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Molecular Basis Of Cardiovascular Diseases Implications Of Natriuretic Peptides
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Book Synopsis Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides by : Speranza Rubattu
Download or read book Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides written by Speranza Rubattu and published by MDPI. This book was released on 2019-10-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.
Book Synopsis Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides by : Speranza Rubattu
Download or read book Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides written by Speranza Rubattu and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.
Book Synopsis Natriuretic Peptides by : Kailash N. Pandey
Download or read book Natriuretic Peptides written by Kailash N. Pandey and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the current knowledge and recent developments to navigate cellular, molecular, and clinical aspects of natriuretic peptides and their receptors in health and disease. State-of-the-art technology in cell and molecular biology has been applied to delineate the expression, function, and regulation of natriuretic peptides and their receptors both in vitro and in vivo model systems. Transgenic and gene-targeted mouse models have clearly demonstrated that the absence of functional natriuretic peptides and/or their cognate receptors cannot only raise blood pressure but also cause severe hypertensive heart, similar to what is seen in untreated human hypertensive patients. The genetically engineered mouse models have been useful to reveal not only the actual functions of the genes for natriuretic peptides and their receptors, but more critically their modifying interactions with other genes. This book presents a comprehensive look at the past developments, current status, and future prospects of the natriuretic peptides and their receptor systems in bedside diagnosis, treatments, and therapeutic advancements. The book comprises of fourteen chapters from eminent scientists in their area of research expertise, and presents a wide range of reviews spanning the research works done on the natriuretic peptides and their receptors. Each chapter provides a comprehensive summary covering the aspects of physiology, molecular biology, and clinical implication of the accomplished experimental findings and future perspectives of research to be performed in this vital and important cardiovascular field. It is expected that this book will provide readers a focused overview of the status and perspectives of the natriuretic peptides and their receptors from the past accomplishments to exciting future investigations.
Book Synopsis Natriuretic Peptides by : Kailash N. Pandey
Download or read book Natriuretic Peptides written by Kailash N. Pandey and published by . This book was released on 2014-06-04 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the current knowledge and recent developments to navigate cellular, molecular, and clinical aspects of natriuretic peptides and their receptors in health and disease. State-of-the-art technology in cell and molecular biology has been applied to delineate the expression, function, and regulation of natriuretic peptides and their receptors both in vitro and in vivo model systems. Transgenic and gene-targeted mouse models have clearly demonstrated that the absence of functional natriuretic peptides and/or their cognate receptors cannot only raise blood pressure but also cause severe hypertensive heart, similar to what is seen in untreated human hypertensive patients. The genetically engineered mouse models have been useful to reveal not only the actual functions of the genes for natriuretic peptides and their receptors, but more critically their modifying interactions with other genes. This book presents a comprehensive look at the past developments, current status, and future prospects of the natriuretic peptides and their receptor systems in bedside diagnosis, treatments, and therapeutic advancements. The book comprises of fourteen chapters from eminent scientists in their area of research expertise, and presents a wide range of reviews spanning the research works done on the natriuretic peptides and their receptors. Each chapter provides a comprehensive summary covering the aspects of physiology, molecular biology, and clinical implication of the accomplished experimental findings and future perspectives of research to be performed in this vital and important cardiovascular field. It is expected that this book will provide readers a focused overview of the status and perspectives of the natriuretic peptides and their receptors from the past accomplishments to exciting future investigations.
Book Synopsis Heart Development and Disease by : Benoit G. Bruneau
Download or read book Heart Development and Disease written by Benoit G. Bruneau and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved"--
Book Synopsis Acute Heart Failure by : Alexandre Mebazaa
Download or read book Acute Heart Failure written by Alexandre Mebazaa and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis General Methods in Biomarker Research and their Applications by : Victor R. Preedy
Download or read book General Methods in Biomarker Research and their Applications written by Victor R. Preedy and published by Springer. This book was released on 2015-08-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists.
Book Synopsis Dilated Cardiomyopathy by : Gianfranco Sinagra
Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Book Synopsis Toxins and Hemostasis by : R. Manjunatha Kini
Download or read book Toxins and Hemostasis written by R. Manjunatha Kini and published by Springer Science & Business Media. This book was released on 2010-10-19 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere with cardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as ‘villains’, several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.
Book Synopsis Heart Failure: A Companion to Braunwald's Heart Disease E-Book by : G. Michael Felker
Download or read book Heart Failure: A Companion to Braunwald's Heart Disease E-Book written by G. Michael Felker and published by Elsevier Health Sciences. This book was released on 2019-02-06 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
Book Synopsis Braunwald's Heart Disease - E-Book by : Peter Libby
Download or read book Braunwald's Heart Disease - E-Book written by Peter Libby and published by Elsevier Health Sciences. This book was released on 2021-10-15 with total page 2473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current, comprehensive, and evidence-based Braunwald’s Heart Disease remains the most trusted reference in the field and the leading source of reliable cardiology information for practitioners and trainees worldwide. The fully updated 12th Edition continues the tradition of excellence with dependable, state-of-the-art coverage of new drugs, new guidelines, more powerful imaging modalities, and recent developments in precision medicine that continue to change and advance the practice of cardiovascular medicine. Written and edited by global experts in the field, this award-winning text is an unparalleled multimedia reference for every aspect of this complex and fast-changing area. Offers balanced, dependable content on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. Includes 76 new contributing authors and 14 new chapters that cover Artificial intelligence in Cardiovascular Medicine; Wearables; Influenza, Pandemics, COVID-19, and Cardiovascular Disease; Tobacco and Nicotine Products in Cardiovascular Disease; Cardiac Amyloidosis; Impact of the Environment on Cardiovascular Health, and more. Features a new introductory chapter Cardiovascular Disease: Past, Present, and Future by Eugene Braunwald, MD, offering his unique, visionary approach to the field of cardiology. Dr. Braunwald also curates the extensive, bimonthly online updates that include "Hot Off the Press" (with links to Practice Update) and "Late-Breaking Clinical Trials". Provides cutting-edge coverage of key topics such as proteomics and metabolomics, TAVR, diabetocardiology, and cardio-oncology. Contains 1,850 high-quality illustrations, radiographic images, algorithms, and charts, and provides access to 215 videos called out with icons in the print version. Highlights the latest AHA, ACC, and ESC guidelines to clearly summarize diagnostic criteria and clinical implications. Provides tightly edited, focused content for quick, dependable reference. Flexible format options include either one or two volumes in print, as well as a searchable eBook with ongoing updates.
Book Synopsis Heart Failure by : Johann Bauersachs
Download or read book Heart Failure written by Johann Bauersachs and published by Springer. This book was released on 2017-06-09 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imaging technologies. The main focus of this book is to review current and emerging heart failure therapies and potential targets for treatment.
Book Synopsis Handbook of Biomarkers and Precision Medicine by : Claudio Carini
Download or read book Handbook of Biomarkers and Precision Medicine written by Claudio Carini and published by CRC Press. This book was released on 2019-04-16 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
Book Synopsis Braunwald's Heart Disease E-Book by : Douglas P. Zipes
Download or read book Braunwald's Heart Disease E-Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2018-01-09 with total page 2040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald’s Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology.
Book Synopsis Nutrition and Cardiovascular Disease by : Elaine B. Feldman
Download or read book Nutrition and Cardiovascular Disease written by Elaine B. Feldman and published by Prentice Hall. This book was released on 1976 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comprehensive Hypertension E-Book by : Gregory Y. H. Lip
Download or read book Comprehensive Hypertension E-Book written by Gregory Y. H. Lip and published by Elsevier Health Sciences. This book was released on 2007-06-28 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.
