Mitochondrial Function In Lung Health And Disease

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Mitochondrial Function in Lung Health and Disease

Author : Viswanathan Natarajan
Publisher : Springer
ISBN 13 : 1493908294
Total Pages : 230 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Mitochondrial Function in Lung Health and Disease by : Viswanathan Natarajan

Download or read book Mitochondrial Function in Lung Health and Disease written by Viswanathan Natarajan and published by Springer. This book was released on 2014-07-26 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Mitochondria in Health and Diseases

Author : Sabzali Javadov
Publisher :
ISBN 13 : 9783039363841
Total Pages : 434 pages
Book Rating : 4.3/5 (638 download)

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Book Synopsis Mitochondria in Health and Diseases by : Sabzali Javadov

Download or read book Mitochondria in Health and Diseases written by Sabzali Javadov and published by . This book was released on 2020-09-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondria in Health and Disease

Author : Carolyn D. Berdanier
Publisher : CRC Press
ISBN 13 : 1420028847
Total Pages : 640 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Mitochondria in Health and Disease by : Carolyn D. Berdanier

Download or read book Mitochondria in Health and Disease written by Carolyn D. Berdanier and published by CRC Press. This book was released on 2005-06-09 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses f

Mitochondrial Signaling in Health and Disease

Author : Sten Orrenius
Publisher : CRC Press
ISBN 13 : 1439880026
Total Pages : 530 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Mitochondrial Signaling in Health and Disease by : Sten Orrenius

Download or read book Mitochondrial Signaling in Health and Disease written by Sten Orrenius and published by CRC Press. This book was released on 2012-06-20 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Mitochondria in Health and in Sickness

Author : Andrea Urbani
Publisher : Springer Nature
ISBN 13 : 9811383677
Total Pages : 277 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Mitochondria in Health and in Sickness by : Andrea Urbani

Download or read book Mitochondria in Health and in Sickness written by Andrea Urbani and published by Springer Nature. This book was released on 2019-08-26 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Mitochondria in Skeletal Muscle Health, Aging and Diseases

Author : Gilles Gouspillou
Publisher : Frontiers Media SA
ISBN 13 : 2889450732
Total Pages : 144 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Mitochondria in Skeletal Muscle Health, Aging and Diseases by : Gilles Gouspillou

Download or read book Mitochondria in Skeletal Muscle Health, Aging and Diseases written by Gilles Gouspillou and published by Frontiers Media SA. This book was released on 2017-02-09 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.

Mitochondrial Plasticity and Quality Control in Health and Disease

Author : Milena Rizzo
Publisher : Frontiers Media SA
ISBN 13 : 2832553176
Total Pages : 166 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Mitochondrial Plasticity and Quality Control in Health and Disease by : Milena Rizzo

Download or read book Mitochondrial Plasticity and Quality Control in Health and Disease written by Milena Rizzo and published by Frontiers Media SA. This book was released on 2024-08-14 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Mitochondrion in Health and Disease

Author : David D. Tyler
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Mitochondrion in Health and Disease by : David D. Tyler

Download or read book The Mitochondrion in Health and Disease written by David D. Tyler and published by . This book was released on 1992 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author : Venkataramana K Sidhaye
Publisher : Academic Press
ISBN 13 : 0128038810
Total Pages : 277 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by : Venkataramana K Sidhaye

Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Mitochondria and Cancer

Author : Keshav Singh
Publisher : Springer Science & Business Media
ISBN 13 : 0387848355
Total Pages : 294 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Mitochondria and Cancer by : Keshav Singh

Download or read book Mitochondria and Cancer written by Keshav Singh and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Disruption of Mitochondrial Trafficking in Lung Epithelial Cells Potentiates Allergic Asthma Phenotypes

Author : Amelia M. Lamberty
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Disruption of Mitochondrial Trafficking in Lung Epithelial Cells Potentiates Allergic Asthma Phenotypes by : Amelia M. Lamberty

Download or read book Disruption of Mitochondrial Trafficking in Lung Epithelial Cells Potentiates Allergic Asthma Phenotypes written by Amelia M. Lamberty and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergic asthma is a serious socioeconomic and health issue that is characterized by chronic inflammation of the lungs and affects as many 300 million people worldwide of all ages. Inhaled environmental factors, such as allergens, can disrupt the airway epithelium, which is the physical barrier and the first line of defense against external irritants. Consequently, exposure to allergens can cause episodes of airway inflammation, increased mucus production and tissue remodeling, that leads to the obstruction and narrowing of the airways, which may present as difficulty breathing, wheezing, and persistent coughing. Unfortunately, there is no cure for allergic asthma, but allergen avoidance and prescription of medication can help manage symptoms. However, current treatment options fail in almost 10% of patients, making it necessary to study uncharacterized molecular causes to better understand this condition. Evidence suggests that mitochondria play a vital role in lung health and disease. Mitochondria are dynamic organelles that can change in size, shape, and distribution depending on cellular demands and are transported through the cell on microtubules. Miro1, a calcium-binding membrane-anchored GTPase that is strongly associated with mitochondrial transport, is the primary adaptor protein required for the subcellular positioning of this organelle. While mitochondria play an important role in lung physiology, the role of localized mitochondrial function in response to allergen-induced inflammation remained unknown. The main goal of this study was to investigate the effects Miro1-mediated mitochondrial trafficking in allergen-induced inflammation and provide a comprehensive phenotypic readout. To achieve this, our laboratory developed a novel tissue-inducible mouse model that allowed for the deletion of Miro1 from club cells, an abundant epithelial cell subtype in mice, and utilized this system with an established model of chronic allergen-induced inflammation. Our results show that epithelial deletion of Miro1 leads to a heightened inflammatory response, enhanced mucus metaplasia, pronounced tissue remodeling and smooth muscle levels that leads to increased airway hyperresponsiveness following chronic exposure to a complex allergen. Results from this study indicate a possible role for Miro1 in the development and progression of allergic asthma, providing insights into the role of Miro1-mediated mitochondrial positioning in allergic asthma severity. Future studies should be conducted to gain a better understanding of the mechanisms of Miro1 and mitochondrial positioning in asthma.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119329744
Total Pages : 816 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by : Yvonne Will

Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-23 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Oxidative Phosphorylation

Author : Bernhard Kadenbach
Publisher : Springer Science & Business Media
ISBN 13 : 1461435730
Total Pages : 378 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Mitochondrial Oxidative Phosphorylation by : Bernhard Kadenbach

Download or read book Mitochondrial Oxidative Phosphorylation written by Bernhard Kadenbach and published by Springer Science & Business Media. This book was released on 2012-06-23 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

Mitochondria and Cell Death

Author : David M. Hockenbery
Publisher : Humana Press
ISBN 13 : 1493936123
Total Pages : 242 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Mitochondria and Cell Death by : David M. Hockenbery

Download or read book Mitochondria and Cell Death written by David M. Hockenbery and published by Humana Press. This book was released on 2016-04-29 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material. Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.

Advances in Asthma

Author : Akihito Yokoyama
Publisher : Springer
ISBN 13 : 9811327904
Total Pages : 189 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Advances in Asthma by : Akihito Yokoyama

Download or read book Advances in Asthma written by Akihito Yokoyama and published by Springer. This book was released on 2018-12-18 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides discussions on bronchial asthma from a clinical perspective, focusing on the recent studies on its pathophysiology, diagnosis and treatment. It also explores the lastest findings regarding the phenotypes and endotypes of asthmatic patients, making it of particular interest to those involved with non-eosinophilic asthma and eosinophilic asthma. Further, it discusses the importance of ILC 2 in eosinophilic asthma, and the accumulated results from the forced oscilliation technique and periostin that are actively practiced in Japan. As some aspects of diagnosis and treatment are different in Western and Asian countries, it is important that the data is disseminated around the globe. The clinical questions addressed by the authors are critical and thought provoking, while the questions raised by the editors are instructive, informative and provide new perspectives on unresolved issues. This book appeals to wide readership from beginning learners to physicians in clinical practice and scholars engaging in basic research.