Metal Ions And Neurodengenerative Disorders

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Metal Ions and Neurodegenerative Disorders

Author : Paolo Zatta
Publisher : World Scientific
ISBN 13 : 9789812796691
Total Pages : 546 pages
Book Rating : 4.7/5 (966 download)

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Book Synopsis Metal Ions and Neurodegenerative Disorders by : Paolo Zatta

Download or read book Metal Ions and Neurodegenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."

Metal Ions And Neurodengenerative Disorders

Author : Paolo Zatta
Publisher : World Scientific
ISBN 13 : 9814485764
Total Pages : 538 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Metal Ions And Neurodengenerative Disorders by : Paolo Zatta

Download or read book Metal Ions And Neurodengenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003-11-03 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on “Metals and the Brain: From Neurochemistry to Neurodegeneration” (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.

Neurodegenerative Diseases and Metal Ions

Author : Astrid Sigel
Publisher : Wiley
ISBN 13 : 9780470014882
Total Pages : 488 pages
Book Rating : 4.0/5 (148 download)

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Book Synopsis Neurodegenerative Diseases and Metal Ions by : Astrid Sigel

Download or read book Neurodegenerative Diseases and Metal Ions written by Astrid Sigel and published by Wiley. This book was released on 2006-05-12 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Neurodegenerative Diseases and Metal Ions

Author : Astrid Sigel
Publisher : John Wiley & Sons
ISBN 13 : 0470028106
Total Pages : 488 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Neurodegenerative Diseases and Metal Ions by : Astrid Sigel

Download or read book Neurodegenerative Diseases and Metal Ions written by Astrid Sigel and published by John Wiley & Sons. This book was released on 2006-07-11 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Metal Ions in Neurological Systems

Author : Wolfgang Linert
Publisher : Springer Science & Business Media
ISBN 13 : 3709110009
Total Pages : 247 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Metal Ions in Neurological Systems by : Wolfgang Linert

Download or read book Metal Ions in Neurological Systems written by Wolfgang Linert and published by Springer Science & Business Media. This book was released on 2012-08 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.

Metal-Based Neurodegeneration

Author : Robert Crichton
Publisher : John Wiley & Sons
ISBN 13 : 1118553519
Total Pages : 628 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Metal-Based Neurodegeneration by : Robert Crichton

Download or read book Metal-Based Neurodegeneration written by Robert Crichton and published by John Wiley & Sons. This book was released on 2013-09-04 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

Neurodegenerative Diseases and Metal Ions

Author : Astrid Sigel
Publisher : John Wiley & Sons
ISBN 13 : 9780470014882
Total Pages : 463 pages
Book Rating : 4.0/5 (148 download)

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Book Synopsis Neurodegenerative Diseases and Metal Ions by : Astrid Sigel

Download or read book Neurodegenerative Diseases and Metal Ions written by Astrid Sigel and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Metallochemistry of Neurodegeneration

Author : Henryk Kozlowski
Publisher : Royal Society of Chemistry
ISBN 13 : 1847555314
Total Pages : 295 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Metallochemistry of Neurodegeneration by : Henryk Kozlowski

Download or read book Metallochemistry of Neurodegeneration written by Henryk Kozlowski and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer's, Parkinson's and prion diseases. Written by leading experts in their fields, each chapter combines elements of genetics, biochemistry and biological inorganic chemistry in its discussion. The book highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis. This book will appeal to both chemists and biologists at the post graduate and research level.

Metal Ions in Neurodegenerative Diseases

Author : Christelle Hureau
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.:/5 (932 download)

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Book Synopsis Metal Ions in Neurodegenerative Diseases by : Christelle Hureau

Download or read book Metal Ions in Neurodegenerative Diseases written by Christelle Hureau and published by . This book was released on 2012 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metal-based Neurodegeneration

Author : Robert Crichton
Publisher : Wiley
ISBN 13 : 9780470022559
Total Pages : 248 pages
Book Rating : 4.0/5 (225 download)

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Book Synopsis Metal-based Neurodegeneration by : Robert Crichton

Download or read book Metal-based Neurodegeneration written by Robert Crichton and published by Wiley. This book was released on 2006 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

Metals and Oxidative Damage in Neurological Disorders

Author : James R. Connor
Publisher : Springer Science & Business Media
ISBN 13 : 1489901973
Total Pages : 383 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Metals and Oxidative Damage in Neurological Disorders by : James R. Connor

Download or read book Metals and Oxidative Damage in Neurological Disorders written by James R. Connor and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate gies in neurological disorders.

Mechanisms and Metal Involvement in Neurodegenerative Diseases

Author : Roberta Ward
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735891
Total Pages : 235 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Mechanisms and Metal Involvement in Neurodegenerative Diseases by : Roberta Ward

Download or read book Mechanisms and Metal Involvement in Neurodegenerative Diseases written by Roberta Ward and published by Royal Society of Chemistry. This book was released on 2013-07-18 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dementia and neurodegenerative diseases such as Parkinson’s and Alzheimer’s are becoming an increasingly important cause of medical and social concern due to the growth in the ageing population. Mechanisms and Metal Involvement in Neurodegenerative Diseases delivers in one volume a streamlined source of information on each of the main neurodegenerative diseases including mild cognitive impairment, Parkinson's, Alzheimer's, Freiderich's ataxia, prion disease, multiple sclerosis and alcoholic brain damage. Each chapter is structured to give the definition of disease, proteins involved with structure of normal protein and abnormal proteins, pathology associated with the abnormal proteins, oxidative stress and inflammation, iron homeostatic mechanisms, primary neurotransmitter involved, other metal involvement and therapeutic strategies. Structures of the adherent protein involved in the disease process are also presented with emphasis on the chemical structures used in the treatment of each neurodegenerative disease together with their biochemical mode of action. Written by acknowledged experts in their respective areas this new book provides readers with readily accessible information on each of the neurodegenerative diseases.

Interrelations between Essential Metal Ions and Human Diseases

Author : Astrid Sigel
Publisher : Springer Science & Business Media
ISBN 13 : 9400775008
Total Pages : 603 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interrelations between Essential Metal Ions and Human Diseases by : Astrid Sigel

Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Brain Diseases and Metalloproteins

Author : David R. Brown
Publisher : CRC Press
ISBN 13 : 9814316016
Total Pages : 440 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Brain Diseases and Metalloproteins by : David R. Brown

Download or read book Brain Diseases and Metalloproteins written by David R. Brown and published by CRC Press. This book was released on 2012-08-07 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

Metal Related Neurodegenerative Disease

Author :
Publisher : Academic Press
ISBN 13 : 0124105351
Total Pages : 443 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Metal Related Neurodegenerative Disease by :

Download or read book Metal Related Neurodegenerative Disease written by and published by Academic Press. This book was released on 2013-11-07 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders An update on advances in neuroimaging and pathology of metal related disease is also presented

Metals and Neurodegeneration: Restoring the Balance

Author : Anthony R. White
Publisher : Frontiers Media SA
ISBN 13 : 2889197395
Total Pages : 134 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Metals and Neurodegeneration: Restoring the Balance by : Anthony R. White

Download or read book Metals and Neurodegeneration: Restoring the Balance written by Anthony R. White and published by Frontiers Media SA. This book was released on 2016-02-02 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.

Alzheimer's Disease

Author : Thimmaiah Govindaraju
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162740
Total Pages : 531 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Alzheimer's Disease by : Thimmaiah Govindaraju

Download or read book Alzheimer's Disease written by Thimmaiah Govindaraju and published by Royal Society of Chemistry. This book was released on 2022-01-04 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.