Mitochondria: the cell powerhouse and nexus of stress

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Publisher : Frontiers E-books
ISBN 13 : 2889192830
Total Pages : 122 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Mitochondria: the cell powerhouse and nexus of stress by : Sabzali Javadov

Download or read book Mitochondria: the cell powerhouse and nexus of stress written by Sabzali Javadov and published by Frontiers E-books. This book was released on 2014-09-23 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and pathological conditions through their participation in many intracellular signaling pathways. Studies over the last 30 years provide strong evidence that mitochondria are the nexus of various stresses which initiate cell death through apoptosis, oncosis, necrosis and autophagy depending on the severity of the stress and cellular energy status. The release of several pro-apoptotic proteins such as cytochrome c, Smac/DIABLO, AIF, endonuclease G from intermembrane space initiates both caspase-dependent and caspase-independent apoptosis. The formation of the mitochondrial permeability transition pore in the IMM promotes cell death mostly through necrosis whereas a mild stress activates autophagy. Due to their critical roles in both cell death and survival mitochondria have been widely considered as an important target for various pharmacological and conditional therapeutic approaches. Currently, a large number of mitochondria-targeted agents are suggested to prevent (in ischemia reperfusion injury, cardiovascular, neurodegenerative and other diseases) or stimulate (in various cancers) cell death. This Research Topic focuses on the role of mitochondria in the regulation of cell metabolism and signaling under physiological and pathological conditions. Studies performed on cultured cells and isolated organs/tissues using different animal and cellular models of various diseases are also included and discussed.

Advanced AI Techniques and Applications in Bioinformatics

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Publisher : CRC Press
ISBN 13 : 1000462986
Total Pages : 282 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Advanced AI Techniques and Applications in Bioinformatics by : Loveleen Gaur

Download or read book Advanced AI Techniques and Applications in Bioinformatics written by Loveleen Gaur and published by CRC Press. This book was released on 2021-10-18 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advanced AI techniques are essential for resolving various problematic aspects emerging in the field of bioinformatics. This book covers the recent approaches in artificial intelligence and machine learning methods and their applications in Genome and Gene editing, cancer drug discovery classification, and the protein folding algorithms among others. Deep learning, which is widely used in image processing, is also applicable in bioinformatics as one of the most popular artificial intelligence approaches. The wide range of applications discussed in this book are an indispensable resource for computer scientists, engineers, biologists, mathematicians, physicians, and medical informaticists. Features: Focusses on the cross-disciplinary relation between computer science and biology and the role of machine learning methods in resolving complex problems in bioinformatics Provides a comprehensive and balanced blend of topics and applications using various advanced algorithms Presents cutting-edge research methodologies in the area of AI methods when applied to bioinformatics and innovative solutions Discusses the AI/ML techniques, their use, and their potential for use in common and future bioinformatics applications Includes recent achievements in AI and bioinformatics contributed by a global team of researchers

Mitochondrial Gene Expression

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Publisher :
ISBN 13 : 9781071608340
Total Pages : pages
Book Rating : 4.6/5 (83 download)

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Book Synopsis Mitochondrial Gene Expression by :

Download or read book Mitochondrial Gene Expression written by and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria and Their Role in Cardiovascular Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 146144599X
Total Pages : 495 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Mitochondria and Their Role in Cardiovascular Disease by : José Marín-García

Download or read book Mitochondria and Their Role in Cardiovascular Disease written by José Marín-García and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Bioinformatics Computing

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Publisher : Prentice Hall Professional
ISBN 13 : 9780131008250
Total Pages : 472 pages
Book Rating : 4.0/5 (82 download)

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Book Synopsis Bioinformatics Computing by : Bryan P. Bergeron

Download or read book Bioinformatics Computing written by Bryan P. Bergeron and published by Prentice Hall Professional. This book was released on 2003 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and concise, this handbook has chapters on computing visualization, large database designs, advanced pattern matching and other key bioinformatics techniques. It is a practical guide to computing in the growing field of Bioinformatics--the study of how information is represented and transmitted in biological systems, starting at the molecular level.

