Modeling Biological Systems With Cybernetic Control Laws And Steady State Flux Distributions

Download Modeling Biological Systems With Cybernetic Control Laws And Steady State Flux Distributions full books in PDF, epub, and Kindle. Read online Modeling Biological Systems With Cybernetic Control Laws And Steady State Flux Distributions ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions

Author : Kritika Kashyap
Publisher :
ISBN 13 :
Total Pages : 78 pages
Book Rating : 4.:/5 (122 download)

DOWNLOAD NOW!

Book Synopsis Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions by : Kritika Kashyap

Download or read book Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions written by Kritika Kashyap and published by . This book was released on 2019 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism is a process by which organisms extract energy from its environment to power itself. The interplay between cellular environment, nutrients present and the chemical reactions occurring within the organisms dictate the execution of metabolism. Single cell microbes, such as E. coli, P. putida and yeast, can be redesigned to be miniature chemical reactors that transform sugars and other carbon sources into biofuels. Enhancing bio-process conditions can stimulate the production of therapeutic proteins in mammalian cells. Hence, understanding the strategy of metabolism in organisms would help us build better technologies for controlling formation of end products like cell mass, biofuels,therapeutic proteins etc. Steady state flux analysis techniques have gained a lot of popularity in the field of systems biology due to successful qualitative analysis of large scale metabolic networks. This technique has been used to improve production of ethanol in Saccharomyces cerevisiae and lactic acid in Escherichia coli (E. coli), to name a few examples. Despite this success, its major shortcoming re-mains in providing quantitative measurements of metabolite profiles that can be further validated with experiments. Previous cybernetic models have accurately validated experimental results and described molecular processes governing metabolism, but their application is limited to small scale metabolic net-works. We have built a mathematical framework that combines solutions from steady state flux analysis with cybernetic principles to overcome the challenge of describing metabolic data for large scale metabolic networks. We have established computational models that can capture dynamic metabolic regulation in bacterial and mammalian cells. These models integrate chemical kinetics, mass balances, enzyme catalysis and stoichiometric laws to predict biology that can help us optimize cellular machinery towards bioproduct formation.

Models of Life

Author : Kim Sneppen
Publisher : Cambridge University Press
ISBN 13 : 1316061655
Total Pages : 353 pages
Book Rating : 4.3/5 (16 download)

DOWNLOAD NOW!

Book Synopsis Models of Life by : Kim Sneppen

Download or read book Models of Life written by Kim Sneppen and published by Cambridge University Press. This book was released on 2014-10-02 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the major advances that have been made in the field over the past decade, this book provides an overview of current models of biological systems. The focus is on simple quantitative models, highlighting their role in enhancing our understanding of the strategies of gene regulation and dynamics of information transfer along signalling pathways, as well as in unravelling the interplay between function and evolution. The chapters are self-contained, each describing key methods for studying the quantitative aspects of life through the use of physical models. They focus, in particular, on connecting the dynamics of proteins and DNA with strategic decisions on the larger scale of a living cell, using E. coli and phage lambda as key examples. Encompassing fields such as quantitative molecular biology, systems biology and biophysics, this book will be a valuable tool for students from both biological and physical science backgrounds.

Biological Systems, Modelling, and Control

Author : D. A. Linkens
Publisher :
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.F/5 ( download)

DOWNLOAD NOW!

Book Synopsis Biological Systems, Modelling, and Control by : D. A. Linkens

Download or read book Biological Systems, Modelling, and Control written by D. A. Linkens and published by . This book was released on 1979 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

Author : Vishwesh V. Kulkarni
Publisher : Springer
ISBN 13 : 9401790418
Total Pages : 338 pages
Book Rating : 4.4/5 (17 download)

DOWNLOAD NOW!

Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations by : Vishwesh V. Kulkarni

Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations written by Vishwesh V. Kulkarni and published by Springer. This book was released on 2014-07-03 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology. Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

Steady State Analysis of Biological Systems Using Mathematical Modeling

Author : Jamian Lamar Smith
Publisher :
ISBN 13 :
Total Pages : 49 pages
Book Rating : 4.:/5 (898 download)

DOWNLOAD NOW!

