Molecular Approaches To Heart Failure Therapy

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Molecular Approaches to Heart Failure Therapy

Author : G. Hasenfuss
Publisher : Springer Science & Business Media
ISBN 13 : 3642577105
Total Pages : 382 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Molecular Approaches to Heart Failure Therapy by : G. Hasenfuss

Download or read book Molecular Approaches to Heart Failure Therapy written by G. Hasenfuss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: G. HASENFUSS, E. MARBAN Heart failure embodies the central irony of modern medicine. As we have become increasingly adept at treating the major proximate causes of death in Western society, we have effectively converted acute illness into chronic malady. The last twenty years have witnessed a revolution in the treatment of acute coronary syndromes, myocardial infarction in particular. Patients who reach the hospital now have every expectation of leaving alive, but not necessarily well. Our ability to blunt the edge of ischemic insults has en gendered new problems: a new cohort of patients whose hearts function well enough to enable short-term survival, but at the cost of decreased ex ercise tolerance, dyspnea and increased long-term mortality. The irony is compounded by our increasingly sophisticated pharmacopeia for the treat ment of heart failure, which, by slowing the progression of ventricular dys function, has created a chronic illness. The fact of its chronicity makes heart failure no less deadly. In symptomatic patients, mortality exceeds 5-10% per year even with the best contemporary therapy. Not all heart failure is ischemic, of course, but the final common phenotype is eerily concordant regardless of the proximate cause. No wonder, then, that heart failure is the leading cause of hospitalization in America and in Western Europe and that the prevalence of the disease continues to rise. Drugs have indeed revolutionized heart failure therapy, ACE inhibitors and beta-adrenergic blockers having the most outstanding records to date.

The Molecular Biology of Chronic Heart Failure

Author : Dhavendra Kumar
Publisher : Biota Publishing
ISBN 13 : 1615045570
Total Pages : 92 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Molecular Biology of Chronic Heart Failure by : Dhavendra Kumar

Download or read book The Molecular Biology of Chronic Heart Failure written by Dhavendra Kumar and published by Biota Publishing. This book was released on 2013-02-01 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical syndrome of chronic heart failure (CHF) is the hallmark of progressive cardiac decompensation, one of the most common chronic medical conditions that affect around 2% of the adult population worldwide irrespective of ethnic and geographic origin (Anonymous). Apart from ischemic heart disease, hypertension, infection, and inflammation, several other etiologic factors account for irreparable and irreversible myocardial damage leading to heart failure (HF). Genetic and genomic factors are now increasingly identified as one of the leading underlying factors (Arab and Liu 2005). These factors may be related to pathogenic alterations (mutation or polymorphism) within specific cardiac genes, mutations in genes incorporating single or multiple molecular pathways (protein families) relevant to cardiac structure and/or function, genetic or genomic polymorphisms of uncertain significance (gene variants, single-nucleotide polymorphisms (SNPs), and copy number variations (CNVs)), and epigenetic or epigenomic changes that influence cardiac gene functions scattered across the human genome. Recent genetic and genomic studies in both systolic and diastolic ventricular dysfunction, the hallmark of CHF, have revealed a number of mutations in genes belonging to specific cardiac protein families. For example, around 200 mutations are now known to exist in around 15 genes coding for several different types of sarcomere proteins (Liew and Dzau 2004). The sarcomere protein family, alone, accounts for the bulk of inherited cardiomyopathies including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM), and left ventricular (LV) non-compaction (LVNC). In addition, there are several other potentially relevant factors involving different genes and genome-level elements. This article presents a systematic account on the available factual information and interpretations based on genetic and genomic studies in CHF (Liew and Dzau 2004). Genomic and molecular approaches have opened the way for a renewed debate for taxonomy of CHF (Ashrafian and Watkins 2007). The review draws attention to the potential diagnostic and therapeutic implications of genomic and transcriptional profiling in HF and translational genomics research that is likely to permit greater personalization of prevention and treatment strategies to address the complexities of managing clinical HF (Creemers, Wilde et al. 2011).

Heart Failure

Author : Arnold M. Katz
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 146980185X
Total Pages : 737 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Heart Failure by : Arnold M. Katz

Download or read book Heart Failure written by Arnold M. Katz and published by Lippincott Williams & Wilkins. This book was released on 2012-11-07 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Second Edition of Dr. Katz's highly acclaimed text has been thoroughly revised to incorporate the latest advances in the study and treatment of heart failure. The book explains the pathophysiology, molecular mechanisms, clinical manifestations, and therapy of heart failure in an integrated, reader-friendly manner that is accessible to both clinicians and basic scientists. More than 100 illustrations, most created for this book by the authors, complement the text. This edition has been completely reorganized. Chapters describe the hemodynamic basis for the clinical manifestations of heart failure; the neurohumoral responses in heart failure and key signaling pathways that mediate functional responses; the proliferative responses in failing hearts; the cellular and molecular abnormalities in the failing heart; the rationale for various therapeutic approaches; and the management of specific groups of patients. The chapters on therapy have been written by a noted clinician, Marvin A. Konstam.

Molecular Cardiology

Author : Zhongjie Sun
Publisher : Springer Science & Business Media
ISBN 13 : 159259879X
Total Pages : 410 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Molecular Cardiology by : Zhongjie Sun

Download or read book Molecular Cardiology written by Zhongjie Sun and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Clinical and Molecular Aspects of Cardiomyopathies: On the road from gene to therapy, An Issue of Heart Failure Clinics, E-Book

Author : Giuseppe Limongelli
Publisher : Elsevier Health Sciences
ISBN 13 : 0323610471
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Clinical and Molecular Aspects of Cardiomyopathies: On the road from gene to therapy, An Issue of Heart Failure Clinics, E-Book by : Giuseppe Limongelli

Download or read book Clinical and Molecular Aspects of Cardiomyopathies: On the road from gene to therapy, An Issue of Heart Failure Clinics, E-Book written by Giuseppe Limongelli and published by Elsevier Health Sciences. This book was released on 2018-04-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Heart Failure Clinics--edited by Drs. Giuseppe Limongelli, Sharlene Day, and Perry Elliott--will cover Clinical and Molecular Aspects of Cardiomyopathies: On the Road from Gene to Therapy. Topics include, but are not limited to, Epidemiology and Clinical aspects of Genetic Cardiomyopathies, Existing and New therapies, Gene editing and gene-based therapeutics, Controversies surrounding exercise in genetic cardiomyopathies, Genetic infiltrative cardiomyopathies, LV Noncompaction, Clinical presentation and natural history of hypertrophic cardiomyopathy in Rasopathies, and Moelcular basis and new treatments of cardiac diseases in Rasopathies.

Therapeutic Strategies for Heart Failure

Author : Naoki Sato
Publisher : Springer
ISBN 13 : 4431560653
Total Pages : 98 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Therapeutic Strategies for Heart Failure by : Naoki Sato

Download or read book Therapeutic Strategies for Heart Failure written by Naoki Sato and published by Springer. This book was released on 2018-01-24 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces pathophysiology and practical heart failure (HF) management at the acute, in-hospital stages during hospitalization and also in the end-stages of HF. Given its increasing incidence and prevalence, we live in a world that is essentially facing an HF pandemic. A country with an ageing population, Japan is unique in terms of the selection of medical treatment, diagnostic techniques, team managing and other approaches. This book sheds new light on the clinical challenges involved in reducing re-hospitalization and improving patients’ prognosis and ADL/QOL, while also reporting on the status quo in Japan. By highlighting these challenges and the methods used to address them, it will encourage experts around the globe to intensively discuss and accelerate research in this field. Including contributions by authors who have played central roles in managing HF in Japan, the book offers an indispensable guide not only for clinicians, technicians and nurses in this field, but also for general physicians, emergency physicians and all others who are involved in the management of acute and end-stage HF.

Principles of Molecular Cardiology

Author : Marschall S. Runge
Publisher : Springer Science & Business Media
ISBN 13 : 1592598781
Total Pages : 604 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Principles of Molecular Cardiology by : Marschall S. Runge

Download or read book Principles of Molecular Cardiology written by Marschall S. Runge and published by Springer Science & Business Media. This book was released on 2007-11-14 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Cardiac Gene Therapy

Author : Kiyotake Ishikawa
Publisher : Springer Nature
ISBN 13 : 1071627074
Total Pages : 342 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Cardiac Gene Therapy by : Kiyotake Ishikawa

Download or read book Cardiac Gene Therapy written by Kiyotake Ishikawa and published by Springer Nature. This book was released on 2022-08-30 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with updated techniques and discussions on topics such as gene suppression, editing, and reprogramming; cardiac gene therapy vectors and promoters; cardiac gene delivery methods; pulmonary hypertension; and patient screening and measuring the efficacy of cardiac gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Cardiac Gene Therapy: Methods and Protocols, Second Edition is a valuable tool for researchers in cardiology who are conducting gene therapy research. This book will lead to further advancements and successful clinical translations in the field. Chapter “Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Author : Monte Willis
Publisher : Academic Press
ISBN 13 : 0124055257
Total Pages : 339 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Cellular and Molecular Pathobiology of Cardiovascular Disease by : Monte Willis

