Microbial Megaplasmids

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Publisher : Springer Science & Business Media
ISBN 13 : 3540854673
Total Pages : 348 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Microbial Megaplasmids by : Edward Schwartz

Download or read book Microbial Megaplasmids written by Edward Schwartz and published by Springer Science & Business Media. This book was released on 2009-01-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Megaplasmids are extrachromosomal genetic elements in the size range of 100 kb and larger. They are found in physiologically and phylogenetically diverse groups of bacteria and archaea. By definition, megaplasmids are not essential for the viability of their hosts under all growth conditions, but paradoxically many megaplasmids carry the genetic information for the defining and characteristic traits of the organism in which they reside. Microbial Megaplasmids reviews our knowledge of the extensively studied representatives, such as the catabolic plasmids of the pseudomonads, the rhizobial Sym plasmids, the Ti plasmids of the genus Agrobacterium and the giant enterobacterial virulence plasmids. It also presents snapshots of more recently discovered megaplasmids. The contribution of megaplasmids to the biology of their hosts is described, highlighting the interactions between megaplasmid and chromosomal genes.

Microbe Mediated Remediation of Environmental Contaminants

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Publisher : Woodhead Publishing
ISBN 13 : 0128232072
Total Pages : 475 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Microbe Mediated Remediation of Environmental Contaminants by : Ajay Kumar

Download or read book Microbe Mediated Remediation of Environmental Contaminants written by Ajay Kumar and published by Woodhead Publishing. This book was released on 2020-10-14 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbe Mediated Remediation of Environmental Contaminants presents recent scientific progress in applying microbes for environmental management. The book explores the current existing practical applications and provides information to help readers develop new practices and applications. Edited by recognized leaders in the field, this penetrating assessment of our progress to date in deploying microorganisms to the advantage of environmental management and biotechnology will be widely welcomed by those working in soil contamination management, agriculture, environment management, soil microbiology, and waste management. The polluting effects on the world around us of soil erosion, the unwanted migration of sediments, chemical fertilizers and pesticides, and the improper treatment of human and animal wastes have resulted in serious environmental and social problems around the world, problems which require us to look for solutions elsewhere than established physical and chemical technologies. Often the answer lies in hybrid applications in which microbial methods are combined with physical and chemical ones. When we remember that these highly effective microorganisms, cultured for a variety of applications, are but a tiny fraction of those to be found in the world around us, we realize the vastness of the untapped and beneficial potential of microorganisms. - Explores microbial application redressing for soil and water contamination challenges - Includes information on microbial synthesized nanomaterials for remediation of contaminated soils - Presents a uniquely hybrid approach, combining microbial interactions with other chemical and physical methods

Biodegradative Bacteria

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Publisher : Springer Science & Business Media
ISBN 13 : 4431545204
Total Pages : 354 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Biodegradative Bacteria by : Hideaki Nojiri

Download or read book Biodegradative Bacteria written by Hideaki Nojiri and published by Springer Science & Business Media. This book was released on 2013-11-01 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradative Bacteria highlights the novel nature of bacterial cell functions in the field of biodegradation by putting them into three parts: (1) Genetic and genomic systems, (2) Degradative enzyme systems, and (3) Bacterial behavior in natural environmental systems. The first part of the book includes cell functions as degradative machinery, genome systems for effective degradation, and the evolution of degradative systems by mobile genetic elements. The second part deals with the structure, function, evolution, diversity, and application of degradative and related enzymes. The third part presents cell or genomic behaviors of biodegradative bacteria in natural ecosystems. Bacterial metabolic capacity, which plays an important role in the global material cycle, contributes significantly to the buffering capacity for the huge and unintended release of various chemicals. Recently, however, the prosperity and globalization of material civilization has led not only to severe local contamination by hazardous chemicals, but also to continuous increment of contaminant concentrations worldwide. To solve such urgent global issues, bacterial functions that are involved in biodegradation of hazardous chemicals have been analyzed. The term “biodegradative bacteria” refers to those bacteria that have the ability to degrade such xenobiotic (man-made) and/or hazardous chemicals. Analyses of biodegradative bacteria include diverse areas of study, such as genetics, enzymology, genomics, cell physiology, ecology, and evolutionary biology. In other words, the targets investigated in research on biodegradative bacteria include single molecules, single cell systems, bacterial consortia (interaction with surrounding microorganisms), and interaction with surrounding biotic and abiotic materials. Such complexity makes the research on biodegradative bacteria difficult but quite interesting.

