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Modification Of Porous Silicon For Dna Synthesis And Drug Delivery Systems
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Book Synopsis Modification of Porous Silicon for DNA Synthesis and Drug Delivery Systems by : Steven James Peter McInnes
Download or read book Modification of Porous Silicon for DNA Synthesis and Drug Delivery Systems written by Steven James Peter McInnes and published by . This book was released on 2005 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device by : Emily Jessica Anglin
Download or read book Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device written by Emily Jessica Anglin and published by . This book was released on 2007 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the fabrication, chemical modification, drug release, and toxicity studies of nanostructured porous silicon for the purposes of developing a smart drug delivery device. The first chapter is an introductory chapter, presenting the chemical and physical properties of porous silicon, the concepts and issues of current drug delivery devices and materials, and how porous silicon can address the issues regarding localized and controlled drug therapies. The second chapter discusses chemical modifications of nanostructured porous Si for stabilizing the material in biologically relevant media while providing an extended release of a therapeutic in vitro. This chapter also demonstrates the utility of the porous silicon optical signatures for effectively monitoring drug release from the system and its applications for development of a self-reporting drug delivery device. In chapter three, the concept of providing a triggered release of a therapeutic from porous silicon microparticles through initiation by an external stimulus is demonstrated. The microparticles are chemically modified, and the release is enhanced by a short application of ultrasound to the particulate system. The effect of ultrasound on the drug release and particle size is discussed. Chapter four presents a new method for sustaining the release of a monoclonal antibody from the porous matrix of porous SiO2. The therapeutic is incorporated into the films through electrostatic adsorption and a slow release is observed in vitro. A new method of quantifying the extent of drug loading is monitored with interferometry. The last chapter of the thesis provides a basic in vivo toxicity study of various porous Si microparticles for intraocular applications. Three types of porous Si particles are fabricated and studied in a rabbit eye model. The toxicity studies were conducted by collaborators at the Shiley Eye Center, La Jolla, CA. This work, demonstrates the feasibility of developing a self-reporting, extended release drug delivery system using porous Si microparticles for intraocular applications.
Book Synopsis Porous Silicon for Biomedical Applications by : Hélder A. Santos
Download or read book Porous Silicon for Biomedical Applications written by Hélder A. Santos and published by Woodhead Publishing. This book was released on 2021-10-23 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy. Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field. Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material. Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings. Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.
Book Synopsis Porous Silicon in Practice by : M. J. Sailor
Download or read book Porous Silicon in Practice written by M. J. Sailor and published by John Wiley & Sons. This book was released on 2012-01-09 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: By means of electrochemical treatment, crystalline silicon can be permeated with tiny, nanostructured pores that entirely change the characteristics and properties of the material. One prominent example of this can be seen in the interaction of porous silicon with living cells, which can be totally unwilling to settle on smooth silicon surfaces but readily adhere to porous silicon, giving rise to great hopes for such future applications as programmable drug delivery or advanced, braincontrolled prosthetics. Porous silicon research is active in the fields of sensors, tissue engineering, medical therapeutics and diagnostics, photovoltaics, rechargeable batteries, energetic materials, photonics, and MEMS (Micro Electro Mechanical Systems). Written by an outstanding, well-recognized expert in the field, this book provides detailed, step-by-step instructions to prepare and characterize the major types of porous silicon. It is intended for those new to the fi eld. Sampling of topics covered: * Principles of Etching Porous Silicon * Etch Cell Construction and Considerations * Photonic Crystals, Microcavities, and Bragg Stacks Etched in Silicon * Preparation of Free-standing Films and Particles of Porous Silicon * Preparation of Photoluminescent Nanoparticles from Porous Silicon * Preparation of Silicon Nanowires by Electrochemical Etch of Silicon * Surface Modifi cation Chemistry and Biochemistry * Measurement of Optical Properties * Measurement of Pore Size, Porosity, Thickness, Surface Area The whole is backed by a generous use of color photographs to illustrate the described procedures in detail, plus a bibliography of further literature pertinent to a wide range of application fi elds. For materials scientists, chemists, physicists, optical physicists, biomaterials scientists, neurobiologists, bioengineers, and graduate students in those fields, as well as those working in the semiconductor industry.
