Minimal Cells Design Construction Biotechnological Applications

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Minimal Cells: Design, Construction, Biotechnological Applications

Author : Alvaro R. Lara
Publisher : Springer Nature
ISBN 13 : 3030318974
Total Pages : 233 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Minimal Cells: Design, Construction, Biotechnological Applications by : Alvaro R. Lara

Download or read book Minimal Cells: Design, Construction, Biotechnological Applications written by Alvaro R. Lara and published by Springer Nature. This book was released on 2019-12-04 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.

Metabolic Engineering

Author : Sang Yup Lee
Publisher : John Wiley & Sons
ISBN 13 : 352782345X
Total Pages : 1075 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Metabolic Engineering by : Sang Yup Lee

Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Issues in Bioengineering and Bioinformatics: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464964165
Total Pages : 2802 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in Bioengineering and Bioinformatics: 2011 Edition by :

Download or read book Issues in Bioengineering and Bioinformatics: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 2802 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Bioengineering and Bioinformatics: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bioengineering and Bioinformatics. The editors have built Issues in Bioengineering and Bioinformatics: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bioengineering and Bioinformatics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Bioengineering and Bioinformatics: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Science and Applications of Synthetic and Systems Biology

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309219396
Total Pages : 570 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine

Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

The Minimal Cell

Author : Pier Luigi Luisi
Publisher : Springer Science & Business Media
ISBN 13 : 9048199441
Total Pages : 298 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis The Minimal Cell by : Pier Luigi Luisi

Download or read book The Minimal Cell written by Pier Luigi Luisi and published by Springer Science & Business Media. This book was released on 2010-11-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last ten years there has been a considerable increase of interest on the notion of the minimal cell. With this term we usually mean a cell-like structure containing the minimal and sufficient number of components to be defined as alive, or at least capable of displaying some of the fundamental functions of a living cell. In fact, when we look at extant living cells we realize that thousands of molecules are organized spatially and functionally in order to realize what we call cellular life. This fact elicits the question whether such huge complexity is a necessary condition for life, or a simpler molecular system can also be defined as alive. Obviously, the concept of minimal cell encompasses entire families of cells, from totally synthetic cells, to semi-synthetic ones, to primitive cell models, to simple biomimetic cellular systems. Typically, in the experimental approach to the construction of minimal the main ingredient is the compartment. Lipid vesicles (liposomes) are used to host simple and complex molecular transformations, from single or multiple enzymic reactions, to polymerase chain reactions, to gene expression. Today this research is seen as part of the broader scenario of synthetic biology but it is rooted in origins of life studies, because the construction of a minimal cell might provide biophysical insights into the origins of primitive cells, and the emergence of life on earth. The volume provides an overview of physical, biochemical and functional studies on minimal cells, with emphasis to experimental approaches. 15 International experts report on their innovative contributions to the construction of minimal cells.

Proceedings of Fourth International Conference on Communication, Computing and Electronics Systems

Author : V. Bindhu
Publisher : Springer Nature
ISBN 13 : 9811977534
Total Pages : 1048 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Proceedings of Fourth International Conference on Communication, Computing and Electronics Systems by : V. Bindhu

Download or read book Proceedings of Fourth International Conference on Communication, Computing and Electronics Systems written by V. Bindhu and published by Springer Nature. This book was released on 2023-03-14 with total page 1048 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes high-quality research papers presented at the Fourth International Conference on Communication, Computing and Electronics Systems (ICCCES 2022), held at the PPG Institute of Technology, Coimbatore, India, on September 15–16, 2022. The book focuses mainly on the research trends in cloud computing, mobile computing, artificial intelligence and advanced electronics systems. The topics covered are automation, VLSI, embedded systems, optical communication, RF communication, microwave engineering, artificial intelligence, deep learning, pattern recognition, communication networks, Internet of things, cyber-physical systems and healthcare informatics.