Role of Mitochondria-Associated Non-Coding RNAs in Intracellular Communication

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832501311
Total Pages : 128 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Role of Mitochondria-Associated Non-Coding RNAs in Intracellular Communication by : Samarjit Das

Download or read book Role of Mitochondria-Associated Non-Coding RNAs in Intracellular Communication written by Samarjit Das and published by Frontiers Media SA. This book was released on 2022-09-30 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autophagy: Biology and Diseases

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Publisher : Springer Nature
ISBN 13 : 9811628300
Total Pages : 453 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Autophagy: Biology and Diseases by : Zhiping Xie

Download or read book Autophagy: Biology and Diseases written by Zhiping Xie and published by Springer Nature. This book was released on 2021-07-14 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

Minimal Selfhood and the Origins of Consciousness

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Publisher : BoD – Books on Demand
ISBN 13 : 3958260780
Total Pages : 262 pages
Book Rating : 4.9/5 (582 download)

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Book Synopsis Minimal Selfhood and the Origins of Consciousness by : Rupert Glasgow

Download or read book Minimal Selfhood and the Origins of Consciousness written by Rupert Glasgow and published by BoD – Books on Demand. This book was released on 2018-07-10 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Minimal Selfhood and the Origins of Consciousness, R.D.V. Glasgow seeks to ground the logical roots of consciousness in what he has previously called the 'minimal self'. The idea is that elementary forms of consciousness are logically dependent not, as is commonly assumed, on ownership of an anatomical brain or nervous system, but on the intrinsic reflexivity that defines minimal selfhood. The aim of the book is to trace the logical pathway by which minimal selfhood gives rise to the possible appearance of consciousness. It is argued that in specific circumstances it thus makes sense to ascribe elementary consciousness to certain predatory single-celled organisms such as amoebae and dinoflagellates as well as to some of the simpler animals. Such an argument involves establishing exactly what those specific circumstances are and determining how elementary consciousness differs in nature and scope from its more complex manifestations.

Mitochondria in Obesity and Type 2 Diabetes

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Publisher : Academic Press
ISBN 13 : 0128117524
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mitochondria in Obesity and Type 2 Diabetes by : Beatrice Morio

Download or read book Mitochondria in Obesity and Type 2 Diabetes written by Beatrice Morio and published by Academic Press. This book was released on 2019-04-12 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.

Clinical Bioenergetics

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Publisher : Academic Press
ISBN 13 : 0128227729
Total Pages : 720 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Clinical Bioenergetics by : Sergej M. Ostojic

Download or read book Clinical Bioenergetics written by Sergej M. Ostojic and published by Academic Press. This book was released on 2020-11-12 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. - Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics - Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders - Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Minimally Invasive Aesthetic Procedures

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Publisher : Springer Nature
ISBN 13 : 3319782657
Total Pages : 785 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Minimally Invasive Aesthetic Procedures by : Adilson Da Costa

Download or read book Minimally Invasive Aesthetic Procedures written by Adilson Da Costa and published by Springer Nature. This book was released on 2020-02-24 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: Minimally invasive aesthetic procedures are an important part of dermatologists’ day-to-day clinical routine. However, plastic surgeons are also becoming more willing to explore them, and minimally invasive cosmetic and aesthetic procedures are now an established interdisciplinary topic. Minimally Invasive Aesthetic Procedures - A Guide for Dermatologists and Plastic Surgeons addresses the needs of both these specialties. It provides a comprehensive overview of the most relevant and widely used minimally invasive procedures, presented in a practical and straightforward style. Rather than a broad overview of the literature, it offers a step-by-step guide to clinical procedures. Each chapter explores a single clinical procedure, discussing the theoretical basis; the materials needed; the methods and techniques; clinical follow-up; before-and-after illustrations; as well as the side effects and complications and their management. It also includes a summary of tips and relevant references. With more than a hundred procedures presented and discussed in a clinically applicable format, Minimally Invasive Aesthetic Procedures - A Guide for Dermatologists and Plastic Surgeons is a practical manual for all dermatology and plastic surgery practitioners who are interested in aesthetic medicine.

Interpersonal Processes

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Publisher : SAGE Publications, Incorporated
ISBN 13 : 9780803929807
Total Pages : 264 pages
Book Rating : 4.9/5 (298 download)

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Book Synopsis Interpersonal Processes by : Stuart Oskamp

Download or read book Interpersonal Processes written by Stuart Oskamp and published by SAGE Publications, Incorporated. This book was released on 1988-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interpersonal Processes presents a wide range of new and existing research on this important field of applied social psychology. Gaining an understanding of the interaction between people in their homes, workplaces and leisure pursuits is not only of importance to social psychologists. The contributors, all well-known researchers, explain the reasons for their specialist topics as well as illustrate the application of these ideas. The main themes and issues in the study of interpersonal processes are outlined by the editors. They discuss both the theories and their possible applications.

