Miraculous Medicines And The Chemistry Of Drug Design

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Miraculous Medicines and the Chemistry of Drug Design

Author : Nathan Keighley
Publisher : CRC Press
ISBN 13 : 1000285375
Total Pages : 126 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Miraculous Medicines and the Chemistry of Drug Design by : Nathan Keighley

Download or read book Miraculous Medicines and the Chemistry of Drug Design written by Nathan Keighley and published by CRC Press. This book was released on 2020-12-14 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of chemistry is widely acknowledged as being conceptually challenging, and regarded with a perceived elitism. This book aims to address this dilemma by breaking down the fundamentals of organic chemistry and its importance in medicine, so that readers with any or no background education in chemistry can access the material and gain an appreciation and understanding for the subject. The text is written in a clear and concise manner, using appropriate figures, to explain how the medicine we are so familiar with is designed and produced. Undergraduate students, medical and nursing students, and general audiences will benefit from the accessible format and enjoyable read. Key Features: User-friendly text dealing with the chemical sciences for the non-scientist Public understanding of science at the interface of biology and chemistry is in high demand The book serves to introduce organic chemistry and its relevance to medicine Describes the foundational principles of chemistry without losing the systematic rigor of the subject

The Organic Chemistry of Drug Design and Drug Action

Author : Richard B. Silverman
Publisher : Academic Press
ISBN 13 : 0123820316
Total Pages : 537 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman

Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Academic Press. This book was released on 2014-03-29 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Organic Chemistry of Drug Design and Drug Action

Author : Richard B. Silverman
Publisher : Elsevier
ISBN 13 : 0080571239
Total Pages : 437 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman

Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

An Introduction to Drug Design

Author : S. N. Pandeya
Publisher : New Age International
ISBN 13 : 9788122409437
Total Pages : 228 pages
Book Rating : 4.4/5 (94 download)

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Book Synopsis An Introduction to Drug Design by : S. N. Pandeya

Download or read book An Introduction to Drug Design written by S. N. Pandeya and published by New Age International. This book was released on 1997 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.

The Ups and Downs in Drug Design

Author : Victor E. Marquez
Publisher : CRC Press
ISBN 13 : 1000462943
Total Pages : 566 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis The Ups and Downs in Drug Design by : Victor E. Marquez

Download or read book The Ups and Downs in Drug Design written by Victor E. Marquez and published by CRC Press. This book was released on 2021-11-15 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students

Drug Design

Author : T. Durai Ananda Kumar
Publisher : CRC Press
ISBN 13 : 1000603881
Total Pages : 486 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Drug Design by : T. Durai Ananda Kumar

Download or read book Drug Design written by T. Durai Ananda Kumar and published by CRC Press. This book was released on 2022-06-02 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design (CADD)”, which has profound application in rational drug design (RDD). The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide. The salient features of this book are: • Systematic and simple approach • Emphasis on traditional and modern drug design strategies • Comprehensive coverage for the current advances in the drug design • Experimental section to ensure hands-on-experience Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

The Art of Drug Synthesis

Author : Douglas S. Johnson
Publisher : John Wiley & Sons
ISBN 13 : 111867846X
Total Pages : 295 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis The Art of Drug Synthesis by : Douglas S. Johnson

Download or read book The Art of Drug Synthesis written by Douglas S. Johnson and published by John Wiley & Sons. This book was released on 2013-02-26 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Introduction to the Principles of Drug Design

Author : H. J. Smith
Publisher : Elsevier
ISBN 13 : 1483183505
Total Pages : 306 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Introduction to the Principles of Drug Design by : H. J. Smith

Download or read book Introduction to the Principles of Drug Design written by H. J. Smith and published by Elsevier. This book was released on 2016-06-14 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

Medicinal Chemistry

Author : A.K. Ganguly
Publisher : CRC Press
ISBN 13 : 1000437213
Total Pages : 118 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Medicinal Chemistry by : A.K. Ganguly

Download or read book Medicinal Chemistry written by A.K. Ganguly and published by CRC Press. This book was released on 2021-09-12 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

Frontiers in Drug Design and Discovery

Author : Atta-ur- Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608052028
Total Pages : 467 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Frontiers in Drug Design and Discovery by : Atta-ur- Rahman

Download or read book Frontiers in Drug Design and Discovery written by Atta-ur- Rahman and published by Bentham Science Publishers. This book was released on 2009 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

A Textbook of Drug Design and Development

Author : Povl Krogsgaard-Larsen
Publisher :
ISBN 13 :
Total Pages : 664 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A Textbook of Drug Design and Development by : Povl Krogsgaard-Larsen

Download or read book A Textbook of Drug Design and Development written by Povl Krogsgaard-Larsen and published by . This book was released on 1991 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Drug Design

Author : Girish Kumar Gupta
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311036882X
Total Pages : 297 pages
Book Rating : 4.1/5 (13 download)

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Book Synopsis Chemical Drug Design by : Girish Kumar Gupta

Download or read book Chemical Drug Design written by Girish Kumar Gupta and published by Walter de Gruyter GmbH & Co KG. This book was released on 2016-10-10 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs.

Structure-based Design of Drugs and Other Bioactive Molecules

Author : Arun K. Ghosh
Publisher : John Wiley & Sons
ISBN 13 : 3527665234
Total Pages : 474 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Structure-based Design of Drugs and Other Bioactive Molecules by : Arun K. Ghosh

Download or read book Structure-based Design of Drugs and Other Bioactive Molecules written by Arun K. Ghosh and published by John Wiley & Sons. This book was released on 2014-07-16 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.

Drug Design and Medicinal Chemistry

Author : Erica Helmer
Publisher :
ISBN 13 : 9781632391544
Total Pages : 0 pages
Book Rating : 4.3/5 (915 download)

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Book Synopsis Drug Design and Medicinal Chemistry by : Erica Helmer

Download or read book Drug Design and Medicinal Chemistry written by Erica Helmer and published by . This book was released on 2015-03-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the different aspects of drug design and medicinal chemistry. Recently, medicinal chemistry has become accountable for clarifying interactions of chemical molecules procedures, such that many experts in life sciences, from agronomy to medication, are occupied in medicinal study. This book comprises of researches centering on molecular features of drug metabolism, pro-drug production, in silico and chemical compounds used in applicable methods. It even deals with fundamental issues and developments in medicinal chemistry and drug design. Particular significance is given to both conjectural and investigational features of contemporary drug design. This book intends to provide some useful knowledge to students and even experts working on the above stated topic. This book is a compilation of data provided by some of the renowned experts working in this field of science for years.

Molecules and Medicine

Author : E. J. Corey
Publisher : John Wiley & Sons
ISBN 13 : 1118361733
Total Pages : 272 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Molecules and Medicine by : E. J. Corey

Download or read book Molecules and Medicine written by E. J. Corey and published by John Wiley & Sons. This book was released on 2012-02-28 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Textbook of Drug Design and Discovery, Fifth Edition

Author : Kristian Stromgaard
Publisher : CRC Press
ISBN 13 : 1315354543
Total Pages : 579 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Textbook of Drug Design and Discovery, Fifth Edition by : Kristian Stromgaard

Download or read book Textbook of Drug Design and Discovery, Fifth Edition written by Kristian Stromgaard and published by CRC Press. This book was released on 2016-08-19 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding). The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

Frontiers in Drug Design and Discovery

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608052036
Total Pages : 206 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Frontiers in Drug Design and Discovery by : Atta-ur-Rahman

Download or read book Frontiers in Drug Design and Discovery written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2011-02-03 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu