Medicinal Chemistry And Drug Discovery Chemotherapeutic Agents

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Medicinal Chemistry of Chemotherapeutic Agents

Author : Pratap Chandra Acharya
Publisher : Academic Press
ISBN 13 : 0323907016
Total Pages : 688 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Medicinal Chemistry of Chemotherapeutic Agents by : Pratap Chandra Acharya

Download or read book Medicinal Chemistry of Chemotherapeutic Agents written by Pratap Chandra Acharya and published by Academic Press. This book was released on 2023-03-09 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents. Includes current research focused on drug resistance and methods to overcome problems Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents Discusses molecules under clinical trials and newly approved drugs

Medicinal Chemistry of Anticancer Drugs

Author : Carmen Avendaño
Publisher : Elsevier
ISBN 13 : 008055962X
Total Pages : 459 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño

Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2008-06-04 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures.* Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs* Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development* Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents

Author : Alfred Burger
Publisher :
ISBN 13 :
Total Pages : 1164 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents by : Alfred Burger

Download or read book Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents written by Alfred Burger and published by . This book was released on 2003 with total page 1164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Medicinal Chemistry

Author : A.K. Ganguly
Publisher : CRC Press
ISBN 13 : 1000437213
Total Pages : 118 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Medicinal Chemistry by : A.K. Ganguly

Download or read book Medicinal Chemistry written by A.K. Ganguly and published by CRC Press. This book was released on 2021-09-12 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

Medicinal Chemistry

Author : Norma K Dunlap
Publisher : Garland Science
ISBN 13 : 1351586211
Total Pages : 375 pages
Book Rating : 4.3/5 (515 download)

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Book Synopsis Medicinal Chemistry by : Norma K Dunlap

Download or read book Medicinal Chemistry written by Norma K Dunlap and published by Garland Science. This book was released on 2018-04-17 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.

Frontiers in Anti-Cancer Drug Discovery

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681081490
Total Pages : 266 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Frontiers in Anti-Cancer Drug Discovery by : Atta-ur-Rahman

Download or read book Frontiers in Anti-Cancer Drug Discovery written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2015-11-03 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Anti-Cancer Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The sixth volume of the series features chapters on several topics including: - Monocarboxylate transporters as anti-cancer drug targets - Interferon α-2b treatment for hepatocellular carcinoma - Anthracyclines in cancer therapy - Magnetosomes and tumor therapy …and more.

Anticancer Therapeutics

Author : Adam Todd
Publisher : John Wiley & Sons
ISBN 13 : 111862212X
Total Pages : 446 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Anticancer Therapeutics by : Adam Todd

Download or read book Anticancer Therapeutics written by Adam Todd and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

Medicinal Chemistry of Anticancer Drugs

Author : Carmen Avendaño
Publisher : Elsevier
ISBN 13 : 0444626670
Total Pages : 767 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño

Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Fundamentals of Medicinal Chemistry

Author : Gareth Thomas
Publisher : John Wiley & Sons
ISBN 13 : 0470871695
Total Pages : 302 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Fundamentals of Medicinal Chemistry by : Gareth Thomas

Download or read book Fundamentals of Medicinal Chemistry written by Gareth Thomas and published by John Wiley & Sons. This book was released on 2004-04-20 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism, The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices. Incorporates summary sections, examples, applications and problems Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text Invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.

Cancer II

Author : Michael J. Waring
Publisher : Springer
ISBN 13 : 3319759264
Total Pages : 475 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Cancer II by : Michael J. Waring

Download or read book Cancer II written by Michael J. Waring and published by Springer. This book was released on 2019-01-25 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent breakthroughs in anti-cancer drug discovery. Building on the previous volume in the series, it outlines some of the most significant developments that have occurred in the field in the subsequent period that have led to new drug approvals or promising clinical candidates. The volume is divided into chapters that each relate to a specific protein or protein class. Each chapter provides an overview of the underlying biology and then emphasises the medicinal chemistry strategies and tactics that led to the most significant drugs and drug candidates. A summary of clinical data and the future outlook for the field is also provided. Each chapter is authored by experts in the topic and who have themselves made significant contributions to their respective fields.

Burger's Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents

Author : Alfred Burger
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (2 download)

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Book Synopsis Burger's Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents by : Alfred Burger

Download or read book Burger's Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents written by Alfred Burger and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers access via basic and advanced search engines to broad coverage of the field of medicinal chemistry and drug discovery for medicinal chemists, biologists, pharmacologists and molecular biologists.

Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set

Author : Donald J. Abraham
Publisher : Wiley-Interscience
ISBN 13 : 9780471370321
Total Pages : 5568 pages
Book Rating : 4.3/5 (73 download)

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Book Synopsis Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set by : Donald J. Abraham

Download or read book Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set written by Donald J. Abraham and published by Wiley-Interscience. This book was released on 2003-03-07 with total page 5568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development. With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50% new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including: * Proteomics * Genomics * Bioinformatics * Combinatorial Chemistry * High-Throughput Screening * Blood Substitutes * Allosteric Effectors as Potential Drugs * COX Inhibitors * Statins * High-Throughput Pharmacology * and More. The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.

Frontiers in Anti-Cancer Drug Discovery

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608058085
Total Pages : 388 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Frontiers in Anti-Cancer Drug Discovery by : Atta-ur-Rahman

Download or read book Frontiers in Anti-Cancer Drug Discovery written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2013-11-29 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Burger's Medicinal Chemistry and Drug Discovery, 5 Volume Set

Author : Manfred E. Wolff
Publisher : Wiley-Interscience
ISBN 13 : 9780471575610
Total Pages : 3992 pages
Book Rating : 4.5/5 (756 download)

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Book Synopsis Burger's Medicinal Chemistry and Drug Discovery, 5 Volume Set by : Manfred E. Wolff

Download or read book Burger's Medicinal Chemistry and Drug Discovery, 5 Volume Set written by Manfred E. Wolff and published by Wiley-Interscience. This book was released on 1997-05-06 with total page 3992 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Natural Products in Medicinal Chemistry

Author : Stephen Hanessian
Publisher : John Wiley & Sons
ISBN 13 : 3527676562
Total Pages : 658 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Natural Products in Medicinal Chemistry by : Stephen Hanessian

Download or read book Natural Products in Medicinal Chemistry written by Stephen Hanessian and published by John Wiley & Sons. This book was released on 2013-12-18 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Early Drug Development

Author : Fabrizio Giordanetto
Publisher : John Wiley & Sons
ISBN 13 : 3527801766
Total Pages : 802 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Early Drug Development by : Fabrizio Giordanetto

Download or read book Early Drug Development written by Fabrizio Giordanetto and published by John Wiley & Sons. This book was released on 2018-06-11 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Inhibitors of Molecular Chaperones as Therapeutic Agents

Author : Timothy D. Machajewski
Publisher : Royal Society of Chemistry
ISBN 13 : 1849736669
Total Pages : 443 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Inhibitors of Molecular Chaperones as Therapeutic Agents by : Timothy D. Machajewski

Download or read book Inhibitors of Molecular Chaperones as Therapeutic Agents written by Timothy D. Machajewski and published by Royal Society of Chemistry. This book was released on 2014 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.