Microrna Detection And Target Identification

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MicroRNA Detection and Target Identification

Author : Tamas Dalmay
Publisher : Springer Nature
ISBN 13 : 1071629824
Total Pages : 267 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis MicroRNA Detection and Target Identification by : Tamas Dalmay

Download or read book MicroRNA Detection and Target Identification written by Tamas Dalmay and published by Springer Nature. This book was released on 2023-01-23 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated volume reflects new and evolved techniques to study detection, profiling, and manipulation of microRNAs (miRNAs) in plants and animals. After overviews of how best to detect, identify, and validate microRNAs, the book continues by exploring state-of-the-art protocols for microRNA detection, approaches to profile the expression level of microRNAs, spatial expression analysis, describe in silico analysis of microRNAs and their targets, as well as protocols for functional analysis of microRNAs and their targets by CRISPR/Cas. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, MicroRNA Detection and Target Identification: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

MicroRNA Target Identification

Author : Alessandro Laganà
Publisher :
ISBN 13 : 9781493992072
Total Pages : 359 pages
Book Rating : 4.9/5 (92 download)

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Book Synopsis MicroRNA Target Identification by : Alessandro Laganà

Download or read book MicroRNA Target Identification written by Alessandro Laganà and published by . This book was released on 2019 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt:

MicroRNA Expression Detection Methods

Author : Zhiguo Wang
Publisher : Springer
ISBN 13 : 3642049281
Total Pages : 388 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis MicroRNA Expression Detection Methods by : Zhiguo Wang

Download or read book MicroRNA Expression Detection Methods written by Zhiguo Wang and published by Springer. This book was released on 2009-12-23 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of - nucleotides, have rapidly emerged as the central players in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiov- cular disorders, metabolic disturbances, etc. Particular expression pro?les have been associated with particular pathological states. Expression pro?ling of miR- NAs have therefore become extremely important not only for fundamentalists but also for clinicians. However, the methodologies used for detecting protein-coding mRNAs cannot be directly applied to miRNAs because of their small size. Over the past years, researchers have made great efforts to developing techniques suitable for miRNA detection and quanti?cation; a wide spectrum of creative and inno- tive techniques (more than 30 different methods) have been invented and validated. It has come to the time now to summarize these methods and present them in an orderly manner for better understanding and utilization of these methods to miRNA research and applications. In particular, the development of methods for quantifying circulating miRNAs opens up a fascinating opportunity for realizing miRNA as diagnostic and prognostic biomarkers of human disease. A book on this subject may help boosting up the passion of researchers to further improve the existing techniques and develop more new methods to ?t to new application needs. These considerations prompted us and urged us to undertake the work: writing a book focusing on miRNA expression detection methods.

MicroRNA Methods

Author : John J. Rossi
Publisher : Academic Press
ISBN 13 : 9780080551395
Total Pages : 304 pages
Book Rating : 4.5/5 (513 download)

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Book Synopsis MicroRNA Methods by : John J. Rossi

Download or read book MicroRNA Methods written by John J. Rossi and published by Academic Press. This book was released on 2007-08-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression. This "expression" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activates this process – or stops it – is a key to understanding the biological process and builds a foundation for advances in medicine and other fields. This volume in Methods in Enzymology presents valuable methods for studying MicroRNA, with three sections covering identification of MicroRNAs and their targets; MicroRNA expression, maturation and functional analysis; and MicroRNAs and disease.

MicroRNA Detection and Pathological Functions

Author : Xueji Zhang
Publisher : Springer
ISBN 13 : 3662472937
Total Pages : 108 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis MicroRNA Detection and Pathological Functions by : Xueji Zhang

Download or read book MicroRNA Detection and Pathological Functions written by Xueji Zhang and published by Springer. This book was released on 2015-05-26 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.

Plant MicroRNAs

Author : Stefan de Folter
Publisher : Humana Press
ISBN 13 : 9781493990412
Total Pages : 363 pages
Book Rating : 4.9/5 (94 download)

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Book Synopsis Plant MicroRNAs by : Stefan de Folter

Download or read book Plant MicroRNAs written by Stefan de Folter and published by Humana Press. This book was released on 2019-01-31 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides a collection of protocols for the study of miRNA functions in plants. Beginning with coverage of miRNA function, biogenesis, activity, and evolution in plants, the book continues by guiding readers through methods on the identification and detection of plant miRNAs, bioinformatic analyses, and strategies for functional analyses of miRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant MicroRNAs: Method and Protocols aims to ensure successful results in the further study of this vital area of plant science.

Handbook of Computational Molecular Biology

Author : Srinivas Aluru
Publisher : CRC Press
ISBN 13 : 1420036270
Total Pages : 1108 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Computational Molecular Biology by : Srinivas Aluru

Download or read book Handbook of Computational Molecular Biology written by Srinivas Aluru and published by CRC Press. This book was released on 2005-12-21 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of

MicroRNA Protocols

Author : Shao-Yao Ying
Publisher : Humana Press
ISBN 13 : 9781627030847
Total Pages : 375 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis MicroRNA Protocols by : Shao-Yao Ying

Download or read book MicroRNA Protocols written by Shao-Yao Ying and published by Humana Press. This book was released on 2012-09-26 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive studies have been conducted on the identification, biogenesis, and processing of microRNA (miRNA) as well as research on the exact mechanism by which miRNAs bring about translational silencing of their targets. In addition, numerous publications point to an important role of miRNAs in development, reprogramming, epigenetics, pathogenesis of cancer, oncogenes and tumor suppressors, biomarkers of various disease onset, and regulation of adipogenesis and obesity; yet many questions still remain. In MicroRNA Protocols, Second Edition, experts in the field provide up-to-date coverage of this diverse area of study. The specific chapters of this edition are related to the analysis of miRNA, targets and expression profiling, various methods to determine its regulation of gene expression, the preparation and isolation of miRNAs in specific tissues, its detection in the saliva, and potential application in cosmetics, wound healing, and prostate cancer. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and known pitfalls. Fully updated and easy to use, MicroRNA Protocols, Second Edition aims to stimulate readers to explore diverse ways to understand the mechanisms in which miRNAs facilitate the molecular aspects of not only biomedical research but also a wide range of other research fields.

MicroRNAs

Author : Krishnarao Appasani
Publisher : Cambridge University Press
ISBN 13 : 9780521118552
Total Pages : 580 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis MicroRNAs by : Krishnarao Appasani

Download or read book MicroRNAs written by Krishnarao Appasani and published by Cambridge University Press. This book was released on 2009-08-20 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

Plant Epigenetics

Author : Nikolaus Rajewsky
Publisher : Springer
ISBN 13 : 3319555200
Total Pages : 536 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Plant Epigenetics by : Nikolaus Rajewsky

Download or read book Plant Epigenetics written by Nikolaus Rajewsky and published by Springer. This book was released on 2017-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.

MicroRNAs in Development

Author : Tamas Dalmay
Publisher : Humana Press
ISBN 13 : 9781617790829
Total Pages : 0 pages
Book Rating : 4.7/5 (98 download)

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Book Synopsis MicroRNAs in Development by : Tamas Dalmay

Download or read book MicroRNAs in Development written by Tamas Dalmay and published by Humana Press. This book was released on 2011-03-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of microRNAs, developmental biologists have striven to understand the role of miRNAs in development and disease. MicroRNAs in Development: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Divided into three convenient sections, this detailed volume covers various techniques to detect and profile miRNA expression, followed by protocols to manipulate the activity of miRNAs in various organisms, and it concludes with a section that outlines different methods to identify and validate miRNA targets in animals and plants. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, MicroRNAs in Development: Methods and Protocols serves as a practical guide for scientists of all backgrounds and conveys the appropriate sense of fascination associated with this vital field of research.

