Metabolomics In Neurodegenerative Disease

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Metabolomics in Neurodegenerative Disease

Author : Brian Green
Publisher : MDPI
ISBN 13 : 3039280406
Total Pages : 184 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Metabolomics in Neurodegenerative Disease by : Brian Green

Download or read book Metabolomics in Neurodegenerative Disease written by Brian Green and published by MDPI. This book was released on 2020-04-21 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease.

Metabolomics in Neurodegenerative Disease

Author : Brian Green
Publisher :
ISBN 13 : 9783039280414
Total Pages : 184 pages
Book Rating : 4.2/5 (84 download)

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Book Synopsis Metabolomics in Neurodegenerative Disease by : Brian Green

Download or read book Metabolomics in Neurodegenerative Disease written by Brian Green and published by . This book was released on 2020 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease.

Mass Spectrometry-Based Metabolomics: Platform Development and Application to Neurodegenerative Disease

Author : He Huang
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (114 download)

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Book Synopsis Mass Spectrometry-Based Metabolomics: Platform Development and Application to Neurodegenerative Disease by : He Huang

Download or read book Mass Spectrometry-Based Metabolomics: Platform Development and Application to Neurodegenerative Disease written by He Huang and published by . This book was released on 2017 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolites are small molecules that participate in critical cellular processes that include energy production, macromolecules biosynthesis, and signaling pathways. Metabolic dysregulation is associated with changes in homeostasis and disease pathology. Measuring metabolite changes at the sites of tissue dysfunction can reveal new mechanisms that could serve as therapeutic targets and aid in the biomarker discovery. In this dissertation, we develop an untargeted metabolomic platform based on tandem mass spectrometry (TripleTOF 5600+, SCIEX). The platform consists of: hydrophilic interaction chromatography - mass spectrometry (HILIC-MS) to separate and detect polar metabolites and direct infusion-based based shotgun lipidomics. The platform allows global metabolic profiling in approximately thirty minutes. Three neurodegenerative diseases, including multiple sclerosis, normal pressure hydrocephalus (NPH), and Chiari malformation type I (CMI) are examined by this platform. First, dimethyl fumarate (DMF) treated oligodendrocytes are examined to provide mechanistic insight into potential neuroprotective pathways that may be upregulated by this treatment. Results indicate DMF alters levels of intermediates in the citric acid cycle to induce antioxidant responses in oligodendrocytes. Secondly, cerebrospinal fluid (CSF) samples were collected longitudinally from NPH patients following moderate exercise in order to elucidate pathological mechanisms of this disease as well as categorize potential biomarkers of treatment response. The results indicate that moderate exercise induces changes in CSF metabolites in NPH patient. These metabolic alterations are associated with the levels of vascular endothelial growth factor (VEGF) and patient clinical responses to shunting. Finally, both CSF and serum metabolites of CMI are investigated. Neurotransmitter and neuropeptide alterations were found to be associated with CMI. These results suggest that alterations in neurotransmission might underlie symptoms such as pain in this disorder. In this dissertation, unique metabolic alterations are detected by the untargeted metabolomic platform and suggest novel pathways that might be further examined as therapeutic interventions to alleviate neurological symptoms and promote CNS regeneration.

Metabolomics in Health and Disease Biology

Author :
Publisher : Elsevier
ISBN 13 : 0443137269
Total Pages : 248 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Metabolomics in Health and Disease Biology by :

Download or read book Metabolomics in Health and Disease Biology written by and published by Elsevier. This book was released on 2024-02-26 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. - Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions - Provides the latest insights into our understanding of diseases using metabolomics-based approaches - Includes graphical material for metabolomics application that provide useful information for ease of reading of audience

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines

Author : Aihua Zhang
Publisher : John Wiley & Sons
ISBN 13 : 3527835741
Total Pages : 292 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines by : Aihua Zhang

Download or read book Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines written by Aihua Zhang and published by John Wiley & Sons. This book was released on 2021-08-20 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Mechanism and Pharmacodynamic Material Basis of Neurodegenerative Disease Therapies

Author : Zhi Sun
Publisher : Frontiers Media SA
ISBN 13 : 2832531660
Total Pages : 168 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Mechanism and Pharmacodynamic Material Basis of Neurodegenerative Disease Therapies by : Zhi Sun

Download or read book Mechanism and Pharmacodynamic Material Basis of Neurodegenerative Disease Therapies written by Zhi Sun and published by Frontiers Media SA. This book was released on 2023-08-25 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are debilitating disorders defined as loss of function or progressive destructing structure of the nervous system with high prevalence among the aging population. These diseases mainly include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). They are significantly associated with age and degeneration, becoming a devastating global health issue as a result of the growth of mean life expectancy worldwide. Few or no effective treatments are available for age-related neurodegenerative diseases, causing large socioeconomic and personal costs. The last 15 years have seen a boom in the use and integration of “omic” approaches (such as genomic, transcriptomic, epigenomic and metabolomic techniques) to study neurodegenerative disease in an unprecedented way. While, to date, no therapy based on these approaches is available to cure neurodegenerative diseases. Therefore, it is necessary to search for new, safe, and effective drug candidates and treatment strategies. In this Research Topic, our prime focus would be on the use and integration of “omic” approaches to study biomarkers, pathogenesis, disease progression and new therapeutic target of neurodegenerative diseases, so as to search for new, safe, and effective drug candidates.