Synthetic Biology

Author : Huimin Zhao
Publisher : Academic Press
ISBN 13 : 0123978203
Total Pages : 352 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Synthetic Biology by : Huimin Zhao

Download or read book Synthetic Biology written by Huimin Zhao and published by Academic Press. This book was released on 2013-03-21 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.

The Mechanisms of DNA Replication

Author : David Stuart
Publisher : BoD – Books on Demand
ISBN 13 : 953510991X
Total Pages : 502 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis The Mechanisms of DNA Replication by : David Stuart

Download or read book The Mechanisms of DNA Replication written by David Stuart and published by BoD – Books on Demand. This book was released on 2013-02-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

Chemical Synthetic Biology

Author : Pier Luigi Luisi
Publisher : John Wiley & Sons
ISBN 13 : 1119990300
Total Pages : 269 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Chemical Synthetic Biology by : Pier Luigi Luisi

Download or read book Chemical Synthetic Biology written by Pier Luigi Luisi and published by John Wiley & Sons. This book was released on 2011-02-10 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.

Systems Biology in Biotech & Pharma

Author : Aleš Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400728492
Total Pages : 137 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Systems Biology in Biotech & Pharma by : Aleš Prokop

Download or read book Systems Biology in Biotech & Pharma written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.

The Bioeconomy to 2030 Designing a Policy Agenda

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264056882
Total Pages : 323 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis The Bioeconomy to 2030 Designing a Policy Agenda by : OECD

Download or read book The Bioeconomy to 2030 Designing a Policy Agenda written by OECD and published by OECD Publishing. This book was released on 2009-04-15 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the current status of biotechnologies and, using quantitative analyses of data, it estimates biotechnological developments to 2015. Using other inputs, it creates scenarios to 2030.

Current Developments in Biotechnology and Bioengineering

Author : Sudhir P. P. Singh
Publisher : Elsevier
ISBN 13 : 044464086X
Total Pages : 442 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Current Developments in Biotechnology and Bioengineering by : Sudhir P. P. Singh

Download or read book Current Developments in Biotechnology and Bioengineering written by Sudhir P. P. Singh and published by Elsevier. This book was released on 2018-11-20 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Developments in Biotechnology and Bioengineering: Synthetic Biology, Cell Engineering and Bioprocessing Technologies covers the current perspectives and outlook of synthetic biology in the agriculture, food and health sectors. This book begins with the basics about synthetic biology and cell engineering, and then explores this in more detail, focusing on topics like applications of synthetic biology, industrial bioprocesses, and future perspectives. Information on cell engineering is also presented, and manipulation in endogenous metabolic network is studied alongside advanced topics such as fine tuning of metabolic pathways, de novo biosynthetic pathway design, enzyme engineering targeted to improved kinetics and stability, and potential applications of the novel biological systems in bioprocess technology to achieve the production of value-added compounds with specific biological activities. Assists in developing a conceptual understanding of synthetic biology and cellular and metabolic engineering. Includes comprehensive information on new developments and advancements. Lists applications of synthetic biology in agriculture, food, and health

Design and Analysis of Biomolecular Circuits

Author : Heinz Koeppl
Publisher : Springer Science & Business Media
ISBN 13 : 1441967664
Total Pages : 407 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Design and Analysis of Biomolecular Circuits by : Heinz Koeppl

Download or read book Design and Analysis of Biomolecular Circuits written by Heinz Koeppl and published by Springer Science & Business Media. This book was released on 2011-05-21 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.

Highlights from Frontiers in Bioengineering and Biotechnology in 2020

Author : Ranieri Cancedda
Publisher : Frontiers Media SA
ISBN 13 : 2889710793
Total Pages : 159 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Highlights from Frontiers in Bioengineering and Biotechnology in 2020 by : Ranieri Cancedda

