Minding Glial Cells in the Novel Understandings of Mental Illness

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889451577
Total Pages : 277 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Minding Glial Cells in the Novel Understandings of Mental Illness by : Takahiro A. Kato

Download or read book Minding Glial Cells in the Novel Understandings of Mental Illness written by Takahiro A. Kato and published by Frontiers Media SA. This book was released on 2017-05-03 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, abnormalities of neurons and neuronal networks including synaptic abnormalities and disturbance of neurotransmitters have dominantly been believed to be the main causes of psychiatric disorders. Recent cellular neuroscience has revealed various unknown roles of glial cells such as astrocytes, oligodendrocytes and microglia. These glial cells have proved to continuously contact with neurons /synapses, and have been shown to play important roles in brain development, homeostasis and various brain functions. Beyond the classic neuronal doctrine, accumulating evidence has suggested that abnormalities and disturbances of neuron-glia crosstalk may induce psychiatric disorders, while these mechanisms have not been well understood. This Research Topic of the Frontiers in Cellular Neuroscience will focus on the most recent developments and ideas in the study of glial cells (astrocytes, oligodendrocytes and microglia) focusing on psychiatric disorders such as schizophrenia, mood disorders and autism. Not only molecular, cellular and pharmacological approaches using in vitro / in vivo experimental methods but also translational research approaches are welcome. Novel translational research approaches, for example, using novel techniques such as induced pluripotent stem (iPS) cells, may lead to novel solutions. We believe that investigations to clarify the correlation between glial cells and psychiatric disorders contribute to a novel understanding of the pathophysiology of these disorders and the development of effective treatment strategies.

Glial Neurobiology in Mental Illness

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Author :
Publisher : American Medical Publishers
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (874 download)

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Book Synopsis Glial Neurobiology in Mental Illness by : Jaxon Blakeley

Download or read book Glial Neurobiology in Mental Illness written by Jaxon Blakeley and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental illness refers to a mental or behavioral pattern which causes significant interference with the functioning of a person. The behavioral patterns can be remitting, relapsing or persistent, and can occur in isolated episodes. Glial cells are important for proper functioning of neurons and dysfunction in glial cells can result in various mental illnesses, like psychiatric disorders, autism, glioblastoma and multiple sclerosis. They do not produce electrical impulses and are found in the peripheral nervous system and the central nervous system. They help homeostasis, produce myelin in the peripheral nervous system, while providing protection and support to the neurons. Glial cells comprise ependymal cells, oligodendrocytes, microglia and astrocytes in the central nervous system. They are made up of satellite cells and schwann cells in the peripheral nervous system. This book strives to provide a fair idea about glial neurobiology in mental illness and to help develop a better understanding of the latest advances in their clinical management. Those with an interest in this field would find it helpful.

Enteric Glia

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Publisher : Biota Publishing
ISBN 13 : 1615046615
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Enteric Glia by : Brian D. Gulbransen

Download or read book Enteric Glia written by Brian D. Gulbransen and published by Biota Publishing. This book was released on 2014-07-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

Neurobiology of Bipolar Disorder

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Publisher : Academic Press
ISBN 13 : 012819183X
Total Pages : 472 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neurobiology of Bipolar Disorder by : Joao Quevedo

Download or read book Neurobiology of Bipolar Disorder written by Joao Quevedo and published by Academic Press. This book was released on 2020-11-25 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Reviews on New Drug Targets in Age-Related Disorders

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Author :
Publisher : Springer Nature
ISBN 13 : 3030550354
Total Pages : 274 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Reviews on New Drug Targets in Age-Related Disorders by : Paul C. Guest

Download or read book Reviews on New Drug Targets in Age-Related Disorders written by Paul C. Guest and published by Springer Nature. This book was released on 2021-03-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.

Molecular Neuropathology

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Publisher : Cambridge University Press
ISBN 13 : 9780521425582
Total Pages : 204 pages
Book Rating : 4.4/5 (255 download)

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Book Synopsis Molecular Neuropathology by : Gareth W. Roberts

Download or read book Molecular Neuropathology written by Gareth W. Roberts and published by Cambridge University Press. This book was released on 1995-06-08 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

Neurobiology of Brain Disorders

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Publisher : Elsevier
ISBN 13 : 0123982804
Total Pages : 823 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Neurobiology of Brain Disorders by : Michael J. Zigmond

Download or read book Neurobiology of Brain Disorders written by Michael J. Zigmond and published by Elsevier. This book was released on 2014-12-03 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Encyclopedia of the Neurological Sciences

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Publisher : Academic Press
ISBN 13 : 0123851580
Total Pages : 4744 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Encyclopedia of the Neurological Sciences by :

Download or read book Encyclopedia of the Neurological Sciences written by and published by Academic Press. This book was released on 2014-04-29 with total page 4744 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Neurobiology of Depression

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Author :
Publisher : Academic Press
ISBN 13 : 9780128133330
Total Pages : 352 pages
Book Rating : 4.1/5 (333 download)

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Book Synopsis Neurobiology of Depression by : Joao Quevedo

Download or read book Neurobiology of Depression written by Joao Quevedo and published by Academic Press. This book was released on 2019-03-15 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Depression is one of the most common mental-health disorders, caused by a variety of genetic, biological, environmental, and psychological factors combined. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission; however, only approximately one third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness, and certain symptomatic clusters may be promising targets for novel therapeutics, such as drug and psychological treatments for the management of the cognitive impairments that can encompass several domains and contribute to psychosocial function, and that can persist for many patients even in periods of symptomatic remission. Neurobiology of Depression synthesizes the basic neurobiology of major depressive disorder with discussion of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing researchers' perspectives and may revolutionize research into depression. The basic foundational understanding of the neurobiology underlying the disorder, as well as the comprehensive summary of the most recent advances in research, combine to aid advanced students and researchers in their understanding of MDD and change the landscape of the management of depression with the development of novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to antidepressants to novel therapeutics Synthesizes discussion of cellular and molecular mechanisms underlying symptoms with clinical aspects of depression for a thorough understanding of the disorder

The Neurobiology of Schizophrenia

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Publisher : Academic Press
ISBN 13 : 0128018771
Total Pages : 470 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Neurobiology of Schizophrenia by : Ted Abel

Download or read book The Neurobiology of Schizophrenia written by Ted Abel and published by Academic Press. This book was released on 2016-07-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. Provides a comprehensive overview of neurobiological aspects of schizophrenia Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance Elucidates connections between the various systems depicted, when possible

The NMDA Receptors

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Publisher : Springer
ISBN 13 : 3319497952
Total Pages : 153 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The NMDA Receptors by : Kenji Hashimoto

Download or read book The NMDA Receptors written by Kenji Hashimoto and published by Springer. This book was released on 2017-02-08 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a history of and an update on the functional status of the NMDA receptors. The NMDA receptors are essential for neuronal development, synaptic plasticity, learning, and cell survival. It covers molecular, cellular, anatomical, biochemical, and behavioral aspects, to highlight their distinctive regulatory properties, their functional significance, and their therapeutic potential in a number of diseases. A group of international experts discuss the development of NMDA receptors, their basic functions, and how they are implicated in a wide range of diseases including depression, psychosis, and pain.

Vibrant and Healthy Kids

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Publisher : National Academies Press
ISBN 13 : 0309493382
Total Pages : 621 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Vibrant and Healthy Kids by : National Academies of Sciences, Engineering, and Medicine

Download or read book Vibrant and Healthy Kids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-12-27 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children are the foundation of the United States, and supporting them is a key component of building a successful future. However, millions of children face health inequities that compromise their development, well-being, and long-term outcomes, despite substantial scientific evidence about how those adversities contribute to poor health. Advancements in neurobiological and socio-behavioral science show that critical biological systems develop in the prenatal through early childhood periods, and neurobiological development is extremely responsive to environmental influences during these stages. Consequently, social, economic, cultural, and environmental factors significantly affect a child's health ecosystem and ability to thrive throughout adulthood. Vibrant and Healthy Kids: Aligning Science, Practice, and Policy to Advance Health Equity builds upon and updates research from Communities in Action: Pathways to Health Equity (2017) and From Neurons to Neighborhoods: The Science of Early Childhood Development (2000). This report provides a brief overview of stressors that affect childhood development and health, a framework for applying current brain and development science to the real world, a roadmap for implementing tailored interventions, and recommendations about improving systems to better align with our understanding of the significant impact of health equity.

Treatment of Neurodevelopmental Disorders

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Publisher : Oxford University Press, USA
ISBN 13 : 019993780X
Total Pages : 401 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Treatment of Neurodevelopmental Disorders by : Randi Jenssen Hagerman

Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.

Nutrient Power

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Publisher : Skyhorse Publishing, Inc.
ISBN 13 : 1626361282
Total Pages : 225 pages
Book Rating : 4.6/5 (263 download)

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Book Synopsis Nutrient Power by : William Walsh

Download or read book Nutrient Power written by William Walsh and published by Skyhorse Publishing, Inc.. This book was released on 2014-05-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: A veteran research scientist who has spent decades establishing biochemical treatment protocols for patients with ADHD, Alzheimer's disease and various mental disorders challenges popular opinions about psychiatric drugs to make recommendations for drug-free nutrient therapies that normalize the brain without producing serious side effects. 15,000 first printing.

Temporomandibular Disorders

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Publisher : National Academies Press
ISBN 13 : 0309670489
Total Pages : 427 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Temporomandibular Disorders by : National Academies of Sciences, Engineering, and Medicine

Download or read book Temporomandibular Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-01 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.

Psychobiology

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1405187433
Total Pages : 677 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Psychobiology by : Chris Chandler

Download or read book Psychobiology written by Chris Chandler and published by John Wiley & Sons. This book was released on 2016-08-22 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychobiology provides a comprehensive, yet accessible introduction to the study of psychobiology and the key concepts, topics and research that are core to understanding the brain and the biological basis of our behaviour. Assuming no prior knowledge of biology, the text emphasises the interaction of psychobiology with other core areas of psychology and disciplines. Through the use of exciting and engaging examples, the role of psychobiology in the real world is explored and emphasisised to allow students to connect theory to practice in this fascinating subject.

The Hostage Brain

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Publisher : Rockefeller Univ. Press
ISBN 13 : 9780874700565
Total Pages : 336 pages
Book Rating : 4.7/5 (5 download)

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Book Synopsis The Hostage Brain by : Bruce S. McEwen

Download or read book The Hostage Brain written by Bruce S. McEwen and published by Rockefeller Univ. Press. This book was released on 1994 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: