Author : Sandhya A. M
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.2/5 (11 download)
Book Synopsis Metabolic Perturbations in Type Two Diabetes During Ramadan Fasting by : Sandhya A. M
Download or read book Metabolic Perturbations in Type Two Diabetes During Ramadan Fasting written by Sandhya A. M and published by . This book was released on 2022-03-19 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction The burst out of Diabetes mellitus over the past 30 years has transformed the disease into a major cause of morbidity and mortality from the simple the tag of a mild disorder of elderly. In countries like India where major population belong to low- and middle-income group, the complete society is all the time more affected by the disease (Whiting et al., 2011). Diabetes mellitus is a chronic condition of multifactorial hyperglycemia with or without excretion of glucose through urine. This deadly disease is known to the mankind since pre-historic era. The etiologies for the rise in blood glucose range from autoimmune destruction of pancreatic beta cell to idiopathic. The key pathophysiology behind the hyperglycemia is the deficiency of insulin or defective response to insulin by tissues. The metabolic alterations in diabetes mellitus over years infuriate the functioning of various organs like heart, brain, kidney, retina, lens, vascular system, peripheral nerves and often compromise the quality and longevity of life (American Diabetes Association, 2010). Diabetes mellitus, which was previously considered as single disease, now recognized as a group of disorders and encompasses several types. The most important and common classes of diabetes mellitus are type 1 and type 2. In this Type 1 commonly turns out due to absolute or relative deficiency in insulin secretion as the pancreatic cells are defective. Type 2 diabetes mellitus is a nonautoimmune disease characterized by an elevation in the blood glucose level by a relative deficiency in insulin secretion or insulin resistance (American Diabetes Association, 2015). 1.1 DISARRANGEMENT OF CIRCADIAN RHYTHM - A MAJOR RISK FACTOR FOR TYPE 2 DIABETES MELLITUS Circadian clocks are endogenous oscillators which regulate daily rhythms in normal physiology, metabolism and behavior. In mammals, the suprachiasmatic nucleus (SCN) of hypothalamus is the area where the circadian clock is located,