Microbial Applications Vol.1

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Publisher : Springer
ISBN 13 : 3319526669
Total Pages : 335 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Microbial Applications Vol.1 by : Vipin Chandra Kalia

Download or read book Microbial Applications Vol.1 written by Vipin Chandra Kalia and published by Springer. This book was released on 2017-04-04 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume sheds new light on waste management and the production of biofuels. The authors share insights into microbial applications to meet the challenges of environmental pollution and the ever- growing need for renewable energy. They also explain how healthy and balanced ecosystems can be created and maintained using strategies ranging from oil biodegration and detoxification of azo dyes to biofouling. In addition, the book illustrates how the metabolic abilities of microorganisms can be used in microbial fuel-cell technologies or for the production of biohydrogen. It inspires young researchers and experienced scientists in the field of microbiology to explore the application of green biotechnology for bioremediation and the production of energy, which will be one of the central topics for future generations.

Stress Challenges and Immunity in Space

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Publisher : Springer Science & Business Media
ISBN 13 : 3642222722
Total Pages : 462 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Stress Challenges and Immunity in Space by : Alexander Chouker

Download or read book Stress Challenges and Immunity in Space written by Alexander Chouker and published by Springer Science & Business Media. This book was released on 2011-12-20 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress of either psychological or physical nature can activate and/or paralyse humans’ innate and adaptive immunity. However, adequate immunity is crucial to the maintenance of health on earth and in space. During space flight, human physiology and health are challenged by complex environmental stressors which might be at their most pronounced during lunar or interplanetary missions. While previous publications have addressed the physiological changes that occur during space flight, this book goes further, by adopting an interdisciplinary approach to analyze the complex interaction of living conditions in space, the immune system, and astronauts’ health. It is explained how such analysis of the consequences of stress for the immune system may help in preventing, diagnosing, and counteracting immune-related alterations in health on earth as well as in space

DNA Replication Origins in Microbial Genomes, Volume 2

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889632458
Total Pages : 140 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis DNA Replication Origins in Microbial Genomes, Volume 2 by : Feng Gao

Download or read book DNA Replication Origins in Microbial Genomes, Volume 2 written by Feng Gao and published by Frontiers Media SA. This book was released on 2019-12-23 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: As guest editor, Prof. Gao has organized the Research Topic “DNA Replication Origins in Microbial Genomes” for Frontiers in Microbiology. Gratifyingly, the papers published in this Research Topic were highly accessed, and well-received by a wide international audience. Given its previous success, we decided to revisit this Research Topic with a second volume. We are pleased that this topic remains one of keen interest, and also surprised by the diversity of the manuscripts submitted for the second volume. The field is certainly moving in interesting new directions. We hope that readers find these articles both informative and entertaining, and we look forward to an exciting future for replication origin research.

Microbial Diversity in the Genomic Era

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Publisher : Academic Press
ISBN 13 : 0128148500
Total Pages : 715 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Microbial Diversity in the Genomic Era by : Surajit Das

Download or read book Microbial Diversity in the Genomic Era written by Surajit Das and published by Academic Press. This book was released on 2018-09-20 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Diversity in the Genomic Era presents insights on the techniques used for microbial taxonomy and phylogeny, along with their applications and respective pros and cons. Though many advanced techniques for the identification of any unknown bacterium are available in the genomics era, a far fewer number of the total microbial species have been discovered and identified to date. The assessment of microbial taxonomy and biosystematics techniques discovered and practiced in the current genomics era with suitable recommendations is the prime focus of this book. - Discusses the techniques used for microbial taxonomy and phylogeny with their applications and respective pros and cons - Reviews the evolving field of bacterial typing and the genomic technologies that enable comparative analysis of multiple genomes and the metagenomes of complex microbial environments - Provides a uniform, standard methodology for species designation

Structure and Function of the Bacterial Genome

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119308798
Total Pages : 437 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Structure and Function of the Bacterial Genome by : Charles J. Dorman

Download or read book Structure and Function of the Bacterial Genome written by Charles J. Dorman and published by John Wiley & Sons. This book was released on 2020-04-28 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an integrated view of the expression of bacterial genetic information, genome architecture and function, and bacterial physiology and pathogenesis This book blends information from the very latest research on bacterial chromosome and nucleoid architecture, whole-genome analysis, cell signaling, and gene expression control with well-known gene regulation paradigms from model organisms (including pathogens) to give readers a picture of how information flows from the environment to the gene, modulating its expression and influencing the competitive fitness of the microbe. Structure and Function of the Bacterial Genome explores the governance of the expression of the genes that make a bacterium what it is, and updates the basics of gene expression control with information about transcription promoter structure and function, the role of DNA as a regulatory factor (in addition to its role as a carrier of genetic information), small RNAs, RNAs that sense chemical signals, ribosomes and translation, posttranslational modification of proteins, and protein secretion. It looks at the forces driving the conservation and the evolution of the dynamic genome and offers chapters that cover DNA replication, DNA repair, plasmid biology, recombination, transposition, the roles of repetitive DNA sequences, horizontal gene transfer, the defense of the genome by CRISPR-Cas, restriction enzymes, Argonaute proteins and BREX systems. The book finishes with a chapter that gives an integrated overview of genome structure and function. Blends knowledge of gene regulatory mechanisms with a consideration of nucleoid structure and dynamics Offers a 'DNA-centric' approach to considering transcription control Views horizontal gene transfer from a gene regulation perspective Assesses the opportunities and limitations of designing synthetic microbes or rewiring existing ones Structure and Function of the Bacterial Genome is an ideal book for graduate and undergraduate students studying microbial cell biology, bacterial pathogenesis, gene regulation, and molecular microbiology. It will also appeal to principal investigators conducting research on these and related topics and researchers in synthetic biology and other arms of biotechnology.

Genomics of Bacterial Metal Resistance

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Author :
Publisher : MDPI
ISBN 13 : 3036503900
Total Pages : 238 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Genomics of Bacterial Metal Resistance by : Alessio Mengoni

Download or read book Genomics of Bacterial Metal Resistance written by Alessio Mengoni and published by MDPI. This book was released on 2021-03-03 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of understanding metal–microbe interactions underlies a number of social–economic issues in the world. The antimicrobial resistance era has created a need for novel antimicrobials and within this fieldm metal and metalloid ions are promising solutions. Pollution sites, either co-contaminated with metals or with metals as the sole pollutant, contain microbes that are present as key participants, with both of these issues habing links to agriculture. Microbes also play key roles in the global geochemical cycle of many elements. Such statements solidify the need to understand metal–microbe interactions. Given that genomics has arguably become the most useful tool in biology, the application of this technology within the field of understanding metal resistance comes as no surprise. Whilst by no means comprehensive, this book provides examples of the applications of genomic approaches in the study of metal–microbe interactions. Here, we present a collection of manuscripts that highlights some present directions in the field. The book starts with a collection of three papers evaluating aspects of the genomics of the archetype metal resistant bacteria, Cuprividus metallidurans. This is followed by four studies that evaluate the mechanisms of metal resistance. The next two papers assess metal resistance in agricultural related situations, including a review on metal resistance in Listeria. The book concludes with a review on metal phytoremediation via Rhizobia and two subsequent studies of metal biotechnology relevance.

Metal Response in Cupriavidus metallidurans

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Author :
Publisher : Springer
ISBN 13 : 3319205943
Total Pages : 97 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Metal Response in Cupriavidus metallidurans by : Max Mergeay

Download or read book Metal Response in Cupriavidus metallidurans written by Max Mergeay and published by Springer. This book was released on 2015-07-09 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this first volume, the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, is sketched to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. A detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals is provided. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands. In addition, in the second volume, structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures of C. metallidurans proteins are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury.

Uncultivated Microorganisms

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Publisher : Springer Science & Business Media
ISBN 13 : 3540854657
Total Pages : 215 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Uncultivated Microorganisms by : Slava S. Epstein

Download or read book Uncultivated Microorganisms written by Slava S. Epstein and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1898, an Austrian microbiologist Heinrich Winterberg made a curious observation: the number of microbial cells in his samples did not match the number of colonies formed on nutrient media (Winterberg 1898). About a decade later, J. Amann qu- tified this mismatch, which turned out to be surprisingly large, with non-growing cells outnumbering the cultivable ones almost 150 times (Amann 1911). These papers signify some of the earliest steps towards the discovery of an important phenomenon known today as the Great Plate Count Anomaly (Staley and Konopka 1985). Note how early in the history of microbiology these steps were taken. Detecting the Anomaly almost certainly required the Plate. If so, then the period from 1881 to 1887, the years when Robert Koch and Petri introduced their key inventions (Koch 1881; Petri 1887), sets the earliest boundary for the discovery, which is remarkably close to the 1898 observations by H. Winterberg. Celebrating its 111th anniversary, the Great Plate Count Anomaly today is arguably the oldest unresolved microbiological phenomenon. In the years to follow, the Anomaly was repeatedly confirmed by all microb- logists who cared to compare the cell count in the inoculum to the colony count in the Petri dish (cf., Cholodny 1929; Butkevich 1932; Butkevich and Butkevich 1936). By mid-century, the remarkable difference between the two counts became a universally recognized phenomenon, acknowledged by several classics of the time (Waksman and Hotchkiss 1937; ZoBell 1946; Jannasch and Jones 1959).

Plastics from Bacteria

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Publisher : Springer Science & Business Media
ISBN 13 : 3642032877
Total Pages : 453 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Plastics from Bacteria by : George Guo-Qiang Chen

Download or read book Plastics from Bacteria written by George Guo-Qiang Chen and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the possibility that petroleum supplies will be exhausted in the next decades to come, more and more attention has been paid to the production of bacterial pl- tics including polyhydroxyalkanoates (PHA), polylactic acid (PLA), poly(butylene succinate) (PBS), biopolyethylene (PE), poly(trimethylene terephthalate) (PTT), and poly(p-phenylene) (PPP). These are well-studied polymers containing at least one monomer synthesized via bacterial transformation. Among them, PHA, PLA and PBS are well known for their biodegradability, whereas PE, PTT and PPP are probably less biodegradable or are less studied in terms of their biodegradability. Over the past years, their properties and appli- tions have been studied in detail and products have been developed. Physical and chemical modifications to reduce their cost or to improve their properties have been conducted. PHA is the only biopolyester family completely synthesized by biological means. They have been investigated by microbiologists, molecular biologists, b- chemists, chemical engineers, chemists, polymer experts, and medical researchers for many years. PHA applications as bioplastics, fine chemicals, implant biomate- als, medicines, and biofuels have been developed. Companies have been est- lished for or involved in PHA related R&D as well as large scale production. It has become clear that PHA and its related technologies form an industrial value chain in fermentation, materials, feeds, and energy to medical fields.

Plant Growth and Health Promoting Bacteria

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Publisher : Springer Science & Business Media
ISBN 13 : 3642136125
Total Pages : 453 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Plant Growth and Health Promoting Bacteria by : Dinesh K. Maheshwari

Download or read book Plant Growth and Health Promoting Bacteria written by Dinesh K. Maheshwari and published by Springer Science & Business Media. This book was released on 2010-09-28 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: To cope with the increasing problems created by agrochemicals such as plant fertilizers, pesticides and other plant protection agents, biological alternatives have been developed over the past years. These include biopesticides, such as bacteria for the control of plant diseases, and biofertilizer to improve crop productivity and quality. Especially plant growth promoting rhizobacteria (PGPR) are as effective as pure chemicals in terms of plant growth enhancement and disease control, in addition to their ability to manage abiotic and other stresses in plants. The various facets of these groups of bacteria are treated in this Microbiology Monograph, with emphasis on their emergence in agriculture. Further topics are Bacillus species that excrete peptides and lipopeptides with antifungal, antibacterial and surfactant activity, plant-bacteria-environment interactions, mineral-nutrient exchange, nitrogen assimilation, biofilm formation and cold-tolerant microorganisms.

Marine Pollution and Microbial Remediation

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Publisher : Springer
ISBN 13 : 9811010447
Total Pages : 274 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Marine Pollution and Microbial Remediation by : Milind Mohan Naik

Download or read book Marine Pollution and Microbial Remediation written by Milind Mohan Naik and published by Springer. This book was released on 2016-09-23 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine environment is the largest habitat covering approximately 70% of the total earth surface. Oceans are the main regulatory agent of earth’s climate and harbour a huge diversity of living organisms. Marine environment provide a unique ecological niche to different microbes which play a significant role in nutrient recycling as well as various environmental activities. However with rapid industrialization, urbanisation, ship trafficking and mining activities enormous amounts of waste including heavy metals, hydrocarbons, chemicals, dyes, organic load, agriculture waste, pesticides, antifoulants (e.g. tributyltin) and bacterial pathogens have accumulated in marine/estuarine environments over several decades and pose a serious threat to marine macro and micro biota and humans and therefore require special attention. However some natural marine microbes are known to possess diverse resistance mechanisms and degradation pathways to variety of toxic pollutants and these unique characteristics of marine/estuarine bacteria proved to be an ideal tool in bioremediation of contaminated marine and estuarine environmental sites. Reclamation of marine polluted environments using marine microbes has been found to be effective, affordable and ecofriendly technological solution over conventional physical and chemical methods. Objective of this book is focus on marine pollution and application of marine microorganisms in cost effective and ecofriendly methods of pollution abatement.

Phagocytosis: Microbial Invasion

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Author :
Publisher : Elsevier
ISBN 13 : 008052608X
Total Pages : 403 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Phagocytosis: Microbial Invasion by : S. Gordon

Download or read book Phagocytosis: Microbial Invasion written by S. Gordon and published by Elsevier. This book was released on 2000-01-27 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume focuses on microbial invasion strategies of pathogen uptake. An accompanying volume (Vol. 5) in the series presents the phagocytic process from the viewpiont of the host cell. This field of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research and brings together cell biologists, microbiologists, and immunologists wiht disthemes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular parasitism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pahtogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is becoming increasingly clear that large viruses (e.g. Vaccinia) and Listeria monocytogenes, share common strategies in invasion and intercellular spread.

Atlas of Material Worlds

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Publisher : Routledge
ISBN 13 : 1000404641
Total Pages : 220 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Atlas of Material Worlds by : Matthew Seibert

Download or read book Atlas of Material Worlds written by Matthew Seibert and published by Routledge. This book was released on 2021-08-17 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Material Worlds is a highly designed narrative atlas illustrating the agency of nonliving materials with unique, ubiquitous, and often hidden influence on our daily lives. Employing new materialism as a jumping-off point, it examines the increasingly blurry lines between the organic and inorganic, engaging the following questions: What roles do nonliving materials play? Might a closer examination of those roles reveal an undeniable agency we have long overlooked or disregarded? If so, does this material agency change our understanding of the social structures, ecologies, economies, cosmologies, technologies, and landscapes that surround us? And, perhaps most importantly, why does material agency matter? This is the story of the world’s driest nonpolar desert, pink flamingos, and cerulean blue lithium ponds; industrial shipping logistics, pudding-like jiggling substrates, and monuments of mud; galactic bodies, radioactive sheep, and the yellowcake of uranium. Put simply, this book dares readers to see the world anew, from material up. Atlas of Material Worlds offers this new relationship to our host environment in a time of mounting crises—accelerating climate change, ballooning socioeconomic inequality, and rising toxic nationalism—uniquely telling materialist stories for practitioners and students in landscape, architecture, and other built environment disciplines.

Reviews of Environmental Contamination and Toxicology Volume 249

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Author :
Publisher : Springer
ISBN 13 : 3030201945
Total Pages : 210 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Reviews of Environmental Contamination and Toxicology Volume 249 by : Pim de Voogt

Download or read book Reviews of Environmental Contamination and Toxicology Volume 249 written by Pim de Voogt and published by Springer. This book was released on 2019-06-19 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.