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Microcirculation Updates In The Next Frontier Of Vascular Disease
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Book Synopsis Microcirculation - Updates in the Next Frontier of Vascular Disease by : Aleksandar Kibel
Download or read book Microcirculation - Updates in the Next Frontier of Vascular Disease written by Aleksandar Kibel and published by BoD – Books on Demand. This book was released on 2024-01-17 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microcirculation reflects the vascular bridge which is the conduit of blood flow between the arteries and veins in the body. It plays a critical role in the delivery of oxygen and nutrients to the cells of the body while also serving to wash away and eliminate biological waste products of metabolism. A complex interplay exists between the normal structure and function of the larger vessels of the body and the blood coursing through. This book discusses the evolving science in understanding the role of microcirculation in some of the most common and devastating diseases that plague humanity. By understanding the role of microcirculation in the normal feedback mechanisms that balance bleeding and clotting with the opportunities to manipulate this balance to treat disease, the impact on the individual and social burden of arterial and venous occlusive and thromboembolic disease can be substantial. Understanding disease mechanisms and enhancing our collective tools for diagnosis and treatment are some of the greatest challenges facing our global healthcare systems. The chapters in this book serve as a foundation for further research into the quest to reduce, if not eliminate, one of the most significant causes of major morbidity, mortality, and overall loss of quality of life worldwide. Without a doubt, the impact of the body’s microcirculation, as our understanding continues to evolve and as emphasized in this text, cannot and should not be underappreciated.
Book Synopsis Inflammation and the Microcirculation by : D. Neil Granger
Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Book Synopsis Coronary Microvascular Dysfunction by : Filippo Crea
Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Book Synopsis Microcirculation in Cardiovascular Diseases by : Enrico Agabiti-Rosei
Download or read book Microcirculation in Cardiovascular Diseases written by Enrico Agabiti-Rosei and published by Springer Nature. This book was released on 2020-10-03 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.
Book Synopsis Highlights of Interdisciplinary Care in Rheumatology, An Issue of Rheumatic Disease Clinics of North America by : Anisha Dua
Download or read book Highlights of Interdisciplinary Care in Rheumatology, An Issue of Rheumatic Disease Clinics of North America written by Anisha Dua and published by Elsevier Health Sciences. This book was released on 2024-06-29 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Rheumatic Disease Clinics, guest editors Anisha Dua and Jeffery A. Sparks bring their considerable expertise to the topic of Interdisciplinary Care in Rheumatology. Top experts in the field cover key topics such as Systemic Diseases and Heart Block; Prospects of Disease-Modifying Osteoarthritis Drugs; The Role of Psychology in Pediatric Rheumatic Diseases; and more. - Contains 10 relevant, practice-oriented topics including Imaging of Pulmonary Manifestations of Connective Tissue Disease; Connective Tissue Disease Associated Interstitial Lung Disease; Newer Immunosuppressants for Rheumatologic Disease; and more. - Provides in-depth clinical reviews on Interdisciplinary care, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis Intracoronary physiology and its use in interventional cardiology, An Issue of Interventional Cardiology Clinics, E-Book by : Allen Jeremias
Download or read book Intracoronary physiology and its use in interventional cardiology, An Issue of Interventional Cardiology Clinics, E-Book written by Allen Jeremias and published by Elsevier Health Sciences. This book was released on 2022-11-12 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Interventional Cardiology Clinics, guest editor Dr. Allen Jeremias brings his considerable expertise to the topic of Intracoronary Physiology and Its Use in Interventional Cardiology. Assessment of intra-coronary physiology can guide percutaneous coronary intervention and is often used for angiographically borderline stenoses. There is now increasing evidence to suggest that more routine use can improve clinical outcomes. In this issue, top experts bring you fully up to date in this key area of interventional cardiology. - Contains 13 practice-oriented topics including updates in coronary physiology: what about all the negative trials?; physiology for post-PCI assessment; physiology and intravascular imaging co-registration; CT-derived physiology assessment; targeted therapies for microvascular disease; and more. - Provides in-depth clinical reviews on intracoronary physiology and its use in interventional cardiology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis Coronary Microvascular Obstruction in Acute Myocardial Infarction by : Giampaolo Niccoli
Download or read book Coronary Microvascular Obstruction in Acute Myocardial Infarction written by Giampaolo Niccoli and published by Academic Press. This book was released on 2018-07-07 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. - Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment - Includes the most up-to-date information on CMVO as presented from top experts around the word - Provides access to a companion website with extra material, including tables, additional references and instructional videos - Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Diseases of the Chest, Breast, Heart and Vessels 2019-2022 by : Juerg Hodler
Download or read book Diseases of the Chest, Breast, Heart and Vessels 2019-2022 written by Juerg Hodler and published by Springer. This book was released on 2019-02-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.