Book Synopsis Steady State Analysis of Biological Systems Using Mathematical Modeling by : Jamian Lamar Smith

Download or read book Steady State Analysis of Biological Systems Using Mathematical Modeling written by Jamian Lamar Smith and published by . This book was released on 2014 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall paper shows the different estimation approaches, the pros and cons of each method, and how the method has been applied to various biological systems.

Feature Papers for Celebrating the Fifth Anniversary of the Founding of Processes

Author : Michael A. Henson
Publisher : MDPI
ISBN 13 : 3038975257
Total Pages : 373 pages
Book Rating : 4.0/5 (389 download)

DOWNLOAD NOW!

Book Synopsis Feature Papers for Celebrating the Fifth Anniversary of the Founding of Processes by : Michael A. Henson

Download or read book Feature Papers for Celebrating the Fifth Anniversary of the Founding of Processes written by Michael A. Henson and published by MDPI. This book was released on 2019-01-24 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Feature Papers for Celebrating the Fifth Anniversary of the Founding of Processes" that was published in Processes

Comprehensive Biotechnology

Author :
Publisher : Newnes
ISBN 13 : 0080885047
Total Pages : 5304 pages
Book Rating : 4.0/5 (88 download)

DOWNLOAD NOW!

Book Synopsis Comprehensive Biotechnology by :

Download or read book Comprehensive Biotechnology written by and published by Newnes. This book was released on 2011-08-26 with total page 5304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Biotechnology, Six Volume Set continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field

Biological Machines

Author : Peter Calow
Publisher : Hodder Education
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.F/5 ( download)

DOWNLOAD NOW!

Book Synopsis Biological Machines by : Peter Calow

Download or read book Biological Machines written by Peter Calow and published by Hodder Education. This book was released on 1976 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Introduction to Modeling Biological Cellular Control Systems

Author : Weijiu Liu
Publisher : Springer
ISBN 13 : 9788847056367
Total Pages : 0 pages
Book Rating : 4.0/5 (563 download)

DOWNLOAD NOW!

Book Synopsis Introduction to Modeling Biological Cellular Control Systems by : Weijiu Liu

Download or read book Introduction to Modeling Biological Cellular Control Systems written by Weijiu Liu and published by Springer. This book was released on 2014-03-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook contains the essential knowledge in modeling, simulation, analysis, and applications in dealing with biological cellular control systems. In particular, the book shows how to use the law of mass balance and the law of mass action to derive an enzyme kinetic model - the Michaelis-Menten function or the Hill function, how to use a current-voltage relation, Nernst potential equilibrium equation, and Hodgkin and Huxley's models to model an ionic channel or pump, and how to use the law of mass balance to integrate these enzyme or channel models into a complete feedback control system. The book also illustrates how to use data to estimate parameters in a model, how to use MATLAB to solve a model numerically, how to do computer simulations, and how to provide model predictions. Furthermore, the book demonstrates how to conduct a stability and sensitivity analysis on a model.

Stochastic Models in Biology

Author : Narendra S. Goel
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Stochastic Models in Biology by : Narendra S. Goel

Download or read book Stochastic Models in Biology written by Narendra S. Goel and published by . This book was released on 1974 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stochastic Models in Biology describes the usefulness of the theory of stochastic process in studying biological phenomena. The book describes analysis of biological systems and experiments though probabilistic models rather than deterministic methods. The text reviews the mathematical analyses for modeling different biological systems such as the random processes continuous in time and discrete in state space. The book also discusses population growth and extinction through Malthus' law and the work of MacArthur and Wilson. The text then explains the dynamics of a population of interacting sp ...

Cybernetic Modeling for Bioreaction Engineering

Author : Doraiswami Ramkrishna
Publisher : Cambridge University Press
ISBN 13 : 1108577164
Total Pages : 295 pages
Book Rating : 4.1/5 (85 download)

DOWNLOAD NOW!

Book Synopsis Cybernetic Modeling for Bioreaction Engineering by : Doraiswami Ramkrishna

Download or read book Cybernetic Modeling for Bioreaction Engineering written by Doraiswami Ramkrishna and published by Cambridge University Press. This book was released on 2018-10-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.

Cybernetic Modeling for Bioreaction Engineering

Author : Doraiswami Ramkrishna
Publisher : Cambridge University Press
ISBN 13 : 1107000521
Total Pages : 295 pages
Book Rating : 4.1/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Cybernetic Modeling for Bioreaction Engineering by : Doraiswami Ramkrishna

A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems

Author : Vishwesh V. Kulkarni
Publisher : Springer
ISBN 13 : 9789402403374
Total Pages : 0 pages
Book Rating : 4.4/5 (33 download)

DOWNLOAD NOW!

Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems by : Vishwesh V. Kulkarni

Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems written by Vishwesh V. Kulkarni and published by Springer. This book was released on 2016-09-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

Unstructured, Structured, and Reduced Order Modeling of Biological Systems

Author : Mason Minot
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (1 download)

DOWNLOAD NOW!

Book Synopsis Unstructured, Structured, and Reduced Order Modeling of Biological Systems by : Mason Minot

Download or read book Unstructured, Structured, and Reduced Order Modeling of Biological Systems written by Mason Minot and published by . This book was released on 2016 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of recombinant DNA technology and genetic engineering has provided the fields of biology and engineering with a powerful tool set for discovery, rational design, and manipulation of biological systems and processes. Mathematical modeling of these biological systems has the potential to provide valuable insight, to guide experimental design, and to optimize industrial products and processes. Modeling of cell biology, growth, metabolism, and product formation can assist in strain development and fermentation processes. This thesis seeks to utilize chemical engineering principles to model several biological systems using a variety of approaches. Unstructured and structured models are developed to model an industrially relevant riboflavin-producing strain of Bacillus subtilis and to maximize product formation based on fed-batch feeding. A new technique is developed that combines cybernetic control variables and flux balance analysis to model cellular metabolism of Escherichia coli capable of capturing dynamic behavior during cell growth while reducing computational overhead. A parameter optimization algorithm is developed for the Julia programming language and applied to biological systems. Finally, a reduced order computational model of the complement system, which plays a significant role in inflammation, host defense as well as many disease processes, is developed and validated in through its ability to predict experimental data trends.

Stochastic and Spatio-temporal Modeling in Systems Biology

Author : Aditya P. Singh
Publisher :
ISBN 13 : 9781109860474
Total Pages : 189 pages
Book Rating : 4.8/5 (64 download)

DOWNLOAD NOW!

Book Synopsis Stochastic and Spatio-temporal Modeling in Systems Biology by : Aditya P. Singh

Download or read book Stochastic and Spatio-temporal Modeling in Systems Biology written by Aditya P. Singh and published by . This book was released on 2007 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The post genome era of systems biology is marked by the need to develop models that explain the emergent behavior of biological systems different from the functioning of the individual parts of their constituents. Models should not only explain the observed experimental findings but should also be able to predict under outcomes that are not currently experimentally amenable.

The Metabolic Pathway Engineering Handbook

Author : Christina Smolke
Publisher : CRC Press
ISBN 13 : 1439802971
Total Pages : 680 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!

Book Synopsis The Metabolic Pathway Engineering Handbook by : Christina Smolke

Download or read book The Metabolic Pathway Engineering Handbook written by Christina Smolke and published by CRC Press. This book was released on 2009-07-28 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction

Systems Metabolic Engineering

Author : Christoph Wittmann
Publisher : Springer Science & Business Media
ISBN 13 : 9400745346
Total Pages : 391 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Systems Metabolic Engineering by : Christoph Wittmann

Download or read book Systems Metabolic Engineering written by Christoph Wittmann and published by Springer Science & Business Media. This book was released on 2012-06-15 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.