimated lifetime risk of developing the disease of 1 in 15 for men and 1 in 17 for women. Whilst being the most prevalent cancer, it is important to note that smoking is the single biggest risk factor for developing Lung Cancer, with over 70% of cases being estimated to have been caused by tobacco smoke, and excessive smoking potentially leading to as much as a 25x increase in the likelihood of the disease developing. Mortality rates have been steadily dropping globally due to declining smoking rates, especially in younger generations who are now more aware of the potential dangers, but also because of the increasing advancements being made in our understanding of the disease. Improved screening methods mean many more cases are now caught earlier than they would otherwise have been, and our ever-advancing ranges of treatments can begin earlier than they could have previously. Recent advances in sequencing technology, computational approaches, and our biological understanding of lung cancer have revolutionized how we diagnose, prognosticate, and treat lung carcinoma. Genetic studies into this disease have revealed a plethora of information which can be used to combat the Cancer, such as novel biomarkers and gene signatures, as well as opening the door to more of a ‘personalized medicine’ approach.
Author : Dani S. Zander
Publisher : Springer Science & Business Media
ISBN 13 : 0387724303
Total Pages : 691 pages
Book Rating : 4.3/5 (877 download)
Download or read book Molecular Pathology of Lung Diseases written by Dani S. Zander and published by Springer Science & Business Media. This book was released on 2010-05-26 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.
Author : Adi F. Gazdar
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 ( download)
Download or read book The Biology and Molecular Genetics of Lung Cancer written by Adi F. Gazdar and published by . This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zhaolin Xu
Publisher : Elsevier Inc. Chapters
ISBN 13 : 012806109X
Total Pages : 49 pages
Book Rating : 4.1/5 (28 download)
Download or read book Cancer Genomics written by Zhaolin Xu and published by Elsevier Inc. Chapters. This book was released on 2013-11-21 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains the leading cause of cancer-related death worldwide. Although surgical resections of these tumors are considered as one of the most effective treatments, most lung cancer patients present at an advanced stage of the disease at the time of diagnosis and are not candidates for surgical resection. Overall, the prognosis of lung cancer is very poor and the 5-year survival rate is only about 16 %, which has not significantly changed in the past several decades. Therefore, seeking new directions of treatment for this most deadly disease becomes crucial. Recent development in the understanding of the molecular pathogenesis of lung cancer has led to new strategies of treatment. Development of lung cancers is thought to be driven by gene mutations in most, if not all, cases. Detailed analysis at the molecular level to identify these gene mutations or alterations in lung cancer provides the insight for understanding the disease and is fundamental for establishment of personalized targeted therapy. Personalized targeted therapy based on particular gene mutations has shown to be effective and is believed to be one of the new directions of the treatment in dealing with this disease. In modern oncology, there is an increasing need to facilitate the development and implementation of biomarkers based on known gene mutations/alterations in clinical practice and identification of new gene mutations/alterations through high-throughput DNA sequencing technology to enter a new era of personalized targeted therapy for lung cancer patients.
Author : Jack A. Roth
Publisher : John Wiley & Sons
ISBN 13 : 1444358669
Total Pages : 680 pages
Book Rating : 4.4/5 (443 download)
Download or read book Lung Cancer written by Jack A. Roth and published by John Wiley & Sons. This book was released on 2011-08-26 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is a major cause of cancer-related deaths in men and women. However, since the first edition of Lung Cancer was published 14 years ago, rapid progress in the biology, prevention, diagnosis, and treatment of the disease has been made.
Author : Yuichi Takiguchi
Publisher : Springer
ISBN 13 : 9811020027
Total Pages : 321 pages
Book Rating : 4.8/5 (11 download)
Download or read book Molecular Targeted Therapy of Lung Cancer written by Yuichi Takiguchi and published by Springer. This book was released on 2017-01-24 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.
Author : Barbara Driscoll
Publisher : Springer Science & Business Media
ISBN 13 : 1592593240
Total Pages : 805 pages
Book Rating : 4.5/5 (925 download)
Download or read book Lung Cancer written by Barbara Driscoll and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer—both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.
Author : Hong Zhu
Publisher : Open Dissertation Press
ISBN 13 : 9781361235812
Total Pages : pages
Book Rating : 4.2/5 (358 download)
Download or read book Genetic and Expression Analysis of Candidate Tumor Loci in Non-Small Cell Lung Cancer written by Hong Zhu and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Genetic and Expression Analysis of Candidate Tumor Loci in Non-small Cell Lung Cancer" by Hong, Zhu, 朱紅, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Genetic and Expression Analysis of Candidate Tumor Loci in Non-Small Cell Lung Cancer Submitted by ZHU Hong For the degree of Doctor of Philosophy at the University of Hong Kong in August 2005 Lung cancer is a common malignancy with high mortality in Hong Kong and worldwide. Although risk factors are well known, the underlying molecular mechanisms are unclear. Non-small cell lung cancer (NSCLC) exhibits multiple chromosome aberrations. Genomic and transcriptional abnormalities of genes encompassed within these aberrant loci could constitute underlying mechanisms for cancer development. The aim of this study was to detect genomic imbalances in lung adenocarcinoma (AD), and to identify cancer-related genes within these altered loci. The strategy consisted of screening by array-based comparative genomic hybridization (array-CGH), followed by comparison with expression microarray data to identify genes with concordant genomic and expression changes. Integration of these results with known data on gene functions was then employed for selection of potential cancer-related gene targets. An array comprising BAC and PAC clones spanning the entire genome at an average of 1 Mb interval was used. Three lung adenocarcinoma cell lines established from local patients and 36 clinical primary lung AD samples were analyzed. Conventional metaphase CGH was performed on the cell lines and 14 of the AD for comparison. The results showed general agreement between chromosome profiles analyzed by CGH and array-CGH. From the cancer cell lines, recurrent genomic gains were found at lp36.33- p36.32, lq, 7, 8q21.13-q21.3, 8q24.13-q24.21, 8q24.3, 17q, 20q and loss at Ip33-pl2, 3p, 3qll.2-ql2.1, 8p23.3-pl2, 9p, 12q24.32, 17p, 18, 19ql3.43. In the clinical samples, recurrent genomic aberrations were found in segmental or focal distribution. The most frequently gained loci were within segments 5pl5.33-pl5.31, 20ql3.31- 20ql3.33 and 16pl3.3-pl3.12, followed by lp36.32, lq32.1 and 17q25.3, while the commonest deleted loci were 9p23, followed by 6ql6.3 and 10q21.1. Many of these segmental aberrations could be matched to minimal overlapping regions according to CGH analysis. Additional alterations involving interstitial short DNA fragments or focal sites spanned by dispersed BAC clones were also identified by array-CGH. Selective loci of gain at 7p, 8q, 20q and loss at 9p were verified by fluorescent in-situ hybridization (FISH) analysis. Comparison with clinicopathological parameters showed more genetic alterations in the more advanced tumors, consistent with the concept that tumour progression was associated with increasing genetic abnormalities. Cancer cells derived from a smoker showed more numerous aberrations than those from non-smokers. Aberrations associated with different types of smoking history were also identified in clinical tumours. By integrated analysis of results from expression array and array-CGH, 25 genes showing concordant gene dosage and transcriptional changes were chosen. Expression analysis by real-time PCR validated the results by microarray analysis. The highest expression was found for EEF1A2 (20q), DDR1 (6p), CHI3L1 (lq), FOXA1 (14q) and CHC1 (lp) with genomic gain; the 2 least expressed genes in deleted regions were MYH10 (17p) and COPEB (lOp). Allelic loss at 3p21 was common and RASSF1A located in this region showed decreased expression. A high proportion of cases s
Author : Philip T. Cagle
Publisher : Springer
ISBN 13 : 3319629417
Total Pages : 289 pages
Book Rating : 4.3/5 (196 download)
Download or read book Precision Molecular Pathology of Lung Cancer written by Philip T. Cagle and published by Springer. This book was released on 2017-11-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
Author : Karol Sikora
Publisher : Wiley
ISBN 13 : 9780471925835
Total Pages : 364 pages
Book Rating : 4.9/5 (258 download)
Download or read book Genes and Cancer written by Karol Sikora and published by Wiley. This book was released on 1990-10-26 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work serves as an introduction to the applications of molecular biology in the field of oncology. It provides a basic understanding of the genetic events involved in fully developed human cancer, including research into inherited and acquired gene defects initiating new neoplasms and the subsequent genetic alterations involved in tumor progression. Some of the specific topics explored include gene control, molecular therapy and antibodies, drug resistance, growth factors and receptors, and tumor biology. While intended primarily as an advanced text for oncologists, postgraduate molecular geneticists and molecular biologists, the book will certainly be of interest to other researchers who frequently encounter cancer in their practice.
