Molecular Determinants Of Head And Neck Cancer

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Molecular Determinants of Head and Neck Cancer

Author : Barbara Burtness
Publisher : Springer
ISBN 13 : 3319787624
Total Pages : 628 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Molecular Determinants of Head and Neck Cancer by : Barbara Burtness

Download or read book Molecular Determinants of Head and Neck Cancer written by Barbara Burtness and published by Springer. This book was released on 2018-08-03 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

Current Research in Head and Neck Cancer

Author : Henning Bier
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805577893
Total Pages : 215 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Current Research in Head and Neck Cancer by : Henning Bier

Download or read book Current Research in Head and Neck Cancer written by Henning Bier and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research.

Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer

Author : Andrew F. Olshan
Publisher : Springer Science & Business Media
ISBN 13 : 1441914722
Total Pages : 211 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer by : Andrew F. Olshan

Download or read book Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer written by Andrew F. Olshan and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a current perspective on the epidemiology head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established risk factors, suggested association with a virus, and potential genetic susceptibility determinants. These tumors offer a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction.

Head and Neck Cancer

Author : Bruce Brockstein
Publisher : Springer Science & Business Media
ISBN 13 : 0306480603
Total Pages : 380 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Head and Neck Cancer by : Bruce Brockstein

Download or read book Head and Neck Cancer written by Bruce Brockstein and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exciting advances are occurring in the understanding of the molecular pathogenesis of squamous head and neck cancers. Epidemiology, staging and screening, as well as premalignancy, chemoprevention and the molecular biology of head and neck cancer, lay the groundwork for the understanding of the clinical chapters that follow. Controversial treatments will be compared to the standard management of patient care. Therapy chapters are divided into stage or category specific (resectable advanced, unresectable advanced or metastatic) problems, allowing the reader to review the current standards and options for patient types or specific patients easily. Considerations of supportive care, late toxicities and quality of life, often overlooked are reviewed in detail. This is a comprehensive summary of the current state of the art research and treatment.

Head and Neck Cancer

Author : Louis B. Harrison
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781771368
Total Pages : 1004 pages
Book Rating : 4.7/5 (713 download)

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Book Synopsis Head and Neck Cancer by : Louis B. Harrison

Download or read book Head and Neck Cancer written by Louis B. Harrison and published by Lippincott Williams & Wilkins. This book was released on 2009 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life. This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include a new chapter on reconstructive techniques; significant updates to all site-specific chapters; updates on chemoprevention and molecular targeting; and discussions of new imaging modalities such as fused PET/CT. A companion Website will offer the fully searchable text with all images.

Molecular-cytogenetic Characterization of Head and Neck Cancer

Author : Volkert B. Wreesmann
Publisher :
ISBN 13 :
Total Pages : 516 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Molecular-cytogenetic Characterization of Head and Neck Cancer by : Volkert B. Wreesmann

Download or read book Molecular-cytogenetic Characterization of Head and Neck Cancer written by Volkert B. Wreesmann and published by . This book was released on 2004 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Academic dissertation for obtaining the degree of doctor by the University of Amsterdam under the authority of Rector Magnificus prof. mr. P.F. van der Heijden in the presence of the regular promotion committee to defend in public in the Auditorium of the University on thursday 2 december 2004, at 10:30 hour with Volkert Boudewijn Wreesmann born in Rotterdam and at 11:30 hours with Bhuvanesh Singh born in Patna (India).

Head and Neck Cancer

Author : Jacques Bernier
Publisher : Springer
ISBN 13 : 3319276018
Total Pages : 877 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Head and Neck Cancer by : Jacques Bernier

Download or read book Head and Neck Cancer written by Jacques Bernier and published by Springer. This book was released on 2016-08-22 with total page 877 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

Head and Neck Cancer

Author : John Frederick Ensley
Publisher : Elsevier
ISBN 13 : 0080533841
Total Pages : 631 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Head and Neck Cancer by : John Frederick Ensley

Download or read book Head and Neck Cancer written by John Frederick Ensley and published by Elsevier. This book was released on 2003-01-07 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer

Author : Andrew F. Olshan
Publisher :
ISBN 13 : 9781441914927
Total Pages : pages
Book Rating : 4.9/5 (149 download)

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Book Synopsis Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer by : Andrew F. Olshan

Download or read book Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer written by Andrew F. Olshan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer provides a current perspective on the epidemiology of head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established associations with tobacco and alcohol use, the human papilloma virus, and potential determinants of genetic susceptibility. Because of these factors, head and neck cancer offers a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction. This book brings together the latest epidemiologic and molecular genetic evidence regarding the patterns of occurrence and causes of head and neck cancer. In addition, Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer considers approaches to chemoprevention, and incorporates a multidisciplinary perspective including salient clinical, pathologic, molecular, and epidemiologic contributions.

Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines

Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : IARC
ISBN 13 : 9789283212850
Total Pages : 354 pages
Book Rating : 4.2/5 (128 download)

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Book Synopsis Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis

Histological Typing of Cancer and Precancer of the Oral Mucosa

Author : J.J. Pindborg
Publisher : Springer Science & Business Media
ISBN 13 : 3642605923
Total Pages : 115 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Histological Typing of Cancer and Precancer of the Oral Mucosa by : J.J. Pindborg

Download or read book Histological Typing of Cancer and Precancer of the Oral Mucosa written by J.J. Pindborg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes more clinical aspects and concentrates on cancer and precancer of the oral mucosa rather than attempting to cover all benign and malignant tumours of the oral and oropharyngeal tissue. One main emphasis is the significance of the clinical features of the various lesions discussed. Attention is also drawn to those conditions particular to the oral mucosa that may give rise to appearances which are important in differential diagnoses but can be misleading to those who do not have detailed knowledge of the tissue involved. The TNM-classification for malignant tumours of the lip and oral cavity is also included.

Critical Issues in Head and Neck Oncology

Author : Jan B. Vermorken
Publisher : Springer Nature
ISBN 13 : 3031231759
Total Pages : 361 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Critical Issues in Head and Neck Oncology by : Jan B. Vermorken

Download or read book Critical Issues in Head and Neck Oncology written by Jan B. Vermorken and published by Springer Nature. This book was released on 2023-03-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Head and Neck Cancer

Author : Jacques Bernier
Publisher : Springer Science & Business Media
ISBN 13 : 1441994645
Total Pages : 700 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Head and Neck Cancer by : Jacques Bernier

Download or read book Head and Neck Cancer written by Jacques Bernier and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

The Molecular Characterization of Head and Neck Cancer in Young Patients

Author : Jerry Machado
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (133 download)

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Book Synopsis The Molecular Characterization of Head and Neck Cancer in Young Patients by : Jerry Machado

Download or read book The Molecular Characterization of Head and Neck Cancer in Young Patients written by Jerry Machado and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and neck squamous cell carcinomas (HNSCCs) most commonly develop in older patients (≥60 years of age) with a history of tobacco and alcohol use. However, young individuals (≤45 years of age) can also develop HNSCC, often without common risk factors. Increasing evidence shows that Human Papillomavirus (HPV) infection is associated with particular HNSCC sites (e.g. oropharynx). We assessed the Roche Linear Array HPV Genotyping Test in several lesions and then examined the prevalence of HPV in HNSCCs from young and older patients. HPV infection was most prevalent in oropharyngeal cancers (16/22, 73%), rarely found in oral cavity cancers (2/53, 4%), and other head and neck sites (1/17, 6%). HPV positive tumors were associated with patients that were >40 and 60 years old (p=0.02). The absence or shortened time of carcinogen exposure from common risk factors and the development of oral squamous cell carcinoma (OSCC) at an early age suggest aberrant genetic events that are different than those in OSSCs from older patients. We used Affymetrix SNP 6.0 arrays to genomically profile oral tumors from young and older patients. Tumors from young patients showed different regions/genes of copy number alterations than those from older patient tumors. An increase of regions of loss of heterozygosity (LOH) in tumors from older patients was observed, and there was a high prevalence of copy number neutral LOH on chromosome 9 in tumors from young and older patients. These data suggest different genetic mechanisms in these patient groups. We have previously shown that HNSCCs from younger patients exhibited a high incidence of microsatellite instability (MSI), a marker of defective mismatch repair (MMR). Deregulated mRNA levels of hPMS1, hPMS2 and hMLH1 were observed and absent/low expression of hPMS1, hPMS2 and hMLH1 protein levels were observed in 50% of OSCCs. No mutations were observed in hPMS1 and hPMS2 and no significant differences of MSI or LOH were observed across genomic loci between tumors of young and older patients. The role of these genetic mechanisms in oral cancer appears complex; studies such as ours should further improve our knowledge of the molecular mechanisms leading to early-onset oral carcinomas.

Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics

Author : Victor C. Kok
Publisher : Frontiers Media SA
ISBN 13 : 2889667596
Total Pages : 357 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics by : Victor C. Kok

Download or read book Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics written by Victor C. Kok and published by Frontiers Media SA. This book was released on 2021-05-11 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Squamous cell Carcinoma

Author : Saman Warnakulasuriya
Publisher : Springer
ISBN 13 : 9402410848
Total Pages : 285 pages
Book Rating : 4.4/5 (24 download)

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Book Synopsis Squamous cell Carcinoma by : Saman Warnakulasuriya

Download or read book Squamous cell Carcinoma written by Saman Warnakulasuriya and published by Springer. This book was released on 2017-03-27 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

AJCC Cancer Staging Manual

Author : Frederick L, Greene
Publisher : Springer Science & Business Media
ISBN 13 : 1475736568
Total Pages : 386 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis AJCC Cancer Staging Manual by : Frederick L, Greene

Download or read book AJCC Cancer Staging Manual written by Frederick L, Greene and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.