Download or read book Highlights from Frontiers in Bioengineering and Biotechnology in 2020 written by Ranieri Cancedda and published by Frontiers Media SA. This book was released on 2021-07-23 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Bioengineering and Biotechnology has evolved to become an established go-to open access publishing option for multidisciplinary bioengineering and biotechnology research and in the process has grown considerably over the last few years achieving our first Journal Impact Factor 2018 in 2019. Here we are pleased to introduce this special eBook entitled ‘Highlights from Frontiers in Bioengineering and Biotechnology in 2020’ edited by our 10 Specialty Chief Editors of Frontiers in Bioengineering and Biotechnology aiming to support Frontiers’ strong community by recognizing highly deserving authors. The work presented here highlights the broad diversity of exciting research performed across the journal and aims to put a spotlight on few areas of interest within each section. This collection showcases one or two exceptional articles published in 2020 per section of the journal. Each article has been specially handpicked by each of our 10 Specialty Chief Editors who have written a short paragraph to explain their selection and why this article is a particularly important and exciting addition to their respective fields. Our eBook thus spans Biomaterials, Biomechanics, Bionics and Biomimetics, Bioprocess Engineering, Biosafety and Biosecurity, Industrial Biotechnology, Nanobiotechnology, Preclinical Cell and Gene Therapy, Synthetic Biology and Tissue Engineering and Regenerative Medicine. All research presented here displays advances in the field of Bioengineering and Biotechnology. We hope you enjoy our selection of key articles; please ensure you are signed into your Frontiers Loop profile to download the free eBook. We also thank all authors, editors and reviewers of Frontiers in Bioengineering and Biotechnology for their contributions to our journal and look forward to another exciting year in 2021. Dr. Ranieri Cancedda (Field Chief Editor)

Synthetic Biology

Author : Markus Schmidt
Publisher : John Wiley & Sons
ISBN 13 : 3527659277
Total Pages : 267 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Synthetic Biology by : Markus Schmidt

Download or read book Synthetic Biology written by Markus Schmidt and published by John Wiley & Sons. This book was released on 2012-05-14 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only book to focus on industrial and environmental applications of synthetic biology, covering 17 of the most promising uses in the areas of biofuel, bioremediation and biomaterials. The contributions are written by experts from academia, non-profit organizations and industry, outlining not only the scientific basics but also the economic, environmental and ethical impact of the new technologies. This makes it not only suitable as supplementary material for students but also the perfect companion for policy makers and funding agencies, if they are to make informed decisions about synthetic biology. Largely coordinated by Markus Schmidt, a policy adviser, and the only European to testify in front of the bioethics commission of the Obama administration.

Systems Biology and Biotechnology of Escherichia coli

Author : Sang Yup Lee
Publisher : Springer Science & Business Media
ISBN 13 : 1402093942
Total Pages : 471 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Systems Biology and Biotechnology of Escherichia coli by : Sang Yup Lee

Download or read book Systems Biology and Biotechnology of Escherichia coli written by Sang Yup Lee and published by Springer Science & Business Media. This book was released on 2009-03-20 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.

Biomanufacturing for Sustainable Production of Biomolecules

Author : Vijai Singh
Publisher : Springer Nature
ISBN 13 : 9811979111
Total Pages : 368 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Biomanufacturing for Sustainable Production of Biomolecules by : Vijai Singh

Download or read book Biomanufacturing for Sustainable Production of Biomolecules written by Vijai Singh and published by Springer Nature. This book was released on 2023-01-26 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elucidates the sustainable production of commercially important biomolecules in medicines, food, and beverage processing, through biological systems, including microorganisms, animal cells, plant cells, tissues, enzymes, and in vitro. It discusses promising technologies for the manipulation of cells including, genetic engineering, synthetic biology, genome editing, and metabolic engineering. The initial chapters of the book introduce topics on biomanufacturing, circular economy, strain design and improvement, upstream and downstream processing. The subsequent chapters cover artificial intelligence-assisted production, designer cell factories, biosensors for monitoring biomolecules, different cells factories, biosynthetic pathways, and genome editing approaches for scale-up biomanufacturing. Lastly, the book discusses the opportunities and challenges of implementing biological systems for the production of biomolecules. This book is a valuable source for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand biomanufacturing for the sustainable production of biomolecules.