Book Synopsis Porous Silicon Microparticles as an Alternative Support for Solid Phase DNA Synthesis by : Steven James Peter McInnes
Download or read book Porous Silicon Microparticles as an Alternative Support for Solid Phase DNA Synthesis written by Steven James Peter McInnes and published by . This book was released on 2006 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery by : Chia-Chen Wu
Download or read book Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery written by Chia-Chen Wu and published by . This book was released on 2013 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous materials with engineered surface properties are of interest for molecular separations, catalysis, drug delivery, and chemical sensing. One of the longstanding chemical challenges in the engineering of nanomaterials is to control the placement of different chemistries in spatially distinct regions on a nanoscale object. This thesis focuses on discovering and understanding processes to prepare such spatially differentiated chemistries on porous silicon. For the porous silicon system, the ability to prepare pores of average diameter anywhere from 1 to 200 nm allows the harnessing of surface tension and capillary forces to promote or obstruct the infiltration of reagent for selective modification. The first process investigated involves placing different chemistries on the pore walls by means of microdroplet patterning. In this method, a chemical resist is drop-coated on a porous silicon sample to mask distinct regions across the plane of the chip for subsequent chemical modification. Two chemistries, silicon oxide and silicon-methyl, are demonstrated here. The differential partitioning of test molecules on the resulting hydrophilic/hydrophobic film is achieved by simultaneous optical reflectance measurement of both regions, where the reflectance spectrum contains a convolution of the Fabry-Pérot interference spectrum for both types of surface chemistries. A second approach to engineer porous Si nanostructures that is investigated uses a hydrophobic organic liquid as a chemical resist; it is infiltrated into the pores to mask the interior of the porous silicon film, while the exterior surface and the pore mouths of the film are subjected to an aqueous chemical reaction with HF and subsequent chemical modification by thermal hydrosilylation. When chemically modified with a hydrophobic dodecyl species, the resulting film has a hydrophilic interior and a hydrophobic outer surface. The ability of these core-shell porous nanostructures to admit and release small molecules is assessed and exploited. The last portion of the thesis focuses on an evaluation of chemically modified porous silicon particles as oral drug delivery material, with an emphasis on the ability of the interior of the porous silicon nanostructure to protect physiologically unstable drugs. Partially oxidized porous silicon particles show no toxicity to nematodes at particle concentration up to 1 mg/mL in culture media. In vitro experiments show the particles protect anthelmintic protein-based drug Cry5B from hydrolytic degradation in simulated gastric fluid, and the bioactivity against nematodes is maintained. However, much reduced bioactivity of the therapeutic particles is observed In vivo on hookworm-infected hamsters. The lack of effectiveness in treating the disease In vivo is attributed to the short residence time of the particles in the gut of the animals.
Book Synopsis In Situ DNA Synthesis in Porous Silicon for Biosensing Applications by : Jenifer L. Lawrie
Download or read book In Situ DNA Synthesis in Porous Silicon for Biosensing Applications written by Jenifer L. Lawrie and published by . This book was released on 2012 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Engineering Porous Silicon for a Top-Down Approach to Controlled Drug Delivery by : Ariella Machness
Download or read book Engineering Porous Silicon for a Top-Down Approach to Controlled Drug Delivery written by Ariella Machness and published by . This book was released on 2020 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanocarriers that localize a therapeutic to a disease site and release it "on-demand" via the clinician's control will mitigate the adverse effects that reduce a patient's quality of life while undergoing oncology treatment. Moreover, magnetically actuated drug delivery carriers are appealing platforms in next-generation targeted medicine, yet these carriers must be compatible with scalable fabrication techniques to realize their clinical translation. In this dissertation, a magnetically capped porous silicon nanocomposite (APTESPSi@Fe3O4), that responds to physiologically relevant temperatures, was developed using cost-effective, highly scalable methods such as electrochemical etching. Fourier transform infrared spectroscopy (FTIR), CHNS elemental analysis, and zeta potential confirmed that accelerated hydrolysis at 45 C altered the porous silicon surface chemistry. This hydrolysis-mediated electrostatic degradation between the porous silicon and Fe3O4 caps translated to a thermoresponsive release behavior in dissolution studies with sorafenib (SFN), where minimal drug was released at room temperature and 37 C, while an enhanced release occurred at 45 C and 50 C. The magnetic heat dissipation capabilities with application of an alternating magnetic field (AMF) was calculated by the specific absorption rate (SAR) through calorimetry and magnetic susceptibility measurements. Comparing these two methods revealed that the electrostatic interactions between the porous silicon and Fe3O4 do not hinder the Brownian relaxation and heat dissipation. The nanocomposite and its components demonstrated high cytocompatibility after 24 hours with RAW 246.7, MDA-MB-231, and HepG2 cells, but not with MCF-7. High cytocompatibility was also observed when the cells incubated with particles were heated to 45 C for 15 min followed by 37 C for the remaining 6 hour incubation period. Porous silicon and its nanocomposite improved the SFN solubility in in vitro studies with MDA-MB-231 and HepG2, resulting in increased anticancer activity in comparison to the free drug. Moreover, the anticancer activity was readily controlled from the magnetic nanocomposite by modulating the amount of SFN released with temperature. Confocal microscopy and flow cytometry showed a higher uptake of the amine-modified porous silicon in comparison to the magnetic nanocomposite in MDA-MB-231 cells. The temperature increase to 45 C showed a reduced particle uptake, yet future studies monitoring the fluorescence from the free drug rather than the nanocarrier will prove useful. This novel system has laid the groundwork for a promising tool for clinicians to lessen the burden that millions of cancer patients face as they receive treatment.
Book Synopsis Multifunctional Nanoparticles for Drug Delivery Applications by : Sonke Svenson
Download or read book Multifunctional Nanoparticles for Drug Delivery Applications written by Sonke Svenson and published by Springer Science & Business Media. This book was released on 2012-02-22 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.
Book Synopsis Advanced Porous Biomaterials for Drug Delivery Applications by : Mahaveer Kurkuri
Download or read book Advanced Porous Biomaterials for Drug Delivery Applications written by Mahaveer Kurkuri and published by CRC Press. This book was released on 2022-11-30 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Porous Biomaterials for Drug Delivery Applications probes cutting-edge progress in the application of advanced porous biomaterials in drug delivery fields. These biomaterials offer promise in improving upon the design, cost, and creation of potent novel drug delivery systems. The book focuses on two categories: nature engineered and synthetic advanced porous biomaterials, with a wide range of low-cost porous biomaterial-based systems that have been used for the delivery of diverse drugs through in vitro/in vivo approaches. Details how advanced porous biomaterial-assisted systems improve essential properties in drug delivery applications Explains how advanced porous biomaterials systems are being used and explored to improve overall performances of drug delivery systems in mitigating a variety of diseases Emphasizes major applications in drug delivery such as controlled release, cancer therapy, and targeted delivery, and with focus on oral, topical, and transdermal applications Focuses on both naturally available and synthetic low-cost advanced porous biomaterials and their role in enhancing important parameters in drug delivery applications Accessible to readers with bio and non-bio backgrounds This book is an ideal reference for academics, researchers, and industry professionals in the interdisciplinary fields of biomedicine and biomedical engineering, pharmaceuticals, materials science, and chemistry.
Book Synopsis Properties of Porous Silicon by : Leigh T. Canham
Download or read book Properties of Porous Silicon written by Leigh T. Canham and published by Institution of Electrical Engineers. This book was released on 1997 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed insight into porous silicon and its diverse novel applications.
Book Synopsis Porous Silicon: From Formation to Application: Biomedical and Sensor Applications, Volume Two by : Ghenadii Korotcenkov
Download or read book Porous Silicon: From Formation to Application: Biomedical and Sensor Applications, Volume Two written by Ghenadii Korotcenkov and published by CRC Press. This book was released on 2016-01-05 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous silicon is rapidly attracting increasing interest from various fields, including optoelectronics, microelectronics, photonics, medicine, chemistry, and biosensing. This nanostructured and biodegradable material has a range of unique properties that make it ideal for many applications. For example, the pores and surface chemistry of the mater
Book Synopsis 21st Century Nanoscience – A Handbook by : Klaus D. Sattler
Download or read book 21st Century Nanoscience – A Handbook written by Klaus D. Sattler and published by CRC Press. This book was released on 2020-04-22 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This eighth volume in a ten-volume set covers nanopharmaceuticals, nanomedicine, and food nanoscience. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in the field. Emphasises presentation and real results and applications. This handbook distinguishes itself from other works by its breadth of coverage, readability and timely topics. The intended readership is very broad, from students and instructors to engineers, physicists, chemists, biologists, biomedical researchers, industry professionals, governmental scientists, and others whose work is impacted by nanotechnology. It will be an indispensable resource in academic, government, and industry libraries worldwide. The fields impacted by nanophysics extend from materials science and engineering to biotechnology, biomedical engineering, medicine, electrical engineering, pharmaceutical science, computer technology, aerospace engineering, mechanical engineering, food science, and beyond.
Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari
Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Book Synopsis Porous Silicon as a Delivery System for Poorly Soluble Drugs by : Feng Wang
Download or read book Porous Silicon as a Delivery System for Poorly Soluble Drugs written by Feng Wang and published by . This book was released on 2010 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Porous Silicon by : Leigh Canham
Download or read book Handbook of Porous Silicon written by Leigh Canham and published by Springer. This book was released on 2021-01-14 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Porous Silicon brings together the expertise of a large, international team of almost 100 academic researchers, engineers, and product developers from industry across electronics, medicine, nutrition and consumer care to summarize the field in its entirity with 150 chapters and 5000 references. The volume presents 5 parts which cover fabrication techniques, material properties, characterization techniques, processing and applications. Much attention was given in the the past to its luminescent properties, but increasingly it is the biodegradability, mechanical, thermal and sensing capabilities that are attracting attention. The volume is divided into focussed data reviews with, wherever possible, quantitative rather than qualitative descriptions of both properties and performance. The book is targeted at undergraduates, postgraduates, and experienced researchers.
Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan
Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
