Metabolic Activation Of Polynuclear Aromatic Hydrocarbons

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The Carcinogenic Effects Of Polycyclic Aromatic Hydrocarbons

Author : Andreas Luch
Publisher : World Scientific
ISBN 13 : 1783260874
Total Pages : 514 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis The Carcinogenic Effects Of Polycyclic Aromatic Hydrocarbons by : Andreas Luch

Download or read book The Carcinogenic Effects Of Polycyclic Aromatic Hydrocarbons written by Andreas Luch and published by World Scientific. This book was released on 2005-08-22 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.

Toxicological Profile for Polycyclic Aromatic Hydrocarbons

Author :
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Polycyclic Aromatic Hydrocarbons by :

Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Adducts

Author : International Agency for Research on Cancer
Publisher : World Health Organization
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis DNA Adducts by : International Agency for Research on Cancer

Download or read book DNA Adducts written by International Agency for Research on Cancer and published by World Health Organization. This book was released on 1994 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first and only handbook to provide a comprehensive review of the critical intermediates in the first step of the process of carcinogenesis. This volume reviews current knowledge of DNA adducts formed by a wide range of classes of chemical compound, including the metabolism of chemicals, mechanisms of adduction, preparation and properties of standard compounds, adduct formation in vitro, measurements of adducts in humans, and biological significance. Additional chapters review our understanding of specific types of gene damage and mutagenecity and their reaction to cancer. This volume will provide invaluable, up-to-date facts for all researchers in mechanism of carcinogenesis, toxicology, and molecular epidemiology.

WHO Guidelines for Indoor Air Quality

Author :
Publisher : World Health Organization
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis WHO Guidelines for Indoor Air Quality by :

Download or read book WHO Guidelines for Indoor Air Quality written by and published by World Health Organization. This book was released on 2010 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

Metabolic Activation of Polynuclear Aromatic Hydrocarbons

Author : Wing-Sum Tsang
Publisher : Elsevier
ISBN 13 : 1483280675
Total Pages : 134 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Metabolic Activation of Polynuclear Aromatic Hydrocarbons by : Wing-Sum Tsang

Download or read book Metabolic Activation of Polynuclear Aromatic Hydrocarbons written by Wing-Sum Tsang and published by Elsevier. This book was released on 2014-05-09 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Activation of Polynuclear Aromatic Hydrocarbons deals with the metabolic activation of polynuclear aromatic hydrocarbons and covers topics ranging from the cytotoxic, mutagenic, and carcinogenic effects of arene oxides to the role of secondary metabolites as ultimate carcinogens. The mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites is also discussed. This book begins with a brief review of the early work on the mechanism of chemical carcinogenesis by polynuclear hydrocarbons, followed by a detailed survey of pertinent literature in the field. The cytotoxic, mutagenic, and carcinogenic effects of arene oxides are analyzed, along with the solvolytic and nucleophilic reactions of benzo[a]pyrene (BaP) diol epoxides. The discussion then turns to the carcinogenicity, mutagenicity, and cytotoxicity of BaP metabolites; the "Bay-region" theory of carcinogenic activity and perturbational molecular orbital theory; and the mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites. Research on polycyclic aromatic hydrocarbons pertaining to the "Bay-region" theory is also presented. This monograph will be of interest to chemists, biochemists, and oncologists.

Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons

Author :
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons by :

Download or read book Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1993 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polycyclic Aromatic Hydrocarbons

Author : Kazuichi Hayakawa
Publisher : Springer
ISBN 13 : 9789811067747
Total Pages : 0 pages
Book Rating : 4.0/5 (677 download)

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Book Synopsis Polycyclic Aromatic Hydrocarbons by : Kazuichi Hayakawa

Download or read book Polycyclic Aromatic Hydrocarbons written by Kazuichi Hayakawa and published by Springer. This book was released on 2018-02-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews Polycyclic Aromatic Hydrocarbons (PAHs) and Nitropolycyclic Aromatic Hydrocarbons (NPAHs) contamination in the context of environmental pollution in Asia. It is comprised of the following sections: 1. Fundamental Chemistry and General Characteristics; 2. Analytical Methods; 3. Emission Source and Atmospheric Behavior; 4. Atmospheric Polycyclic Aromatic Hydrocarbons and PM2.5; 5. Polycyclic Aromatic Hydrocarbons in Marine Environments; 6. Metabolic Activation/Toxicities; and 7. Environmental Standards and Guidelines. This volume concentrates on the Far East due to the massive consumption of coal and petroleum in China, which has led to considerable levels of air pollution. High concentration of atmospheric PM2.5 in Beijing have been reported since January 2013 and exposure to such high concentrations may cause respiratory, cardiac and lung diseases. Gathering contributions from international experts, this volume provides a valuable reference guide for global researchers and students interested in learning from the East Asian experience.

Encyclopedic Reference of Immunotoxicology

Author : Hans-Werner Vohr
Publisher : Springer
ISBN 13 : 9783540441724
Total Pages : 0 pages
Book Rating : 4.4/5 (417 download)

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Book Synopsis Encyclopedic Reference of Immunotoxicology by : Hans-Werner Vohr

Download or read book Encyclopedic Reference of Immunotoxicology written by Hans-Werner Vohr and published by Springer. This book was released on 2005-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.

