Mechanisms Of Psoriatic Arthritis

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Mechanisms of Psoriatic Arthritis

Author : Laurel K. Myers
Publisher :
ISBN 13 :
Total Pages : 36 pages
Book Rating : 4.:/5 (824 download)

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Book Synopsis Mechanisms of Psoriatic Arthritis by : Laurel K. Myers

Download or read book Mechanisms of Psoriatic Arthritis written by Laurel K. Myers and published by . This book was released on 2012 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Psoriasis (Ps) is the most common chronic autoimmune disease in the United States. The immune system releases proinflammatory cytokines and growth factors that accelerate the growth of skin cells which accumulate and form thick red patches of skin on various parts of the body. About 25 percent of psoriasis patients develop inflammatory arthritis in which inflammation progresses to joints and entheses. Psoriatic Arthritis (PsA) patients exhibit joint pain, stiffness, and swelling which can affect any part of the body. PsA occurs when the immune cells release cytokines that act on healthy cells and tissues to induce skin and joint inflammation. Genetic and environmental factors interact to trigger the cellular pathways that promote skin and joint disease. Research studies on the pathophysiology of psoriatic arthritis have revealed that alterations in both immune cells and resident cells in the skin and joint characterize this disease. Dr. Christopher Ritchlin's research focuses on the links between skin and joint inflammation. his laboratory is examining the mechanisms of bone resorption and formation, the effect of anti-TNF agents on dendritic cell differentiation, and the mechanisms of bone marrow edema (a finding on MRI of the joints) observed in PsA and rheumatoid arthritis. His current research demonstrates a mechanism for the destructive pathology in psoriatic joints. The purpose of my thesis is to illustrate Dr. Ritchlin's research. It will be a 2-dimensional animation explaining normal bone remodeling and the bi-directional attack on PsA joints. Accompanying the animation is a voice over explaining what is happening on screen."--Abstract.

Psoriasis and Psoriatic Arthritis

Author : Siba P. Raychaudhuri
Publisher : CRC Press
ISBN 13 : 1351648950
Total Pages : 513 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Psoriasis and Psoriatic Arthritis by : Siba P. Raychaudhuri

Download or read book Psoriasis and Psoriatic Arthritis written by Siba P. Raychaudhuri and published by CRC Press. This book was released on 2017-12-15 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and flake off about every four weeks, but psoriasis causes new skin cells to move rapidly to the surface of the skin in days rather than weeks. Psoriasis symptoms often appear on the elbows, scalp, feet, knees, hands, or lower back, or as flaking or patches on the skin. It is most common in adults, but teenagers and children can also suffer from psoriasis. Psoriasis is not only a skin condition; it is a chronic disease of the immune system. Chronic psoriasis is associated with other health conditions such as psoriatic arthritis, several inflammatory disorders, type 2 diabetes, and cardiovascular disease. This book provides extensive coverage of psoriasis and psoriatic arthritis. It features information on epidemiology and etiology of psoriasis, pathogenesis, genetics of psoriasis, clinical manifestations, and treatment options using cutting-edge drugs including adalimumab and tofacitinib. Natural phytochemicals and nutraceuticals have demonstrated efficacy in ameliorating psoriasis. The book dedicates comprehensive coverage of nutraceutical therapeutic options including antioxidants, bioactive peptides, carotenoids, alpha lipoic acid, curcumin, and whey protein. These inexpensive natural therapeutics are not associated with any known adverse side effects.

Psoriatic Arthritis and Psoriasis

Author : Adewale Adebajo
Publisher : Springer
ISBN 13 : 3319195301
Total Pages : 315 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Psoriatic Arthritis and Psoriasis by : Adewale Adebajo

Download or read book Psoriatic Arthritis and Psoriasis written by Adewale Adebajo and published by Springer. This book was released on 2016-01-11 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA’s aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and other stakeholders focused on psoriasis and PsA.Psoriatic Arthritis (PsA) ranks with rheumatoid arthritis and axial spondyloarthritis as one of the most prevalent inflammatory arthropathies worldwide. There is now a significant global awareness among Rheumatologists, Dermatologists, Internal Medicine Specialists, Gastroenterologists, General Practitioners, Family Practitioners, Physiotherapists, Nurse Specialists, Immunogenetics and many other Health Care Professionals with regards to the importance of psoriatic arthritis.

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Immunology of Psoriatic Disease

Author : Eva Reali
Publisher : Frontiers Media SA
ISBN 13 : 2889459187
Total Pages : 193 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Immunology of Psoriatic Disease by : Eva Reali

Download or read book Immunology of Psoriatic Disease written by Eva Reali and published by Frontiers Media SA. This book was released on 2019-07-31 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psoriasis is a chronically relapsing inflammatory skin disorder affecting about 2% of the worldwide population. The disease is associated with important systemic manifestations, including cardiovascular comorbidities and metabolic syndrome. In addition, about 30% of patients develop joint inflammation known as psoriatic arthritis (PsA). Our knowledge on the pathogenesis of psoriasis has dramatically expanded in the last decade, suggesting the existence (or co-existence) of both auto-immune and auto-inflammatory components. Skin lesions develop from a complex interplay between keratinocytes, vascular endothelium, dendritic cells, and T cells, generating a self-sustaining inflammatory cycle. Within this cycle, epidermal CD8+ T lymphocytes specific for self-antigens may represent the major autoimmune mechanism. Despite the recent progress in the comprehension of the pathogenesis of psoriasis many questions remain open, ranging from the plaque-initiating events to the characterization of the autoimmune /autoinflammatory components of the disease. The mechanisms that link cutaneous psoriasis to its extra-cutaneous and systemic manifestations also remain vague. In this Research Topic we invited top scientists to summarize the front-line research in the field of immunology of cutaneous psoriasis and its systemic and joint manifestations. Our intention was to integrate the pillar concepts of psoriasis immunopathology with the most novel insights, aiming at providing an advanced view of this rapidly evolving and fascinating field.

Psoriatic Arthritis, An Issue of Rheumatic Disease Clinics 41-4

Author : Christopher T. Ritchlin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323413536
Total Pages : 241 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Psoriatic Arthritis, An Issue of Rheumatic Disease Clinics 41-4 by : Christopher T. Ritchlin

Download or read book Psoriatic Arthritis, An Issue of Rheumatic Disease Clinics 41-4 written by Christopher T. Ritchlin and published by Elsevier Health Sciences. This book was released on 2016-01-07 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some people with psoriasis can also develop psoriatic arthritis, when the immune system attacks the joints as well, causing inflammation. Like psoriasis, psoriatic arthritis symptoms flare and subside, vary from person to person, and even change locations in the same person over time. Psoriatic arthritis can affect any joint in the body, and it may affect just one joint, several joints or multiple joints. For example, it may affect one or both knees. This issue will include articles on Genetic and Epigenetic aspects of psoriatic arthritis, Clinical features and diagnostic considerations in psoriatic arthritis, Natural history, prognosis and socioeconomic aspects of psoriatic arthritis, Etiology and pathogenesis of psoriasis and many more!

Psoriatic and Reactive Arthritis E-Book

Author : Christopher T. Ritchlin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323070604
Total Pages : 260 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Psoriatic and Reactive Arthritis E-Book by : Christopher T. Ritchlin

Download or read book Psoriatic and Reactive Arthritis E-Book written by Christopher T. Ritchlin and published by Elsevier Health Sciences. This book was released on 2007-06-25 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork focuses on the momentous recent advances in our understanding of the genetics and immunology of psoriatic and reactive arthritis, and their implications for diagnosis and management. Leading international authorities explore new concepts in genetic and pathogenic mechanisms and early diagnosis; provide comprehensive, well-illustrated coverage of clinical features; evaluate the very latest therapeutic options, including biologics; and discuss clinical outcome measures. Examines the very latest pathogenic mechanisms and diagnostic criteria, providing the necessary tools for early diagnosis and monitoring of disease progression. Offers comprehensive coverage of the clinical manifestations of psoriatic and reactive arthritis, including a ‘mini atlas' of color plates. Examines the pros and cons of the available therapeutic options, including the very latest biological as well as traditional therapies. Includes practical discussions of clinical outcome measures, delivering ongoing tools for assessment of function, disease activity, and quality of life.

Psoriasis and Psoriatic Arthritis

Author : Kenneth B. Gordon
Publisher : Springer Science & Business Media
ISBN 13 : 9783540212805
Total Pages : 280 pages
Book Rating : 4.2/5 (128 download)

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Book Synopsis Psoriasis and Psoriatic Arthritis by : Kenneth B. Gordon

Download or read book Psoriasis and Psoriatic Arthritis written by Kenneth B. Gordon and published by Springer Science & Business Media. This book was released on 2005-02-16 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: First comprehensive book on this topic: Textbooks on psoriasis and psoriatic arthritis in one Newest information on Psoriasis. Written by well-known international experts. Well-structured with reader-friendly format.

Moderate to Severe Psoriasis, Fourth Edition

Author : John Y. M. Koo
Publisher : CRC Press
ISBN 13 : 1482215160
Total Pages : 422 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Moderate to Severe Psoriasis, Fourth Edition by : John Y. M. Koo

Download or read book Moderate to Severe Psoriasis, Fourth Edition written by John Y. M. Koo and published by CRC Press. This book was released on 2014-03-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis patient that are perfect for the dermatologist in daily practice. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics.