Download or read book Cellular and Molecular Pathobiology of Cardiovascular Disease written by Monte Willis and published by Academic Press. This book was released on 2013-12-23 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Congestive Heart Failure

Author : Jeffrey D. Hosenpud
Publisher :
ISBN 13 :
Total Pages : 888 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Congestive Heart Failure by : Jeffrey D. Hosenpud

Download or read book Congestive Heart Failure written by Jeffrey D. Hosenpud and published by . This book was released on 2000 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now thoroughly revise and updated -- and with many renowned new contributors -- the Second Edition of this highly acclaimed text is the most complete, current, and authoritative reference on congestive heart failure. The book is written by the leaders in the field and covers every aspect of congestive heart failure, from molecular and cellular biology to pathophysiology, diagnosis, and treatment. This edition reflects numerous major developments in the study of the pathogenesis of heart failure and in therapy. The timely coverage also includes cost-effectiveness issues in diagnosis and treatment, as well as a greater emphasis on clinical epidemiology. Nine entirely new chapters focus on key areas such as progression from left ventricular hypertrophy to heart failure; remodeling of the heart after myocardial infarction; cardia interstitium and its role in the pathogenesis of heart failure; cytokine activity; management of atrial arrhythmias; and surgical treatment of heart failure.

Cardiovascular Genomics

Author : Mohan K. Raizada
Publisher : Springer Science & Business Media
ISBN 13 : 1592598838
Total Pages : 367 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cardiovascular Genomics by : Mohan K. Raizada

Download or read book Cardiovascular Genomics written by Mohan K. Raizada and published by Springer Science & Business Media. This book was released on 2008-02-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Chronic Heart Failure

Author : Michael Böhm
Publisher : Springer Science & Business Media
ISBN 13 : 3642859135
Total Pages : 270 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Chronic Heart Failure by : Michael Böhm

Download or read book Chronic Heart Failure written by Michael Böhm and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the past decades, the understanding of the pathophysiology of chronic heart failure and the therapeutic approach to this condition have un dergone considerable change. New developments are reported every year. Perhaps it is because of this continuing interest of researchers and physi th cians that the chapter on chronic heart failure of the 4 edition of Klinische Kardiologie has been so positively received. Several colleagues asked the authors to publish the chapter on chronic heart failure separately, because it would be more practical to use in daily work. When the request for an En glish version of this chapter reached the authors and Springer-Verlag, we were happy, on the one hand, because of the interest, but did wonder whether it would be wise to translate a typically German textbook into Eng lish. We invite you to send us your critical comments. Although Guidelines for the Treatment of Heart Failure have been pub lished recently by the WHO, by the European Society of Cardiology, and by the American Heart Association Task Force clinicians, practitioners, and stu dents still seem to need , a comprehensive view with emphasis on pathophys iology, epidemiology and therapy. The authors are grateful to Springer-Verlag for the good co-operation and tremendous personal commitment in making the English edition of Chronic Heart Failure possible. We hope to give our readers a good overview on this important clinical syndrome, one which re quires intelligent clinical research and sound clinical practice as weIl.

Dilated Cardiomyopathy

Author : Gianfranco Sinagra
Publisher : Springer
ISBN 13 : 303013864X
Total Pages : 241 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Dilated Cardiomyopathy by : Gianfranco Sinagra

Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Gene Therapy for Cardiomyopathies

Author : Yves Fromes
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Gene Therapy for Cardiomyopathies by : Yves Fromes

Download or read book Gene Therapy for Cardiomyopathies written by Yves Fromes and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart disease remains the prevalent cause of premature death and accounts for a significant proportion of all hospital admissions. Molecular genetics was integrated quite late in cardiology, but introduced new concepts like sarcolemmopathies, cytoskeletalopathies, and channelopathies useful to better understand the pathophysiology of the development of inherited cardiomyopathies (CMs). As our understanding of the cellular and molecular processes involved in the development and progression of heart disease improved, new therapeutic targets were identified, as were novel approaches such as delivery of genes to replace defective or deficient components and thereby restore structure or function in a diseased heart. We discuss gene addition strategies in the context of monogenic disorders. Moreover, a broader nucleic acid-based modulation of cardiac gene expression for the treatment of cardiac diseases might have larger clinical indications. Inadequate gene delivery remains a potential cause of negative trials. However, progress in innovative formulations and clinically relevant ways of administration should lead to significant progress in the future. Cardiac gene therapy will be integrated into the therapeutic armamentarium for CM and heart failure.

Diastology

Author : Allan L. Klein
Publisher : Elsevier Health Sciences
ISBN 13 : 0323755399
Total Pages : 564 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Diastology by : Allan L. Klein

Download or read book Diastology written by Allan L. Klein and published by Elsevier Health Sciences. This book was released on 2020-10-24 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accounting for more than 40% of all heart failure problems, diastolic heart failure is a complex and often difficult diagnosis with rapidly evolving diagnostic management protocols. Diastology: Clinical Approach to Heart Failure with Preserved Ejection Fraction, 2nd Edition, brings you up to date and equips you to successfully diagnose and manage even the most challenging incidences of diastolic heart failure and their comorbidities. It incorporates the latest guidelines for the diagnostic evaluation of the patient with suspected or known diastolic dysfunction, provides a comprehensive review of clinical conditions associated with heart failure with preserved ejection fraction, and describes the complementary role of imaging modalities and novel therapeutic approaches. Keeps you current with recent extensive changes in the understanding of the mechanisms of diastolic heart failure with preserved ejection fraction (HFpEF) that have resulted in dramatic changes in treatment guidelines. Covers the latest molecular, genetic, and cellular mechanisms behind diastolic heart failure as a basis for the latest clinical approaches, diagnosis, and treatment of common and uncommon pathological conditions such as hypertensive heart disease, cardiomyopathies, arterial and valvular diseases, pericardial diseases, congenital heart disease, diabetes mellitus, and metabolic syndrome. Features 50 video cases, new key summary points, new multiple-choice review questions, and six new chapters: Evaluation of Diastolic Function by Radionuclide Techniques; Diastology Stress Test; ASE/EACVI Diastolic Guidelines; Valve Disease; Perioperative Assessment of Diastolic Dysfunction; and Pulmonary Hypertension. Reviews new techniques and indices for assessing diastolic function, such as 3D echo, strain rate imaging, late gadolinium enhancement and T1-mapping by CMR, and novel nuclear scintigraphic methods – as well as the traditional indices of LV filling, LA function, and tissue Doppler indices. Covers emerging topics such as the role of neurohormones, global and regional systolic function of the left ventricle, chronotopic incompetence and pacing, aging, perioperative assessment, and more. Presents information in a quick-retrieval format, covering Epidemiology, Pathophysiology, Diagnostic Evaluation, Differential Diagnosis, Treatment, and Future Directions. Helps you learn efficiently and prepare for self-assessment with key summaries and multiple-choice questions and answers for each chapter.

Heart Failure in Children and Young Adults

Author : Anthony C. Chang
Publisher : Saunders
ISBN 13 :
Total Pages : 856 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Heart Failure in Children and Young Adults by : Anthony C. Chang

Download or read book Heart Failure in Children and Young Adults written by Anthony C. Chang and published by Saunders. This book was released on 2006 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique resource provides today's state-of-the-art guidance on the diagnosis and treatment of heart failure in children and adolescents. Contributions from the fields of surgery, intensive care, pediatrics, and cardiology emphasize a balanced, team approach to heart failure management. Compendium of pharmacologic treatment options in pediatric heart failure. Covers all options of pediatric management, including surgical strategies and future treatment options. Focuses on team management of pediatric heart failure. From the latest technologies and drug treatments...to the results of important clinical trials, you'll find it all here. Turn to Heart Failure in Children and Young Adults for the expertise you need to offer your patients the best possible care.

Genetic Cardiomyopathies

Author : Gianfranco Sinagra
Publisher : Springer Science & Business Media
ISBN 13 : 8847027578
Total Pages : 170 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Genetic Cardiomyopathies by : Gianfranco Sinagra

Download or read book Genetic Cardiomyopathies written by Gianfranco Sinagra and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, genetics has been emerging as a primary issue in the diagnosis and management of cardiomyopathies. This book is intended to be a state-of-the-art monograph on these diseases, describing their genetic causes, defining the molecular basis and presenting extensive descriptions of genotype–phenotype correlations. Other chapters are focused on the role of clinical observation, on ECG and echocardiography. With its highlight on the most recent discoveries in the field of molecular genetics as well as on the correct clinical approach to patients with heart muscle disease, the book is aimed at physicians and clinical cardiologists with a particular interest in myocardial diseases and in their genetic causes.