Mitochondrial Dynamics In Cardiovascular Medicine

Download Mitochondrial Dynamics In Cardiovascular Medicine full books in PDF, epub, and Kindle. Read online Mitochondrial Dynamics In Cardiovascular Medicine ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Mitochondrial Dynamics in Cardiovascular Medicine

Author : Gaetano Santulli
Publisher : Springer
ISBN 13 : 3319553305
Total Pages : 646 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Dynamics in Cardiovascular Medicine by : Gaetano Santulli

Download or read book Mitochondrial Dynamics in Cardiovascular Medicine written by Gaetano Santulli and published by Springer. This book was released on 2017-05-25 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Mitochondria and Their Role in Cardiovascular Disease

Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 146144599X
Total Pages : 495 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!

Book Synopsis Mitochondria and Their Role in Cardiovascular Disease by : José Marín-García

Download or read book Mitochondria and Their Role in Cardiovascular Disease written by José Marín-García and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Mitochondria and Their Role in Cardiovascular Disease

Author : José Marín-García
Publisher : Springer
ISBN 13 : 9781461446002
Total Pages : 500 pages
Book Rating : 4.4/5 (46 download)

DOWNLOAD NOW!

Book Synopsis Mitochondria and Their Role in Cardiovascular Disease by : José Marín-García

Download or read book Mitochondria and Their Role in Cardiovascular Disease written by José Marín-García and published by Springer. This book was released on 2012-11-17 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Mitochondrial Dysfunction and Cardiovascular Diseases

Author : Sebastiano Sciarretta
Publisher : Frontiers Media SA
ISBN 13 : 2889665569
Total Pages : 111 pages
Book Rating : 4.8/5 (896 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Dysfunction and Cardiovascular Diseases by : Sebastiano Sciarretta

Download or read book Mitochondrial Dysfunction and Cardiovascular Diseases written by Sebastiano Sciarretta and published by Frontiers Media SA. This book was released on 2021-03-04 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology

Author : Giampaolo Morciano
Publisher : Frontiers Media SA
ISBN 13 : 2889669424
Total Pages : 182 pages
Book Rating : 4.8/5 (896 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology by : Giampaolo Morciano

Download or read book Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology written by Giampaolo Morciano and published by Frontiers Media SA. This book was released on 2021-06-21 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria and the Heart

Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 0387255753
Total Pages : 416 pages
Book Rating : 4.3/5 (872 download)

DOWNLOAD NOW!

Book Synopsis Mitochondria and the Heart by : José Marín-García

Download or read book Mitochondria and the Heart written by José Marín-García and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.

Post-Genomic Cardiology

Author : José Marín-García
Publisher : Academic Press
ISBN 13 : 0124046428
Total Pages : 935 pages
Book Rating : 4.1/5 (24 download)

DOWNLOAD NOW!

Book Synopsis Post-Genomic Cardiology by : José Marín-García

Download or read book Post-Genomic Cardiology written by José Marín-García and published by Academic Press. This book was released on 2014-05-09 with total page 935 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Mitochondrial Diseases

Author : Eylem Taskin
Publisher : BoD – Books on Demand
ISBN 13 : 1789236746
Total Pages : 498 pages
Book Rating : 4.7/5 (892 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Diseases by : Eylem Taskin

Download or read book Mitochondrial Diseases written by Eylem Taskin and published by BoD – Books on Demand. This book was released on 2018-08-29 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119329744
Total Pages : 816 pages
Book Rating : 4.1/5 (193 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by : Yvonne Will

Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-23 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Metabolic Cardiomyopathy

Author : H. Böhles
Publisher : CRC Press
ISBN 13 : 9783887631048
Total Pages : 188 pages
Book Rating : 4.6/5 (31 download)

DOWNLOAD NOW!

Book Synopsis Metabolic Cardiomyopathy by : H. Böhles

Download or read book Metabolic Cardiomyopathy written by H. Böhles and published by CRC Press. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

DOWNLOAD NOW!

Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Neuroprotection

Author : Matilde Otero-Losada
Publisher : BoD – Books on Demand
ISBN 13 : 1838804390
Total Pages : 350 pages
Book Rating : 4.8/5 (388 download)

DOWNLOAD NOW!

Book Synopsis Neuroprotection by : Matilde Otero-Losada

Download or read book Neuroprotection written by Matilde Otero-Losada and published by BoD – Books on Demand. This book was released on 2020-11-26 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

The Rise of Mitochondria in Medicine

Author : Loredana Moro
Publisher :
ISBN 13 : 9783039369188
Total Pages : 322 pages
Book Rating : 4.3/5 (691 download)

DOWNLOAD NOW!

Book Synopsis The Rise of Mitochondria in Medicine by : Loredana Moro

Download or read book The Rise of Mitochondria in Medicine written by Loredana Moro and published by . This book was released on 2020-09-04 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are critical bioenergetic and biosynthetic machines that are essential for normal cell function. Traditionally, mitochondria have been considered the powerhouse of the cell, as they supply most of the cellular energy through oxidative phosphorylation. In addition, they supply the building blocks needed for the synthesis of cellular biomass. More recently, mitochondria have been recognized as signaling hubs that receive and transmit signals throughout the cell, thereby affecting cell functionality and fate. The signals generated by mitochondria include changes in metabolites, the NAD+/NADH ratio, ATP/ADP ratio, Ca2+, and reactive oxygen species (ROS), but our understanding of their nature, dynamics, targets, and roles in different physiopathological contexts is still under development. Mitochondrial dysfunction, which may originate from primary defects within the organelles or from stress conditions in the microenvironment, is a hallmark of many common diseases, including ischaemia-reperfusion injury, cancer, metabolic disease, and neurodegenerative disorders, and has become a major research focus in medicine. Understanding the biology of mitochondrial signaling and the role of mitochondrial dysfunction in the pathogenesis of many metabolic, degenerative, cardiovascular, and neoplastic diseases is crucial for the development of strategies aimed at therapeutically restoring mitochondrial functionality. This Special Issue presents current knowledge in the field of mitochondrial signaling in health and disease, and recent advances in mitochondrial pharmacology.

Clinical Mitochondrial Medicine

Author : Patrick F. Chinnery
Publisher : Cambridge University Press
ISBN 13 : 0521132983
Total Pages : 229 pages
Book Rating : 4.5/5 (211 download)

DOWNLOAD NOW!

Book Synopsis Clinical Mitochondrial Medicine by : Patrick F. Chinnery

Download or read book Clinical Mitochondrial Medicine written by Patrick F. Chinnery and published by Cambridge University Press. This book was released on 2018-05-17 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.

Mitochondria in Health and Diseases

Author : Sabzali Javadov
Publisher :
ISBN 13 : 9783039363841
Total Pages : 434 pages
Book Rating : 4.3/5 (638 download)

DOWNLOAD NOW!

Book Synopsis Mitochondria in Health and Diseases by : Sabzali Javadov

Download or read book Mitochondria in Health and Diseases written by Sabzali Javadov and published by . This book was released on 2020-09-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Cardiac Hypertrophy and Failure

Author : Bernard Swynghedauw
Publisher :
ISBN 13 :
Total Pages : 718 pages
Book Rating : 4.3/5 (555 download)

DOWNLOAD NOW!

Book Synopsis Cardiac Hypertrophy and Failure by : Bernard Swynghedauw

Download or read book Cardiac Hypertrophy and Failure written by Bernard Swynghedauw and published by . This book was released on 1990 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac insufficiency, a major cause of premature mortality, is a key focus of medical and pharmaceutical research. This book aims to bring clinicians and researchers up-to-date on recent biophysical, cellular physiological and molecular biological developments and their clinical applications.

Drug-Induced Mitochondrial Dysfunction

Author : James A. Dykens
Publisher : John Wiley & Sons
ISBN 13 : 0470372524
Total Pages : 648 pages
Book Rating : 4.4/5 (73 download)

DOWNLOAD NOW!

Book Synopsis Drug-Induced Mitochondrial Dysfunction by : James A. Dykens

Download or read book Drug-Induced Mitochondrial Dysfunction written by James A. Dykens and published by John Wiley & Sons. This book was released on 2008-09-11 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.