Bitumens and Bitumen Emissions, and Some N- and S-heterocyclic Polycyclic Aromatic Hydrocarbons

Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : World Health Organization
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Bitumens and Bitumen Emissions, and Some N- and S-heterocyclic Polycyclic Aromatic Hydrocarbons by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Bitumens and Bitumen Emissions, and Some N- and S-heterocyclic Polycyclic Aromatic Hydrocarbons written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2013 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides evaluations of the carcinogenicity of bitumens and their emissions, the N-heterocyclic polycyclic aromatic hydrocarbons benz[a]acridine, benz[c]acridine, dibenz[a,h]acridine, dibenz[a,j]acridine, dibenz[c,h]acridine, carbazole and 7H-dibenzo[c,g]carbazole, as well as the S-hetrocyclic polycyclic aromatic hydrocarbons benzo[b]naphtho[2,1-d]thiophene and dibenzothiophene. Bitumens are produced by distillation of crude oil during petroleum refining, and also occur naturally. Bitumens can be divided into six broad classes, according to their physical properties and specifications required for different applications. The major use (about 80%) of bitumens is for road paving; other uses include roofing, waterproofing, sealing and painting. The term "bitumen" should not be confused with "asphalt", which refers to the mixture of bitumen (4-10% by weight), small stones, sand and filler used for road paving. Bitumens are complex mixtures that contain a large number of organic chemical compounds. Application of bitumens may generate emissions (fumes and vapours) that may contain, among volatile and non-volatile compounds, a number of known or probable carcinogens. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of various occupations that entail exposure to bitumens and bitumen emissions, including road paving, roofing, and application of mastic asphalt, and to various heterocyclic polycyclic aromatic compounds.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Process-Induced Food Toxicants

Author : Richard H. Stadler
Publisher : John Wiley & Sons
ISBN 13 : 0470430095
Total Pages : 744 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Process-Induced Food Toxicants by : Richard H. Stadler

Download or read book Process-Induced Food Toxicants written by Richard H. Stadler and published by John Wiley & Sons. This book was released on 2008-12-09 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Process-Induced Food Toxicants combines the analytical, health, and risk management issues relating to all of the currently known processing-induced toxins that may be present in common foods. It considers the different processing methods used in the manufacture of foods, including thermal treatment, drying, fermentation, preservation, fat processing, and high hydrostatic pressure processing, and the potential contaminants for each method. The book discusses the analysis, formation, mitigation, health risks, and risk management of each hazardous compound. Also discussed are new technologies and the impact of processing on nutrients and allergens.

Tattooed Skin and Health

Author : J. Serup
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318027774
Total Pages : 270 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Tattooed Skin and Health by : J. Serup

Download or read book Tattooed Skin and Health written by J. Serup and published by Karger Medical and Scientific Publishers. This book was released on 2015-03-26 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: With about 10–20% of the adult population in Europe being tattooed, there is a strong demand for publications discussing the various issues related to tattooed skin and health. Until now, only a few scientific studies on tattooing have been published. This book discusses different aspects of the various medical risks associated with tattoos, such as allergic reactions from red tattoos, papulo-nodular reactions from black tattoos as well as technical and psycho-social complications, in addition to bacterial and viral infections. Further sections are dedicated to the composition of tattoo inks, and a case is made for the urgent introduction of national and international regulations. Distinguished authors, all specialists in their particular fields, have contributed to this publication which provides a comprehensive view of the health implications associated with tattooing. The book covers a broad range of topics that will be of interest to clinicians and nursing staff, toxicologists and regulators as well as laser surgeons who often face the challenge of having to remove tattoos, professional tattooists and producers of tattoo ink.

Reviews of Environmental Contamination and Toxicology Volume 237

Author : W.P. de Voogt
Publisher : Springer
ISBN 13 : 3319235737
Total Pages : 204 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Reviews of Environmental Contamination and Toxicology Volume 237 by : W.P. de Voogt

Download or read book Reviews of Environmental Contamination and Toxicology Volume 237 written by W.P. de Voogt and published by Springer. This book was released on 2015-11-27 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Environmental Carcinogens

Author : G. Grimmer
Publisher : CRC Press
ISBN 13 : 1351088653
Total Pages : 376 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Environmental Carcinogens by : G. Grimmer

Download or read book Environmental Carcinogens written by G. Grimmer and published by CRC Press. This book was released on 2018-01-18 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present survey comprises today‘s knowledge of environmental pollution in particular of the atmosphere by PAH and of the biological effects of this class of substance, putting special emphasis on their carcinogenic activity. The research data and conclusions derived therefrom are meant to assist the government of the Federal Republic of Germany in determining an air quality standard.

Polycyclic Hydrocarbons and Carcinogenesis

Author : Ronald G. Harvey
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Polycyclic Hydrocarbons and Carcinogenesis by : Ronald G. Harvey

Download or read book Polycyclic Hydrocarbons and Carcinogenesis written by Ronald G. Harvey and published by . This book was released on 1985 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.

Coal Tar Creosote

Author : C. Melber
Publisher : WHO
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Coal Tar Creosote by : C. Melber

Download or read book Coal Tar Creosote written by C. Melber and published by WHO. This book was released on 2004 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: On cover: IPCS International Programme on Chemical Safety. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-organization Programme for the Sound Management of Chemicals (IOMC)

Carcinogenesis

Author : Kathryn Tonissen
Publisher : BoD – Books on Demand
ISBN 13 : 9535109456
Total Pages : 332 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Carcinogenesis by : Kathryn Tonissen

Download or read book Carcinogenesis written by Kathryn Tonissen and published by BoD – Books on Demand. This book was released on 2013-01-23 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment. Animal models are particularly useful for evaluating therapeutic or chemopreventive agents and examples are presented. Finally, natural products that ether prevent or treat cancer are described. Together these topics will provide the reader with examples of the latest cutting edge research and discoveries, with the goal of stimulating further advances.