MicroRNA in Human Infectious Diseases

Author : Vijay Kumar Prajapati
Publisher : Elsevier
ISBN 13 : 0323996620
Total Pages : 346 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis MicroRNA in Human Infectious Diseases by : Vijay Kumar Prajapati

Download or read book MicroRNA in Human Infectious Diseases written by Vijay Kumar Prajapati and published by Elsevier. This book was released on 2024-01-23 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA in Human Infectious Diseases offers a detailed overview of the therapeutic and diagnostic role microRNAs can play in the treatment of various infectious diseases. Beginning with an introduction on microRNAs and their mechanisms, the book then delves into the therapeutic role of microRNAs in various categories of diseases: bacterial, viral, and parasitic. A wide range of diseases are explored in these sections, including sexually transmitted diseases, typhoid, tuberculosis, Dengue fever, Ebola, Covid-19, Malaria, Leishmaniasis, and Lymphatic filariasis. The final section of the book covers microRNA-based system approaches, considering aspects such as web-based tools available for detecting and predicting microRNA targets, and the latest technologies for modifying and manipulating microRNAs. This volume explores microRNA across a multitude of conditions and is an ideal reference for those involved in the investigation and development of treatments in this area. Includes foundational knowledge on microRNAs and the fundamental aspects of its biogenesis Explores the potential role microRNAs can play in therapeutics and diagnostics to treat various infectious diseases, including sexually-transmitted diseases, bacterial diseases, viral infections, and parasitic diseases Features a chapter dedicated to the role of microRNA for therapeutics in respiratory viral infections, such as Covid-19 Considers technologies used for manipulating and modifying microRNAs in preparation for applications to treat infectious diseases

MicroRNA

Author : Junjie Xiao
Publisher : Academic Press
ISBN 13 : 0323885586
Total Pages : 655 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis MicroRNA by : Junjie Xiao

Download or read book MicroRNA written by Junjie Xiao and published by Academic Press. This book was released on 2022-07-19 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques. Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation. Covers the topic of microRNA in detail, from foundational knowledge to clinical application Explores the physiological and pathological roles of microRNAs in various human diseases, including neurological, cardiovascular and age-related diseases Discusses future directions and challenges in the field Includes chapters on methodology and bioinformatics for microRNA research

Clinical Bioinformatics

Author : Ronald Trent
Publisher : Humana
ISBN 13 : 9781493947003
Total Pages : 0 pages
Book Rating : 4.9/5 (47 download)

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Book Synopsis Clinical Bioinformatics by : Ronald Trent

Download or read book Clinical Bioinformatics written by Ronald Trent and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.

MicroRNAs in Diseases and Disorders

Author : Philip V Peplow
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017811
Total Pages : 500 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis MicroRNAs in Diseases and Disorders by : Philip V Peplow

Download or read book MicroRNAs in Diseases and Disorders written by Philip V Peplow and published by Royal Society of Chemistry. This book was released on 2019-05-07 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.

Plant MicroRNAs

Author : Blake C. Meyers
Publisher : Humana Press
ISBN 13 : 9781617796531
Total Pages : 0 pages
Book Rating : 4.7/5 (965 download)

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Book Synopsis Plant MicroRNAs by : Blake C. Meyers

Download or read book Plant MicroRNAs written by Blake C. Meyers and published by Humana Press. This book was released on 2012-08-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs constitute a particularly important class of small RNAs given their abundance, broad phylogenetic conservation and strong regulatory effects, with plant miRNAs uniquely divulging their ancient evolutionary origins and their strong post-transcriptional regulatory effects. In Plant MicroRNAs: Methods and Protocols, experts in the field present chapters that focus on the identification, validation, and characterization of the miRNA class of RNAs, and address important aspects about heterochromatic small interfering RNAs. In addition, the methods contained in this volume emphasize miRNA analyses, but also include ways to distinguish one class of small RNAs from another. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Plant MicroRNAs: Methods and Protocols provides the research community with a set of protocols that will help advance vital miRNA research for all plant species, both in typical model species and non-model species alike.

Plant Small RNA

Author : Praveen Guleria
Publisher : Academic Press
ISBN 13 : 012817336X
Total Pages : 638 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Plant Small RNA by : Praveen Guleria

Download or read book Plant Small RNA written by Praveen Guleria and published by Academic Press. This book was released on 2020-02-19 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Small RNA: Biogenesis, Regulation and Application describes the biosynthesis of small RNA in plant systems. With an emphasis on the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival, this books presents the basics and most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. In addition, it emphasizes the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival. Final sections cover the most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. Presents foundational information about small RNA biology and regulation in plants Includes small RNA pathway advances Describes the application and scope of small RNA technology for agricultural stability