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders

Author : Paul C. Guest
Publisher : Springer
ISBN 13 : 3030055426
Total Pages : 328 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders by : Paul C. Guest

Download or read book Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders written by Paul C. Guest and published by Springer. This book was released on 2019-02-12 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Establishing Parameters for the Characterization of Rare Neurometabolic and Neurodegenerative Diseases Using Mass-spectrometry Based Metabolomics

Download Establishing Parameters for the Characterization of Rare Neurometabolic and Neurodegenerative Diseases Using Mass-spectrometry Based Metabolomics PDF Online Free

Author : Henry Gerd Klemp
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (127 download)

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Book Synopsis Establishing Parameters for the Characterization of Rare Neurometabolic and Neurodegenerative Diseases Using Mass-spectrometry Based Metabolomics by : Henry Gerd Klemp

Download or read book Establishing Parameters for the Characterization of Rare Neurometabolic and Neurodegenerative Diseases Using Mass-spectrometry Based Metabolomics written by Henry Gerd Klemp and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead to neuropediatric, neurometabolic, and neurodegenerative disorders. The high diversity of disorders and widespread missing information hinder potentially life-saving diagnoses. While newborn screening successfully alleviated diagnostic problems for the most common rare disorders, the majority remain unstudied. Next-generation sequencing methods have led to a giant leap for...

Omic Studies of Neurodegenerative Disease - Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128047631
Total Pages : 251 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Omic Studies of Neurodegenerative Disease - Part B by :

Download or read book Omic Studies of Neurodegenerative Disease - Part B written by and published by Academic Press. This book was released on 2015-11-23 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research. Provides the expertise of leading contributors in the field Demonstrates how findings in the fields of genomics, proteomics, and metabolomic studies can combined for further insights Informs the reader on the current state of the studies used to study the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Metabolic Alterations in Neurodegenerative Disorders

Author : David Baglietto-Vargas
Publisher : Frontiers Media SA
ISBN 13 : 2889746720
Total Pages : 173 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Metabolic Alterations in Neurodegenerative Disorders by : David Baglietto-Vargas

Download or read book Metabolic Alterations in Neurodegenerative Disorders written by David Baglietto-Vargas and published by Frontiers Media SA. This book was released on 2022-03-14 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases

Author : Namita Agrawal
Publisher : Springer Nature
ISBN 13 : 9819742889
Total Pages : 442 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases by : Namita Agrawal

Download or read book Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases written by Namita Agrawal and published by Springer Nature. This book was released on with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Metabolomics 2018

Author : Paula Guedes De Pinho
Publisher : MDPI
ISBN 13 : 3039213458
Total Pages : 184 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Cancer Metabolomics 2018 by : Paula Guedes De Pinho

Download or read book Cancer Metabolomics 2018 written by Paula Guedes De Pinho and published by MDPI. This book was released on 2019-09-03 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Neurodegenerative and Metabolomic Impact of Genetic Elimination of the Orphan Metallo [beta]-lactamase, SWIP-10/MBLAC1

Author : Chelsea Lynne Gibson
Publisher :
ISBN 13 :
Total Pages : 295 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Neurodegenerative and Metabolomic Impact of Genetic Elimination of the Orphan Metallo [beta]-lactamase, SWIP-10/MBLAC1 by : Chelsea Lynne Gibson

Download or read book Neurodegenerative and Metabolomic Impact of Genetic Elimination of the Orphan Metallo [beta]-lactamase, SWIP-10/MBLAC1 written by Chelsea Lynne Gibson and published by . This book was released on 2018 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Natural Products as a Source of New Therapies for Neurodegenerative Disease and Efforts Toward the Development of a Metabolomics-based Drug Discovery Platform

Download Natural Products as a Source of New Therapies for Neurodegenerative Disease and Efforts Toward the Development of a Metabolomics-based Drug Discovery Platform PDF Online Free

Author : Phillip Matthew Joyner
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.:/5 (652 download)

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Book Synopsis Natural Products as a Source of New Therapies for Neurodegenerative Disease and Efforts Toward the Development of a Metabolomics-based Drug Discovery Platform by : Phillip Matthew Joyner

Download or read book Natural Products as a Source of New Therapies for Neurodegenerative Disease and Efforts Toward the Development of a Metabolomics-based Drug Discovery Platform written by Phillip Matthew Joyner and published by . This book was released on 2010 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Understanding PTMs in Neurodegenerative Diseases

Author : Victor Corasolla Carregari
Publisher : Springer Nature
ISBN 13 : 3031054601
Total Pages : 150 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Understanding PTMs in Neurodegenerative Diseases by : Victor Corasolla Carregari

Download or read book Understanding PTMs in Neurodegenerative Diseases written by Victor Corasolla Carregari and published by Springer Nature. This book was released on 2022-08-27 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs.

Mass Spectrometry Based Metabolomics for Biomarkers of Parkinson's Disease

Author : Hemi Luan
Publisher :
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Mass Spectrometry Based Metabolomics for Biomarkers of Parkinson's Disease by : Hemi Luan

Download or read book Mass Spectrometry Based Metabolomics for Biomarkers of Parkinson's Disease written by Hemi Luan and published by . This book was released on 2017 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: In summary, metabolomics study has its inherent advantage in the characterization of biomarkers for the development of PD and may bring new scientific knowledge as well as impact on the progression of PD and other related neurodegenerative diseases.