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Microrna Profiling
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Download or read book MicroRNA Profiling written by Sweta Rani and published by Springer Nature. This book was released on 2022-11-28 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides updated and comprehensive methods on miRNA biogenesis and their role in the development and progression of various human diseases. Chapters detail miRNA biogenesis, isolating RNA, extracellular vesicles (EVs), circulating miRNAs, analyzing miRNA and miRDeep-P2, protocols for total RNA isolation from cells, cell-derived products, isolation and characterization of exosomes, serum, plasma specimens, and software tools. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, MicroRNA Profiling: Methods and Protocols, Second Edition aims to provide comprehensive and accessible methods to undergraduate, graduate, and established scientist.
Book Synopsis MicroRNA Profiling in Cancer by : Yuriy Gusev
Download or read book MicroRNA Profiling in Cancer written by Yuriy Gusev and published by CRC Press. This book was released on 2019-09-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.
Book Synopsis MicroRNA Expression Detection Methods by : Zhiguo Wang
Download or read book MicroRNA Expression Detection Methods written by Zhiguo Wang and published by Springer. This book was released on 2009-12-23 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of - nucleotides, have rapidly emerged as the central players in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiov- cular disorders, metabolic disturbances, etc. Particular expression pro?les have been associated with particular pathological states. Expression pro?ling of miR- NAs have therefore become extremely important not only for fundamentalists but also for clinicians. However, the methodologies used for detecting protein-coding mRNAs cannot be directly applied to miRNAs because of their small size. Over the past years, researchers have made great efforts to developing techniques suitable for miRNA detection and quanti?cation; a wide spectrum of creative and inno- tive techniques (more than 30 different methods) have been invented and validated. It has come to the time now to summarize these methods and present them in an orderly manner for better understanding and utilization of these methods to miRNA research and applications. In particular, the development of methods for quantifying circulating miRNAs opens up a fascinating opportunity for realizing miRNA as diagnostic and prognostic biomarkers of human disease. A book on this subject may help boosting up the passion of researchers to further improve the existing techniques and develop more new methods to ?t to new application needs. These considerations prompted us and urged us to undertake the work: writing a book focusing on miRNA expression detection methods.
Book Synopsis Next-Generation MicroRNA Expression Profiling Technology by : Jian-Bing Fan
Download or read book Next-Generation MicroRNA Expression Profiling Technology written by Jian-Bing Fan and published by Humana Press. This book was released on 2011-12-08 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid pace of microRNA (miRNA) research continues to drive the advances of techniques for miRNA expression profiling, and innovative technologies that are more sensitive, specific, quantitative, and that are compatible with a wide range of biospecimens have been developed during the past few years. In Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols, expert researchers in the field contribute detailed examinations of the most current approaches being used today. This volume includes comprehensive coverage of methodologies that have been developed for miRNA profiling, as well as next-gen sequencing technology, miRNA databases, and specialized applications, such as cancer studies and miRNA-based non-invasive biomarker development. Written in the highly successful Methods in Molecular BiologyTM series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols provides an ideal guide for novices and experts alike who are seeking to utilize these powerful technologies.
Book Synopsis microRNA: Medical Evidence by : Gaetano Santulli
Download or read book microRNA: Medical Evidence written by Gaetano Santulli and published by Springer. This book was released on 2015-12-11 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today’s initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling. microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Scienceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
Book Synopsis MicroRNA Detection and Target Identification by : Tamas Dalmay
Download or read book MicroRNA Detection and Target Identification written by Tamas Dalmay and published by Springer Nature. This book was released on 2023-01-23 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated volume reflects new and evolved techniques to study detection, profiling, and manipulation of microRNAs (miRNAs) in plants and animals. After overviews of how best to detect, identify, and validate microRNAs, the book continues by exploring state-of-the-art protocols for microRNA detection, approaches to profile the expression level of microRNAs, spatial expression analysis, describe in silico analysis of microRNAs and their targets, as well as protocols for functional analysis of microRNAs and their targets by CRISPR/Cas. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, MicroRNA Detection and Target Identification: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Book Synopsis Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance by : Peter Igaz
Download or read book Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance written by Peter Igaz and published by Springer. This book was released on 2015-11-25 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
Book Synopsis MicroRNAs as Tools in Biopharmaceutical Production by : Niall Barron
Download or read book MicroRNAs as Tools in Biopharmaceutical Production written by Niall Barron and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.
Book Synopsis MicroRNA as Biomarkers in Cancer Diagnostics and Therapy by : Lorenzo F. Sempere
Download or read book MicroRNA as Biomarkers in Cancer Diagnostics and Therapy written by Lorenzo F. Sempere and published by MDPI. This book was released on 2019-07-30 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue MicroRNA as Biomarkers in Cancer Diagnostics and Therapy that was published in IJMS
Download or read book MicroRNA written by James A. Mulligan and published by Nova Science Pub Incorporated. This book was released on 2011 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs are involved in crucial biological processes, including developmental timing, cell proliferation, apoptosis, and stress responses. This book presents topical research in the study of microRNAs, including their potential applications in aquaporin associated pathogenesis; microRNAs as novel biomarkers and therapeutic targets for cancer; microRNAs used in regulating EMT and blood circulation metastasis of lung cancer stem cells; and, the biological functions of microRNAs in animals and the regulation of metabolism, ageing and lifespan by microRNAs.
