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Modeling Estimation And On Line Optimal Control Of Induced Foreign Protein Production In Fed Batch Reactors
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Book Synopsis Modeling, Estimation, and On-line Optimal Control of Induced Foreign Protein Production in Fed-batch Reactors by : Jongdae Lee
Download or read book Modeling, Estimation, and On-line Optimal Control of Induced Foreign Protein Production in Fed-batch Reactors written by Jongdae Lee and published by . This book was released on 1992 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Food Process Design, 2 Volume Set by : Jasim Ahmed
Download or read book Handbook of Food Process Design, 2 Volume Set written by Jasim Ahmed and published by John Wiley & Sons. This book was released on 2012-05-21 with total page 1543 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 21st Century, processing food is no longer a simple or straightforward matter. Ongoing advances in manufacturing have placed new demands on the design and methodology of food processes. A highly interdisciplinary science, food process design draws upon the principles of chemical and mechanical engineering, microbiology, chemistry, nutrition and economics, and is of central importance to the food industry. Process design is the core of food engineering, and is concerned at its root with taking new concepts in food design and developing them through production and eventual consumption. Handbook of Food Process Design is a major new 2-volume work aimed at food engineers and the wider food industry. Comprising 46 original chapters written by a host of leading international food scientists, engineers, academics and systems specialists, the book has been developed to be the most comprehensive guide to food process design ever published. Starting from first principles, the book provides a complete account of food process designs, including heating and cooling, pasteurization, sterilization, refrigeration, drying, crystallization, extrusion, and separation. Mechanical operations including mixing, agitation, size reduction, extraction and leaching processes are fully documented. Novel process designs such as irradiation, high-pressure processing, ultrasound, ohmic heating and pulsed UV-light are also presented. Food packaging processes are considered, and chapters on food quality, safety and commercial imperatives portray the role process design in the broader context of food production and consumption.
Book Synopsis Computational Intelligence Techniques for Bioprocess Modelling, Supervision and Control by : Maria Carmo Nicoletti
Download or read book Computational Intelligence Techniques for Bioprocess Modelling, Supervision and Control written by Maria Carmo Nicoletti and published by Springer Science & Business Media. This book was released on 2009-06-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1993 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1992 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :American Chemical Society. Committee on Professional Training Publisher : ISBN 13 :9780841227231 Total Pages :1700 pages Book Rating :4.2/5 (272 download)
Book Synopsis ACS Directory of Graduate Research 1993 by : American Chemical Society. Committee on Professional Training
Download or read book ACS Directory of Graduate Research 1993 written by American Chemical Society. Committee on Professional Training and published by . This book was released on 1993 with total page 1700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of Metaheuristics in Process Engineering by : Jayaraman Valadi
Download or read book Applications of Metaheuristics in Process Engineering written by Jayaraman Valadi and published by Springer. This book was released on 2014-08-07 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metaheuristics exhibit desirable properties like simplicity, easy parallelizability and ready applicability to different types of optimization problems such as real parameter optimization, combinatorial optimization and mixed integer optimization. They are thus beginning to play a key role in different industrially important process engineering applications, among them the synthesis of heat and mass exchange equipment, synthesis of distillation columns and static and dynamic optimization of chemical and bioreactors. This book explains cutting-edge research techniques in related computational intelligence domains and their applications in real-world process engineering. It will be of interest to industrial practitioners and research academics.
Book Synopsis Iterative Dynamic Programming by : Rein Luus
Download or read book Iterative Dynamic Programming written by Rein Luus and published by CRC Press. This book was released on 2019-09-17 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic programming is a powerful method for solving optimization problems, but has a number of drawbacks that limit its use to solving problems of very low dimension. To overcome these limitations, author Rein Luus suggested using it in an iterative fashion. Although this method required vast computer resources, modifications to his original schem
Book Synopsis Taming Heterogeneity and Complexity of Embedded Control by : Françoise Lamnabhi-Lagarrigu
Download or read book Taming Heterogeneity and Complexity of Embedded Control written by Françoise Lamnabhi-Lagarrigu and published by John Wiley & Sons. This book was released on 2013-05-21 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers together a selection of papers presented at the Joint CTS-HYCON Workshop on Nonlinear and Hybrid Control held at the Paris Sorbonne, France, 10-12 July 2006. The main objective of the Workshop was to promote the exchange of ideas and experiences and reinforce scientific contacts in the large multidisciplinary area of the control of nonlinear and hybrid systems.
Book Synopsis Current Advances in Applied Microbiology & Biotechnology by :
Download or read book Current Advances in Applied Microbiology & Biotechnology written by and published by . This book was released on 1996 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pattern Recognition of Historical Fermentation Data for Optimization of Recombinant Protein Production by : Matthew Charles Coleman
Download or read book Pattern Recognition of Historical Fermentation Data for Optimization of Recombinant Protein Production written by Matthew Charles Coleman and published by . This book was released on 2005 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Control and Intelligent Systems by :
Download or read book Control and Intelligent Systems written by and published by . This book was released on 1998 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recombinant Protein Expression: Prokaryotic hosts and cell-free systems by :
Download or read book Recombinant Protein Expression: Prokaryotic hosts and cell-free systems written by and published by Academic Press. This book was released on 2021-10-29 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant Protein Expression, Part A, Volume 659 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on Multiplexed analysis protein: Protein interactions of polypeptides translated in Leishmania cell-free system, MultiBac system and its applications, performance and recent, Production of antibodies in Shuffle, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to enhance transcription in yeast, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to deregulate transcription in yeast, Antibody or protein-based vaccine production in plants, Cell-free protein synthesis, Plant-based expression of biologic drugs, and much more. Additional sections cover the Use of native mass spectrometry to guide detergent-based rescue of non-native oligomerization by recombinant proteins, Advancing overexpression and purification of recombinant proteins by pilot optimization through tandem affinity-buffer exchange chromatography online with native mass spectrometry, Method for High-Efficiency Fed-batch cultures of recombinant Escherichia coli, Method to transfer Chinese hamster ovary (CHO) shake flask experiments to the ambr® 250, and Expression of recombinant antibodies in Leishmania tarentolae. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology serial Updated release includes the latest information on Recombinant Protein Expression
Book Synopsis Production and Modeling of Recombinant Protein by : Jason Yaeck
Download or read book Production and Modeling of Recombinant Protein written by Jason Yaeck and published by . This book was released on 2006 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational models of recombinant production of tissue-type Plasminogen Activator (tPA) were created, studied and compared for two hosts, Chinese Hamster Ovary (CHO)cells and Escherichia coli (E. coli), using SuperPro® Designer. In addition, several fermentations were run using enhanced Yellow Fluorescent Protein (eYFP) in E. coli to provide knowledge for the SuperPro model and to explore the effect of temperature when used to maintain dissolved oxygen in a high density fed-batch fermentation. The models show that production of tPA is feasible using either host, but under the current basecase CHO holds the economic advantage despite the initial higher capital costs. In order to become more competitive with CHO, production using E. coli must become higher on a cell specific level and the potential of refolding insoluble protein in inclusion bodies should be explored. Since E. coli's growth rate allows for higher plant throughput in a given production year, if this was combined with strains which produce higher titers of protein than those available in literature, it would allow E. coli to become competitive with CHO for the production of recombinant tPA. Experiments demonstrate that temperature control can be used to slow the metabolic rate of E. coli, allowing aerobic conditions to be maintained in the high density fermentations. Although temperature reduction has also been used to increase the yield of soluble protein, it is likely this occurs with reduced protein production. Temperature control was initiated using five minute moving averages to monitor overall oxygen and stirrer speed trends. Temperature was dropped 5 °C when averaged oxygen content fell below 18% and averaged stirrer speeds were greater than 1000 rpm. Temperature controlled runs for E. coli BL21DE3 producing eYFP appeared to allow the cultures to maintain better aerobic conditions. It is known that eYFP was produced since homogenized cell paste fluoresced yellow under UV light. However, protein analysis was hampered due to low protein production even after induction. Purifications involving large amounts of cell paste (50 g or more) were difficult to perform and all purificitiatons resulted in contamination by other proteins. Several recommendations can be made. The modeling would be greatly facilitated by additional information such as equipment specifications at large-scale production. The work with eYFP containing E. coli would be greatly enhanced by better strain selection. Choosing strains which over-express the protein of interest on the small scale would lead to better results in the fermentor. A densiometric analysis of the SDS PAGE gels run would allow a better understanding of general proteomic response to temperature control. When combined with mass spectrometry this may lead to different approaches in reducing temperature. Temperature control is often thought to increase soluble protein. From the densiometric SDS PAGE analysis of both the supernatant and pellet after homogenization it would be interesting to examine the partioning of recombinant protein into soluble and insoluble forms in future experiments.
Book Synopsis Optimization and Control of Recombinant Protein Expression by : Casey Preston
Download or read book Optimization and Control of Recombinant Protein Expression written by Casey Preston and published by . This book was released on 2004 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis On-line Computer Control and Optimization of a Fed-batch Process for the Production of Single Cell Protein from Ethanol by : William Michael Ziegler
Download or read book On-line Computer Control and Optimization of a Fed-batch Process for the Production of Single Cell Protein from Ethanol written by William Michael Ziegler and published by . This book was released on 1980 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Perfusion Cell Culture Processes for Biopharmaceuticals by : Moritz Wolf
Download or read book Perfusion Cell Culture Processes for Biopharmaceuticals written by Moritz Wolf and published by Cambridge University Press. This book was released on 2020-08-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter.
