Metalloenzymes

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The Coordination Chemistry of Metalloenzymes

Author : I. Bertini
Publisher : Springer Science & Business Media
ISBN 13 : 9789027715302
Total Pages : 426 pages
Book Rating : 4.7/5 (153 download)

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Book Synopsis The Coordination Chemistry of Metalloenzymes by : I. Bertini

Download or read book The Coordination Chemistry of Metalloenzymes written by I. Bertini and published by Springer Science & Business Media. This book was released on 1983-01-31 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling a program in bioinorganic chemistry that is scientifi cally relevant, well defined, and self-consistent is not an easy task. In this attempt we decided to consider zinc enzymes, copper oxidases, cytochromes and cytochrome oxidase. The choice is in part due to the great attention that the current specialized literature devotes to these topics, which are now debated among chemists, biochemists, biophysicists, etc .. We believe that hydration reactions, hydrolytic and oxidative processes have much in common from the point of view of the reaction mechanisms, the comprehension of which represents a frontier of science. For these reasons these topics have been the subject of the NATO-ASI held at San Miniato, Pisa, Italy, from May 28 to June 8, 1982. We hope we can transfer here the main conclusions of what (we believe) was a very stimulating scientific meeting. We would like to thank the local saving bank, Cassa di Risparmio di San Miniato, for helping in many ways. The financial contribution from the European Research Office of the US Army, and from the Bruker Spectrospin s.r.l., Italy, is also acknowledged. The National Science Foundation of the United States has provided a travel grant to one of the participants from the U.S.A. We are grateful to the NATO Scientific Affairs Division which provided a grant to finance this Institute.

Metalloenzymes

Author : Claudiu T. Supuran
Publisher : Elsevier
ISBN 13 : 0128242353
Total Pages : 636 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Metalloenzymes by : Claudiu T. Supuran

Download or read book Metalloenzymes written by Claudiu T. Supuran and published by Elsevier. This book was released on 2023-08-30 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application Features chapter contributions from international experts in the field

Artificial Metalloenzymes and MetalloDNAzymes in Catalysis

Author : Montserrat Diéguez
Publisher : John Wiley & Sons
ISBN 13 : 3527341781
Total Pages : 428 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis by : Montserrat Diéguez

Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-06-05 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Metalloenzymes: Potential Drug Targets

Author : Jamshed Iqbal
Publisher : Frontiers Media SA
ISBN 13 : 2889716279
Total Pages : 145 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Metalloenzymes: Potential Drug Targets by : Jamshed Iqbal

Download or read book Metalloenzymes: Potential Drug Targets written by Jamshed Iqbal and published by Frontiers Media SA. This book was released on 2021-11-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in the Development of Artificial Metalloenzymes

Author : Tatjana N. Parac-Vogt
Publisher : Frontiers Media SA
ISBN 13 : 2889631532
Total Pages : 167 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Advances in the Development of Artificial Metalloenzymes by : Tatjana N. Parac-Vogt

Download or read book Advances in the Development of Artificial Metalloenzymes written by Tatjana N. Parac-Vogt and published by Frontiers Media SA. This book was released on 2019-11-05 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactions catalyzed by metalloenzymes have great potential for applications in the biotechnology and pharmaceutical industries. While only a few of these enzymes have yet been used in such applications, in the last few decades numerous efficient, selective, environmentally friendly and economical synthetic analogues have been described, including supramolecular, polymeric, nanoparticulate and lowmolecular- weight organometallic complexes, and metal organic frameworks. In this Research Topic, we present a collection of original research and review articles that show significant recent advances made in the rational design of such artificial metalloenzymes.

Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases

Author : Peter M. H Kroneck
Publisher : Springer
ISBN 13 : 3319124153
Total Pages : 329 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases by : Peter M. H Kroneck

Download or read book Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases written by Peter M. H Kroneck and published by Springer. This book was released on 2015-02-23 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-15 provides an up-to-date review of the metalloenzymes involved in the activation, production, and conversion of molecular oxygen as well as the functionalization of the chemically inert gases methane and ammonia. Found either in aerobes (humans, animals, plants, microorganisms) or in anaerobes (so-called “impossible bacteria”) these enzymes employ preferentially iron and copper at their active sites, in order to conserve energy by redox-driven proton pumps, to convert methane to methanol, or ammonia to hydroxylamine or other compounds. When it comes to the light-driven production of molecular oxygen, the tetranuclear manganese cluster of photosystem II must be regarded as the key player. However, dioxygen can also be produced in the dark, by heme iron-dependent dismutation of oxyanions. Metalloenzymes Mastering Dioxygen and Other Chewy Gases is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry, and environmental biochemistry. All this is covered in an authoritative manner in 7 stimulating chapters, written by 21 internationally recognized experts, and supported by nearly 1100 references, informative tables, and over 140 illustrations (many in color). MILS-15 provides excellent information for teaching; it is also closely related to MILS-14, The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Peter M. H. Kroneck is a bioinorganic chemist who is exploring the role of transition metals in biology, with a focus on functional and structural aspects of microbial iron, copper, and molybdenum enzymes and their impact on the biogeochemical cyles of nitrogen and sulfur. Martha E. Sosa Torres is an inorganic chemist, with special interests in magnetic properties of newly synthesized transition metal complexes and their reactivity towards molecular oxygen, applying kinetic, electrochemical, and spectroscopic techniques.