Book Synopsis Mapping of Nervous System Diseases via MicroRNAs by : Christian Barbato
Download or read book Mapping of Nervous System Diseases via MicroRNAs written by Christian Barbato and published by CRC Press. This book was released on 2016-02-24 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, understanding of microRNA (miRNA) biogenesis, the molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has expanded. Mapping of Nervous System Diseases via MicroRNAs provides an up-to-date review on the function of miRNA in neurological diseases as well as advancements in technology for therapeutic modulation of miRNA activity. MicroRNAs are small RNA molecules that regulate gene expression post-transcriptionally. A growing body of evidence suggests that miRNAs are dysregulated in several neurological disorders. In addition to reviewing general concepts and novel insights on brain function in relation to miRNA, this book also examines the role of miRNA in: Neurological diseases Neurodegenerative diseases Neuropsychiatric diseases Neurodevelopmental diseases The book also discusses the significance of miRNAs as diagnostic tools, biomarkers, agents, and targets in the detection and treatment of neurological diseases. Each chapter contains material regarding future diagnostic and therapeutic advances. Molecular and cellular neurobiological studies of miRNA-mediated gene silencing in the nervous system have opened new frontiers for the development of new diagnostic tests and genetic therapies for neurological diseases. Covering the full range of relevant concepts and giving a look into present and future possibilities, Mapping of Nervous System Diseases via MicroRNAs is a necessary cutting-edge reference for neurologists, neuropathologists, and researchers and practitioners in a wide range of related fields.
Book Synopsis MicroRNA Protocols by : Shao-Yao Ying
Download or read book MicroRNA Protocols written by Shao-Yao Ying and published by Humana. This book was released on 2019-02-27 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the analysis of miRNA and its many components such as targets and expression profiling, regulation of gene expression, miRNA detection in biofluids, and its application in cancer and wound healing. The chapters in this book explore topics that’s cover biogenesis, isolation and profiling of miRNA, exosomal miRNAs, and the study of the functional significance of miRNAs. The chapters also cover screening miRNAs in mR-302/367 induced iPSCs, exosomal miRNAs from iPSC-derived cardiomyocytes proliferation, and the recently discovered sugar-like RNA glycylglycerins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, MicroRNA Protocols, Third Edition is a valuable resource that provides researchers with a comprehensive study of miRNAs and its numerous components and uses.
Download or read book MicroRNA Methods written by John J. Rossi and published by Academic Press. This book was released on 2007-08-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression. This "expression" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activates this process – or stops it – is a key to understanding the biological process and builds a foundation for advances in medicine and other fields. This volume in Methods in Enzymology presents valuable methods for studying MicroRNA, with three sections covering identification of MicroRNAs and their targets; MicroRNA expression, maturation and functional analysis; and MicroRNAs and disease.
Book Synopsis Data Mining and Big Data by : Ying Tan
Download or read book Data Mining and Big Data written by Ying Tan and published by Springer. This book was released on 2016-07-04 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LNCS volume LNCS 9714 constitutes the refereed proceedings of the International Conference on Data Mining and Big Data, DMBD 2016, held in Bali, Indonesia, in June 2016. The 57 papers presented in this volume were carefully reviewed and selected from 115 submissions. The theme of DMBD 2016 is "Serving Life with Data Science". Data mining refers to the activity of going through big data sets to look for relevant or pertinent information.The papers are organized in 10 cohesive sections covering all major topics of the research and development of data mining and big data and one Workshop on Computational Aspects of Pattern Recognition and Computer Vision.
Book Synopsis MicroRNA: Medical Evidence by : Gaetano Santulli
Download or read book MicroRNA: Medical Evidence written by Gaetano Santulli and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today's initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling. microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Science and microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
Book Synopsis MicroRNA Technologies by : Min Jeong Kye
Download or read book MicroRNA Technologies written by Min Jeong Kye and published by Humana. This book was released on 2018-08-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines different approaches toward understanding the function of microRNA (miRNA) and the tools used to regulate microRNA expression in nervous systems. MicroRNA Technologies also explores newly established techniques to study the role of miRNAs in the nervous system. The chapters in this book cover topics such as: high content screening for looking at the impact of overexpressed miRNAs on primary motor neurons; miRNA expression profiling by PCR array in 2D and 3D neural culture systems; analysis of cortical neuron migration using miRNA silencing; isolating and screening subcellular miRNAs in neurons; and measuring miRNA mediated translational regulation with live cell imaging. The Neuromethods series offers chapters with key advice and procedure specifics to empower the readers to successfully achieve their own scientific and experimental goals. Cutting-edge and practical, MicroRNA Technologies is a valuable resource for students and researchers who are interested about microRNAs in nervous systems.
Book Synopsis MicroRNA Target Identification by : Alessandro Laganà
Download or read book MicroRNA Target Identification written by Alessandro Laganà and published by . This book was released on 2019 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt:
