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Author : Latha Ramakrishnan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (116 download)
Download or read book Molecular Characterization of Novel ADP-ribosyl Cyclases from the Sea Urchin written by Latha Ramakrishnan and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : L. Ramakrishnan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (829 download)
Download or read book Molecular Characterization of Novel ADP-ribosyl Cyclases from the Sea Urchin written by L. Ramakrishnan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles. These molecules are structurally and mechanistically distinct but synthesised by a common enzyme, ADP-ribosyl cyclase (ARC). The sea urchin has long been a model system for both calcium signalling and embryogenesis. In fact, cADPR and NAADP were both discovered in the sea urchin. However, molecular details of ARCs and their roles during development are limited. Recently three ARC isoforms: SpARC1, SpARC2 and SpARC3 were identified from the sea urchin. In this study, additional novel isoforms including SpARC4 were cloned from S.purpuratus, highlighting the further expansion of ARCs in basal deuterostomes. SpARC2, SpARC3 and SpARC4 were found to be glycoproteins tethered to the plasma membrane via a GPI-anchor. SpARC2 and SpARC4 were multi-functional and able to produce both cADPR and NAADP over a wide pH range. SpARC2 was a preferential base-exchanger and SpARC4 a preferential cyclase. A unique non-canonical active site tyrosine residue regulated the cyclisation: base-exchange activity ratio of SpARC4. Both SpARC2 and SpARC4 were poor hydrolases and unable to cyclise NGD, a NAD surrogate. A single non-conserved glycine residue in the "TLEDTL domain" of SpARC2 was responsible for its poor hydrolase activity. All SpARC isoforms were detectable in S.purpuratus egg and the majority of ARC activity was GPI-anchored. During the course of early development, SpARC isoforms were differentially expressed and the endogenous ARC activity also varied. Over-expression and knock-down of SpARC4 during embryo development interfered with gastrulation. These findings provide new insights into the molecular mechanisms of multifunctionality of this remarkable family of enzymes and suggest that the expression and activities of ARCs could be fine-tuned for production of specific calcium messengers during embryogenesis of S.purpuratus.
Author : Lianne Caroline Davis
Publisher :
ISBN 13 :
Total Pages : 408 pages
Book Rating : 4.:/5 (428 download)
Download or read book Characterization of Sea Urchin ADP-ribosyl Cyclases written by Lianne Caroline Davis and published by . This book was released on 2008 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Md. Shahidul Islam
Publisher : Springer Nature
ISBN 13 : 3030124576
Total Pages : 1110 pages
Book Rating : 4.0/5 (31 download)
Download or read book Calcium Signaling written by Md. Shahidul Islam and published by Springer Nature. This book was released on 2019-10-23 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author :
Publisher : Academic Press
ISBN 13 : 0128170735
Total Pages : 552 pages
Book Rating : 4.1/5 (281 download)
Download or read book Echinoderms Part B written by and published by Academic Press. This book was released on 2019-04-02 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems Highlights new advances in the field, with this update presenting interesting chapters on echinoderms
Author : Peter Sutovsky
Publisher : Springer
ISBN 13 : 1493908170
Total Pages : 259 pages
Book Rating : 4.4/5 (939 download)
Download or read book Posttranslational Protein Modifications in the Reproductive System written by Peter Sutovsky and published by Springer. This book was released on 2014-07-16 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book's aim is to increase the awareness of a great variety of posttranslational modifications in the male and female reproductive system. Some of the most intriguing reproductive strategies, mechanisms, and pathways involving PTM are discussed, with an added angle of evolutionary conservation and diversity. The book also chapters on sperm-egg binding, as well as on histone modification in both the embryo and sperm. Chapters are also devoted to protein ubiquitination, the regulation of sperm function during fertilization in mammals and tubulin modifications in gametes and embryos. There are no other current books on posttranslational protein modifications as they relate to reproduction, making this contribution unique in the field. It is useful for both researchers and graduate students alike.
Author : Angela Elizabeth Kell
Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.:/5 (319 download)
Download or read book Characterization of a Novel ADP-ribosyl Cyclase Member in the CD38 Knock-out Model written by Angela Elizabeth Kell and published by . This book was released on 2006 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Annette L. Parks
Publisher :
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.3/5 ( download)
Download or read book Evolution of Regulation and Molecular Characterization of MSP130, a Mesenchyme Cell Lineage-specific Protein of the Sea Urchin written by Annette L. Parks and published by . This book was released on 1990 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hon Cheung Lee
Publisher : Springer Science & Business Media
ISBN 13 : 1461502691
Total Pages : 462 pages
Book Rating : 4.4/5 (615 download)
Download or read book Cyclic ADP-Ribose and NAADP written by Hon Cheung Lee and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.
Author : Allan Veh Tuc Wang
Publisher :
ISBN 13 :
Total Pages : 418 pages
Book Rating : 4.:/5 (196 download)
Download or read book Molecular Characterization of a Cytoplasmic Actin Gene Developmentally Regulated During Sea Urchin Embryogenesis written by Allan Veh Tuc Wang and published by . This book was released on 1987 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Margaret Louise Just
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (436 download)
Download or read book Molecular Characterization of the Sea Urchin Extracellular Matrix Protein Hyalin written by Margaret Louise Just and published by . This book was released on 1999 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anthony K. Campbell
Publisher : John Wiley & Sons
ISBN 13 : 0470695110
Total Pages : 841 pages
Book Rating : 4.4/5 (76 download)
Download or read book Intracellular Calcium, 2 Volume Set written by Anthony K. Campbell and published by John Wiley & Sons. This book was released on 2014-12-15 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular calcium, through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic, reveals: The pathway of discovery and invention of intracellular calcium over more than 100 years. The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells How the components required for calcium signalling are named and classified. The ingenious technology, which has been developed to study intracellular calcium. How calcium is regulated inside cells and how it works to trigger an event. The role of intracellular calcium in disease, cell injury and cell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of many natural toxins. How the intracellular calcium signalling system has evolved over 4000 million years, showing why it was crucial to the origin of life. A key principle presented throughout the book is the molecular variation upon which the intracellular calcium signalling system depends. This variation occurs within the same cell type and between cells with different functions, providing the invisible matrix upon which Darwin and Wallace’s Natural Selection depends. Featuring more than 100 figures, including detailed chemical structures as well as pictures of key pioneers in the field, a bibliography of more than 1500 references, as well as detailed subject and organism indices, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond.
Author : Fred Asare
Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.:/5 (484 download)
Download or read book Molecular Characterization of an Intermediate Filament-like Nuclear Matrix-associated Protein During Sea Urchin Embryogenesis written by Fred Asare and published by . This book was released on 2001 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 9401006881
Total Pages : 746 pages
Book Rating : 4.4/5 (1 download)
Download or read book Calcium: The molecular basis of calcium action in biology and medicine written by R. Pochet and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Author : R. Alvarez-Gonzalez
Publisher : Springer Science & Business Media
ISBN 13 : 1441987401
Total Pages : 156 pages
Book Rating : 4.4/5 (419 download)
Download or read book ADP-Ribosylation Reactions written by R. Alvarez-Gonzalez and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10-14, 1997. The Symposium was hosted by the Sociedad Mexicana de Bioquimica and was sponsored by the University of North Texas Health Science Center, Fort Worth, TX, USA. This volume provides a state-of-the-art source of information for basic scientists and clinicians who are interested in the molecular, biochemical, and cellular aspects of protein-(ADP-ribose) transfer reactions in human health and disease.
Author :
Publisher :
ISBN 13 :
Total Pages : 700 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2000 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James W. Putney Jr.
Publisher : CRC Press
ISBN 13 : 1420038230
Total Pages : 540 pages
Book Rating : 4.4/5 (2 download)
Download or read book Calcium Signaling written by James W. Putney Jr. and published by CRC Press. This book was released on 2005-11-21 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of James Putney's Calcium Signaling offered readers a comprehensive view of the fascinating diversity of technologies that the new field of calcium signaling employed. And while that work is still regarded as a premier text on the basics of calcium signaling, progress has been so dramatic that an update is now required. In Cal
