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Microbial Metabolomics
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Book Synopsis Microbial Metabolomics by : David J. Beale
Download or read book Microbial Metabolomics written by David J. Beale and published by Springer. This book was released on 2016-12-05 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together contributions from global experts who have helped to facilitate the exciting and rapid advances that are taking place in microbial metabolomics. The main application of this field is in clinical and veterinary microbiology, but there is a great potential to apply metabolomics to help to better understand complex biological systems that are dominated by multiple-species microbial populations exposed to changing growth and nutritional conditions. In particular, environmental (e.g., water, soil), food (e.g., microbial spoilage, food pathogens), and agricultural and industrial applications are seen as developing areas for microbial metabolomics. As such, the book includes contributions with clinical, environmental, and industrial perspectives.
Book Synopsis Microbial Metabolomics by : Edward E.K. Baidoo
Download or read book Microbial Metabolomics written by Edward E.K. Baidoo and published by Humana. This book was released on 2018-11-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume includes protocols that represent the breadth of microbial metabolomics approaches to both large-scale and small-scale experiments with intention of highlighting techniques that can be used for applications ranging from environmental microbiology to human disease. Utilizing mass spectrometry as their primary measurement tool, the chapters explore microbial metabolomics, metabolism and microbial physiology, metabolite sample preparation, current analytical techniques used to profile primary and secondary metabolites and lipids, as well as establishing data analysis workflows for targeted metabolomics, untargeted metabolomics, analysis of metabolic fluxes, and genome-scale models. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microbial Metabolomics: Methods and Protocols serves as an ideal reference for both novice and advanced users and can be adapted to similar analytical platforms or customized to suit the needs of the researcher.
Book Synopsis Microbial Metabolomics by : Silas Villas-Boas
Download or read book Microbial Metabolomics written by Silas Villas-Boas and published by Cab Publishing. This book was released on 2015-02-28 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics enables new scientific discoveries in the life sciences that make it of increasing interest in biology. Focusing on analysing different small molecules produced or modified by living cells in a high throughput fashion, metabolomics plays an essential role in functional genomics and systems biology studies. Starting with a general introduction to the field, this research-level book addresses the unique challenges associated with microbial metabolomics, such as low biomass concentration and distinction between intra- and extracellular compounds, covering the latest developments in microbial metabolomics before discussing data generation and analysis and applications of quantitative metabolomics.
Book Synopsis Microbial Natural Products Chemistry by : Taícia Pacheco Fill
Download or read book Microbial Natural Products Chemistry written by Taícia Pacheco Fill and published by Springer Nature. This book was released on 2023-10-16 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the importance of omics strategies and de-replication analysis to unveil new molecules from microbial sources with diverse chemical structures and biological functions. Chapters address metabolomics strategies, which will lead to a better understanding of the chemical interactions between microorganisms, plant-microorganisms, and virus-microorganisms. Authors also describe analytical tools used in microbial metabolomics and natural products discovery, in addition to describing a step-by-step protocol to identify and annotate metabolites using various databases and online platforms. The book presents the newest research, tools, and protocols for chemists, biochemists, bio-and chemical engineers, and biotechnologists, among others.
Book Synopsis Metabolomics in Practice by : Michael Lämmerhofer
Download or read book Metabolomics in Practice written by Michael Lämmerhofer and published by John Wiley & Sons. This book was released on 2013-02-14 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the insight and advice offered here helps to clear the hurdles in setting up and running a successful analysis, resulting in high-quality data from every experiment. Based on more than a decade of practical experience in developing, optimizing and validating metabolomics approaches as a routine technology in the academic and industrial research laboratory, the lessons taught here are highly relevant for all systems-level approaches, whether in systems biology, biotechnology, toxicology or pharmaceutical sciences. From the Contents: * Sampling and Sample Preparation in Microbial Metabolomics * Tandem Mass Spectrometry Hyphenated with HPLC and UHPLC for Targeted Metabolomics * GC-MS, LC-MS, CE-MS and Ultrahigh Resolution MS (FTICR-MS) in Metabolomics * NMR-based metabolomics analysis * Potential of Microfluidics and Single Cell Analysis in Metabolomics * Data Processing in Metabolomics * Validation and Measurement Uncertainty in Metabolomic Studies * Metabolomics and its Role in the Study of Mammalian Systems and in Plant Sciences * Metabolomics in Biotechnology and Nutritional Metabolomics and more.
Book Synopsis Bacterial metabolomics approach towards antimicrobials and resistance by : Vijay Soni
Download or read book Bacterial metabolomics approach towards antimicrobials and resistance written by Vijay Soni and published by Frontiers Media SA. This book was released on 2023-06-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Metabolomics written by Shen Hu and published by Springer Nature. This book was released on 2021-04-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
Book Synopsis Marine Microbial Metabolomics by : Angela Kelsey Boysen
Download or read book Marine Microbial Metabolomics written by Angela Kelsey Boysen and published by . This book was released on 2020 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms control the flux of energy, stored as organic matter, into the ocean through the cumulative effects of individual metabolisms and community interactions. Metabolites are the currency of microbial metabolism, are carefully regulated to meet the metabolic demands of organisms living in dynamic environments, and reflect cellular status and metabolic strategies for nutrient acquisition, energy storage, redox maintenance, and more. This dissertation focuses on developing metabolomics techniques for the marine environment and using them to study microbial dynamics over time and space to identify compounds that are key microbial currencies. In order to study natural populations of marine microbes, I developed a method for targeted and untargeted metabolomics data acquisition and analysis with the unique challenges of marine samples in mind (Chapter 2). I use this method to study the influence of the diel cycle on the marine microbial community at Station ALOHA in the North Pacific Subtropical Gyre, ultimately showing synchrony of daytime anabolism and nighttime catabolism as seen through diel oscillations of ubiquitous metabolites including cofactors and vitamins. Through pairing metabolite and gene expression data, I demonstrate the strategies that specific photoautotrophs use to manage the daily fluctuations in solar energy (Chapter 3). To examine how microorganisms respond to other environmental forcings, I investigate the metabolism of microbial communities across the North Pacific Transition Zone and identify metabolic currencies used by those communities to adapt to varying nutrient supply (Chapter 4). Nutrient amendment experiments show the dominance of nitrogen limitation throughout this region and the potential for iron-nitrogen co-limitation near the subtropical chlorophyll front. Finally, in order to explore the potential for metabolites to be nutrient sources to the microbial community, I investigate the ability of natural microbial communities to use the abundant osmolyte glycine betaine. I determine the kinetics of uptake and identify the metabolic uses of glycine betaine in two different natural microbial communities and show that its use as a nutrient differs depending on DIN availability (Chapter 5). In full, this dissertation provides some of the first metabolomics measurements in the natural marine environment and identifies and explores the roles of key organic molecules in shaping the microbial community structure and function.
Book Synopsis Microbial Biofilms by : Sanket Joshi
Download or read book Microbial Biofilms written by Sanket Joshi and published by Elsevier. This book was released on 2023-06-10 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Biofilms: Challenges and Advances in Metabolomic Study is a volume in the Advances in Biotechnology and Bioengineering Series. The volume covers the metabolomic characteristics of bacterial biofilms and examines the techniques used in the analysis of the metabolomics of the biofilm, its formation, and related infections. The book includes the metabolomics study of various types of biofilms and details new strategies in targeting metabolic pathways for inhibiting the biofilm. The book also describes various types of metabolomics studies like metabolomics of oral biofilm and metabolomics of biofilm by nosocomial microbes. It also points out the recent advancements on various aspects of metabolomics studies pertaining to biofilms, related infections, their pathogenesis, and present-day treatment strategies. Microbial Biofilms: Challenges and Advances in Metabolomic Study is a helpful resource to scientists and researchers engaged in biofilm studies, precisely on the metabolomic changes at molecular level occurring in the participating microorganisms. It is also fascinating and thought provoking for the clinicians and health professionals actively involved in the treatment of biofilm mediated chronic infections, since it depicts the pathogenic consequences of the small molecular interactions of the metabolites in biofilm. Discusses recent trends in biofilms research Details newer strategies in treating the biofilm by targeting metabolic pathways Covers chronic infections caused by biofilm and their metabolomics studies Examines various analytical aspects on the metabolomics study of biofilm as well as how metabolomics regulate the formation of the biofilm Incorporates relevant case studies
Book Synopsis Extremophilic Microbes and Metabolites by : Afef Najjari
Download or read book Extremophilic Microbes and Metabolites written by Afef Najjari and published by BoD – Books on Demand. This book was released on 2021-02-24 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the diversity and biotechnological applications of metabolites produced by extremophilic microbes thriving in different ecological niches citing the low troposphere, the gastrointestinal tract of ruminants, tropical dry forest, and saline ecosystems. These studies were based on metabolomics and molecular approaches like metagenomics and single-cell genomic analyses. Various implications of Electro-Rheological Fluid are also discussed. The editor embarked on this writing project entitled “Extremophilic Microbes and Metabolites - Diversity, Bioprospecting, and Biotechnological Applications” to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will benefit from the chapters of this book.
Book Synopsis Metabonomics and Gut Microbiota in Nutrition and Disease by : Sunil Kochhar
Download or read book Metabonomics and Gut Microbiota in Nutrition and Disease written by Sunil Kochhar and published by Springer. This book was released on 2014-10-21 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans. Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established. Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine.
Book Synopsis Metabolome Analysis by : Silas G. Villas-Boas
Download or read book Metabolome Analysis written by Silas G. Villas-Boas and published by John Wiley & Sons. This book was released on 2007-02-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing information on the main approaches for the analysis of metabolites, this textbook: Covers basic methodologies in sample preparation and separation techniques, as well as the most recent techniques of mass spectrometry. Differentiates between primary and secondary metabolites. Includes four chapters discussing successful metabolome studies of different organisms. Highlights the analytical challenges of studying metabolites. Illustrates applications of metabolome analysis through the use of case studies.
Book Synopsis Statistical Data Analysis of Microbiomes and Metabolomics by : Yinglin Xia
Download or read book Statistical Data Analysis of Microbiomes and Metabolomics written by Yinglin Xia and published by American Chemical Society. This book was released on 2022-02-03 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compared with other research fields, both microbiome and metabolomics data are complicated and have some unique characteristics, respectively. Thus, choosing an appropriate statistical test or method is a very important step in the analysis of microbiome and metabolomics data. However, this is still a difficult task for those biomedical researchers without a statistical background and for those biostatisticians who do not have research experiences in these fields. Graduate students studying microbiome and metabolomics; statisticians, working on microbiome and metabolomics projects, either for their own research, or for their collaborative research for experimental design, grant application, and data analysis; and researchers who investigate biomedical and biochemical projects with the microbiome, metabolome, and multi-omics data analysis will benefit from reading this work.
Download or read book Metabolomics written by Vijay Soni and published by Springer Nature. This book was released on 2023-10-24 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book Introduces the extensive applications of metabolomics from all possible areas of research and development so that not only an undergraduate can understand the advancement of metabolomics, but an entrepreneur can harness the knowledge to address possible problems to make a perfect tool to address their research question. Topics covered include the role of metabolomics in the development of agriculture, plant pathology, and their applications; the generalized application of the metabolomics and use of related technologies in various sectors of industries; and the future of metabolomics and upcoming related technologies that can fill the gap between different -omics and their applications for the betterment of humankind. This is an ideal book for university professors, researchers, and advanced-level scientists who are exploring different avenues in metabolomics. Availability of this concise information in one place will aid scientists by expanding their arsenal of techniques and can be helpful to bring more collaborations and to identify the expert at the global level.
Book Synopsis Microbial Metagenomics, Metatranscriptomics, and Metaproteomics by :
Download or read book Microbial Metagenomics, Metatranscriptomics, and Metaproteomics written by and published by Academic Press. This book was released on 2013-09-19 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers microbial metagenomics, metatranscriptomics, and metaproteomics, and includes chapters on such topics as in-solution FISH for single cell genome preparation, preparation of BAC libraries from marine microbial community DNA, and preparation of microbial community cDNA for metatranscriptomic analysis in marine plankton. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers microbial metagenomics, metatranscriptomics, and metaproteomics Contains chapters on such topics as in-solution fluorescence in situ hybridization (FISH) for single cell genome preparation, preparation of BAC libraries from marine microbial community DNA, and preparation of microbial community cDNA for metatranscriptomic analysis in marine plankton
Book Synopsis Metabolomics by : Sanjoy K. Bhattacharya
Download or read book Metabolomics written by Sanjoy K. Bhattacharya and published by Humana. This book was released on 2019-05-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume brings together some of the best experts in the field of modern metabolomics to discuss various techniques used today to study specific metabolite classes, and metabolomics in bacterial systems and mammalian systems. The chapters in this book cover topics such as Isotopic Ratio Outlier Analysis (IROA) for quantitative analysis; cholesterol and derivatives in ocular tissues using LC-MS/MS methods; microbial siderophores analysis by mass spectrometry; the metabolomic study of tissues in Parkinson’s Disease; and NMR analysis in livestock metabolomics. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, tips on troubleshooting and avoiding pitfalls. Cutting-edge and thorough, Metabolomics: Methods and Protocols is an essential resource for any researcher interested in this exciting and evolving field.
Book Synopsis Methodologies for Metabolomics by : Norbert W. Lutz
Download or read book Methodologies for Metabolomics written by Norbert W. Lutz and published by Cambridge University Press. This book was released on 2013-01-21 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
