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Mesenchymal Stromal Cells As Tumor Stromal Modulators
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Book Synopsis Mesenchymal Stromal Cells as Tumor Stromal Modulators by : Marcela Bolontrade
Download or read book Mesenchymal Stromal Cells as Tumor Stromal Modulators written by Marcela Bolontrade and published by Academic Press. This book was released on 2016-10-24 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. - Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function - Discusses the bidirectional communication between tumor stroma and MSCs derived from bonemarrow, from adipose tissue and from other tissue types - Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression,such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges
Book Synopsis Mesenchymal Stem Cell Derived Exosomes by : Yaoliang Tang
Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Book Synopsis Early Osteoarthritis by : Christian Lattermann
Download or read book Early Osteoarthritis written by Christian Lattermann and published by Springer Nature. This book was released on 2021-10-09 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.
Book Synopsis Scientific Principles of Adipose Stem Cells by : Lauren Kokai
Download or read book Scientific Principles of Adipose Stem Cells written by Lauren Kokai and published by Academic Press. This book was released on 2021-08-19 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. - Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche - Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype - An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications
Book Synopsis Gynecologic and Urologic Pathology by : Maria Rosaria Raspollini
Download or read book Gynecologic and Urologic Pathology written by Maria Rosaria Raspollini and published by Cambridge University Press. This book was released on 2019-02-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the similarities and differences in the pathology of the genital and urinary tracts in males and females.
Download or read book Angiogenesis written by William D. Figg and published by Springer Science & Business Media. This book was released on 2008-05-24 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.
Book Synopsis Leong's Manual of Diagnostic Antibodies for Immunohistology by : Runjan Chetty
Download or read book Leong's Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.
Download or read book The Tumor Stroma written by Jai Prakash and published by CRC Press. This book was released on 2022-01-27 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.
Book Synopsis Stem Cell Manufacturing by : Joaquim M.S. Cabral
Download or read book Stem Cell Manufacturing written by Joaquim M.S. Cabral and published by Elsevier. This book was released on 2016-07-24 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. - Presents the first 'Flowchart' of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner - Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. - Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area - Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer - Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book
Book Synopsis Biobanking and Cryopreservation of Stem Cells by : Feridoun Karimi-Busheri
Download or read book Biobanking and Cryopreservation of Stem Cells written by Feridoun Karimi-Busheri and published by Springer. This book was released on 2016-11-10 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biobanking is considered to be one of the ten ideas changing the world with an estimated value of $45 billion by 2025. Despite the challenges, as the climate for innovation in the biobanking industry continues to flourish around the world, it is certain that amazing discoveries will emerge from this large-scale method of preserving and accessing human samples; biobanking is no longer just a place for collecting and storing samples. This book will cover a wide variety of subjects from across the future biobanking spectrum including scientific strategies, personalized medicine, regenerative medicine and stem cell challenges, disease surveillance, population genetics and innovative methods of biobanking.
Book Synopsis Metronomic Chemotherapy by : Guido Bocci
Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Book Synopsis Research on Melanoma by : Mandi Murph
Download or read book Research on Melanoma written by Mandi Murph and published by BoD – Books on Demand. This book was released on 2011-09-12 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented.
Book Synopsis Bone Marrow Niche by : Takashi Nagasawa
Download or read book Bone Marrow Niche written by Takashi Nagasawa and published by Springer Nature. This book was released on 2021-12-01 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.
Book Synopsis Ccn Proteins: A New Family Of Cell Growth And Differentiation Regulators by : Masaharu Takigawa
Download or read book Ccn Proteins: A New Family Of Cell Growth And Differentiation Regulators written by Masaharu Takigawa and published by World Scientific. This book was released on 2005-06-17 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely.CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development.
Book Synopsis Epidemiology of Brain and Spinal Tumors by : Jahangir Moini
Download or read book Epidemiology of Brain and Spinal Tumors written by Jahangir Moini and published by Academic Press. This book was released on 2021-04-09 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. - Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others - Includes full color figures, photos, tables, graphs and radioimaging - Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors - Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment
Book Synopsis Vertebrate Skeletal Histology and Paleohistology by : Vivian de Buffrénil
Download or read book Vertebrate Skeletal Histology and Paleohistology written by Vivian de Buffrénil and published by CRC Press. This book was released on 2021-06-24 with total page 1882 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertebrate Skeletal Histology and Paleohistology summarizes decades of research into the biology and biological meaning of hard tissues, in both living and extinct vertebrates. In addition to outlining anatomical diversity, it provides fundamental phylogenetic and evolutionary contexts for interpretation. An international team of leading authorities review the impact of ontogeny, mechanics, and environment in relation to bone and dental tissues. Synthesizing current advances in the biological problems of growth, metabolism, evolution, ecology, and behavior, this comprehensive and authoritative volume is built upon a foundation of concepts and technology generated over the past fifty years.
Book Synopsis Biology of Mesenchymal Stromal Cells -Emerging New Concepts to Improve Function and Scalability by : Tokiko Nagamura-Inoue
Download or read book Biology of Mesenchymal Stromal Cells -Emerging New Concepts to Improve Function and Scalability written by Tokiko Nagamura-Inoue and published by Frontiers Media SA. This book was released on 2024-10-28 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human mesenchymal stromal cells (MSCs) can be harvested from many tissues, including bone marrow (BM), cord blood (CB), adipose tissue, umbilical cord (UC), placenta and others. In recent years, there has been an overwhelming interest in MSC as reflected in the number of reports regarding their characterization, biological properties and clinical application. One of the specific areas of research involves the characterization of MSCs derived from different sources as well as the potential differences between them. More recently, reports have been published on derivatives from MSCs such as extracellular vesicles (EVs)/exosomes and mitochondria, but their characterization, mechanisms of action in immunomodulatory functions and regeneration aspects have not been fully elucidated.
