Membrane Estrogen And Her 2 Receptors In Human Breast Cancer

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Membrane Estrogen and HER-2 Receptors in Human Breast Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 103 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Membrane Estrogen and HER-2 Receptors in Human Breast Cancer by :

Download or read book Membrane Estrogen and HER-2 Receptors in Human Breast Cancer written by and published by . This book was released on 2002 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with breast cancers that express estrogen receptor (ER) commonly receive anti-estrogen therapy. The efficacy of this treatment depends on tight regulation of breast growth by estrogen. However, as breast cancers progress, they often become resistant to estrogens, and most patients no longer respond to anti-estrogen therapy. New anti-estrogen treatment options are needed, and alternative therapies may result from findings showing that some ER molecules occur in plasma membranes of breast cancer cells and interact with transmembrane HER-2 growth factor receptors. Expression of HER-2 receptors occurs in many breast cancers, and the protein kinase activity of HER-2 may modulate the ligand-independent activation of ER. Active cross-communication between ER and HER-2 receptors occurs in breast tumors, leading to the promotion of cancer growth. Thus, this axis may offer a new target for therapeutic intervention. The authors have partially purified a membrane-associated form of ER in breast cancer cells and has evidence that it promotes tumor growth. Using this novel signaling pathway as a target, the authors are assessing new treatments to prevent cancer progression in models of human breast cancer. Since HER-2 overexpression in breast cancer is associated with the failure of anti-estrogen therapy, understanding the basis of interactions between ER and HER-2 receptors may help to improve patient management and survival. (1 figure, 91 refs.).

HER2-Positive Breast Cancer

Author : Sara Hurvitz
Publisher : Elsevier Health Sciences
ISBN 13 : 0323581234
Total Pages : 264 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis HER2-Positive Breast Cancer by : Sara Hurvitz

Download or read book HER2-Positive Breast Cancer written by Sara Hurvitz and published by Elsevier Health Sciences. This book was released on 2018-07-26 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.

Estrogen Receptors in Human Breast Cancer

Author : William L. McGuire
Publisher :
ISBN 13 :
Total Pages : 308 pages
Book Rating : 4.:/5 (49 download)

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Book Synopsis Estrogen Receptors in Human Breast Cancer by : William L. McGuire

Download or read book Estrogen Receptors in Human Breast Cancer written by William L. McGuire and published by . This book was released on 1975 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Estrogen Receptors in Human Breast Cancer

Author : William L. McGuire
Publisher :
ISBN 13 : 9780720475401
Total Pages : 284 pages
Book Rating : 4.4/5 (754 download)

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Book Synopsis Estrogen Receptors in Human Breast Cancer by : William L. McGuire

Download or read book Estrogen Receptors in Human Breast Cancer written by William L. McGuire and published by . This book was released on 1975 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Estrogens, Estrogen Receptor and Breast Cancer

Author : Fritz F. Parl
Publisher : IOS Press
ISBN 13 : 9780967335544
Total Pages : 280 pages
Book Rating : 4.3/5 (355 download)

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Book Synopsis Estrogens, Estrogen Receptor and Breast Cancer by : Fritz F. Parl

Download or read book Estrogens, Estrogen Receptor and Breast Cancer written by Fritz F. Parl and published by IOS Press. This book was released on 2000 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.

Regulatory Mechanisms in Breast Cancer

Author : Marc E. Lippman
Publisher : Springer Science & Business Media
ISBN 13 : 1461539404
Total Pages : 455 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Regulatory Mechanisms in Breast Cancer by : Marc E. Lippman

Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.

Hormone Receptors in Breast Cancer

Author : Suzanne A. W. Fuqua
Publisher : Springer Science & Business Media
ISBN 13 : 0387094636
Total Pages : 289 pages
Book Rating : 4.3/5 (87 download)

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Book Synopsis Hormone Receptors in Breast Cancer by : Suzanne A. W. Fuqua

Download or read book Hormone Receptors in Breast Cancer written by Suzanne A. W. Fuqua and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

The Identities of Membrane Steroid Receptors

Author : Cheryl S. Watson
Publisher : Springer Science & Business Media
ISBN 13 : 9781402073441
Total Pages : 234 pages
Book Rating : 4.0/5 (734 download)

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Book Synopsis The Identities of Membrane Steroid Receptors by : Cheryl S. Watson

Download or read book The Identities of Membrane Steroid Receptors written by Cheryl S. Watson and published by Springer Science & Business Media. This book was released on 2003-02-28 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the nature of rapid (nongenomic) steroid signaling depends upon identifying the protein(s) which binds hormone at the cell periphery and mediates the initial signal transmission. This book juxtaposes identifications from different laboratories and collectively presents several possibilities: nuclear steroid receptors in nonnuclear locations, other known membrane receptors with additional steroid binding sites, enzymes, transporters, receptors for blood-borne steroid-binding proteins, and unique, previously undescribed proteins.

Biologic Effects of HER-2/Neu Gene Overexpression and Agonists and Antagonists to the Receptor in Human Breast Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Biologic Effects of HER-2/Neu Gene Overexpression and Agonists and Antagonists to the Receptor in Human Breast Cancer by :

Download or read book Biologic Effects of HER-2/Neu Gene Overexpression and Agonists and Antagonists to the Receptor in Human Breast Cancer written by and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alteration of the HER-2/neu gene has been shown to correlate with poor prognosis in patients whose tumors contain it. This led to studies from our laboratory indicating it may play a role in the pathogenesis of the disease for some patients. Given that the HER-2/neu gene encodes a growth factor receptor found on the membrane of tumor cells and given its potential role in the pathogenesis of some human breast cancers, it is a logical target for the development of new therapeutic approaches directed at this alteration. Studies with monoclonal antibodies directed against the extra cellular domain of the receptor indicate that many may have significant growth inhibitory properties. Recently ligands have been identified which interact either directly or indirectly with the human HER-2/neu receptor, however little is known about the biologic effects of these molecules. There is some controversy as to whether the ligands mediate growth stimulatory or growth inhibitory effects or both. A greater understanding about the biologic effects of HER- 2/neu overexpression as well as the impact of agonists and antagonists to the receptor has been and will continue to be required to fully therapeutically exploit this gene alteration in human breast cancer. Finally, little is know about the biologic effects of other molecular alterations which may occur in combination with HER-2/neu expression such as changes in the estrogen receptor. The proposal has been conducted to expand our knowledge base regarding the role of this critical gene in human breast cancer and to determine how to exploit this information clinically.

Structural Integrity of Estrogen Receptors in Human Breast Cancer

Author : Melissa Kounine
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (323 download)

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Book Synopsis Structural Integrity of Estrogen Receptors in Human Breast Cancer by : Melissa Kounine

Download or read book Structural Integrity of Estrogen Receptors in Human Breast Cancer written by Melissa Kounine and published by . This book was released on 1994 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dissecting the Role of Estrogen Receptor Palmitoylation in Breast Cancer Cells

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (914 download)

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Book Synopsis Dissecting the Role of Estrogen Receptor Palmitoylation in Breast Cancer Cells by :

Download or read book Dissecting the Role of Estrogen Receptor Palmitoylation in Breast Cancer Cells written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogen signaling is primarily mediated by two estrogen receptors (ERs), ER[alpha] and ER[beta]. ER[alpha] is expressed in ~70% of breast cancers and is an important diagnostic and therapeutic target. Developing better treatment options and overcoming limitations of endocrine therapy depend on a detailed understanding of ER[alpha]-signaling pathways. ER[alpha], a member of the class I nuclear receptor superfamily of transcription factors, localizes mainly to the nucleus and interacts with DNA regulatory sequences either directly or through interaction with other transcription factors to regulate gene transcription. ER[alpha] is also rapidly activates signaling cascades. S-palmitoylation, a reversible lipid modification is catalyzed by palmitoyl acyl-transferases (PAT), which increase affinity of proteins to the membrane. Based on the results of previous studies, it is hypothesized that palmitoylation of ER[alpha] regulates extranuclear and nuclear signaling of ER[alpha]. We utilized palmitoylation-defective mutant ER[alpha]C447A-expressing MDA-MB-468 breast cancer cells to dissect the role of palmitoylation in a breast cancer cell line model. The substitution of ER[alpha] palmitoylation site abrogated ER[alpha] palmitoylation, membrane localization and estrogen-dependent phosphorylation of ERK1/2 in MDA-MB-468 cell line. Besides loss of E2-dependent extranuclear signaling, the substitution of palmitoylation sites led to the loss of other ER[alpha]-dependent events in ER[alpha]C447A-expressing MDA-MB-468 cells, such as decreased E2-dependent S118 phosphorylation, impaired regulation of certain target genes, and loss of estrogen-dependent cell cycle inhibition. This study thus highlights the importance of ER[alpha] palmitoylation in both nuclear and extranuclear ER signaling pathways in breast cancer cells. A better understanding of the mechanisms of estrogen action will help us to design more effective drugs affecting signal pathways depending on both membrane and nuclear receptors.

Extracellular Matrix: Pathobiology and Signaling

Author : Nikos Karamanos
Publisher : Walter de Gruyter
ISBN 13 : 3110258773
Total Pages : 940 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Extracellular Matrix: Pathobiology and Signaling by : Nikos Karamanos

Download or read book Extracellular Matrix: Pathobiology and Signaling written by Nikos Karamanos and published by Walter de Gruyter. This book was released on 2012-08-31 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Understanding the Role of Estrogen Receptor Beta in Triple Negative Breast Cancers

Author :
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (857 download)

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Book Synopsis Understanding the Role of Estrogen Receptor Beta in Triple Negative Breast Cancers by :

Download or read book Understanding the Role of Estrogen Receptor Beta in Triple Negative Breast Cancers written by and published by . This book was released on 2013 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogen signaling is primarily mediated by two estrogen receptors (ERs), ERÎI and ERÎø. ERÎI is expressed in ~70% of breast cancers and is an important diagnostic and therapeutic target. Approximately 10-15% of breast cancers lack expression of ERÎI, its target gene progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) and are known as triple negative breast cancers (TNBCs). Based on in vitro and clinical data, it is hypothesized that ERÎø could be targeted with selective ligands to inhibit the growth of TNBCs. In order to identify and characterize subtype selective ligands in breast cancer cells, two isogenic reporter cell lines with inducible ERÎI or ERÎø expression and a stably integrated estrogen responsive luciferase reporter were developed. These cell lines were highly sensitive to estrogenic ligands and could be used to characterize known subtype selective ligands. In order to assess the effects of ERÎø expression and ligand treatment on the growth of TNBC cells in vitro and in vivo, the tumorigenic triple negative MDA-MB-468 cell line was engineered with inducible expression of full length ERÎø. These cells were then used to assess growth effects and globally identify the ligand dependent and independent ERÎø target genes using RNA sequencing. In order to specifically detect full length ERÎø in ERÎI negative breast cancers, MDA-MB-468-ERÎø xenograft tumor tissues were used to optimize immunohistochemical protocols for detecting full length ERÎø in breast cancer tissues. The expression of full length ERÎø was then confirmed in a subset of ERÎI/PR/HER2 negative breast cancers using a cohort of triple negative breast cancers. This comprehensive study provides tools to identify subtype selective ligands and detect ERÎø expression in clinical samples, confirms the expression of full length ERÎø in a subset of TNBCs, demonstrates the growth inhibitory effects of ERÎø expression and activation in vitro and in vivo, and globally identifies ERÎø target genes in the context of triple negative breast cancer cells. The results ultimately provide a foundation on which to further develop ERÎø selective ligands with the aim of inhibiting the growth of triple negative, ERÎø-positive breast cancers.

Membrane Estrogen Receptors - Improving Predictions of Responsiveness of Breast Cancers to Anti-Estrogenic Therapies

Author : Cheryl S. Watson
Publisher :
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Membrane Estrogen Receptors - Improving Predictions of Responsiveness of Breast Cancers to Anti-Estrogenic Therapies by : Cheryl S. Watson

Download or read book Membrane Estrogen Receptors - Improving Predictions of Responsiveness of Breast Cancers to Anti-Estrogenic Therapies written by Cheryl S. Watson and published by . This book was released on 2002 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: An alternative mechanism of action of steroids B action via a membrane form of steroid receptors B is not well studied. The pathway for steroid action is likely to be just as important as the well-studied genomic pathway for predicting responsiveness of cells for a variety of functions. There are basic responses to steroids that have not been fully explained; the most clinically important of these is how a steroid causes a cancer cell to divide. The significance of the membrane form of the estrogen receptor-a (mER) in estrogen-induced cell proliferation is unexplored. If the mER is involved, its measurement should contribute to the accuracy of clinical tests for predicting if breast cancer patients will respond to estrogen-antagonist therapies. We used immunocytochemical strategies to distinguish mER from the nuclear receptor to determine the expression levels and appearance of mER in mER+ and mER- breast cancer cells. We adapted an enzyme-linked detection and quantitation system, nuclear and membrane forms of ERalpha, and made these measurements in mER+, mER-, and wild type MCF-7 cells. We used determinations of cell number to assess cell proliferation and apoptosis responses of mER+, mER-, and wild-type cells to a wide range of concentrations of estrogens.

Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer

Download Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer PDF Online Free

Author : Kyuri Kim
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (774 download)

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Book Synopsis Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer by : Kyuri Kim

Download or read book Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer written by Kyuri Kim and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogens are associated with the development and progression of breast cancer in addition to their role in normal reproductive physiology, and estrogen receptors (ER) mediate the actions of estrogen in target tissues by regulating the expression of numerous biologically important target genes. The progression of human breast cancer and the development of resistance to endocrine therapies are thought to be associated with ER phosphorylation. We generated multiple combinations of ER phospho-mutants, at residues serine 104, 106, 118, 167, 236, and 305, and examined their impact on receptor half-life, the agonist and antagonist balance of selective estrogen receptor modulators (SERMs) and selective estrogen receptor downregulators (SERDs), the regulation of ER transcriptional activity, and stimulation of cell proliferation in response to estradiol and SERMs/SERD. We showed that changes in ER affecting the phosphorylation status of the receptor greatly impact receptor function and differential SERM and SERD modulated cellular responses that could contribute to resistance to endocrine therapies in breast cancer. We also studied the regulation of microRNAs (miRNAs) by estradiol and growth factors through ER and extracellular signal-regulated kinase 2 (ERK2) in order to understand their physiological impact on breast cancer. We identified nine miRNA- encoding genes harboring overlapping ER and ERK2 binding sites close to their transcription start sites, which require ER and ERK2 for transcriptional induction as well as estradiol- mediated miRNA regulation. We then identified TP63, a target of miR-101, miR-190 and miR- 196a2, and showed that TP63 plays an important role in estradiol- or growth factor-mediated cellular response in breast cancer cells (MCF-7 and MDA-MB-231) by increasing tumor cell growth and in vitro invasion mainly controlled by miR-196a2 action. These results suggest a tumor-suppressive role of miR-196a2 in regulating TP63 expression and the aggressive behavior of breast cancers.

WHO Classification of Tumours of the Breast

Author : Sunil R. Lakhani
Publisher : World Health Organization
ISBN 13 : 9789283224334
Total Pages : 240 pages
Book Rating : 4.2/5 (243 download)

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Book Synopsis WHO Classification of Tumours of the Breast by : Sunil R. Lakhani

Download or read book WHO Classification of Tumours of the Breast written by Sunil R. Lakhani and published by World Health Organization. This book was released on 2012 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO Classification of Tumours of the Breast is the fourth volume of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 90 authors from 24 countries, contains more than 340 colour photographs, tables and figures, and more than 1600 references.

Membrane Estrogen Receptor Alpha Targeting and Its Association With SHC in Regulating Breast Cancer Cell Proliferation

Author :
Publisher :
ISBN 13 :
Total Pages : 37 pages
Book Rating : 4.:/5 (644 download)

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Book Synopsis Membrane Estrogen Receptor Alpha Targeting and Its Association With SHC in Regulating Breast Cancer Cell Proliferation by :

Download or read book Membrane Estrogen Receptor Alpha Targeting and Its Association With SHC in Regulating Breast Cancer Cell Proliferation written by and published by . This book was released on 2003 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: 17BETA-ESTRADIOL (E2) induces rapid, non-genomic effect in MCF-7 breast cancer cells, including rapid activation of MAPK, phosphorylation of adapter protein Shc, increase of the interaction between Shc and estrogen receptor (ERalpha). More strikingly E2 also induced a rapid membrane association of ERalpha: (1) Further studying the structure and function of ERalpha, we demonstrated that only membrane-associated ERalpha, but not cytosol and nuclear ones, mediates E2 effect on MAPK activation. (2) To study the mechanism of ERalpha membrane association, we further investigated the role of Shc in estrogen action. Here we demonstrated that in MCF-7 cells, Shc acts as a chaperon linking ERalpha to the cell membrane by binding to a transmembrane receptor IGF-1R. Further study is under the way to investigate the molecular mechanism among these protein complex formation and their biological effects in estrogen non-genomic action.