Book Synopsis Blood Substitutes, Present and Future Perspectives by : E. Tsuchida
Download or read book Blood Substitutes, Present and Future Perspectives written by E. Tsuchida and published by Elsevier. This book was released on 1999-01-14 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the selected papers presented at the seventh International Symposium on Blood Substitutes (7th ISBS) held at the International Conference Center of Waseda University in Tokyo on 7-10 September 1997. In keeping with the scientific design of the 7th ISBS Symposium, chapters have been carefully selected and organized to showcase the advancements in recent research. This book includes up-to-date clinical results of leading companies which are manufacturing hemoglobin-based or fluorocarbon-based blood substitutes, and covers issues of hemoglobin toxicity and side effects such as vasoconstriction in more detail using carefully designed in vivo and ex vivo techniques. This book is also a collection of various new types of red cell substitutes such as recombinant Hbs, recombinant albumine-lipidheme complex, modified red blood cells, and perfluorochemicals using material science and molecular engineering.
Book Synopsis Early Vascular Aging (EVA) by : Pedro Guimarães Cunha
Download or read book Early Vascular Aging (EVA) written by Pedro Guimarães Cunha and published by Elsevier. This book was released on 2024-02-29 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. - Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) - Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities - Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Ion Channels and Calcium Signaling in the Microcirculation by :
Download or read book Ion Channels and Calcium Signaling in the Microcirculation written by and published by Academic Press. This book was released on 2020-05-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more. Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.
Book Synopsis Microcirculation Revisited by : Helena Lenasi
Download or read book Microcirculation Revisited written by Helena Lenasi and published by BoD – Books on Demand. This book was released on 2016-10-26 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive overview of selected topics in microcirculation, from physiology to pathophysiology including molecular mechanisms and clinical aspects. It contains 10 chapters written by reputed authors, which comprehensively sum up the current knowledge and some interesting new insights in the field of microcirculation. It will be useful to a broad range of audience, from students to highly profiled experts, helping them to expand their knowledge on microcirculation and opening up additional questions for further investigation.
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Book Synopsis The Diabetic Foot by : Robert Hinchliffe
Download or read book The Diabetic Foot written by Robert Hinchliffe and published by JP Medical Ltd. This book was released on 2014-09-08 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of diabetes is increasing both in the western world and in developing countries; type 2 diabetes increase is partly the result of greater obesity. Diabetes can cause two major problems to the foot – diabetic neuropathy resulting in nerve damage and peripheral vascular disease reducing the flow of blood. These can result in ulceration of the foot which needs careful management to avoid the possibility of amputation. This management is best undertaken by multidisciplinary teams using the latest evidence to support their practice. This book presents a comprehensive and authoritative coverage of the latest evidence-based investigations, techniques and management of the diabetic foot. Evidenced-based management of the diabetic foot International, multidisciplinary team of editors and contributors Comprehensive reference for all health professionals involved in the care of diabetic foot problems
Book Synopsis Microcirculation by : Maria Dorobantu
Download or read book Microcirculation written by Maria Dorobantu and published by Springer. This book was released on 2019-11-18 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference book of coronary microcirculation broadly covers theoretical aspects, clinical cases and therapeutic considerations from an innovative perspective. Topics covered include: ischemic heart disease, silent cerebral damage, heart failure, left ventricular hypertrophy arrhythmias, and cerebral and renal microcirculation. Microcirculation: From Bench to Bedside underlines the clinical importance of addressing coronary microcirculation with relevant clinical examples that are often encountered by practitioners. It therefore provides a critical resource on microcirculation for both specialist and non-specialist practitioners.
