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Author : Chun-Xiang Wang
Publisher :
ISBN 13 :
Total Pages : 292 pages
Book Rating : 4.:/5 ( download)
Download or read book Mechanisms of Malignant Progression in B Cell Lymphomagenesis written by Chun-Xiang Wang and published by . This book was released on 1999 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mourad Aribi
Publisher : BoD – Books on Demand
ISBN 13 : 178985430X
Total Pages : 163 pages
Book Rating : 4.7/5 (898 download)
Download or read book Normal and Malignant B-Cell written by Mourad Aribi and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.
Author : Dean Walton Felsher
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 ( download)
Download or read book A Murine Model for the Pathophysiology of CD5+ B-cells written by Dean Walton Felsher and published by . This book was released on 1991 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shanique Katrice Elaine Edwards
Publisher :
ISBN 13 :
Total Pages : 201 pages
Book Rating : 4.:/5 (922 download)
Download or read book Molecular Mechanisms of TRAF3-deficient B Lymphomagenesis written by Shanique Katrice Elaine Edwards and published by . This book was released on 2015 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: B cell neoplasms, including leukemias, lymphomas and myelomas, are a common type of cancer, but they remain difficult to treat. This outlines a need for a better understanding of the mechanisms by which malignant transformation occurs, in order to come up with better therapeutic strategies. Recently, TRAF3 has been shown to act as a tumor suppressor, as mice with this gene specifically deleted in B cells develop B lymphomas. TRAF3 deletion causes prolonged B cell survival, allowing other secondary oncogenic alterations to occur. To elucidate these secondary alterations, we performed microarray analyses to identify genes which are differentially expressed in mouse B lymphomas. Two such genes that I have investigated in my thesis research are MCC and Sox5, both of which are significantly upregulated specifically in malignant B cells. MCC, mutated in colorectal cancer, has been previously identified as a tumor suppressor in colorectal cancer. We discovered that in malignant B cells, MCC acts as an oncogene to promote B cell survival and proliferation by modulating the signaling network centered at PARP1 and PHB1/2. The Sox5 gene encodes a transcription factor. Interestingly, we found that the Sox5 expressed in TRAF3 /- mouse B lymphomas represents a novel isoform of Sox 5, Sox5-BLM, which regulates malignant B cell proliferation by affecting the expression of p27 and B-catenin. These two genes have the potential to be used as diagnostic markers and therapeutic targets in B cell malignancies. Based on the understanding of TRAF3 signaling mechanisms, we also conducted translational studies using anti-cancer drugs to manipulate TRAF3 downstream signaling components. We have tested drugs targeting NF-kB2 and PKCd, and found that oridonin and AD198 exhibit potent anti-tumor activities on B cell neoplasms with TRAF3 deletions or mutations. Furthermore, oridonin or AD 198 drastically potentiated the anti-cancer effects of bortezomib, an effective clinical drug for multiple myeloma. Taken together, our studies have gained new insights into the mechanisms underlying TRAF3 inactivation-initiated B lymphomagenesis, and have discovered novel therapeutic targets for B cell neoplasms. Our findings also provide a rationale for clinical evaluation of several drugs or drug combinations in the treatment of B cell malignancies.
Author : Gheorghita Isvoranu
Publisher : BoD – Books on Demand
ISBN 13 : 9535133438
Total Pages : 194 pages
Book Rating : 4.5/5 (351 download)
Download or read book Lymphocyte Updates written by Gheorghita Isvoranu and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.
Author : Domenico Coppola
Publisher : Springer Science & Business Media
ISBN 13 : 904813725X
Total Pages : 317 pages
Book Rating : 4.0/5 (481 download)
Download or read book Mechanisms of Oncogenesis written by Domenico Coppola and published by Springer Science & Business Media. This book was released on 2010-03-17 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive update on mechanisms of tumorigenesis. The first portion discusses pediatric cancer, the influence of environmental factors and oncogene activity in tumorigenesis; the second portion is structured by organ site for easy access.
Author : Katrina Kaye Hoyer
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 ( download)
Download or read book Mechanisms of Lymphomagenesis written by Katrina Kaye Hoyer and published by . This book was released on 2003 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Potter
Publisher : Springer Science & Business Media
ISBN 13 : 3642776337
Total Pages : 484 pages
Book Rating : 4.6/5 (427 download)
Download or read book Mechanisms in B-Cell Neoplasia 1992 written by Michael Potter and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Main topics covered: B-Cell Development; Immunoglobulin Gene Rearrangement; Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli- cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa- ted Lymphomas; Oncogenes and Transcriptional Factors (text to follow)
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Margarita Guenova
Publisher : BoD – Books on Demand
ISBN 13 : 178923350X
Total Pages : 212 pages
Book Rating : 4.7/5 (892 download)
Download or read book Hematology written by Margarita Guenova and published by BoD – Books on Demand. This book was released on 2018-06-27 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of blood diseases. This has in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options in hematology requires a frequent update of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research in hematological diseases with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients, as well as on some molecular and pathogenetic mechanisms and the respective translation into novel therapies.
Author : Ken H. Young
Publisher : Frontiers Media SA
ISBN 13 : 2889459810
Total Pages : 127 pages
Book Rating : 4.8/5 (894 download)
Download or read book Immunotherapy and The Regulatory Immune System in Blood Cancers: From Mechanisms to Clinical Applications written by Ken H. Young and published by Frontiers Media SA. This book was released on 2019-08-16 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : M. A. Epstein
Publisher : Springer Science & Business Media
ISBN 13 : 3642672361
Total Pages : 467 pages
Book Rating : 4.6/5 (426 download)
Download or read book The Epstein-Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Laura Soucek
Publisher : Humana
ISBN 13 : 9781071614785
Total Pages : 349 pages
Book Rating : 4.6/5 (147 download)
Download or read book The Myc Gene written by Laura Soucek and published by Humana. This book was released on 2021-05-23 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated chapters detailing recent advances in MYC research and current techniques. Chapters guide readers through protocols on how to express and purify MYC protein, X-ray crystallography, NMR, techniques to study how MYC is modified, apoptosis, senescence, proliferation, metabolic changes, translation, tumorigenesis,reprogramming, and clinical application of MYC studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Myc Gene: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Author : Gema Perez-Chacon
Publisher : Frontiers Media SA
ISBN 13 : 2889718964
Total Pages : 202 pages
Book Rating : 4.8/5 (897 download)
Download or read book Mouse Models of B Cell Malignancies written by Gema Perez-Chacon and published by Frontiers Media SA. This book was released on 2021-12-31 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