Chemical Induced Apoptosis

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Author :
Publisher : Nordic Council of Ministers
ISBN 13 : 9789289305143
Total Pages : 108 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Chemical Induced Apoptosis by :

Download or read book Chemical Induced Apoptosis written by and published by Nordic Council of Ministers. This book was released on 2000 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Climate Resilience and Environmental Sustainability Approaches

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Publisher : Springer Nature
ISBN 13 : 9811609020
Total Pages : 418 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Climate Resilience and Environmental Sustainability Approaches by : Anubha Kaushik

Download or read book Climate Resilience and Environmental Sustainability Approaches written by Anubha Kaushik and published by Springer Nature. This book was released on 2021-09-07 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is about climate resilience and environmental sustainability approaches, discussing knowledge at global level and the local challenges, presented by authors from various countries. Environmental sustainability is at stake and implications of climate change are clearly visible in most parts of the world. In the times of the prevailing global environmental crisis, this book discusses key issues of climate change and sustainable energy alternatives, waste management and development. It discusses climate change scenario using simulation models in various Asian countries, signatures of climate change in Antarctica, implications in the Indian Ocean and the Indian scenario of REDD+. A special focus has been given on building climate resilience in our agricultural ecosystems and sustainable agriculture. It discusses the prospects and challenges of renewable energy options including biofuels and energy from wastewaters, explores the technical aspects of eco-friendly bioremediation of pollutants, sustainable solid waste management practices and challenges, carbon footprints of industry, and emphasizes on the significance of combining traditional knowledge with modern technology with novel approaches including involvement of social enterprises and corporate social responsibility to achieve the Sustainable Development Goals. This is an important document for researchers and policy makers working in multidisciplinary fields of sustainability sciences.

Biotechnology for Biofuels: A Sustainable Green Energy Solution

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Publisher : Springer Nature
ISBN 13 : 9811537615
Total Pages : 291 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Biotechnology for Biofuels: A Sustainable Green Energy Solution by : Nitish Kumar

Download or read book Biotechnology for Biofuels: A Sustainable Green Energy Solution written by Nitish Kumar and published by Springer Nature. This book was released on 2020-05-16 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: The depletion of petroleum-derived fuel and environmental concerns have prompted many millennials to consider biofuels as alternative fuel sources. But completely replacing petroleum-derived fuels with biofuels is currently impossible in terms of production capacity and engine compatibility. Nevertheless, the marginal replacement of diesel with biofuel could delay the depletion of petroleum resources and abate the radical climate change caused by automotive pollutants. Energy security and climate change are the two major driving forces for worldwide biofuel development, and also have the potential to stimulate the agro-industry. The development of biofuels as alternative and renewable sources of energy has become critical in national efforts towards maximum self-reliance, the cornerstone of our energy security strategy. At the same time, the production of biofuels from various types of biomass such as plants, microbes, algae and fungi is now an ecologically viable and sustainable option. This book describes the biotechnological advances in biofuel production from various sources, while also providing essential information on the genetic improvement of biofuel sources at both the conventional and genomic level. These innovations and the corresponding methodologies are explained in detail.

Laser Precision Microfabrication

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Publisher : Springer
ISBN 13 : 3642105238
Total Pages : 353 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Laser Precision Microfabrication by : Koji Sugioka

Download or read book Laser Precision Microfabrication written by Koji Sugioka and published by Springer. This book was released on 2010-08-13 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Miniaturization and high precision are rapidly becoming a requirement for many industrial processes and products. As a result, there is greater interest in the use of laser microfabrication technology to achieve these goals. This book composed of 16 chapters covers all the topics of laser precision processing from fundamental aspects to industrial applications to both inorganic and biological materials. It reviews the sate of the art of research and technological development in the area of laser processing.

Heavy Metal Remediation

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Publisher : Springer Nature
ISBN 13 : 3031536886
Total Pages : 338 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Heavy Metal Remediation by : Nitish Kumar

Download or read book Heavy Metal Remediation written by Nitish Kumar and published by Springer Nature. This book was released on with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: