Microsomes, Drug Oxidations and Chemical Carcinogenesis V1

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Publisher : Elsevier
ISBN 13 : 0323144098
Total Pages : 645 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 by : Minor Coon

Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Microsomes, Drug Oxidations and Chemical Carcinogenesis V2

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Publisher : Elsevier
ISBN 13 : 0323143873
Total Pages : 655 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 by : Minor Coon

Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Microsomes and Drug Oxidations

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Publisher : Elsevier
ISBN 13 : 1483159086
Total Pages : 805 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Microsomes and Drug Oxidations by : Volker Ullrich

Download or read book Microsomes and Drug Oxidations written by Volker Ullrich and published by Elsevier. This book was released on 2013-10-22 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.

Microsomes, Drug Oxidations, and Chemical Carcinogenesis

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Publisher :
ISBN 13 :
Total Pages : 664 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Microsomes, Drug Oxidations, and Chemical Carcinogenesis by : Minor Jesser Coon

Download or read book Microsomes, Drug Oxidations, and Chemical Carcinogenesis written by Minor Jesser Coon and published by . This book was released on 1980 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 ...

How Tobacco Smoke Causes Disease

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Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

N-Oxidation of Drugs

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Publisher : Springer Science & Business Media
ISBN 13 : 9401131120
Total Pages : 487 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis N-Oxidation of Drugs by : P. Hlavica

Download or read book N-Oxidation of Drugs written by P. Hlavica and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Carcinogenesis and Mutagenesis I

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Publisher : Springer Science & Business Media
ISBN 13 : 3642747752
Total Pages : 617 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Chemical Carcinogenesis and Mutagenesis I by :

Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.

Short-Term Tests for Chemical Carcinogens

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Publisher : Springer Science & Business Media
ISBN 13 : 1461258472
Total Pages : 535 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Short-Term Tests for Chemical Carcinogens by : H.F. Stich

Download or read book Short-Term Tests for Chemical Carcinogens written by H.F. Stich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.

Chemistry and Biochemistry of Flavoenzymes

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Publisher : CRC Press
ISBN 13 : 1351079034
Total Pages : 516 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Chemistry and Biochemistry of Flavoenzymes by : Franz Muller

Download or read book Chemistry and Biochemistry of Flavoenzymes written by Franz Muller and published by CRC Press. This book was released on 2018-01-18 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biochemistry of Flavoenzymes summarizes the present knowledge of the chemical and physical properties of free flavin, modified flavins occurring in nature, and deazaflavin. This information forms the fundamental basis for understanding the catalytic properties of flavoenzymes. Flavoproteins involved in transport, electron transfer, oxidation, dehydrogenation and hydroxylation reactions are discussed with respect to their biochemical and biophysical properties. The book presents the catalytic mechanisms of the flavoproteins in detail and, where available, three-dimensional structures and molecular biology data are included. The medical aspects of free and protein-bound flavin are also briefly discussed. Chemistry and Biochemistry of Flavoenzymes is an essential reference source for chemists, biochemists, toxicologists, biologists, pharmacologists, and researchers in the pharmaceutical industry.

Research Grants Index

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Publisher :
ISBN 13 :
Total Pages : 1224 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biochemical Immunological Pharmacology

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Publisher : Elsevier
ISBN 13 : 1483148491
Total Pages : 289 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Biochemical Immunological Pharmacology by : H. Yoshida

Download or read book Biochemical Immunological Pharmacology written by H. Yoshida and published by Elsevier. This book was released on 2016-02-06 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology & Therapeutics II, Volume 4: Biochemical Immunological Pharmacology covers papers on the developments in pharmacology and therapeutics. The book contains invited lectures on the effect of drugs on immunological control mechanisms; the pharmacology of specific, pure and potent serotonin 5-HT2 or S2-antagonists; and the pharmacology of phospholipases A2 isolated from snake venoms. The text also contains papers on leukotrienes; the guanine nucleotide-binding regulatory component of adenylate cyclase; and the pharmacological and toxicological implications of multiple cytochromes P-450. The impact of the emerging biotechnologies on pharmacology; the action of antipsychotics on LSD-induced neurochemical and behavioral effects in rats; and the effect of histamine and related compounds on the immune response are also considered. The book also presents papers on inflammation; prostacyclin; prostaglandins; and chemical hazards to humans.

Research Awards Index

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Publisher :
ISBN 13 :
Total Pages : 834 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Introduction to Drug Metabolism

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Publisher : Nelson Thornes
ISBN 13 : 9780748760114
Total Pages : 274 pages
Book Rating : 4.7/5 (61 download)

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Book Synopsis Introduction to Drug Metabolism by : G. Gordon Gibson

Download or read book Introduction to Drug Metabolism written by G. Gordon Gibson and published by Nelson Thornes. This book was released on 2001 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of drug-metabolising reactions. p. 25.

Insect Control

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Publisher : Elsevier
ISBN 13 : 148328624X
Total Pages : 864 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Insect Control by : G. A. Kerkut

Download or read book Insect Control written by G. A. Kerkut and published by Elsevier. This book was released on 1985-06-20 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 12 is devoted to current and future approaches to insect management and control. The topics discussed cover chemical control, including the use of juvenile hormone analogs, microbiological methods, including viral and fungal agents, biological control, and genetic approaches to insect control. The 20 chapters, all amply referenced and illustrated, well demonstrate the multidisciplinary nature of the subject and the degree of international effort that has led to the present state of knowledge. Fifteen of the chapters are devoted to the action of insecticides, reflecting the immensity of the subject. The past 30 years have witnessed remarkable advances in the scientific basis of insect control and this volume provides a convenient point of entry into the massive amount of literature now available.

Environment, Chemistry, and metabolism

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Publisher : Elsevier
ISBN 13 : 032315056X
Total Pages : 433 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Environment, Chemistry, and metabolism by : Harry Gelboin

Download or read book Environment, Chemistry, and metabolism written by Harry Gelboin and published by Elsevier. This book was released on 2012-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polycyclic Hydrocarbons and Cancer, Volume 1: Environment, Chemistry, and Metabolism brings together information from many diverse disciplines in the environmental, chemical, biological, and medical sciences to provide a comprehensive account of the link between polycyclic aromatic hydrocarbons (PAHs) and cancer. This volume consists of 19 chapters divided into seven sections based on the following themes: Energy Sources; Environmental Occurrence and Monitoring; Tobacco Carcinogenesis; Chemistry, Carcinogenicity, and Theory; Metabolism and Activation; Enzymology; and Pharmacokinetics. The first three chapters focus on the energy sources, occurrence and surveillance, and environmental monitoring of PAHs. The discussion then turns to the link between smoking and cancer; the carcinogenicity of 5-methylchrysene; synthesis and reactions of diol epoxides and related metabolites of carcinogenic hydrocarbons; and enzymes of oxygenation. The final chapter is devoted to the pharmacokinetics of chemically reactive metabolites. This book will be of interest to investigators and educators concerned with scientific aspects of PAH research; government officials and elected representatives as well as industry leaders who must confront and solve the problems related to PAHs; and others in various fields such as chemistry, environmental science, biochemistry and enzymology, pharmacology, molecular and cell biology, and genetics.

国立国会図書館所蔵科学技術関係欧文会議錄目錄

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Publisher :
ISBN 13 :
Total Pages : 672 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis 国立国会図書館所蔵科学技術関係欧文会議錄目錄 by : 国立国会図書館 (Japan)

Download or read book 国立国会図書館所蔵科学技術関係欧文会議錄目錄 written by 国立国会図書館 (Japan) and published by . This book was released on 1972 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Profile for Chloroform

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Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Chloroform by :

Download or read book Toxicological Profile for Chloroform written by and published by . This book was released on 1997 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: