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Methods Of Discovery
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Author :Andrew Delano Abbott Publisher :W W Norton & Company Incorporated ISBN 13 :9780393978148 Total Pages :281 pages Book Rating :4.9/5 (781 download)
Book Synopsis Methods of Discovery by : Andrew Delano Abbott
Download or read book Methods of Discovery written by Andrew Delano Abbott and published by W W Norton & Company Incorporated. This book was released on 2004 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abbott helps social science students discover what questions to ask. This exciting book is not about habits and the mechanics of doing social science research, but about habits of thinking that enable students to use those mechanics in new ways, by coming up with new ideas and combining them more effectively with old ones. Abbott organizes his book around general methodological moves, and uses examples from throughout the social sciences to show how these moves can open new lines of thinking. In each chapter, he covers several moves and their reverses (if these exist), discussing particular examples of the move as well as its logical and theoretical structure. Often he goes on to propose applications of the move in a wide variety of empirical settings. The basic aim of Methods of Discovery is to offer readers a new way of thinking about directions for their research and new ways to imagine information relevant to their research problems. Methods of Discovery is part of the Contemporary Societies series.
Book Synopsis Models of Discovery by : Herbert A. Simon
Download or read book Models of Discovery written by Herbert A. Simon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: We respect Herbert A. Simon as an established leader of empirical and logical analysis in the human sciences while we happily think of him as also the loner; of course he works with many colleagues but none can match him. He has been writing fruitfully and steadily for four decades in many fields, among them psychology, logic, decision theory, economics, computer science, management, production engineering, information and control theory, operations research, confirmation theory, and we must have omitted several. With all of them, he is at once the technical scientist and the philosophical critic and analyst. When writing of decisions and actions, he is at the interface of philosophy of science, decision theory, philosophy of the specific social sciences, and inventory theory (itself, for him, at the interface of economic theory, production engineering and information theory). When writing on causality, he is at the interface of methodology, metaphysics, logic and philosophy of physics, systems theory, and so on. Not that the interdisciplinary is his orthodoxy; we are delighted that he has chosen to include in this book both his early and little-appreciated treatment of straightforward philosophy of physics - the axioms of Newtonian mechanics, and also his fine papers on pure confirmation theory.
Book Synopsis Data Mining Methods for Knowledge Discovery by : Krzysztof J. Cios
Download or read book Data Mining Methods for Knowledge Discovery written by Krzysztof J. Cios and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Mining Methods for Knowledge Discovery provides an introduction to the data mining methods that are frequently used in the process of knowledge discovery. This book first elaborates on the fundamentals of each of the data mining methods: rough sets, Bayesian analysis, fuzzy sets, genetic algorithms, machine learning, neural networks, and preprocessing techniques. The book then goes on to thoroughly discuss these methods in the setting of the overall process of knowledge discovery. Numerous illustrative examples and experimental findings are also included. Each chapter comes with an extensive bibliography. Data Mining Methods for Knowledge Discovery is intended for senior undergraduate and graduate students, as well as a broad audience of professionals in computer and information sciences, medical informatics, and business information systems.
Book Synopsis Drug Discovery Strategies and Methods by : Alexandros Makriyannis
Download or read book Drug Discovery Strategies and Methods written by Alexandros Makriyannis and published by CRC Press. This book was released on 2003-11-04 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
Book Synopsis Target Discovery and Validation by : Alleyn T. Plowright
Download or read book Target Discovery and Validation written by Alleyn T. Plowright and published by John Wiley & Sons. This book was released on 2020-02-18 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
Book Synopsis Modern Methods of Drug Discovery by : Alexander Hillisch
Download or read book Modern Methods of Drug Discovery written by Alexander Hillisch and published by Springer Science & Business Media. This book was released on 2002-12-11 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
Author :American Bar Association. House of Delegates Publisher :American Bar Association ISBN 13 :9781590318737 Total Pages :216 pages Book Rating :4.3/5 (187 download)
Book Synopsis Model Rules of Professional Conduct by : American Bar Association. House of Delegates
Download or read book Model Rules of Professional Conduct written by American Bar Association. House of Delegates and published by American Bar Association. This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.
Book Synopsis California Deposition and Discovery Practice by : J. N. DeMeo
Download or read book California Deposition and Discovery Practice written by J. N. DeMeo and published by . This book was released on 2011 with total page 1338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Knowledge Discovery Process and Methods to Enhance Organizational Performance by : Kweku-Muata Osei-Bryson
Download or read book Knowledge Discovery Process and Methods to Enhance Organizational Performance written by Kweku-Muata Osei-Bryson and published by CRC Press. This book was released on 2015-03-16 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the terms "data mining" and "knowledge discovery and data mining" (KDDM) are sometimes used interchangeably, data mining is actually just one step in the KDDM process. Data mining is the process of extracting useful information from data, while KDDM is the coordinated process of understanding the business and mining the data in order to identify previously unknown patterns. Knowledge Discovery Process and Methods to Enhance Organizational Performance explains the knowledge discovery and data mining (KDDM) process in a manner that makes it easy for readers to implement. Sharing the insights of international KDDM experts, it details powerful strategies, models, and techniques for managing the full cycle of knowledge discovery projects. The book supplies a process-centric view of how to implement successful data mining projects through the use of the KDDM process. It discusses the implications of data mining including security, privacy, ethical and legal considerations. Provides an introduction to KDDM, including the various models adopted in academia and industry Details critical success factors for KDDM projects as well as the impact of poor quality data or inaccessibility to data on KDDM projects Proposes the use of hybrid approaches that couple data mining with other analytic techniques (e.g., data envelopment analysis, cluster analysis, and neural networks) to derive greater value and utility Demonstrates the applicability of the KDDM process beyond analytics Shares experiences of implementing and applying various stages of the KDDM process in organizations The book includes case study examples of KDDM applications in business and government. After reading this book, you will understand the critical success factors required to develop robust data mining objectives that are in alignment with your organization’s strategic business objectives.
Book Synopsis Drug Design and Discovery by : Seetharama D. Satyanarayanajois
Download or read book Drug Design and Discovery written by Seetharama D. Satyanarayanajois and published by Humana Press. This book was released on 2011-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Protocols, leading experts provide an in-depth view of key protocols that are commonly used in drug discovery laboratories. Covering both classic and cutting-edge techniques, this volume explores computational docking, quantitative structure-activity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNA-microarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and accessible, Drug Design and Discovery: Methods and Protocols serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.
Book Synopsis Small Molecule Drug Discovery by : Andrea Trabocchi
Download or read book Small Molecule Drug Discovery written by Andrea Trabocchi and published by Elsevier. This book was released on 2019-11-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. - Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery - Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics - Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches - Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Book Synopsis Knowledge Discovery in the Social Sciences by : Xiaoling Shu
Download or read book Knowledge Discovery in the Social Sciences written by Xiaoling Shu and published by University of California Press. This book was released on 2020-02-04 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge Discovery in the Social Sciences helps readers find valid, meaningful, and useful information. It is written for researchers and data analysts as well as students who have no prior experience in statistics or computer science. Suitable for a variety of classes—including upper-division courses for undergraduates, introductory courses for graduate students, and courses in data management and advanced statistical methods—the book guides readers in the application of data mining techniques and illustrates the significance of newly discovered knowledge. Readers will learn to: • appreciate the role of data mining in scientific research • develop an understanding of fundamental concepts of data mining and knowledge discovery • use software to carry out data mining tasks • select and assess appropriate models to ensure findings are valid and meaningful • develop basic skills in data preparation, data mining, model selection, and validation • apply concepts with end-of-chapter exercises and review summaries
Author :Evangelos Triantaphyllou Publisher :Springer Science & Business Media ISBN 13 :144191630X Total Pages :371 pages Book Rating :4.4/5 (419 download)
Book Synopsis Data Mining and Knowledge Discovery via Logic-Based Methods by : Evangelos Triantaphyllou
Download or read book Data Mining and Knowledge Discovery via Logic-Based Methods written by Evangelos Triantaphyllou and published by Springer Science & Business Media. This book was released on 2010-06-08 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of having ef cient and effective methods for data mining and kn- ledge discovery (DM&KD), to which the present book is devoted, grows every day and numerous such methods have been developed in recent decades. There exists a great variety of different settings for the main problem studied by data mining and knowledge discovery, and it seems that a very popular one is formulated in terms of binary attributes. In this setting, states of nature of the application area under consideration are described by Boolean vectors de ned on some attributes. That is, by data points de ned in the Boolean space of the attributes. It is postulated that there exists a partition of this space into two classes, which should be inferred as patterns on the attributes when only several data points are known, the so-called positive and negative training examples. The main problem in DM&KD is de ned as nding rules for recognizing (cl- sifying) new data points of unknown class, i. e. , deciding which of them are positive and which are negative. In other words, to infer the binary value of one more attribute, called the goal or class attribute. To solve this problem, some methods have been suggested which construct a Boolean function separating the two given sets of positive and negative training data points.
Book Synopsis Basic Principles of Drug Discovery and Development by : Benjamin E. Blass
Download or read book Basic Principles of Drug Discovery and Development written by Benjamin E. Blass and published by Academic Press. This book was released on 2021-03-30 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
Book Synopsis Fragment-Based Drug Discovery by : Edward R. Zartler
Download or read book Fragment-Based Drug Discovery written by Edward R. Zartler and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.
Book Synopsis Teaching Children Science by : Donald A. DeRosa
Download or read book Teaching Children Science written by Donald A. DeRosa and published by . This book was released on 2019 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOTE: Used books, rentals, and purchases made outside of Pearson If purchasing or renting from companies other than Pearson, the access codes for the Enhanced Pearson eText may not be included, may be incorrect, or may be previously redeemed. Check with the seller before completing your purchase. This package includes the Enhanced Pearson eText. Provide the pedagogical and content knowledge needed to teach elementary school students science and scientific ways of thinking Teaching Children Science: A Discovery Approach encompasses everything pre-service elementary educators need to learn to effectively teach science to their students. Written in a clear, motivating style, this text helps aspiring elementary teachers become leaders who can inspire young children to experience science through the joys and challenges of inquiry and discovery. Additionally, six chapters devoted specifically to content knowledge in the areas of earth/space, life, and physical sciences provide readers with the foundations they will need as beginning science teachers. The 9th Edition further integrates the Next Generation Science Standards, new teaching vignettes, and engaging videos (in the Enhanced Pearson eText), in order to provide a realistic view of teaching science in today's classrooms. Improve mastery and retention with the Enhanced Pearson eText* The Enhanced Pearson eText provides a rich, interactive learning environment designed to improve student mastery of content with embedded videos and new self-check quizzes with feedback. The Enhanced Pearson eText is: Engaging. The new interactive, multimedia learning features were developed by the authors and other subject-matter experts to deepen and enrich the learning experience. Convenient. Enjoy instant online access from your computer or download the Pearson eText App to read on or offline on your iPad® and Android® tablet.** Affordable. Experience the advantages of the Enhanced Pearson eText along with all the benefits of print for 40% to 50% less than a print bound book. *The Enhanced eText features are only available in the Pearson eText format. They are not available in third-party eTexts or downloads. **The Pearson eText App is available on Google Play and in the App Store. It requires Android OS 3.1-4, a 7" or 10" tablet, or iPad iOS 5.0 or later. 0134691792 / 9780134691794 Teaching Children Science: A Discovery Approach, with Enhanced Pearson eText -- Access Card Package Package consists of: 0134742877 / 9780134742878 Teaching Children Science: A Discovery Approach 0134742931 / 9780134742939 Teaching Children Science: A Discovery Approach, Enhanced Pearson eText -- Access Card
Book Synopsis Bioinformatics and Drug Discovery by : Richard S. Larson
Download or read book Bioinformatics and Drug Discovery written by Richard S. Larson and published by Humana Press. This book was released on 2005-10-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