Artificial Metalloenzymes and MetalloDNAzymes in Catalysis

Author : Montserrat Diéguez
Publisher : John Wiley & Sons
ISBN 13 : 3527804072
Total Pages : 1200 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis by : Montserrat Diéguez

Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Metalloenzymes in Denitrification

Author : Isabel Moura
Publisher : Royal Society of Chemistry
ISBN 13 : 1782623345
Total Pages : 468 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Metalloenzymes in Denitrification by : Isabel Moura

Download or read book Metalloenzymes in Denitrification written by Isabel Moura and published by Royal Society of Chemistry. This book was released on 2016-11-15 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reduction of nitrate to nitrogen by metalloenzymes is a vital step in the nitrogen cycle. The importance of this pathway has inspired efforts to understand in greater depth the mechanisms involved. This book presents and discusses the latest information on multiple aspects of denitrification. Written by recognized specialists in the field, this book describes the bioinorganic aspects and the key enzymes involved in denitrification, including their structure, function and mechanisms. Active site modelling, novel methodologies for monitoring denitrification in vivo and biotechnological methods for water treatment are discussed. The book also focusses on the environmental implications of denitrification, such nitrate accumulation and the release of nitrous oxide into the atmosphere from excessive fertiliser use. An important topic in many biological, environmental and agricultural contexts, this book will aid teaching and help bioinorganic chemists and biotechnologists gain an up-to-date picture of the science behind the denitrification process.

High Resolution EPR

Author : Graeme Hanson
Publisher : Springer Science & Business Media
ISBN 13 : 0387848568
Total Pages : 666 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis High Resolution EPR by : Graeme Hanson

Download or read book High Resolution EPR written by Graeme Hanson and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.

Encyclopedia of Geobiology

Author : Joachim Reitner
Publisher : Springer
ISBN 13 : 9781402092138
Total Pages : 927 pages
Book Rating : 4.0/5 (921 download)

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Book Synopsis Encyclopedia of Geobiology by : Joachim Reitner

Download or read book Encyclopedia of Geobiology written by Joachim Reitner and published by Springer. This book was released on 2011-03-10 with total page 927 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between Geology and Biology has shaped the Earth from the early Precambrian, 4 billion years ago. Moving beyond the borders of the classical core disciplines, Geobiology strives to identify chains of cause-and-effect and synergisms between the geo- and the biospheres that have been driving the evolution of life in modern and ancient environments. Combining modern methods, geobiological information can be extracted not only from visible remains of organisms, but also from organic molecules, rock fabrics, minerals, isotopes and other tracers. An understanding of these processes and their signatures reveals enormous applied potentials with respect to issues of environment protection, public health, energy and resource management. The Encyclopedia of Geobiology has been designed to act as a key reference for students, researchers, teachers, and the informed public and to provide basic, but comprehensible knowledge on this rapidly expanding discipline that sits at the interface between modern geo- and biosciences.

Chemistry of Metalloproteins

Author : Joseph J. Stephanos
Publisher : John Wiley & Sons
ISBN 13 : 1118801520
Total Pages : 448 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Chemistry of Metalloproteins by : Joseph J. Stephanos

Download or read book Chemistry of Metalloproteins written by Joseph J. Stephanos and published by John Wiley & Sons. This book was released on 2014-07-22 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Metalloenzymes with Carboxamido N-metal and Thiolato S-metal Bonds

Author : Todd Christopher Harrop
Publisher :
ISBN 13 :
Total Pages : 930 pages
Book Rating : 4.:/5 (71 download)

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Book Synopsis Metalloenzymes with Carboxamido N-metal and Thiolato S-metal Bonds by : Todd Christopher Harrop

Download or read book Metalloenzymes with Carboxamido N-metal and Thiolato S-metal Bonds written by Todd Christopher Harrop and published by . This book was released on 2004 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Models of Manganese Metalloenzymes

Author : Eduardo Libby
Publisher :
ISBN 13 :
Total Pages : 428 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Chemical Models of Manganese Metalloenzymes by : Eduardo Libby

Download or read book Chemical Models of Manganese Metalloenzymes written by Eduardo Libby and published by . This book was released on 1990 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Application of X-ray Absorption Spectroscopy to O2-reactive Metalloenzymes and Inorganic Complexes

Author : Jennifer Lynn Marie DuBois
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Application of X-ray Absorption Spectroscopy to O2-reactive Metalloenzymes and Inorganic Complexes by : Jennifer Lynn Marie DuBois

Download or read book Application of X-ray Absorption Spectroscopy to O2-reactive Metalloenzymes and Inorganic Complexes written by Jennifer Lynn Marie DuBois and published by . This book was released on 2000 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inorganic Model Complexes of Manganese Metalloenzymes

Author : John Stanley Bashkin
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Inorganic Model Complexes of Manganese Metalloenzymes by : John Stanley Bashkin

Download or read book Inorganic Model Complexes of Manganese Metalloenzymes written by John Stanley Bashkin and published by . This book was released on 1988 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Evolution of Metalloenzymes, Metalloproteins, and Related Materials

Author : G. J. Leigh
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Evolution of Metalloenzymes, Metalloproteins, and Related Materials by : G. J. Leigh

Download or read book The Evolution of Metalloenzymes, Metalloproteins, and Related Materials written by G. J. Leigh and published by . This book was released on 1977 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Spectroscopic and Computational Studies of Metal-thiolate Interactions in Metalloenzymes and Related Model Complexes

Author : Adam T. Fiedler
Publisher :
ISBN 13 :
Total Pages : 548 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Spectroscopic and Computational Studies of Metal-thiolate Interactions in Metalloenzymes and Related Model Complexes by : Adam T. Fiedler

Download or read book Spectroscopic and Computational Studies of Metal-thiolate Interactions in Metalloenzymes and Related Model Complexes written by Adam T. Fiedler and published by . This book was released on 2006 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: