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Author : Graziella Madeo
Publisher : Frontiers Media SA
ISBN 13 : 2889631893
Total Pages : 144 pages
Book Rating : 4.8/5 (896 download)
Download or read book Modeling Parkinson's Disease: Bridging the Translational Gap written by Graziella Madeo and published by Frontiers Media SA. This book was released on 2019-11-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309266335
Total Pages : 111 pages
Book Rating : 4.3/5 (92 download)
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030921954X
Total Pages : 42 pages
Book Rating : 4.3/5 (92 download)
Download or read book Guidance for the Description of Animal Research in Scientific Publications written by National Research Council and published by National Academies Press. This book was released on 2011-09-16 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Author : Dag Aarsland
Publisher : Cambridge University Press
ISBN 13 : 1107039223
Total Pages : 311 pages
Book Rating : 4.1/5 (7 download)
Download or read book Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders written by Dag Aarsland and published by Cambridge University Press. This book was released on 2013-08-29 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: A broad and in-depth discussion of the important, but still uninformed, field of behavioral disturbances associated with Parkinson's disease.
Author : Sachchida Nand Rai
Publisher : CRC Press
ISBN 13 : 1040160123
Total Pages : 255 pages
Book Rating : 4.0/5 (41 download)
Download or read book Neurodegenerative Diseases written by Sachchida Nand Rai and published by CRC Press. This book was released on 2024-12-02 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches. Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease
Author : Georg Striedter
Publisher : MIT Press
ISBN 13 : 0262370034
Total Pages : 303 pages
Book Rating : 4.2/5 (623 download)
Download or read book Model Systems in Biology written by Georg Striedter and published by MIT Press. This book was released on 2022-08-23 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure. In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer’s disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists. Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a “big tent” biology, in which a diverse set of models and research strategies can coexist productively.
Author : Jiehui Jiang
Publisher : Frontiers Media SA
ISBN 13 : 2889763714
Total Pages : 845 pages
Book Rating : 4.8/5 (897 download)
Download or read book Translational Advances in Alzheimer's, Parkinson's, and Other Neurodegenerative Dementias written by Jiehui Jiang and published by Frontiers Media SA. This book was released on 2022-07-05 with total page 845 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Santiago Perez-Lloret
Publisher : Humana
ISBN 13 : 9781071609118
Total Pages : 0 pages
Book Rating : 4.6/5 (91 download)
Download or read book Clinical Trials In Parkinson's Disease written by Santiago Perez-Lloret and published by Humana. This book was released on 2020-08-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.
Author :
Publisher : Elsevier
ISBN 13 : 044319405X
Total Pages : 304 pages
Book Rating : 4.4/5 (431 download)
Download or read book Blood-Brain Barrier written by and published by Elsevier. This book was released on 2024-07-20 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the latest information on blood-brain barrier research - Offers outstanding and original reviews on a range ofblood-brain barrier research topics - Serves as an indispensable reference for researchers and students alike
Author : Jeffrey R. Capadona
Publisher : Frontiers Media SA
ISBN 13 : 2889638502
Total Pages : 378 pages
Book Rating : 4.8/5 (896 download)
Download or read book Bridging the Gap in Neuroelectronic Interfaces written by Jeffrey R. Capadona and published by Frontiers Media SA. This book was released on 2020-07-09 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ana Aragon
Publisher :
ISBN 13 : 9781905944163
Total Pages : 76 pages
Book Rating : 4.9/5 (441 download)
Download or read book Occupational Therapy for People with Parkinson's Disease written by Ana Aragon and published by . This book was released on 2010 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: These practice guidelines draw upon the widest relevant knowledge and evidence available to describe and inform contemporary best practice occupational therapy for people with Parkinson's disease. They include practical examples of interventions to allow occupational therapists to apply new treatments to their practice.
Author : Indranath Chatterjee
Publisher : CRC Press
ISBN 13 : 1040216293
Total Pages : 273 pages
Book Rating : 4.0/5 (42 download)
Download or read book Integrating Neuroimaging, Computational Neuroscience, and Artificial Intelligence written by Indranath Chatterjee and published by CRC Press. This book was released on 2024-12-18 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unveil the next frontier in neurodegenerative disorder research with Integrating Neuroimaging, Computational Neuroscience, and Artificial Intelligence. This groundbreaking book goes beyond traditional approaches, utilizing the power of interdisciplinary integration to illuminate new pathways in diagnosis and treatment. From AI-driven diagnostics to computational neuroscience models, this book showcases the forefront of innovation. Join us in exploring the future of neurodegenerative care, where collaboration and cutting-edge technology converge to redefine possibilities. Key Features: Integrates diverse fields of research, from neuroimaging to computational neuroscience and Artificial Intelligence. Emphasizes the translation of research findings into practical applications, ultimately benefitting patients and clinical practice. Reviews the implementation of Artificial Intelligence and computational models in diagnostic settings. Elucidates the current state of translational neuroscience exploring potential areas for further research and collaboration, including personalized treatments and drug development. Contributions from an international team of experts from diverse disciplines.
Author : Na Li
Publisher : Frontiers Media SA
ISBN 13 : 2832540333
Total Pages : 135 pages
Book Rating : 4.8/5 (325 download)
Download or read book Bridging the Gap in Neuroscience and Neurotherapeutics: from Fundamental Research to Clinical Translational Applications written by Na Li and published by Frontiers Media SA. This book was released on 2023-12-04 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Monique R. Bernsen
Publisher : Frontiers Media SA
ISBN 13 : 2832511384
Total Pages : 152 pages
Book Rating : 4.8/5 (325 download)
Download or read book Small animal imaging: Technological and methodological advances to improve the translational power written by Monique R. Bernsen and published by Frontiers Media SA. This book was released on 2023-01-13 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Akhlaq A. Farooqui
Publisher : Academic Press
ISBN 13 : 0128167319
Total Pages : 387 pages
Book Rating : 4.1/5 (281 download)
Download or read book Molecular Mechanisms of Dementia written by Akhlaq A. Farooqui and published by Academic Press. This book was released on 2019-04-15 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. - Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia - Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia - Discusses the synthesis, metabolism, and role of lipid mediators in dementia
Author : Wendy Noble
Publisher : Frontiers Media SA
ISBN 13 : 2889711080
Total Pages : 170 pages
Book Rating : 4.8/5 (897 download)
Download or read book Neurodegeneration Editors' Pick 2021 written by Wendy Noble and published by Frontiers Media SA. This book was released on 2021-07-28 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wael Mohamed
Publisher : CRC Press
ISBN 13 : 1040115896
Total Pages : 315 pages
Book Rating : 4.0/5 (41 download)
Download or read book Zebrafish as a Model for Parkinson’s Disease written by Wael Mohamed and published by CRC Press. This book was released on 2024-10-04 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the zebrafish (ZF) as a model for studying Parkinson’s disease (PD). This book aims to present readers with a comprehensive understanding of the clinical application of the ZF model in treating PD, encompassing the latest developments, challenges, safety considerations, toxicity issues, regulatory aspects, future potential, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain stand to benefit from this resource. Key Features Provides a comparative perspective of the zebrafish–Parkinson’s disease model Highlights the restrictions of available medicines Describes biochemical and histopathological characteristics, advantages, and disadvantages of this model Emphasizes distinct facets of histopathology Presents advances and developments of the future potential perspectives
