Membrane Estrogen Receptor Alpha Targeting And Its Association With Shc In Regulating Breast Cancer Cell Proliferation

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Hormone Receptors in Breast Cancer

Author : Suzanne A. W. Fuqua
Publisher : Springer Science & Business Media
ISBN 13 : 0387094636
Total Pages : 289 pages
Book Rating : 4.3/5 (87 download)

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Book Synopsis Hormone Receptors in Breast Cancer by : Suzanne A. W. Fuqua

Download or read book Hormone Receptors in Breast Cancer written by Suzanne A. W. Fuqua and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Endocrine Disruption and Human Health

Author : Philippa D. Darbre
Publisher : Academic Press
ISBN 13 : 0128011203
Total Pages : 390 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Steroid Hormone Action

Author : Malcolm G. Parker
Publisher : IRL Press
ISBN 13 :
Total Pages : 242 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Steroid Hormone Action by : Malcolm G. Parker

Download or read book Steroid Hormone Action written by Malcolm G. Parker and published by IRL Press. This book was released on 1993 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a detailed overview of the mechanisms by which steroid hormones regulate gene activity in target cells. It should be of interest to molecular biologists, endocrinologists, pharmacologists and clinicians interested in gene regulation hormones and steroid antagonists.

Extracellular Matrix: Pathobiology and Signaling

Author : Nikos Karamanos
Publisher : Walter de Gruyter
ISBN 13 : 3110258773
Total Pages : 940 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Extracellular Matrix: Pathobiology and Signaling by : Nikos Karamanos

Download or read book Extracellular Matrix: Pathobiology and Signaling written by Nikos Karamanos and published by Walter de Gruyter. This book was released on 2012-08-31 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

G Protein-Coupled Receptors in Energy Homeostasis and Obesity Pathogenesis

Author :
Publisher : Academic Press
ISBN 13 : 0123869528
Total Pages : 403 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis G Protein-Coupled Receptors in Energy Homeostasis and Obesity Pathogenesis by :

Download or read book G Protein-Coupled Receptors in Energy Homeostasis and Obesity Pathogenesis written by and published by Academic Press. This book was released on 2013-01-10 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans. - Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs - Chapters are written by leading experts

Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy

Author : Julita Kulbacka
Publisher : Springer
ISBN 13 : 3319568957
Total Pages : 145 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy by : Julita Kulbacka

Download or read book Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy written by Julita Kulbacka and published by Springer. This book was released on 2017-10-04 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics. The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).

The Identities of Membrane Steroid Receptors

Author : Cheryl S. Watson
Publisher : Springer Science & Business Media
ISBN 13 : 1461503396
Total Pages : 220 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Identities of Membrane Steroid Receptors by : Cheryl S. Watson

Download or read book The Identities of Membrane Steroid Receptors written by Cheryl S. Watson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cheryl S. Watson University o/Texas Medical Branch Cellular steroid action has been thoroughly studied in the nuclear compartment. However, nuclear steroid receptor mechanisms have been unable to explain some of the rapid activities of steroids, partiCUlarly those which occur in a time frame of seconds to minutes [reviewed in (1;2)]. Based on these and other considerations, an alternative membrane-associated receptor form was long ago proposed to exist (3). Others interpret the location of the steroid receptors mediating these rapid effects as peri membrane or cytoplasmic. New experimental tools have been brought to bear on the topic of receptors for steroids which mediate non-genomic actions, and thus investigative activity and focus regarding this type of steroid receptor has recently increased significantly. However, there may be multiple answers to the question "how do steroids mediate rapid nongenomic effects?" Steroid actions initiated at the cell membrane can impinge on important phases in the lifespan of a cell: proliferation, migration, differentiation, and release of hormones or neurotransmitters functioning as signals to other cells.

Aquaporin Regulation

Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 0128208090
Total Pages : 374 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Aquaporin Regulation by : Gerald Litwack

Download or read book Aquaporin Regulation written by Gerald Litwack and published by Academic Press. This book was released on 2020-02-13 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.

Targeted Therapies in Breast Cancer

Author : Gw Sledge
Publisher : Clinical Pub
ISBN 13 : 9781846920660
Total Pages : 0 pages
Book Rating : 4.9/5 (26 download)

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Book Synopsis Targeted Therapies in Breast Cancer by : Gw Sledge

Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Textbook of Diabetes

Author : Richard I. G. Holt
Publisher : John Wiley & Sons
ISBN 13 : 1118912020
Total Pages : 1104 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Textbook of Diabetes by : Richard I. G. Holt

Download or read book Textbook of Diabetes written by Richard I. G. Holt and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.

Alcohol and Cancer

Author : Vasilis Vasiliou
Publisher : Springer
ISBN 13 : 3319987887
Total Pages : 274 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Alcohol and Cancer by : Vasilis Vasiliou

Download or read book Alcohol and Cancer written by Vasilis Vasiliou and published by Springer. This book was released on 2018-10-26 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes. Alcohol and Cancer: Proceedings of the Third International Conference is a timely update to Biological Basis of Alcohol-Induced Cancer, which followed the Second Alcohol and Cancer Conference, compiling cutting-edge research from graduate students, young scientists, and researchers. It is ideal for graduate students and researchers in oncology, hepatology, epigenetics, and alcohol consumption.

The Science of Flavonoids

Author : Erich Grotewold
Publisher : Springer Science & Business Media
ISBN 13 : 9780387745503
Total Pages : 300 pages
Book Rating : 4.7/5 (455 download)

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Book Synopsis The Science of Flavonoids by : Erich Grotewold

Download or read book The Science of Flavonoids written by Erich Grotewold and published by Springer Science & Business Media. This book was released on 2008 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only book of its kind to provide an overview of the science of flavonoids in plants.

Sex differences and cardiovascular therapeutics

Author : Sheng Wu
Publisher : Frontiers Media SA
ISBN 13 : 2832549993
Total Pages : 138 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Sex differences and cardiovascular therapeutics by : Sheng Wu

Download or read book Sex differences and cardiovascular therapeutics written by Sheng Wu and published by Frontiers Media SA. This book was released on 2024-06-05 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific evidence from both preclinical, and clinical studies indicates that male and female patients with cardiovascular disease (CVD) exhibit different clinical, epidemiological, and pathological characteristics, with sexually dimorphic biological factors exhibiting a significant influence in the development of CVD and therapeutic responses. Sexually dimorphic physiology that contributes to sex differences in cardiovascular therapeutic responses may include; immune responses, cardio-renal health, the blood-brain barrier, coronary atherosclerosis pathology, complications of COVID-19 infections, and the interplay between psychological factors and sedentarism. Furthermore, current knowledge indicates the role of hormonal regulation has a significant impact in sex-specific differences across the clinical cardiology field. The National Institute of Health (NIH) previously adopted a policy to encourage researchers to consider sex as a biological variable (SABV) as well as Sex and Gender Equity in Research (SAGER). In order to promote sexual dimorphic cardiovascular therapeutic development, we have organized this special topic “Sex Differences and Cardiovascular Therapeutics” to provide a scientific forum for cardiovascular scientists and clinicians to present their newest findings in characterizing sex differences in cardiovascular therapeutics. Potential areas of research within this collection may include, but are not limited to: 1) Different outcomes and responses to drug treatment in cardiovascular disease between male and female. 2) Mechanisms of sexual dimorphic response and outcomes related to drug treatment of cardiovascular disease. 3) Sex hormones and their receptors in cardiovascular function in animal studies and clinical therapeutic applications. 4) Gender affirming hormone therapy and cardiovascular function. 5) Regulatory guidance for cardiovascular therapeutics in relation to sex-specific differences.

Principles of Endocrinology and Hormone Action

Author : Antonino Belfiore
Publisher : Springer
ISBN 13 : 9783319446745
Total Pages : 0 pages
Book Rating : 4.4/5 (467 download)

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Book Synopsis Principles of Endocrinology and Hormone Action by : Antonino Belfiore

Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

The Identities of Membrane Steroid Receptors

Author : Cheryl S. Watson
Publisher : Springer Science & Business Media
ISBN 13 : 9781402073441
Total Pages : 234 pages
Book Rating : 4.0/5 (734 download)

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Book Synopsis The Identities of Membrane Steroid Receptors by : Cheryl S. Watson

Download or read book The Identities of Membrane Steroid Receptors written by Cheryl S. Watson and published by Springer Science & Business Media. This book was released on 2003-02-28 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the nature of rapid (nongenomic) steroid signaling depends upon identifying the protein(s) which binds hormone at the cell periphery and mediates the initial signal transmission. This book juxtaposes identifications from different laboratories and collectively presents several possibilities: nuclear steroid receptors in nonnuclear locations, other known membrane receptors with additional steroid binding sites, enzymes, transporters, receptors for blood-borne steroid-binding proteins, and unique, previously undescribed proteins.

Innovative Endocrinology of Cancer

Author : Lev M. Berstein
Publisher : Springer Science & Business Media
ISBN 13 : 0387788182
Total Pages : 242 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Innovative Endocrinology of Cancer by : Lev M. Berstein

Download or read book Innovative Endocrinology of Cancer written by Lev M. Berstein and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to new developments in a huge range of topics, such as the mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and antihormonal therapy of cancer and its prevention.

Hormonal Carcinogenesis V

Author : Jonathan J. Li
Publisher : Springer Science & Business Media
ISBN 13 : 0387690808
Total Pages : 647 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Hormonal Carcinogenesis V by : Jonathan J. Li

Download or read book Hormonal Carcinogenesis V written by Jonathan J. Li and published by Springer Science & Business Media. This book was released on 2008-04-24 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information gathered from cell-free systems, cell cultures, animal models, and human studies, together provide important insights to our understanding of hormonal cancer causation, development, and prevention; the primary objective of these Symposia. A special emphasis is placed on the two major endocrine-related cancers, that is, breast and prostate. The emerging fields of colon, lung, and pancreatic cancers in relation to hormones are examined.