Comorbidity in Rheumatic Diseases

Author : Yasser El Miedany
Publisher : Springer
ISBN 13 : 3319599631
Total Pages : 439 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Comorbidity in Rheumatic Diseases by : Yasser El Miedany

Download or read book Comorbidity in Rheumatic Diseases written by Yasser El Miedany and published by Springer. This book was released on 2017-08-24 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores comorbidity in patients with rheumatic diseases and details both care and treatment options in standard clinical practice. Patients with rheumatic diseases are clinically complex, and the interplay of their disease activity with associated conditions may lead to increased morbidity and mortality. Recently there have been major advances in the management of rheumatic diseases, however, without addressing the potential comorbid conditions, including cardiovascular disease; pulmonary disease; and depression; outcomes remain poor. With its 19 chapters, covering the management of major rheumatic diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus , and osteoarthritis), potential comorbidities and treatment recommendations, as well as possible interactions between conditions; this book addresses the gap between textbook medicine and day to day patients' care. Authors also discuss the new hot issue of the comorbidity index, comparing the standard tools to the recently developed indices and how they can assist the rheumatologists in determining disease burden, prognosis, and comorbidity probability. This book is an ideal clinical guide and reference that enables rheumatologists, internal medicine physicians, and residents to address the full clinical expression of these rheumatic diseases with views towards prevention or early management of comorbid conditions.

Research of Pathogenesis and Novel Therapeutics in Arthritis

Author : Chih-Hsin Tang
Publisher : MDPI
ISBN 13 : 3038970654
Total Pages : 366 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Research of Pathogenesis and Novel Therapeutics in Arthritis by : Chih-Hsin Tang

Download or read book Research of Pathogenesis and Novel Therapeutics in Arthritis written by Chih-Hsin Tang and published by MDPI. This book was released on 2019-06-04 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.

Psoriasis and Psoriatic Arthritis

Author : Taylor & Francis Group
Publisher : CRC Press
ISBN 13 : 9781032095868
Total Pages : 350 pages
Book Rating : 4.0/5 (958 download)

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Book Synopsis Psoriasis and Psoriatic Arthritis by : Taylor & Francis Group

Download or read book Psoriasis and Psoriatic Arthritis written by Taylor & Francis Group and published by CRC Press. This book was released on 2021-06-30 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and flake off about every four weeks, but psoriasis causes new skin cells to move rapidly to the surface of the skin in days rather than weeks. Psoriasis symptoms often appear on the elbows, scalp, feet, knees, hands, or lower back, or as flaking or patches on the skin. It is most common in adults, but teenagers and children can also suffer from psoriasis. Psoriasis is not only a skin condition; it is a chronic disease of the immune system. Chronic psoriasis is associated with other health conditions such as psoriatic arthritis, several inflammatory disorders, type 2 diabetes, and cardiovascular disease. This book provides extensive coverage of psoriasis and psoriatic arthritis. It features information on epidemiology and etiology of psoriasis, pathogenesis, genetics of psoriasis, clinical manifestations, and treatment options using cutting-edge drugs including adalimumab and tofacitinib. Natural phytochemicals and nutraceuticals have demonstrated efficacy in ameliorating psoriasis. The book dedicates comprehensive coverage of nutraceutical therapeutic options including antioxidants, bioactive peptides, carotenoids, alpha lipoic acid, curcumin, and whey protein. These inexpensive natural therapeutics are not associated with any known adverse side effects.

Arthritis in Black and White

Author : Anne C. Brower
Publisher : W.B. Saunders Company
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Arthritis in Black and White by : Anne C. Brower

Download or read book Arthritis in Black and White written by Anne C. Brower and published by W.B. Saunders Company. This book was released on 1988 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of this popular book is a well-written and practical introduction to the radiographic diagnosis of articular disorders. Features numerous high-quality radiographs and a new chapter on the evaluation of the foot and ankle.

Therapy and Prevention of Atopic Dermatitis and Psoriasis

Author : Masutaka Furue
Publisher : MDPI
ISBN 13 : 3039365371
Total Pages : 274 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Therapy and Prevention of Atopic Dermatitis and Psoriasis by : Masutaka Furue

Download or read book Therapy and Prevention of Atopic Dermatitis and Psoriasis written by Masutaka Furue and published by MDPI. This book was released on 2020-12-10 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atopic dermatitis and psoriasis are common inflammatory skin diseases. The excellent therapeutic success of anti-IL-4/IL-13 biologics for atopic dermatitis and anti-TNF-α/IL-23/IL-17A biologics for psoriasis highlights the major pathogenic roles of these cytokines in the respective diseases. Although atopic dermatitis and psoriasis are distinct clinical entities, they share similar inflammatory processes, including increased Th17, Th22, and Th1 signatures. In addition to skin inflammation, both skin diseases exhibit a significant association with systemic diseases such as cardiovascular diseases, metabolic syndrome, and autoimmune diseases. In contrast to atopic dermatitis, males are more susceptible to psoriasis than females. Differential risk factors may be involved in the development and exacerbation in atopic dermatitis and psoriasis. In this issue, we will publish cutting-edge information regarding skin inflammation, clinical aspects, risk factors, microbiome, and therapeutics related to psoriatic and atopic inflammation.

European Handbook of Dermatological Treatments

Author : Andreas D. Katsambas
Publisher : Springer Science & Business Media
ISBN 13 : 3662071312
Total Pages : 830 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis European Handbook of Dermatological Treatments by : Andreas D. Katsambas

Download or read book European Handbook of Dermatological Treatments written by Andreas D. Katsambas and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermatology is a specialty in the field of medicine which constantly changes at a vast rate. Alongside technology, new drugs, methods and treatments are continuously developed for the treatment of all common skin diseases. The first edition of the European Handbook of Dermatological Treatments received an overwhelming response from dermatovenereologists all over Europe. Its easy-to-read format, which is also used for this 2nd edition, is aimed at helping the physician to obtain comprehensive information at a glance. The three main sections listed alphabetically define the different diseases, the drugs available and the various methods of treatment used in dermatological practice. Each chapter begins with a brief section of the aetiology and pathogenesis of the skin disease, and leads into the description of the clinical characteristics, the diagnosis and the differential diagnosis. Followed by a detailed discussion on treatment methods, alternative methods are covered as well. Each section ends with a reference list for further reading. This new edition provides an excellent update including the newest developments of drugs, methods and treatments in dermatological practice, maintaining the clear structure and well-proven format. It is a very comprehensive and practical guide and should not be missed by those treating patients with skin diseases.

Oxford Textbook of Psoriatic Arthritis

Author : Oliver FitzGerald
Publisher : Oxford University Press
ISBN 13 : 0192515284
Total Pages : 803 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis Oxford Textbook of Psoriatic Arthritis by : Oliver FitzGerald

Download or read book Oxford Textbook of Psoriatic Arthritis written by Oliver FitzGerald and published by Oxford University Press. This book was released on 2018-06-28 with total page 803 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psoriatic arthritis, or PsA, is now acknowledged the second most prevalent and important inflammatory arthropathy worldwide. The addition of this new textbook on PsA is a fitting and important inclusion to the Oxford Textbooks in Rheumatology series, written to reflect the significant advances in the field in recent years. With the recent advances in the understanding of pathogenesis, and the development of novel therapies, the Oxford Textbook of Psoriatic Arthritis provides a comprehensive overview of the disease. Each chapter is written by leading clinicians and scientists in the field of psoriatic arthritis, to provide a contemporary view of PsA, and a look into the future directions of research. Covering everything from epidemiology and diagnosis to genetics and pathology, detailed sections on treatment and outcomes provide an invaluable resource for the clinician. The book is also highly illustrated with both clinical images such as x-rays and histological photographs to aid clinical knowledge, and diagrams of the immunology and genetics that underlie the disease. Practical and all-inclusive, with summary boxes to distil the most important information, the Oxford Textbook of Psoriatic Arthritis will prove an invaluable resource for rheumatologists, dermatologists, trainees, and all members of the multidisciplinary team who are interested in recent advances in PsA.

Psoriatic Arthritis

Author : Dafna Gladman
Publisher : Oxford University Press
ISBN 13 : 0191014885
Total Pages : 109 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Psoriatic Arthritis by : Dafna Gladman

Download or read book Psoriatic Arthritis written by Dafna Gladman and published by Oxford University Press. This book was released on 2014-04-17 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 30 years, there has been increasing recognition of psoriatic arthritis as a distinct clinical entity. Psoriatic arthritis occurs mostly in patients with psoriasis and may affect up to 1% of the general population. It has many similarities to other forms of spondyloarthritis, and must be differentiated from related conditions. Given that most patients with psoriatic arthritis have skin and musculoskeletal diseases that significantly affect their quality of life and function, patients are ideally managed in a multidisciplinary clinic with rheumatologists, dermatologists and a nurse specialist, physical therapist and occupational therapist. Psoriatic Arthritis covers the epidemiology and diagnostic and classification criteria, describing the clinical features of the disease, including skin and nail involvement, articular, and other extra-articular manifestations. Laboratory features and imaging characteristics are covered in detail, along with co-morbidities and their impact. A comprehensive review of skin disease therapy is also provided, along with the various treatment options for joint disease, including traditional disease modifying therapy and newer biologic agents . This comprehensive yet concise and practical volume is the perfect guide to psoriatic arthritis for the busy practitioner, and will be of interest to trainees and specialists in rheumatology and dermatology.